EKS-NOL-00017
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00017
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR516.21.5E-1559791246268
StatusUnreviewed
Ensembl ProteinENSNLEP00000015550
UniProt AccessionG1RQN6;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameINSRR
Gene Synonyms/Alias INSRR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000012803ENSNLEP00000015550ENSNLET00000016339
OrganismNomascus leucogenys
Functional Description
Protein Length1301
Protein Sequence
(FASTA)
MAVPSLWPWG ACLPVIFLSL GFGLDTVEVC PSLDIRSEVA ELRQLENCSV VEGHLQILLM 60
FTATGEDFRG LSFPRLTQVT DYLLLFRVYG LESLRDLFPN LAVIRGTRLF LGYALVIFEM 120
PHLRDVALPA LGAVLRGAVR VEKNQELCHL STIDWGLLQP APGANHIVGN KLGEECADVC 180
PGVLGAAGEP CARTTFSGHT DYRCWTSSHC QRVCPCPHGL ACTARGECCH TECLGGCSQP 240
EDPRACVACR HLYFQGACLW ACPPGTYQYE SWRCVTAERC ASLHSVPGRT STFGIHQGSC 300
LAQCPSGFTR NSSSIFCHKC EGLCPKECKV GTKTIDSIQA AQDLVGCTHV EGSLILNLRQ 360
GYNLEPQLQH SLGLVETITG FLKIKHSFAL VSLGFFKNLK LIRGDAMVDG NYTLYVLDNQ 420
NLQQLGSWWA AGLTIPVGKI YFAFNPRLCL EHIYRLEEVT GTRGRQNKAE INPRTNGDRA 480
ACQTRTLRFV YNVTEADRIL LRWERYEPLE ARDLLSFIVY YKESPFQNAT EHVGPDACGT 540
QSWNLLDVEL PLSRTQEPGV TLASLKPWTQ YAVFVRAITL TTEEDSPHQG AQSPIVYLRT 600
LPAAPTVPQD VISTSNSSSH LLVRWKPPTQ RNGNLTYYLV LWQRLAEDGD LYLNDYCHRG 660
LRLPTSNNDP RFDREDGDPE AEVESDCCPC QHPPPGQVLP PLEAQEASFQ KKFENFLHNA 720
ITIPMCEERA RPVRLALPRD SGRHRRAAGP LRLGGNSSDF EIQEDKVPRE RAVLSGLRHF 780
TEYRIDIHAC NHAAHTVGCS AATFVFARTM PHRGADGIPG KVAWEASSKN SVLLRWLEPP 840
DPNGLILKYE IKYRRLGEEA TVLCVSRLRY AKFGGVHLAL LPPGNYSARV RATSLAGNGS 900
WTDSVAFYIL GPEEEDAGGL HVLLTATPVG LTLLIVLAAL GFFYGKKRNR TVYASVNPEY 960
FSASDMYVPD EWEVSREQIS IIRELGQGSF GMVYEGLARG LEAGEESTPV ALKTVNELAS 1020
PRERIEFLKE ASVMKAFKCH HVVRLLGVVS QGQPTLVIME LMTRGDLKSH LRSLRPEAEN 1080
NPGLPQPALG EMIQMAGEIA DGMAYLAANK FVHRDLAARN CMVSQDFTVK IGDFGMTRDV 1140
YETDYYRKGG KGLLPVRWMA PESLKDGIFT THSDVWSFGV VLWEIATLAE QPYQGLSNEQ 1200
VLKFVMDGGV LEELEGCPLQ LQELMSRCWQ PNPRLRPSFT HILDSIQEEL RPSFRLLSFY 1260
YSPECRGARG SLPPTDVDPD SSPNPRGASS DCSPQNGGPG Y 1301
Nucleotide Sequence
(FASTA)
ATGGCAGTGC CTAGTCTGTG GCCCTGGGGA GCATGCCTGC CTGTGATCTT CCTCTCCTTG 60
GGATTTGGCC TGGATACAGT AGAGGTGTGC CCCAGCCTGG ACATTCGCTC AGAGGTGGCA 120
GAGCTTCGTC AGCTGGAGAA CTGCAGCGTG GTGGAGGGCC ACCTGCAGAT CCTGCTCATG 180
TTCACAGCCA CGGGGGAGGA CTTCCGCGGC CTCAGCTTCC CTCGCCTCAC CCAGGTCACC 240
GACTACCTGC TGCTCTTCCG TGTCTACGGA CTGGAGAGCC TGCGCGACCT CTTCCCCAAC 300
CTAGCAGTCA TCCGCGGGAC GCGCCTCTTC CTAGGCTATG CACTGGTCAT CTTTGAGATG 360
CCACATCTGC GTGACGTGGC ACTGCCTGCG CTTGGGGCTG TGCTGCGTGG GGCTGTGCGT 420
GTGGAGAAGA ACCAGGAGCT CTGCCACCTC TCCACCATTG ATTGGGGACT GCTGCAGCCA 480
GCACCTGGCG CCAACCACAT CGTGGGCAAC AAGCTGGGCG AGGAGTGTGC TGACGTGTGC 540
CCTGGTGTGC TGGGTGCTGC TGGTGAGCCC TGTGCCAGGA CCACCTTCAG CGGGCACACT 600
GACTACAGAT GCTGGACCTC CAGCCACTGC CAGAGAGTGT GCCCCTGCCC CCATGGGCTG 660
GCTTGCACAG CGAGGGGCGA GTGCTGCCAC ACCGAATGCC TGGGGGGCTG CAGCCAGCCA 720
GAAGACCCTC GTGCCTGTGT AGCTTGCCGC CACCTCTACT TCCAGGGTGC CTGCCTGTGG 780
GCCTGCCCGC CAGGCACCTA CCAGTATGAG TCCTGGCGCT GTGTCACAGC TGAGCGCTGT 840
GCCAGCCTGC ACTCTGTGCC TGGCCGCACC TCCACCTTCG GCATACACCA GGGCAGTTGC 900
CTGGCCCAGT GCCCTTCTGG CTTCACCCGT AATAGCAGCA GCATATTCTG CCACAAGTGC 960
GAGGGGCTGT GCCCTAAAGA GTGCAAGGTA GGCACCAAGA CCATCGACTC CATCCAGGCC 1020
GCACAGGATC TTGTGGGCTG CACGCATGTG GAGGGAAGCC TCATCCTCAA CCTTCGCCAG 1080
GGCTATAACC TGGAGCCACA GCTGCAGCAC AGCCTGGGGC TGGTAGAAAC CATTACTGGC 1140
TTCCTCAAAA TCAAGCACTC CTTTGCCCTC GTGTCCCTGG GCTTTTTCAA GAATCTCAAA 1200
CTAATCCGGG GAGACGCCAT GGTGGATGGG AACTACACTC TCTACGTGCT GGACAACCAG 1260
AACCTACAGC AGCTAGGGTC CTGGTGGGCC GCGGGGCTCA CCATTCCCGT GGGCAAGATC 1320
TACTTCGCCT TCAACCCGCG CCTCTGCTTG GAGCACATCT ACCGACTGGA GGAGGTGACA 1380
GGCACGCGAG GTCGGCAGAA CAAGGCTGAG ATCAACCCCC GCACCAACGG AGACCGCGCC 1440
GCCTGCCAGA CTCGCACCCT GCGCTTCGTG TACAACGTGA CGGAGGCAGA CCGCATCCTG 1500
CTACGCTGGG AGCGCTATGA GCCACTGGAG GCCCGCGACC TGCTCAGCTT CATCGTGTAC 1560
TACAAGGAGT CCCCATTCCA GAATGCCACA GAGCACGTGG GTCCAGATGC TTGTGGAACC 1620
CAGAGCTGGA ACCTGCTGGA TGTGGAGCTG CCCCTAAGCC GCACCCAGGA GCCAGGGGTG 1680
ACCCTAGCCT CCCTCAAGCC TTGGACACAG TATGCAGTGT TTGTGAGGGC CATCACACTA 1740
ACCACTGAGG AGGACAGCCC CCATCAAGGA GCCCAGAGTC CCATCGTCTA CCTCCGAACG 1800
CTACCTGCAG CTCCCACGGT GCCCCAAGAC GTCATCTCCA CGTCCAACTC CTCCTCCCAC 1860
CTCCTGGTGC GCTGGAAGCC ACCCACCCAG CGCAATGGGA ACCTCACCTA CTACCTGGTG 1920
CTGTGGCAGC GGCTGGCAGA GGACGGCGAC CTCTACCTCA ATGACTACTG CCACCGCGGC 1980
TTGCGGCTGC CCACCAGCAA CAACGATCCG CGCTTCGACC GCGAAGACGG GGATCCTGAG 2040
GCCGAGGTGG AGTCCGACTG CTGCCCTTGC CAGCACCCAC CTCCTGGTCA GGTTCTGCCC 2100
CCGCTGGAGG CGCAAGAGGC CTCGTTCCAG AAGAAGTTTG AAAACTTTCT ACACAACGCG 2160
ATCACCATCC CCATGTGCGA AGAGCGCGCG CGGCCTGTGC GGCTCGCTCT CCCCAGGGAC 2220
TCAGGGCGGC ACCGCCGGGC AGCTGGGCCC CTCCGGCTGG GGGGCAACAG CTCGGATTTC 2280
GAGATCCAGG AGGACAAGGT GCCCCGTGAG CGAGCGGTGC TGAGCGGCCT GCGCCACTTC 2340
ACGGAATACC GGATCGATAT CCATGCCTGC AACCACGCGG CGCACACCGT GGGCTGCAGC 2400
GCCGCCACCT TCGTCTTTGC GCGCACCATG CCCCACAGAG GGGCTGATGG TATTCCAGGA 2460
AAGGTGGCCT GGGAGGCCTC CAGCAAGAAC AGCGTCCTCC TGCGCTGGCT CGAGCCACCA 2520
GACCCCAACG GACTCATCCT CAAGTACGAA ATCAAGTACC GCCGCTTGGG AGAGGAGGCC 2580
ACAGTGCTGT GTGTGTCCCG TCTTCGATAT GCGAAGTTTG GGGGAGTCCA CCTGGCCCTG 2640
CTGCCCCCTG GAAACTACTC TGCCAGGGTT AGGGCAACCT CACTGGCTGG CAATGGCTCT 2700
TGGACAGACA GTGTTGCATT CTACATCCTT GGCCCAGAGG AGGAGGATGC TGGGGGACTG 2760
CATGTCCTCC TCACTGCCAC CCCTGTGGGG CTCACGCTGC TCATCGTTCT TGCTGCCCTT 2820
GGTTTCTTCT ACGGCAAGAA GAGAAACAGA ACCGTGTATG CTTCTGTGAA TCCGGAGTAC 2880
TTCAGCGCCT CCGATATGTA CGTCCCTGAT GAATGGGAGG TGTCTCGGGA GCAGATCTCG 2940
ATAATCCGGG AACTGGGCCA GGGCTCTTTT GGGATGGTAT ATGAGGGGCT GGCACGAGGA 3000
CTTGAGGCTG GAGAGGAGTC CACACCTGTG GCCCTGAAGA CGGTGAATGA GCTGGCCAGC 3060
CCACGGGAAC GCATTGAGTT CCTCAAGGAA GCTTCTGTCA TGAAAGCCTT CAAGTGTCAC 3120
CATGTGGTGC GTCTCCTGGG TGTGGTGTCT CAGGGCCAGC CAACTCTGGT CATCATGGAG 3180
TTAATGACCC GTGGGGACCT CAAGAGCCAT CTTCGATCTT TGCGGCCTGA GGCAGAGAAC 3240
AACCCTGGGC TCCCACAGCC AGCATTGGGG GAAATGATCC AAATGGCTGG TGAGATTGCA 3300
GACGGCATGG CCTACCTTGC TGCCAACAAG TTTGTGCACC GAGATCTAGC AGCCCGCAAC 3360
TGCATGGTGT CCCAGGACTT CACCGTCAAG ATCGGGGACT TCGGGATGAC TCGGGACGTG 3420
TATGAGACAG ACTATTACCG CAAGGGTGGG AAGGGGCTGC TGCCTGTGCG CTGGATGGCC 3480
CCAGAGTCCC TCAAAGATGG GATCTTCACC ACCCACTCGG ATGTCTGGTC CTTCGGCGTG 3540
GTACTCTGGG AGATTGCCAC CCTGGCTGAA CAACCCTACC AGGGCCTGTC CAACGAGCAG 3600
GTGCTGAAGT TCGTCATGGA TGGCGGGGTC CTGGAGGAGC TGGAGGGCTG TCCCCTTCAG 3660
CTGCAGGAGC TGATGAGCCG CTGCTGGCAG CCAAACCCAC GCCTGCGCCC GTCTTTCACA 3720
CACATTCTGG ACAGCATACA GGAGGAGCTG CGGCCCTCCT TCCGCCTCCT CTCCTTCTAC 3780
TATAGCCCTG AGTGCCGGGG GGCCCGGGGC TCCCTGCCTC CCACCGATGT AGACCCTGAC 3840
TCCTCACCCA ACCCAAGAGG GGCTTCCTCA GACTGCAGCC CTCAAAATGG GGGTCCAGGG 3900
TAC 3903
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i+++relGqGsfGmvyeG+a+++++gee+t+va+ktvne as rerieflkeasvmk+fk
Q: 979   ISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRERIEFLKEASVMKAFK  1038
         6799********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120
         +hhvvrllGvvs+gqp+lv+melm++Gdlks+lrslrpe+en+++l++pal+++iqma+e
Q: 1039  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEMIQMAGE  1098
         ************************************************************
S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180
         iadGmayl+a+kfvhrdlaarncmv++d+tvkiGdfGmtrd+yetdyyrkggkgllpvrw
Q: 1099  IADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRW  1158
         ************************************************************
S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240
         m+peslkdG+ft++sdvwsfGvvlwei+tlaeqpyqGlsneqvlkfv+dggvle++e cp
Q: 1159  MAPESLKDGIFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLKFVMDGGVLEELEGCP  1218
         ************************************************************
S: 241   elltelmrlcwqynpklrpsfleivell  268
          +l+elm++cwq np+lrpsf++i++++
Q: 1219  LQLQELMSRCWQPNPRLRPSFTHILDSI  1246
         ************************9976
Domain Sequence
(FASTA)
ISIIRELGQG SFGMVYEGLA RGLEAGEEST PVALKTVNEL ASPRERIEFL KEASVMKAFK 60
CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SHLRSLRPEA ENNPGLPQPA LGEMIQMAGE 120
IADGMAYLAA NKFVHRDLAA RNCMVSQDFT VKIGDFGMTR DVYETDYYRK GGKGLLPVRW 180
MAPESLKDGI FTTHSDVWSF GVVLWEIATL AEQPYQGLSN EQVLKFVMDG GVLEELEGCP 240
LQLQELMSRC WQPNPRLRPS FTHILDSI 268
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-ANC-00014
EKS-BOT-00016
EKS-CAE-00002
EKS-CAJ-00018
EKS-CAF-00018
EKS-CAP-00017
EKS-CII-00007
EKS-CIS-00008
EKS-DAR-00020
EKS-DRM-00003
EKS-EQC-00019
EKS-FEC-00017
EKS-GAG-00015
EKS-GAA-00024
EKS-GOG-00020
EKS-HOS-00019
EKS-ICT-00018
EKS-LOA-00016
EKS-MAM-00017
EKS-MOD-00016
EKS-MUM-00016
EKS-MUP-00019
EKS-MYL-00019
EKS-ORN-00025
EKS-ORC-00016
EKS-OTG-00017
EKS-PAT-00018
EKS-PES-00018
EKS-PEM-00008
EKS-POA-00017
EKS-RAN-00018
EKS-SAH-00015
EKS-SUS-00014
EKS-TAG-00014
EKS-TAR-00024
EKS-TEN-00028
EKS-TUT-00007
EKS-XET-00017
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0071469; P:cellular response to alkalinity
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016246; Tyr_kinase_insulin-like_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00041; fn3; 1.
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 3.
SM00261; FU; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013