EKS-NOL-00335

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00335

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	444.9	7.5E-134	270	517	248

Status

Unreviewed

Ensembl Protein

ENSNLEP00000015723

UniProt Accession

G1RR57;

Protein Name

Protein Synonyms/Alias

Gene Name

FYN

Gene Synonyms/Alias

FYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000012937	ENSNLEP00000015723	ENSNLET00000016523

Organism

Nomascus leucogenys

Functional Description

Protein Length

534

Protein Sequence
(FASTA)

MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG 60

LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW 120

EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET 180

TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSEKADGLCF 240

NLTVIASSCT PQTSGLAKDA WEVARRSLCL EKKLGQGCFA EVWLGTWNGN TKVAIKTLKP 300

GTMSPESFLE EAQIMKKLKH DKLVQLYAVV SEEPIYIVTE YMNKGSLLDF LKDGEGRALK 360

LPNLVDMAAQ VAAGMAYIER MNYIHRDLRS ANILVGNGLI CKIADFGLAR LIEDNEYTAR 420

QGAKFPIKWT APEAALYGRF TIKSDVWSFG ILLTELVTKG RVPYPGMNNR EVLEQVERGY 480

RMPCPQDCPI SLHELMIHCW KKDPEERPTF EYLQSFLEDY FTATEPQYQP GENL 534

Nucleotide Sequence
(FASTA)

ATGGGCTGTG TGCAATGTAA GGATAAAGAA GCAACAAAAC TGACGGAGGA GAGGGACGGC 60

AGCCTGAACC AGAGCTCCGG GTACCGCTAT GGCACAGACC CCACCCCTCA GCACTACCCC 120

AGCTTCGGCG TGACCTCCAT CCCCAACTAC AACAACTTCC ACGCAGCCGG GGGCCAAGGA 180

CTCACTGTCT TTGGAGGTGT GAACTCTTCG TCTCACACGG GGACCTTGCG TACGAGAGGA 240

GGAACAGGAG TGACACTGTT TGTGGCCCTT TATGACTATG AAGCACGGAC AGAAGATGAC 300

CTGAGTTTTC ACAAAGGAGA AAAATTTCAA ATATTGAACA GCTCGGAAGG AGATTGGTGG 360

GAAGCCCGCT CCTTGACAAC TGGAGAGACA GGTTACATTC CCAGCAATTA TGTGGCTCCA 420

GTTGACTCTA TCCAGGCAGA AGAGTGGTAC TTTGGAAAAC TTGGCCGAAA AGATGCTGAG 480

CGACAGCTAT TGTCCTTTGG AAACCCAAGA GGTACCTTTC TTATCCGCGA GAGTGAAACC 540

ACCAAAGGTG CCTATTCACT TTCCATCCGT GATTGGGATG ATATGAAAGG AGACCATGTC 600

AAACATTATA AAATTCGCAA ACTTGACAAT GGTGGATACT ACATTACCAC CCGGGCCCAG 660

TTTGAAACAC TTCAGCAGCT TGTACAACAT TACTCAGAGA AAGCTGATGG TTTGTGTTTT 720

AACTTAACTG TGATTGCATC GAGTTGTACC CCACAAACTT CTGGATTGGC TAAAGATGCT 780

TGGGAAGTTG CACGTCGTTC GTTGTGTCTG GAGAAGAAGC TGGGTCAGGG GTGTTTCGCT 840

GAAGTGTGGC TTGGTACCTG GAATGGAAAC ACAAAAGTAG CCATAAAGAC TCTTAAACCA 900

GGCACAATGT CCCCCGAATC ATTCCTTGAG GAAGCGCAGA TCATGAAGAA GCTGAAGCAC 960

GACAAGCTGG TCCAGCTCTA CGCAGTGGTG TCTGAGGAGC CCATCTACAT CGTCACCGAG 1020

TATATGAATA AAGGAAGTTT ACTGGATTTC TTAAAAGATG GGGAAGGAAG AGCTCTGAAA 1080

TTACCAAATC TTGTGGACAT GGCAGCACAG GTGGCTGCAG GAATGGCTTA CATCGAGCGC 1140

ATGAATTATA TCCATAGAGA TCTGCGATCA GCAAACATTC TAGTGGGGAA TGGACTCATA 1200

TGCAAGATTG CTGACTTCGG ATTGGCCCGA TTGATCGAAG ACAATGAATA CACAGCAAGA 1260

CAAGGTGCAA AGTTCCCCAT CAAGTGGACG GCCCCCGAGG CAGCCCTGTA CGGGAGGTTC 1320

ACAATCAAGT CTGACGTGTG GTCTTTTGGA ATCTTACTCA CAGAGCTGGT CACCAAAGGA 1380

AGAGTGCCAT ACCCAGGCAT GAACAACCGG GAGGTGCTGG AGCAGGTGGA GCGAGGCTAC 1440

AGGATGCCCT GCCCGCAGGA CTGCCCCATC TCTCTGCATG AGCTCATGAT CCACTGCTGG 1500

AAAAAGGACC CTGAAGAGCG CCCCACTTTT GAGTACTTGC AGAGCTTCCT GGAAGACTAC 1560

TTTACCGCGA CAGAGCCCCA GTACCAACCT GGTGAAAACC TGTAA 1605

Domain Profile

S: 3     lvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklyav  62

         l+kklG+G+f evwlg+w+g++kva+ktlk+gt+spe+fleeaqi+kkl+h+klv+lyav

Q: 270   LEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAV  329

         89**********************************************************

S: 63    vseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrdl  122

         vse ePiyivte+m+kGslldflk+ eg++lklp+lvd+aaqva+Gmay+e++n+ihrdl

Q: 330   VSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDL  388

         **9.********************************************************

S: 123   aarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvWs  182

         +++n+lvg+ l++k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdvWs

Q: 389   RSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS  448

         ************************************************************

S: 183   fGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeerP  242

         fGillte+vtkG+vPypGm+n+evleqvergyr+p+p++cp +l+el+++cwkkdpeerP

Q: 449   FGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERP  508

         ************************************************************

S: 243   tfetlqevl  251

         tfe+lq++l

Q: 509   TFEYLQSFL  517

         ******986

Domain Sequence
(FASTA)

LEKKLGQGCF AEVWLGTWNG NTKVAIKTLK PGTMSPESFL EEAQIMKKLK HDKLVQLYAV 60

VSEEPIYIVT EYMNKGSLLD FLKDGEGRAL KLPNLVDMAA QVAAGMAYIE RMNYIHRDLR 120

SANILVGNGL ICKIADFGLA RLIEDNEYTA RQGAKFPIKW TAPEAALYGR FTIKSDVWSF 180

GILLTELVTK GRVPYPGMNN REVLEQVERG YRMPCPQDCP ISLHELMIHC WKKDPEERPT 240

FEYLQSFL 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005768	; C:endosome
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0050852	; P:T cell receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013