EKS-NOL-00340

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00340

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	421.5	9.9E-127	234	487	254

Status

Unreviewed

Ensembl Protein

ENSNLEP00000015863

UniProt Accession

G1RRJ9;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000013075	ENSNLEP00000015863	ENSNLET00000016673

Organism

Nomascus leucogenys

Functional Description

Protein Length

505

Protein Sequence
(FASTA)

MSNICQRLWD YLEHYLPCLS TEADKSTVIE NPGAHCSPQS QRHGHYFVAL FDYQARTAED 60

LSFRAGDKLQ VLDTSHEGWW FARHLEKRRD GSSQQLQGYI PSNYVAEDRS LQAEPWFFGA 120

IGRSDAEKQL LYSENKTGAF LIRESESQKG EFSLSVLDGA VVKHYRIKRL DEGGFFLTRR 180

RTFSTLNEFV SHYTKTSDGL CVKLGKPCLK IQVPAPFDLS YKTVDQWEID RNSIQLLKRL 240

GSGQFGEVWE GLWNNTTPVA VKTLKPGSMD PDDFLREAQI MKNLRHPKLI QLYAVCTLED 300

PIYIITELMR HGSLQEYLQN DAGSKIHLTQ QVDIAAQVAS GMAYLESRNY IHRDLAARNV 360

LVGEHNIYKV ADFGLARVFK VDNEDIYESK HEIKLPVKWT APEAIRTNKF SIKSDVWSFG 420

ILLYEIITYG KMPYSGMTGA QVIQMLAQNY RLPQPSNCPQ QFYNIMLECW NAEPKERPTF 480

ETLHWKLEDY FETDSSYSDA NNFIR 505

Nucleotide Sequence
(FASTA)

ATGAGCAACA TCTGTCAGAG GCTCTGGGAT TACCTAGAAC ACTATCTCCC CTGTTTGTCC 60

ACGGAGGCAG ACAAGTCAAC CGTGATTGAA AATCCAGGGG CCCATTGCTC TCCCCAGTCA 120

CAGAGGCATG GCCACTACTT TGTGGCTTTG TTTGATTACC AGGCTCGGAC TGCTGAGGAC 180

TTGAGCTTCC GGGCAGGTGA CAAACTTCAA GTTCTGGACA CTTCGCATGA GGGCTGGTGG 240

TTTGCCAGAC ACTTGGAGAA AAGACGAGAT GGCTCCAGTC AGCAACTACA GGGCTATATT 300

CCGTCTAACT ACGTGGCTGA GGACAGAAGC CTACAGGCAG AGCCGTGGTT CTTTGGAGCA 360

ATTGGAAGAT CAGATGCAGA GAAACAACTG TTATATTCAG AAAACAAGAC GGGTGCCTTT 420

CTAATCAGAG AAAGTGAAAG CCAAAAAGGA GAATTCTCTC TTTCAGTTTT AGATGGAGCA 480

GTTGTAAAAC ACTACAGAAT TAAAAGACTG GATGAAGGGG GCTTTTTTCT CACGCGGAGA 540

AGAACCTTTT CAACACTGAA CGAATTTGTG AGCCACTACA CCAAGACAAG TGACGGCCTG 600

TGTGTCAAGC TGGGGAAACC ATGCTTAAAG ATCCAGGTCC CAGCTCCATT TGATTTGTCG 660

TATAAAACCG TGGACCAATG GGAGATAGAC CGCAACTCCA TACAGCTTCT AAAGCGATTG 720

GGATCTGGTC AGTTTGGCGA AGTATGGGAA GGTCTGTGGA ACAATACCAC TCCAGTAGCA 780

GTGAAAACAT TAAAACCAGG TTCGATGGAT CCAGATGACT TCCTGAGGGA GGCACAGATA 840

ATGAAGAACC TAAGACATCC AAAGCTTATC CAGCTTTATG CTGTTTGCAC TTTAGAAGAT 900

CCAATTTATA TTATTACAGA GTTGATGAGA CATGGAAGTC TGCAAGAATA TCTCCAAAAT 960

GACGCCGGAT CAAAAATCCA TCTGACTCAA CAGGTAGACA TAGCGGCACA GGTTGCCTCT 1020

GGAATGGCCT ATCTGGAGTC TCGGAACTAC ATTCACAGAG ATCTGGCTGC CAGAAATGTC 1080

CTCGTTGGTG AACATAATAT CTACAAAGTA GCAGATTTTG GACTTGCCAG AGTTTTTAAG 1140

GTAGATAATG AAGACATCTA TGAATCTAAA CACGAAATAA AGCTGCCGGT GAAGTGGACT 1200

GCGCCTGAAG CCATTCGTAC TAATAAATTC AGCATTAAGT CCGATGTGTG GTCATTTGGA 1260

ATCCTTCTTT ATGAAATCAT TACTTATGGC AAAATGCCTT ACAGTGGTAT GACAGGTGCC 1320

CAGGTAATCC AGATGTTGGC TCAAAACTAT AGACTTCCGC AACCATCCAA CTGTCCACAG 1380

CAGTTTTACA ACATCATGTT GGAGTGCTGG AATGCAGAGC CTAAGGAACG ACCTACATTT 1440

GAGACACTGC ATTGGAAACT TGAAGACTAT TTTGAAACAG ACTCTTCATA TTCAGATGCA 1500

AATAACTTCA TAAGATGA 1518

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         ++l+k+lG+GqfGevw+g+w+++++vavktlk+g+++p++fl+eaqi+k+lrh+kl++ly

Q: 234   IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPDDFLREAQIMKNLRHPKLIQLY  293

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyi+telm++Gsl+++l+++ g+k++l+++vd+aaqva+Gmayle++n+ihr

Q: 294   AVCTLEDPIYIITELMRHGSLQEYLQNDAGSKIHLTQQVDIAAQVASGMAYLESRNYIHR  353

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++kvadfGlar+++   +d+y++k++ klP+kWtaPeai+++kf+ik

Q: 354   DLAARNVLVGEHNIYKVADFGLARVFKvdnEDIYESKHEIKLPVKWTAPEAIRTNKFSIK  413

         ************************998878999***************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t+Gk+Py+Gmt ++v++++ ++yrlp+p++cp+++y+++lecw+++

Q: 414   SDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAE  473

         ************************************************************

S: 238   peerPtfetlqevl  251

         p+erPtfetl+++l

Q: 474   PKERPTFETLHWKL  487

         **********9986

Domain Sequence
(FASTA)

IQLLKRLGSG QFGEVWEGLW NNTTPVAVKT LKPGSMDPDD FLREAQIMKN LRHPKLIQLY 60

AVCTLEDPIY IITELMRHGS LQEYLQNDAG SKIHLTQQVD IAAQVASGMA YLESRNYIHR 120

DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYESKHEI KLPVKWTAPE AIRTNKFSIK 180

SDVWSFGILL YEIITYGKMP YSGMTGAQVI QMLAQNYRLP QPSNCPQQFY NIMLECWNAE 240

PKERPTFETL HWKL 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013