EKS-NOL-00394

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00394

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	377.2	4.5E-113	9	271	263

Status

Unreviewed

Ensembl Protein

ENSNLEP00000016149

UniProt Accession

G1RSC6;

Protein Name

Protein Synonyms/Alias

Gene Name

ULK2

Gene Synonyms/Alias

ULK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000013195	ENSNLEP00000016149	ENSNLET00000016974

Organism

Nomascus leucogenys

Functional Description

Protein Length

1036

Protein Sequence
(FASTA)

MEEVGDFEYS KRDLVPPGAF SAVFRGGHRQ KTDWEVAIKS INKKNLSKSQ ILLGKEIKIL 60

KELQHENIVA LYDVQELPNS VFLVMEYCNG GDLADYLQAK GTLSEDTISV FLHQIAAAMR 120

ILHSKGIIHR DLKPQNILLS YASRRKSSIS GIRIKIADFG FARYLHSNMM AATLCGSPMY 180

MAPEVIMSQH YDAKADLWSI GTVIYQCLVG KPPFQANSPQ DLRMFYEKNR SLMPSIPRET 240

SPYLANLLLG LLQRNQKDRM DFEAFFSHPF LEQVPVKKSC PVPVPVYSGS VSGSSCGSSP 300

SCRFASPPSL PDMQHIQEEN LSSPPLGPPN YLQVSKDSAS TSSKNSSCDT DDFVLVPHNI 360

SSDHSYDMPM GTAGRRASNE FLVCGGQCQP TVSPHSETAP IPVPTQIRNY QRIEQNLTST 420

ASSGTNVHGS PRSAVVRRSN TSPMGFLRLG SCSPVPADTA QTVGRRLSTG SSRPYSPSPL 480

VGTIPEQFSQ CCCGHPQGHD SRSRNSSGSP VPQAQSPQSL LLGARLQSAP TLTDIYQNKQ 540

KLRKQHSDPV CPSHTGAGYS YSPQPSRPGS LGTSPTKHLG SSPRSSDWFF KTPLPTIIGS 600

PTKTTAPFKI PKTQASSNLL ALVTRHGPAE EQSKDGNEPR ECAHCLLVQG SERQRAEQQS 660

KAVFGRSVST GKLSDQQGKT PICRHQGSTD SLSTERPMDI APAGACGGVL APPAGTAASS 720

RAVLFTVGSP PHSAAAPTCT HMFLQTRTTS VGPSNSGGSL CAMSGRVCMG SPPGPGFGSS 780

PPGAEAAPSL RYVPYGASPP SLEGLITFEA PELPEETLME REHTDTLHHL NVMLMFTECV 840

LDLTAMRGGN PELYTSAVSL YQIQESVVVD QISQLSKDWG RVEQLVLYMK AAQLLAASLH 900

LAKAQIKSGK LSPSTAVKQV VKNLNERYKF CITMCKKLTE KLNRFFSDKQ RFIDEINSVT 960

AEKLIYNCAV EMVQSAALDE MFQQTEDIVY RYHKAALLLE GLSKILQDPG DIENVHKYKC 1020

SIERRLSALC HSTATV 1036

Nucleotide Sequence
(FASTA)

ATGGAGGAGG TGGGCGACTT CGAGTACAGC AAGAGGGATC TCGTGCCACC CGGGGCCTTC 60

TCCGCGGTCT TCCGGGGTGG GCATCGCCAG AAAACTGATT GGGAGGTAGC TATTAAAAGT 120

ATTAATAAAA AGAACTTGTC AAAATCACAG ATACTGCTTG GAAAGGAAAT TAAAATCTTA 180

AAGGAACTTC AGCATGAAAA TATTGTAGCA CTCTATGATG TTCAGGAATT ACCCAACTCT 240

GTCTTTTTGG TGATGGAGTA TTGCAATGGT GGAGACCTCG CAGATTATTT GCAAGCGAAA 300

GGAACTCTCA GTGAAGATAC CATCAGCGTG TTTCTGCATC AGATTGCTGC TGCCATGCGA 360

ATTCTGCACA GCAAAGGAAT CATCCACAGA GATCTCAAAC CACAGAACAT CTTGCTGTCC 420

TATGCCAGTC GCAGAAAATC AAGCATCAGT GGTATTCGCA TCAAAATAGC GGATTTTGGT 480

TTTGCTCGTT ACCTACATAG TAACATGATG GCTGCAACAC TGTGTGGATC CCCGATGTAC 540

ATGGCTCCTG AGGTTATTAT GTCTCAACAT TATGATGCTA AGGCTGACTT GTGGAGCATA 600

GGAACAGTGA TATACCAATG CCTAGTTGGA AAACCACCTT TTCAGGCCAA TAGTCCTCAA 660

GACTTAAGGA TGTTTTATGA AAAAAACAGG AGCTTAATGC CTAGTATTCC CAGAGAAACA 720

TCACCTTATT TGGCCAATCT CCTTTTGGGT TTGCTTCAGA GAAACCAAAA AGATAGAATG 780

GACTTTGAAG CATTTTTTAG CCATCCTTTT CTTGAACAAG TTCCAGTAAA AAAATCTTGC 840

CCAGTTCCAG TGCCCGTGTA TTCTGGTTCT GTCTCTGGAA GCTCCTGTGG CAGCTCTCCA 900

TCTTGCCGTT TTGCTTCTCC ACCATCCCTT CCAGATATGC AGCATATTCA GGAAGAAAAC 960

TTATCTTCCC CACCATTGGG TCCTCCCAAC TATCTACAAG TTTCCAAAGA TTCTGCCAGT 1020

ACTAGTAGCA AGAACTCTTC TTGTGACACG GATGACTTTG TTTTGGTGCC ACACAACATC 1080

TCGTCAGACC ACTCATATGA TATGCCAATG GGGACTGCTG GCAGACGTGC TTCAAATGAG 1140

TTCTTGGTGT GTGGAGGGCA GTGTCAGCCT ACTGTGTCAC CTCACAGCGA AACAGCACCA 1200

ATTCCAGTTC CTACTCAAAT AAGGAATTAT CAGCGCATAG AGCAGAATCT TACATCTACT 1260

GCCAGCTCAG GCACAAATGT ACATGGTTCT CCAAGATCTG CAGTGGTACG AAGGTCCAAC 1320

ACCAGCCCCA TGGGCTTCCT CCGGCTGGGA TCATGTTCCC CGGTGCCAGC AGACACAGCA 1380

CAGACAGTTG GACGAAGGCT CTCGACTGGG TCTTCTAGGC CTTACTCACC TTCCCCTTTG 1440

GTTGGTACCA TTCCTGAGCA ATTCAGTCAG TGCTGCTGTG GGCATCCTCA GGGCCATGAC 1500

TCCAGGAGTA GAAACTCCTC AGGTTCTCCA GTGCCACAAG CTCAGTCACC ACAGTCTCTC 1560

TTATTGGGTG CTAGACTGCA GAGCGCCCCC ACCCTCACTG ACATCTATCA GAACAAGCAG 1620

AAGCTCAGAA AACAGCACTC TGACCCCGTG TGCCCATCCC ATACTGGGGC TGGGTACAGC 1680

TACTCGCCTC AGCCCAGTCG GCCTGGCAGC CTTGGAACTT CTCCCACCAA GCACTTGGGG 1740

TCCTCTCCAC GGAGTTCTGA CTGGTTCTTT AAAACTCCTT TGCCAACAAT CATTGGCTCT 1800

CCTACTAAGA CCACAGCTCC TTTCAAAATC CCTAAAACGC AAGCATCTTC CAACCTGTTA 1860

GCCTTGGTTA CTCGTCATGG GCCTGCTGAA GAACAGTCCA AAGATGGGAA TGAGCCACGG 1920

GAATGTGCCC ATTGCCTCTT AGTGCAAGGA AGTGAGAGGC AGCGGGCCGA GCAGCAGAGC 1980

AAGGCAGTGT TTGGCAGATC TGTCAGTACT GGGAAGTTAT CAGATCAACA AGGAAAGACT 2040

CCTATATGTC GACATCAGGG CAGCACAGAC AGTTTAAGTA CAGAACGACC AATGGATATA 2100

GCTCCGGCAG GAGCCTGTGG TGGTGTTCTG GCACCTCCTG CAGGTACAGC AGCAAGTTCC 2160

AGGGCTGTCC TCTTCACTGT AGGGTCTCCT CCACACAGTG CAGCGGCTCC CACTTGTACC 2220

CACATGTTCC TTCAAACAAG AACAACCTCA GTGGGGCCCA GCAACTCCGG GGGCTCTCTG 2280

TGTGCCATGA GTGGCCGCGT GTGCATGGGG TCCCCGCCTG GCCCAGGCTT CGGCTCTTCC 2340

CCTCCAGGAG CAGAGGCAGC TCCCAGCCTG AGATACGTGC CTTATGGTGC TTCACCCCCC 2400

AGCCTAGAGG GGCTCATCAC CTTTGAAGCC CCTGAACTGC CGGAGGAGAC GCTGATGGAG 2460

CGGGAACACA CAGACACCTT ACACCATCTG AATGTGATGC TGATGTTCAC TGAGTGTGTG 2520

CTGGACCTGA CAGCCATGAG GGGAGGAAAC CCTGAGCTGT ACACATCTGC TGTGTCCTTG 2580

TACCAGATCC AGGAGAGTGT GGTGGTGGAC CAGATCAGTC AGCTGAGCAA AGACTGGGGG 2640

CGGGTGGAGC AGCTGGTATT GTACATGAAA GCAGCACAGC TGCTTGCGGC TTCTCTGCAT 2700

CTTGCCAAAG CCCAGATCAA GTCCGGGAAA CTGAGCCCAT CCACAGCTGT GAAACAAGTT 2760

GTCAAGAATC TGAATGAACG ATACAAATTC TGCATCACCA TGTGCAAGAA ACTTACAGAA 2820

AAGCTGAATC GATTCTTCTC TGACAAACAG AGGTTTATTG ATGAAATCAA CAGTGTGACT 2880

GCAGAGAAAC TCATCTATAA TTGTGCTGTA GAAATGGTTC AGTCTGCAGC CCTGGATGAG 2940

ATGTTTCAGC AGACCGAAGA TATTGTTTAT CGCTATCATA AGGCAGCCCT TCTTTTGGAA 3000

GGCCTAAGTA AGATTCTACA GGACCCTGGA GATATTGAAA ATGTGCATAA ATATAAATGT 3060

AGTATTGAGA GAAGACTGTC AGCGCTCTGC CATAGCACCG CAACCGTGTG A 3111

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkklkkslenlekeikilkelkheni  60

         ys+++ +  G+f+ v++g +r+kt+++vAik+++kk+l+ks+  l keikilkel+heni

Q: 9     YSKRDLVPPGAFSAVFRGGHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENI  68

         78999999****************************************************

S: 61    valldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskkiv  120

         val+dv+e  ++v+lvmeyc+ggdLa++l++k++Lsedt+ +fl+q+a+a+++Lhsk+i+

Q: 69    VALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTISVFLHQIAAAMRILHSKGII  128

         ************************************************************

S: 121   hrDlkPqniLlsyadakk.elkkvtlkladFglarvlkeesmaatlkGsplYmaPEvvke  179

         hrDlkPqniLlsya+++k +++ +++k+adFg+ar+l++++maatl+Gsp+YmaPEv+++

Q: 129   HRDLKPQNILLSYASRRKsSISGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMS  188

         **************999989****************************************

S: 180   qqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdll  239

         q+ydakaDlWSiGt++y++lvGkpPf+a+s+++L++++ekn++l+p+ip+e+s+ l++ll

Q: 189   QHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLL  248

         ************************************************************

S: 240   qsLLqrdpkkRisfeelfahpfl  262

          +LLqr++k+R++fe +f+hpfl

Q: 249   LGLLQRNQKDRMDFEAFFSHPFL  271

         *********************96

Domain Sequence
(FASTA)

YSKRDLVPPG AFSAVFRGGH RQKTDWEVAI KSINKKNLSK SQILLGKEIK ILKELQHENI 60

VALYDVQELP NSVFLVMEYC NGGDLADYLQ AKGTLSEDTI SVFLHQIAAA MRILHSKGII 120

HRDLKPQNIL LSYASRRKSS ISGIRIKIAD FGFARYLHSN MMAATLCGSP MYMAPEVIMS 180

QHYDAKADLW SIGTVIYQCL VGKPPFQANS PQDLRMFYEK NRSLMPSIPR ETSPYLANLL 240

LGLLQRNQKD RMDFEAFFSH PFL 263

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0034045	; C:pre-autophagosomal structure membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0010506	; P:regulation of autophagy

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR022708	; Ser/Thr_kinase_C.

Pfam

PF12063	; DUF3543; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013