EKS-NOL-00257

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00257

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	452.4	6.2E-136	204	491	288

Status

Unreviewed

Ensembl Protein

ENSNLEP00000017194

UniProt Accession

G1RVC0;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1B

Gene Synonyms/Alias

BMPR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000014109	ENSNLEP00000017194	ENSNLET00000018057
ENSNLEG00000014109	ENSNLEP00000017197	ENSNLET00000018060

Organism

Nomascus leucogenys

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

MLLRSAGKLN VGTKKEDGES TAPTPRPKVL RCKCHHHCPE DSVNNICSTD GYCFTMIEED 60

DSGMPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD 120

GPIHHKALLI SVTVCSLLLV LIILFCYFRY KRQETRPRYS IGLEQDETYI PPGESLRDLI 180

EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 240

WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDTKS 300

MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD 360

TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEV ARRCVSGGIV 420

EEYQLPYHDL VPSDPSYEDM REIVCIKKLR PSFPNRWSSD ECLRQMGKLM TECWAHNPAS 480

RLTALRVKKT LAKMSESQDI KL 502

Nucleotide Sequence
(FASTA)

ATGCTTTTGC GAAGTGCAGG AAAATTAAAC GTGGGCACCA AGAAAGAGGA TGGTGAGAGT 60

ACAGCTCCCA CCCCCCGTCC AAAGGTCTTG CGTTGTAAAT GCCACCACCA TTGTCCAGAA 120

GACTCAGTCA ACAATATTTG CAGCACAGAC GGATATTGTT TCACGATGAT AGAAGAGGAT 180

GACTCTGGGA TGCCTGTGGT CACTTCTGGA TGCCTAGGAC TAGAAGGCTC AGATTTTCAG 240

TGTCGGGACA CTCCCATTCC TCATCAAAGA AGATCAATTG AATGCTGCAC AGAAAGGAAT 300

GAATGTAATA AAGACCTGCA CCCTACACTG CCTCCATTGA AAAACAGAGA CTTTGTTGAT 360

GGACCTATAC ACCACAAGGC TTTACTTATA TCTGTGACTG TCTGTAGTTT GCTCTTGGTC 420

CTTATCATTT TATTTTGTTA CTTCCGGTAT AAAAGACAAG AAACCAGACC TCGATACAGC 480

ATTGGGTTAG AACAGGATGA AACTTACATT CCTCCTGGAG AATCCCTGAG AGACTTAATT 540

GAGCAGTCTC AGAGCTCAGG AAGTGGGTCA GGCCTCCCTC TGCTGGTCCA AAGGACTATA 600

GCTAAGCAGA TTCAGATGGT GAAACAGATT GGAAAAGGTC GCTATGGGGA AGTTTGGATG 660

GGAAAGTGGC GTGGCGAAAA GGTAGCTGTG AAAGTGTTCT TCACCACAGA GGAAGCCAGC 720

TGGTTCAGAG AGACAGAAAT ATATCAGACA GTGTTGATGA GGCATGAAAA CATTTTGGGT 780

TTCATTGCTG CAGATATCAA AGGGACAGGG TCCTGGACCC AGTTGTACCT AATCACAGAC 840

TATCATGAAA ATGGTTCTCT TTATGATTAT CTGAAGTCCA CCACCCTAGA CACTAAATCA 900

ATGCTGAAGT TAGCCTACTC TTCTGTCAGT GGCTTATGTC ATTTACACAC AGAAATCTTT 960

AGTACTCAAG GCAAACCAGC AATTGCCCAT CGAGATCTGA AAAGTAAAAA CATTCTGGTG 1020

AAGAAAAATG GAACTTGCTG TATTGCTGAC CTGGGCCTGG CTGTTAAATT TATTAGTGAT 1080

ACAAATGAAG TTGACATACC ACCTAACACT CGAGTTGGCA CCAAACGCTA TATGCCTCCA 1140

GAAGTGTTGG ACGAGAGCTT GAACAGAAAT CACTTCCAGT CTTACATCAT GGCTGACATG 1200

TATAGTTTTG GCCTCATCCT TTGGGAGGTT GCTAGGAGAT GTGTATCAGG AGGTATAGTG 1260

GAAGAATACC AGCTTCCTTA TCATGACCTA GTGCCCAGTG ACCCCTCTTA TGAGGACATG 1320

AGGGAGATTG TGTGCATCAA GAAGTTGCGC CCCTCATTCC CAAACCGGTG GAGCAGTGAT 1380

GAGTGTCTAA GGCAGATGGG GAAACTCATG ACAGAATGCT GGGCTCACAA TCCTGCATCA 1440

AGGCTGACAG CCCTGCGGGT TAAGAAAACA CTTGCCAAAA TGTCAGAGTC CCAGGACATT 1500

AAACTCTGA 1509

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 204   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  263

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld++++l+la+s +sGl+hLH+ei+ t+

Q: 264   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTKSMLKLAYSSVSGLCHLHTEIFSTQ  323

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 324   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  381

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWEva+Rc + +++veey+lp+++ v+sdPs+e+m

Q: 382   VLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS-GGIVEEYQLPYHDLVPSDPSYEDM  440

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +e+v+ kklrP++p++w+++e+l+++ kl++ecW+++p++Rltalrvkk+l

Q: 441   REIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL  491

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDTKSMLK LAYSSVSGLC HLHTEIFSTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL 180

DESLNRNHFQ SYIMADMYSF GLILWEVARR CVSGGIVEEY QLPYHDLVPS DPSYEDMREI 240

VCIKKLRPSF PNRWSSDECL RQMGKLMTEC WAHNPASRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0035108	; P:limb morphogenesis
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0023014	; P:signal transduction by phosphorylation
GO:0001501	; P:skeletal system development

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013