EKS-NOL-00298
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00298
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20325.91.8E-97453700248
StatusUnreviewed
Ensembl ProteinENSNLEP00000017513
UniProt AccessionG1RW86;
Protein Name
Protein Synonyms/Alias
Gene NamePAK7
Gene Synonyms/Alias PAK7;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000014377ENSNLEP00000017513ENSNLET00000018387
OrganismNomascus leucogenys
Functional Description
Protein Length719
Protein Sequence
(FASTA)
MFGKKKKKIE ISGPSNFEHR VHTGFDPQEQ KFTGLPQQWH SLLADTANRP KPMVDPSCIT 60
PIQLAPMKTI VRGNKPCKET SINGLLEDFD NISVTRSNSL RKESPPTPDQ GASSHGPGHG 120
EENGFITFSQ YSSESDTTAD YTTEKYREKS LYGDDLDPYY RGSHAAKQNG HVMKMKHGEA 180
YYSEIKPLKS DFARFSADYH SHLDSLSKPS EYSDLKWEYQ RASSSSPLDY SFQFTPSRTA 240
GTSGCSKESL AYSESEWGPS LDDYDRRPKS SYLNQMSPQP TMRQRSRSGS GLQEPMMPFG 300
ASAFKTHPQG HSYNSYTYPR LSEPTMCIPK VDYDRAQMVL SPPLSGSDTY PRGPAKLPQS 360
QSKSGYSSSS HQYPSGYHKA TLYHHPSLQS SSQYISTASY LSSLSLSSST YPPPSWGSSS 420
DQQPSRVSHE QFRAALQLVV SPGDPREYLD NFIKIGEGST GIVCIATEKH TGKQVAVKKM 480
DLRKQQRREL LFNEVVIMRD YHHDNVVDMY NSYLVGDELW VVMEFLEGGA LTDIVTHTRM 540
NEEQIATVCL SVLRALSYLH NQGVIHRDIK SDSILLTSDG RIKLSDFGFC AQVSKEVPKR 600
KSLVGTPYWM APEVISRLPY GTEVDIWSLG IMVIEMIDGE PPYFNEPPLQ AMRRIRDSLP 660
PRVKDLHKVS SVLRGFLDLM LVREPSQRAT AQELLRHPFL KLAGPPSCIV PLMRQYRHH 719
Nucleotide Sequence
(FASTA)
ATGTTTGGGA AGAAAAAGAA AAAGATTGAA ATATCTGGCC CATCCAACTT TGAACACAGG 60
GTTCATACTG GGTTTGATCC ACAAGAGCAG AAGTTTACCG GCCTTCCCCA GCAGTGGCAC 120
AGCCTGTTAG CAGATACGGC CAACAGGCCA AAGCCTATGG TGGACCCTTC ATGCATCACA 180
CCCATCCAGC TGGCTCCTAT GAAGACAATC GTTAGAGGAA ACAAACCCTG CAAGGAAACC 240
TCCATCAACG GCCTGCTAGA GGATTTTGAC AACATCTCGG TGACTCGCTC CAACTCCCTA 300
AGGAAAGAAA GCCCACCCAC CCCAGATCAG GGAGCCTCCA GCCACGGTCC AGGCCACGGG 360
GAAGAAAATG GCTTCATCAC CTTCTCCCAG TATTCCAGCG AATCCGATAC TACTGCTGAC 420
TACACGACCG AAAAGTACAG AGAGAAGAGT CTCTATGGAG ACGATCTGGA TCCGTATTAT 480
AGAGGCAGCC ACGCAGCCAA GCAAAATGGG CACGTAATGA AAATGAAGCA CGGGGAGGCC 540
TACTATTCTG AGATAAAGCC TTTGAAATCC GATTTTGCCA GATTTTCTGC CGATTATCAC 600
TCACATTTGG ACTCGCTGAG CAAACCAAGT GAATATAGTG ACCTCAAGTG GGAGTATCAG 660
AGAGCCTCGA GTAGCTCCCC TCTGGATTAT TCATTCCAAT TCACACCTTC TAGAACTGCA 720
GGGACCAGTG GGTGCTCCAA GGAGAGCCTG GCATACAGTG AAAGTGAATG GGGACCCAGC 780
CTGGATGACT ATGACAGGAG GCCAAAGTCT TCGTACCTGA ATCAGATGAG CCCTCAGCCC 840
ACCATGCGGC AGAGGTCCAG GTCAGGCTCG GGACTCCAGG AACCGATGAT GCCATTTGGA 900
GCAAGTGCAT TTAAAACCCA TCCCCAAGGA CACTCCTACA ACTCCTACAC CTACCCTCGC 960
TTGTCCGAGC CCACAATGTG CATTCCAAAG GTGGATTATG ATCGAGCACA GATGGTCCTC 1020
AGCCCTCCAC TGTCAGGGTC TGACACCTAC CCCAGGGGCC CTGCCAAACT ACCTCAAAGT 1080
CAAAGCAAAT CGGGCTATTC CTCAAGCAGT CACCAGTACC CGTCTGGGTA CCACAAAGCC 1140
ACCTTGTACC ATCACCCCTC CCTGCAGAGC AGTTCGCAGT ACATCTCCAC GGCTTCCTAC 1200
CTGAGCTCCC TCAGCCTCTC ATCCAGCACC TACCCGCCGC CCAGCTGGGG CTCCTCCTCC 1260
GACCAGCAGC CCTCCAGGGT GTCCCATGAA CAGTTTCGGG CGGCCCTGCA GCTGGTGGTC 1320
AGCCCAGGAG ACCCCAGGGA ATACTTGGAC AACTTTATCA AAATCGGGGA AGGCTCCACC 1380
GGCATCGTAT GCATCGCCAC CGAGAAACAC ACAGGGAAAC AAGTTGCAGT GAAGAAAATG 1440
GACCTCCGGA AGCAACAGAG ACGAGAACTG CTTTTCAATG AGGTCGTGAT CATGCGGGAT 1500
TACCATCATG ACAATGTGGT TGATATGTAC AACAGCTACC TTGTTGGCGA TGAACTCTGG 1560
GTGGTCATGG AGTTTCTAGA AGGTGGTGCC TTGACAGACA TTGTGACTCA CACCAGAATG 1620
AATGAAGAAC AGATAGCTAC TGTCTGCCTG TCAGTTCTGA GAGCTCTCTC CTACCTTCAT 1680
AACCAAGGAG TGATTCACAG GGACATAAAA AGTGACTCCA TCCTCCTGAC AAGCGATGGC 1740
CGGATAAAGT TGTCTGATTT TGGTTTCTGT GCTCAAGTTT CCAAAGAGGT GCCGAAGAGG 1800
AAATCGTTGG TTGGCACTCC CTACTGGATG GCCCCTGAGG TGATTTCTAG GCTACCTTAT 1860
GGGACAGAGG TGGACATCTG GTCCCTTGGG ATCATGGTGA TAGAAATGAT CGATGGTGAG 1920
CCCCCCTACT TCAACGAACC TCCCCTCCAG GCGATGCGGA GGATCCGGGA CAGTTTACCT 1980
CCAAGAGTGA AGGACCTACA CAAGGTTTCT TCAGTGCTCC GGGGGTTCCT AGACCTGATG 2040
CTGGTGAGGG AGCCCTCTCA GAGAGCAACA GCCCAGGAAC TCCTCAGACA TCCATTCTTA 2100
AAACTAGCAG GTCCACCGTC TTGCATCGTC CCTCTCATGA GACAATACAG GCATCACTGA 2160
Domain Profile
S: 5     eeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyles  64
          +ig+G++g v++a+ek+tg++va+kk++l+kq++ e+l++e+ ++++++h n+v++++s
Q: 453   IKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYNS  512
         68**********************************************************
S: 65    flkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdi  124
         +l+ +elw+vme+l+gG+l+d+v+   +++++Eeqia+++ +vl+aL+ylH+++viHrdi
Q: 513   YLVGDELWVVMEFLEGGALTDIVT---HTRMNEEQIATVCLSVLRALSYLHNQGVIHRDI  569
         ************************...9********************************
S: 125   kakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDiw  184
         k+++iLlt++g++kLsdfg++aq++k++ krk++vgtpywmAPEvi+  +  Y +++Diw
Q: 570   KSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS--RLPYGTEVDIW  627
         ***********************************************..9**********
S: 185   slGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpek  244
         slGI++ie+++gepP+++++pl+a+ +i ++ pp++k+ +k+s+ ++ f++ +l ++p++
Q: 628   SLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQ  687
         ************************************************************
S: 245   RpsasellkhkFl  257
         R++a+ell+h+Fl
Q: 688   RATAQELLRHPFL  700
         ************7
Domain Sequence
(FASTA)
IKIGEGSTGI VCIATEKHTG KQVAVKKMDL RKQQRRELLF NEVVIMRDYH HDNVVDMYNS 60
YLVGDELWVV MEFLEGGALT DIVTHTRMNE EQIATVCLSV LRALSYLHNQ GVIHRDIKSD 120
SILLTSDGRI KLSDFGFCAQ VSKEVPKRKS LVGTPYWMAP EVISRLPYGT EVDIWSLGIM 180
VIEMIDGEPP YFNEPPLQAM RRIRDSLPPR VKDLHKVSSV LRGFLDLMLV REPSQRATAQ 240
ELLRHPFL 248
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00298
EKS-ANC-00312
EKS-BOT-00324
EKS-CAJ-00332
EKS-CAF-00328
EKS-CAP-00356
EKS-CII-00182
EKS-CIS-00085
EKS-DIO-00041
EKS-DRM-00158
EKS-EQC-00313
EKS-ERE-00042
EKS-FEC-00309
EKS-GAG-00272
EKS-GAA-00400
EKS-GOG-00322
EKS-HOS-00335
EKS-ICT-00305
EKS-LAC-00329
EKS-LOA-00331
EKS-MAM-00327
EKS-MEG-00258
EKS-MOD-00315
EKS-MUM-00358
EKS-MUP-00317
EKS-MYL-00321
EKS-ORN-00419
EKS-ORA-00277
EKS-ORC-00302
EKS-ORL-00384
EKS-OTG-00328
EKS-PAT-00310
EKS-PES-00283
EKS-PEM-00172
EKS-POA-00326
EKS-PRC-00052
EKS-RAN-00339
EKS-SAH-00299
EKS-SUS-00283
EKS-TAG-00334
EKS-TAS-00032
EKS-TEN-00416
EKS-TUT-00079
EKS-VIP-00038
EKS-XET-00391
EKS-XIM-00412
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000095; PAK_box_Rho-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00786; PBD; 1.
PF00069; Pkinase; 1.
SMARTs
SM00285; PBD; 1.
SM00220; S_TKc; 1.
Prosites
PS50108; CRIB; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013