EPS-NOL-00016

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-NOL-00016

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	122.0	1.7E-35	42	182	141

Status

Unreviewed

Ensembl Protein

ENSNLEP00000017664

UniProt Accession

G1RWN7;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP12

Gene Synonyms/Alias

DUSP12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000014515	ENSNLEP00000017664	ENSNLET00000018545

Organism

Nomascus leucogenys

Functional Description

Protein Length

353

Protein Sequence
(FASTA)

MVAQGAAWPL GAAMLDAPGP SHGCELGNPS ASRVSCAGQM LEVQPGLYLG GAAAVAEPDH 60

LREAGITAVL TVDSEEPSFK AGPGVEGLWH LFVPALDKPE TDLLSHLDRC VAFIGQARAE 120

GRAVLVHCHA GVSRSVAIIT AFLMKTDQLP FEKAYEKLQI LKPEAKMNEG FEWQLKLYQA 180

MGCEVDTSSA IYKQYRLQKV TEKYPELQNL PQELFAVDPT TISQGLKDEV LYKCRKCRRS 240

LFRSSSILDH HEGSGPIAFA HKRMTPSFML TTGRQAQCTS YFIEPVQWME SALLGVMDGQ 300

LLCPKCSAKL GSFNWYGEQC SCGRWITPAF QIHKNRVDEM KILPVLGSQT RKI 353

Nucleotide Sequence
(FASTA)

ATGGTAGCGC AGGGAGCCGC CTGGCCTCTG GGTGCGGCCA TGTTGGACGC TCCGGGCCCG 60

AGTCATGGCT GCGAGCTCGG CAACCCCAGC GCCAGCAGAG TCAGCTGCGC CGGGCAGATG 120

CTGGAAGTGC AGCCAGGATT GTATCTCGGT GGGGCCGCGG CCGTCGCGGA GCCAGACCAC 180

TTGAGGGAAG CGGGCATCAC GGCCGTGCTA ACAGTGGACT CGGAGGAGCC CAGCTTCAAG 240

GCGGGGCCTG GGGTCGAGGG TCTATGGCAC CTCTTCGTGC CGGCGCTGGA CAAACCCGAG 300

ACGGACCTGC TCAGCCATCT GGACCGGTGC GTGGCCTTCA TCGGTCAGGC CCGCGCTGAG 360

GGCCGTGCGG TGTTGGTGCA CTGTCATGCA GGAGTCAGTC GAAGTGTGGC CATAATAACT 420

GCTTTTCTCA TGAAGACTGA CCAGCTTCCC TTTGAAAAAG CCTATGAAAA GCTCCAGATT 480

CTCAAACCAG AGGCTAAGAT GAATGAGGGG TTTGAGTGGC AACTGAAATT ATACCAGGCA 540

ATGGGATGTG AAGTGGATAC CTCTAGTGCA ATTTATAAGC AATATCGTTT ACAAAAGGTT 600

ACAGAGAAGT ATCCAGAATT GCAGAATTTA CCTCAAGAAC TCTTTGCTGT TGACCCAACC 660

ACCATTTCAC AAGGATTGAA AGATGAGGTT CTCTACAAGT GTAGAAAGTG CAGGCGATCA 720

TTATTTCGAA GTTCTAGTAT TCTGGATCAC CATGAAGGAA GTGGACCTAT AGCCTTTGCC 780

CACAAGAGAA TGACACCATC TTTCATGCTT ACCACAGGGA GGCAAGCTCA ATGTACATCT 840

TATTTCATTG AACCTGTACA GTGGATGGAA TCTGCTTTGT TGGGAGTGAT GGATGGACAG 900

CTTCTTTGCC CAAAATGCAG TGCCAAGTTG GGTTCCTTCA ACTGGTATGG TGAACAGTGC 960

TCTTGTGGTA GGTGGATAAC ACCTGCTTTT CAAATACATA AGAATAGAGT GGATGAAATG 1020

AAAATATTGC CTGTTTTGGG ATCACAAACA AGAAAAATAT GA 1062

Domain Profile

S: 4     eilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvdDs  63

         e+ pglylg++a + +  +L+++git v+++  +   ++++P +    g   + +p+ D+

Q: 42    EVQPGLYLGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGPGVE---GLWHLFVPALDK  98

         799***************************************986...9999********

S: 64    dvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAieav  123

         ++tdll+++d++++fi +a+ +g++vlvHC+aGvsRS+++++a+Lmk+ +l +++A+e++

Q: 99    PETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKL  158

         ************************************************************

S: 124   krkrpsiepnegfleQLlelekkl  147

         +  +p++++negf +QL +++ ++

Q: 159   QILKPEAKMNEGFEWQLKLYQAMG  182

         ********************9886

Domain Sequence
(FASTA)

EVQPGLYLGG AAAVAEPDHL REAGITAVLT VDSEEPSFKA GPGVEGLWHL FVPALDKPET 60

DLLSHLDRCV AFIGQARAEG RAVLVHCHAG VSRSVAIITA FLMKTDQLPF EKAYEKLQIL 120

KPEAKMNEGF EWQLKLYQAM G 141

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0008270	; F:zinc ion binding
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR016278	; DUSP12.
IPR000387	; Tyr/Dual-specificity_Pase.
IPR007087	; Znf_C2H2.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.
PS50157	; ZINC_FINGER_C2H2_2; 1.

Prints

Created Date

20-Feb-2013