EKS-NOL-00385

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00385

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/SGK	540.2	8.6E-163	193	450	258

Status

Unreviewed

Ensembl Protein

ENSNLEP00000017886

UniProt Accession

G1RXA9;

Protein Name

Protein Synonyms/Alias

Gene Name

SGK1

Gene Synonyms/Alias

SGK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000014679	ENSNLEP00000017886	ENSNLET00000018778

Organism

Nomascus leucogenys

Functional Description

Protein Length

526

Protein Sequence
(FASTA)

MVNKDMNGFP VKKCSAFQFF KKRVRRWIKS PMVSVDKHQS PSLKYTGSSM VHIPPGEPDF 60

EPSLCQTCLG EHAFQRGVLP QEKESCSWET QSGCEVREPC NHANILTKPD PRTFWTNDDP 120

AFMKQRRMGL NDFIQKIANN SYACKHPEVQ SILKISQPQE PELMNANPSP PPSPSQQINL 180

GPSSNPHAKP SDFHFLKVIG KGSFGKVLLA RHKAEEVFYA VKVLQKKAIL KKKEEKHIMS 240

ERNVLLKNVK HPFLVGLHFS FQTADKLYFV LDYINGGELF YHLQRERCFL EPRARFYAAE 300

IASALGYLHS LNIVYRDLKP ENILLDSQGH IVLTDFGLCK ENIEHNSTTS TFCGTPEYLA 360

PEVLHKQPYD RTVDWWCLGA VLYEMLYGLP PFYSRNTAEM YDNILNKPLQ LKPNITNSAR 420

HLLEGLLQKD RTKRLGAKDD FMEIKSHVFF SLINWDDLIN KKITPPFNPN VSGPNDLRHF 480

DPEFTEEPVP NSIGKSPDSV LVTASVKEAA EAFLGFSYAP PTDSFL 526

Nucleotide Sequence
(FASTA)

ATGGTAAACA AAGACATGAA TGGATTCCCA GTCAAGAAAT GCTCAGCCTT CCAATTTTTT 60

AAGAAGCGGG TACGAAGATG GATCAAGAGC CCAATGGTCA GTGTGGACAA GCATCAGAGT 120

CCCAGCCTGA AGTACACTGG CTCCTCGATG GTGCACATCC CTCCAGGGGA GCCAGACTTC 180

GAGCCTTCCT TGTGTCAAAC ATGCCTGGGT GAACATGCTT TCCAAAGAGG GGTTCTCCCT 240

CAGGAGAAGG AGTCATGTTC ATGGGAAACT CAGTCCGGGT GTGAAGTGAG AGAGCCATGT 300

AATCATGCCA ACATCCTGAC CAAGCCCGAT CCGAGAACCT TCTGGACTAA TGATGATCCA 360

GCTTTCATGA AGCAGAGGAG GATGGGTCTG AACGACTTTA TTCAGAAGAT TGCCAATAAC 420

TCCTATGCAT GCAAACACCC TGAAGTTCAG TCCATCTTGA AAATCTCCCA ACCTCAGGAA 480

CCTGAGCTTA TGAATGCCAA CCCTTCTCCT CCACCAAGTC CTTCTCAGCA AATCAACCTT 540

GGCCCGTCGT CCAATCCTCA TGCTAAACCA TCTGACTTTC ACTTCTTGAA AGTGATCGGG 600

AAGGGCAGTT TTGGAAAGGT TCTTCTAGCA AGACACAAGG CAGAAGAAGT GTTCTATGCA 660

GTCAAAGTTT TACAGAAGAA AGCAATCCTG AAAAAGAAAG AGGAGAAGCA TATTATGTCG 720

GAGCGGAATG TTCTGTTGAA GAATGTGAAG CACCCTTTCC TGGTGGGCCT TCACTTCTCT 780

TTCCAGACTG CTGACAAGTT GTACTTTGTC CTAGACTACA TTAATGGTGG AGAGTTGTTC 840

TACCATCTCC AGAGGGAACG CTGCTTCCTA GAACCACGGG CTCGTTTCTA TGCTGCTGAA 900

ATAGCCAGTG CCTTGGGCTA CCTGCATTCA CTGAACATCG TTTATAGAGA CTTAAAACCA 960

GAGAATATTT TGCTAGATTC ACAGGGACAC ATTGTCCTTA CTGACTTCGG ACTCTGCAAG 1020

GAGAACATTG AACACAACAG CACGACATCC ACCTTCTGTG GCACGCCGGA GTATCTTGCA 1080

CCTGAGGTGC TTCATAAGCA GCCTTATGAC AGGACCGTGG ACTGGTGGTG CCTGGGAGCC 1140

GTCTTATATG AGATGCTGTA TGGCCTGCCT CCTTTTTATA GCCGAAACAC AGCTGAAATG 1200

TATGACAACA TTCTGAACAA GCCCCTCCAG TTGAAACCAA ATATTACAAA TTCCGCAAGA 1260

CACCTCCTGG AGGGCCTCCT GCAGAAGGAC AGGACAAAGC GGCTCGGGGC CAAGGATGAC 1320

TTTATGGAGA TTAAGAGTCA TGTCTTCTTC TCCCTAATTA ACTGGGATGA TCTCATTAAT 1380

AAGAAGATTA CTCCCCCTTT TAACCCAAAT GTGAGTGGGC CCAACGACCT GCGGCACTTT 1440

GACCCTGAGT TTACCGAAGA GCCTGTCCCC AACTCCATTG GCAAGTCCCC TGACAGCGTC 1500

CTCGTCACAG CCAGCGTCAA GGAAGCTGCC GAGGCTTTCC TAGGCTTTTC CTATGCGCCT 1560

CCCACGGACT CTTTCCTCTG A 1581

Domain Profile

S: 1     fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp  60

         f+flkvigkgsfgkvlla++ka+e+fyavkvlqkkailkkkeekhim+ernvllknvkhp

Q: 193   FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP  252

         9***********************************************************

S: 61    flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln  120

         flvglh+sfqta+klyfvldy+nggelf+hlqrer+fleprarfyaaeiasalgylhsln

Q: 253   FLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLN  312

         ************************************************************

S: 121   ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt  180

         ivyrdlkpenillds+gh+vltdfglcke+ie+++ttstfcgtpeylapevl+k+pydrt

Q: 313   IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRT  372

         ************************************************************

S: 181   vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk  240

         vdwwclgavlyemlyglppfysr++aemydnilnkplqlkp+i+++a++lle+ll+kdr+

Q: 373   VDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRT  432

         ************************************************************

S: 241   krlgakedfleiknhvff  258

         krlgak+df+eik+hvff

Q: 433   KRLGAKDDFMEIKSHVFF  450

         *****************9

Domain Sequence
(FASTA)

FHFLKVIGKG SFGKVLLARH KAEEVFYAVK VLQKKAILKK KEEKHIMSER NVLLKNVKHP 60

FLVGLHFSFQ TADKLYFVLD YINGGELFYH LQRERCFLEP RARFYAAEIA SALGYLHSLN 120

IVYRDLKPEN ILLDSQGHIV LTDFGLCKEN IEHNSTTSTF CGTPEYLAPE VLHKQPYDRT 180

VDWWCLGAVL YEMLYGLPPF YSRNTAEMYD NILNKPLQLK PNITNSARHL LEGLLQKDRT 240

KRLGAKDDFM EIKSHVFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0035091	; F:phosphatidylinositol binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007154	; P:cell communication

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR001683	; Phox.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013