EPS-NOL-00012

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-NOL-00012

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	152.5	6.7E-45	173	318	146

Status

Unreviewed

Ensembl Protein

ENSNLEP00000017980

UniProt Accession

G1RXK3;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP27

Gene Synonyms/Alias

DUSP27;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000014783	ENSNLEP00000017980	ENSNLET00000018875

Organism

Nomascus leucogenys

Functional Description

Protein Length

1202

Protein Sequence
(FASTA)

MTPEPKALPP VALVRVTEGQ LRLPQQRQMG VHGHRGWQVV MATSKDPEEE QVVPSEEDEA 60

NVRAVQAHYL RSPSPSQYSM VSDAETESIF MEPIHLSSAI AAKQIINEEL KPRGVRADAG 120

CPGMLESAEQ LLVEDLYNRV REKMDDTSLY STPCVLDLQR ALVQDRQEAP WNEVDEVWPN 180

VFIAEKSVAV NKGRLKRLGI THILNAAHGT GVYTGPEFYT GLEIQYLGVE VDDFPEVDIS 240

QHFRKAAEFL DEALLTYRGK VLVSSEMGIS RSAVLVVAYL MIFHNMAILE ALMTVRKKRA 300

IYPNDGFLKQ LRELNEKLME EREEDYGREG GSAEAEEGEG TGSTLGARVH ALTVEEEDDS 360

ASHLSGSSLG KATQASKPLT LIDEEEEEKL YEEWKKGQGL LSDKVPRDGG GPRSASSGQG 420

GEELEDEDED VERIIQEWQS RNERYQAEGH RKWGREEEEE EEESDAGSSV GRRRRTLSES 480

SAWESVSSHD IWVLKQQLEL NRPDHGRRRR ADSMSSESTW DAWNERLLEI EKEASRRYHA 540

KSKREEAADR SSEAGSRVRE DDEESMGSEA SSFYNFCSRN KDKLTALERW KIKRIQFGFH 600

KKDLEAGDSS SELGAEEAVG EKKNPSDVSL TAYQAWKLKH QKKVGSENKE EVVELSKGED 660

SALAKKRQRR LELLERSRQT LEESQSMASW EADSSTASGS IPLSAFWSAA PSVSADGDTV 720

SVLSTQSHRS HLSQPASSIA GCSTSNSTTP LPNLPVGPGD TISIASIQNW IANVVSETLA 780

QKQNEMLLLS RSPSLASTKA VPAASCLGDD QVSMLSGQSS SSLGGCLLPQ SQARPSSDMQ 840

SVLSCNTTLS SPAESSRSKV RGTSKPIYSL FADNVDLKKL GWKEKEMQME LREKMSEYKM 900

EKLASDNKRS SLFKKKKVKE DEDDGVGDGD EDTDSAIGSF RYSFRSNSQK PETDTSSSLA 960

VCDHYASGSR VGKEMDSSIN KWLSGLRTEE KPPFQSDWSG SSRGKYTRSS LLRETESKSS 1020

SYKFSKSQSE EQDTSSYHEA NGNSVRSTSR FSSASTREGR EMHKFSRSTY NETSSSREES 1080

PEPYFFRRTP EPSETEESPE PQRPNWARSR DWEDVEESSK SDFSEFGAKR KFTQSFMRSE 1140

EEGEKERTEN REEGRFASGR RSQYRRSTDR EEEEEMDDEA IIAAWRRRQE EIRTKLQRRR 1200

ED 1202

Nucleotide Sequence
(FASTA)

ATGACGCCTG AGCCAAAGGC CCTGCCTCCT GTGGCCTTGG TTAGAGTCAC CGAAGGCCAG 60

CTGCGTCTTC CCCAGCAGAG ACAAATGGGT GTGCATGGGC ATAGAGGTTG GCAGGTTGTC 120

ATGGCGACCA GCAAGGACCC AGAGGAGGAG CAGGTAGTCC CAAGCGAGGA GGACGAAGCC 180

AACGTGAGGG CGGTGCAGGC CCACTACCTC CGAAGCCCCT CCCCTAGCCA GTATTCGATG 240

GTCTCAGATG CAGAAACAGA AAGCATTTTC ATGGAACCCA TTCACCTCTC CTCAGCCATT 300

GCAGCCAAAC AGATCATCAA TGAAGAACTC AAGCCACGGG GGGTCAGAGC AGACGCAGGG 360

TGTCCAGGCA TGCTGGAGTC TGCTGAACAG CTGCTGGTGG AGGACCTGTA CAACCGCGTC 420

AGGGAGAAGA TGGATGACAC CAGCCTGTAT AGTACGCCCT GTGTCCTGGA CCTACAGCGG 480

GCCCTGGTTC AGGATCGCCA AGAGGCTCCC TGGAATGAAG TGGATGAGGT CTGGCCCAAT 540

GTCTTCATAG CTGAGAAGAG TGTCGCTGTG AACAAGGGGA GGCTGAAGAG GCTGGGAATC 600

ACCCACATTC TGAATGCTGC GCATGGCACC GGTGTTTACA CTGGCCCCGA ATTCTACACT 660

GGCCTGGAGA TCCAGTACCT GGGTGTAGAG GTGGATGACT TTCCTGAAGT GGACATTTCC 720

CAGCATTTCC GGAAGGCGGC TGAGTTCCTC GATGAGGCGC TGCTGACTTA CAGAGGGAAA 780

GTCCTGGTCA GCAGCGAAAT GGGCATCAGC CGGTCAGCAG TGCTGGTGGT CGCCTACCTG 840

ATGATCTTCC ACAACATGGC CATCCTGGAG GCTTTGATGA CCGTGCGTAA GAAGCGGGCC 900

ATCTACCCCA ACGACGGCTT CCTGAAGCAG CTGCGGGAGC TCAATGAGAA GCTGATGGAG 960

GAGAGAGAAG AGGACTATGG CCGGGAGGGG GGATCAGCTG AGGCTGAGGA GGGCGAGGGC 1020

ACTGGGAGCA CGCTTGGGGC CAGAGTGCAC GCCCTGACGG TGGAAGAGGA GGACGACAGC 1080

GCCAGCCACC TGAGTGGCTC CTCCCTGGGG AAGGCCACTC AGGCCTCCAA GCCCCTCACC 1140

CTCATAGACG AGGAGGAGGA GGAGAAACTG TACGAGGAGT GGAAGAAGGG GCAGGGCCTC 1200

CTCTCGGACA AGGTACCCCG GGATGGAGGT GGCCCGCGCT CAGCCTCCTC TGGCCAGGGT 1260

GGGGAGGAGC TCGAGGACGA GGACGAGGAC GTGGAGAGGA TCATCCAGGA GTGGCAGAGC 1320

CGAAACGAGA GGTACCAAGC AGAAGGGCAC CGGAAGTGGG GAAGGGAGGA GGAGGAGGAG 1380

GAGGAGGAGA GCGACGCTGG CTCCTCGGTG GGGAGGCGGC GGCGCACCCT GAGCGAGAGC 1440

AGCGCCTGGG AGAGTGTGAG CAGCCACGAC ATCTGGGTCC TGAAGCAGCA GCTGGAGCTG 1500

AACCGCCCGG ACCACGGCCG GAGGCGCCGC GCAGACTCGA TGTCCTCGGA GAGCACCTGG 1560

GACGCGTGGA ACGAGAGGCT GCTGGAGATT GAGAAGGAGG CTTCCCGGAG GTACCACGCC 1620

AAGAGCAAGA GAGAGGAGGC GGCGGACAGG AGCTCAGAAG CAGGGAGCAG GGTGCGGGAA 1680

GATGATGAGG AGAGCATGGG CTCTGAGGCC AGCTCCTTCT ACAACTTCTG CAGCAGGAAC 1740

AAGGACAAGC TCACTGCCCT GGAAAGATGG AAGATCAAGA GAATCCAATT TGGATTTCAC 1800

AAGAAAGACT TGGAAGCGGG AGACAGCAGC AGTGAGCTCG GTGCAGAGGA GGCAGTAGGG 1860

GAGAAGAAGA ACCCCTCCGA TGTCAGCCTG ACAGCCTACC AGGCCTGGAA GCTGAAACAC 1920

CAGAAGAAGG TGGGCAGTGA GAACAAGGAG GAGGTGGTGG AGCTCAGCAA GGGGGAGGAC 1980

TCGGCCTTGG CTAAGAAGAG GCAACGGAGG CTGGAGCTGC TGGAGAGAAG CCGGCAGACG 2040

CTGGAGGAGA GCCAGTCTAT GGCAAGCTGG GAGGCGGACA GCTCCACCGC CAGCGGGAGC 2100

ATTCCCCTGT CTGCGTTCTG GTCTGCAGCC CCCTCAGTCA GTGCTGATGG GGACACGGTG 2160

TCAGTACTGA GCACCCAGAG CCACCGCTCC CACCTGTCTC AGCCTGCAAG CAGCATAGCG 2220

GGGTGTTCAA CCTCCAACTC CACCACACCC CTGCCTAACC TGCCAGTGGG GCCTGGAGAC 2280

ACCATTTCCA TTGCCAGTAT CCAGAACTGG ATTGCCAACG TAGTCAGCGA GACCCTTGCT 2340

CAGAAGCAAA ATGAAATGCT GCTGTTATCC CGCTCACCGT CTCTTGCAAG CACGAAGGCA 2400

GTACCAGCGG CCAGCTGCCT GGGGGATGAC CAAGTCTCCA TGCTCAGTGG ACAGAGCAGC 2460

TCCTCCTTGG GTGGCTGCCT ATTGCCTCAG AGCCAGGCAA GACCCAGCTC TGACATGCAG 2520

TCTGTGCTGT CCTGCAACAC CACACTGAGC TCACCCGCCG AAAGTTCCAG GAGCAAAGTG 2580

AGGGGGACCA GCAAGCCCAT CTACAGCCTC TTTGCTGACA ATGTGGACCT AAAGAAACTT 2640

GGCTGGAAGG AGAAGGAGAT GCAGATGGAG CTTAGGGAGA AGATGTCCGA GTACAAAATG 2700

GAAAAGCTGG CCTCAGACAA CAAACGCAGC TCCCTCTTCA AGAAGAAGAA GGTCAAGGAA 2760

GATGAGGATG ATGGTGTGGG TGATGGGGAT GAGGACACTG ACAGTGCCAT AGGGAGCTTT 2820

CGATATTCTT TCCGCAGTAA TTCCCAGAAA CCTGAAACAG ACACATCCTC CTCCCTGGCT 2880

GTCTGTGATC ACTATGCAAG TGGCAGCAGA GTTGGCAAAG AGATGGATAG CAGTATTAAT 2940

AAGTGGCTCA GTGGCCTCAG GACAGAGGAA AAACCTCCTT TCCAAAGTGA CTGGTCTGGA 3000

AGTTCCAGGG GGAAGTACAC CAGATCGTCC CTGCTCAGGG AGACAGAGTC TAAATCCTCC 3060

AGTTACAAGT TTTCCAAATC CCAGTCAGAG GAACAGGACA CCTCTTCCTA CCACGAGGCA 3120

AATGGCAACT CTGTAAGAAG CACTTCACGG TTCTCATCTG CCTCCACCAG GGAGGGCAGA 3180

GAGATGCACA AGTTCTCTAG GTCCACGTAC AATGAGACCT CAAGTTCCCG AGAGGAGAGC 3240

CCAGAGCCCT ATTTCTTCCG CCGGACCCCA GAGCCCTCAG AAACGGAAGA GTCCCCAGAG 3300

CCACAACGCC CAAACTGGGC CAGGTCCAGG GACTGGGAAG ATGTGGAAGA GTCATCCAAG 3360

TCAGACTTCT CTGAATTTGG AGCCAAGAGG AAGTTCACCC AGAGCTTTAT GAGGTCTGAA 3420

GAAGAGGGAG AGAAAGAGAG GACAGAAAAC AGAGAAGAAG GGAGGTTTGC ATCTGGACGG 3480

CGGTCCCAGT ATCGGAGAAG CACTGACAGG GAGGAAGAGG AAGAAATGGA CGATGAAGCC 3540

ATCATTGCTG CTTGGAGACG CCGGCAAGAA GAAATCAGGA CCAAGCTGCA GAGAAGGAGG 3600

GAGGACTGA 3609

Domain Profile

S: 1     evteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipv  60

         ev+e++p+++++++ +a+++  L++lgit+++na++++    ++Pe+++  +i+y++++v

Q: 173   EVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGV-YTGPEFYTGLEIQYLGVEV  231

         69**********************************8765.79*****************

S: 61    dDsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA  119

         dD ++ d++q+f++aaef+dea  + +gkvlv +++G+sRSa+lv+aYLm+++++++ +A

Q: 232   DDFPEVDISQHFRKAAEFLDEAlLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEA  291

         **********************8999**********************************

S: 120   ieavkrkrpsiepnegfleQLlelekkl  147

         +++v++kr +i+pn+gfl+QL+el++kl

Q: 292   LMTVRKKR-AIYPNDGFLKQLRELNEKL  318

         ********.***************9987

Domain Sequence
(FASTA)

EVDEVWPNVF IAEKSVAVNK GRLKRLGITH ILNAAHGTGV YTGPEFYTGL EIQYLGVEVD 60

DFPEVDISQH FRKAAEFLDE ALLTYRGKVL VSSEMGISRS AVLVVAYLMI FHNMAILEAL 120

MTVRKKRAIY PNDGFLKQLR ELNEKL 146

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013