EKS-NOL-00355
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00355
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11364.83.0E-109527783257
StatusUnreviewed
Ensembl ProteinENSNLEP00000018084
UniProt AccessionG1RXV7;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K5
Gene Synonyms/Alias MAP3K5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000014849ENSNLEP00000018084ENSNLET00000018981
OrganismNomascus leucogenys
Functional Description
Protein Length1219
Protein Sequence
(FASTA)
MSDAFRQPSL FYHLGVRESF SMANNIILYC DTNSDSLQSL KEIICQKNTM CTGNYTFVPY 60
MITPHNKVYC CDSSFMKGLT ELMQPNFELL LGPICLPLVD RFIQLLKVAQ ASSSQYFRES 120
ILNDIRKARN LYTGRELAAE LARIRQRVDN IEVLTADIVI NLLLSYRDIQ DYDSIVKLVE 180
TLEKLPTFDL ASHHHVKFHY AFALNRRNLP GDRAKALDIM IPMVQSEGQV ASDMYCLVGR 240
IYKDMFLDSN FTDTESRDHG ASWFKKAFES EPTLQSGINY AVLLLAAGHQ FESSFELRKV 300
GVKLSSLLGK KGNLEKLQSY WEVGFFLGAS VLANDHMRVI QASEKLFKLK TPAWYLKSIV 360
ETILIYKHFV KLTTEQPVAK QELVDFWMDF LVEATKTDVT VVRFPVLILE PTKIYQPSYL 420
SINNEVEEKT ISIWHVLPDD KKGIHEWNFS ASSVRGVSIS KFEERCCFLY VLHNSDDFQI 480
YFCTELHCKK FFEMVNTITE EKGRSTEEGD CESDSLEYDY EYDENGDRVV LGKGTYGIVY 540
AGRDLSNQVR IAIKEIPERD SRYSQPLHEE IALHKHLKHK NIVQYLGSFS ENGFIKIFME 600
QVPGGSLSAL LRSKWGPLKD NEQTIGFYTK QILEGLKYLH DNQIVHRDIK GDNVLINTYS 660
GVLKISDFGT SKRLAGINPC TETFTGTLQY MAPEIIDKGP RGYGKAADIW SLGCTIIEMA 720
TGKPPFYELG EPQAAMFKVG MFKVHPEIPE SMSAEAKAFI LKCFEPDPDK RACANDLLVD 780
EFLKVSSKKK KTQPKLSALS AGSNEYLRSI SLPVPVLVED TSSSSEYGSV SPDTELKADP 840
FSFKTRAKSC GERDVKGIRT LFLGIPDENF EDHSAPPSPE EKDSGFFMLR KDSERRATLH 900
RILTEDQDKI VRNLMESLAQ GAEEPKLKWE HITTLIASLR EFVRSTDRKI IATTLSKLKL 960
ELDFDSHGIS QVQVVLFGFQ DAVNKVLRNH NIKPHWMFAL DSIIRKAVQT AITILVPELR 1020
PHFSLASESD TADQEDLDVE DDHEEQPSNQ TVRRPQAVFE DAVATSGVST LSSTVSHDSQ 1080
SAHRSLNVQL GRMKIETNRL LEELVRKEKE LQALLHRAIE EKDQEIKHLK LKSQPIEIPE 1140
LPVFHLNSSG TNTEDSELTD WLRVNGADED TISRFLAEDY TLLDVLYYVT RDDLKCLRLR 1200
GGMLCTLWKA IIDFRNKQT 1219
Nucleotide Sequence
(FASTA)
ATGAGCGATG CCTTCCGGCA GCCGTCCTTG TTTTACCACC TTGGGGTGAG AGAAAGTTTC 60
AGCATGGCCA ACAACATCAT CCTCTACTGT GATACTAACT CGGACTCTCT GCAGTCACTG 120
AAGGAAATCA TTTGCCAGAA GAATACTATG TGCACTGGGA ACTACACCTT TGTTCCTTAC 180
ATGATAACTC CACATAACAA AGTCTACTGC TGTGACAGCA GCTTCATGAA GGGGTTGACA 240
GAGCTCATGC AACCAAACTT CGAGCTGCTT CTTGGACCCA TCTGCTTACC TCTTGTGGAT 300
CGTTTTATTC AACTTTTGAA GGTGGCACAA GCAAGTTCTA GCCAGTATTT CCGGGAATCT 360
ATACTCAATG ACATCAGGAA AGCTCGTAAT TTATACACTG GTAGAGAATT GGCAGCTGAG 420
TTGGCAAGAA TTCGGCAGCG AGTAGATAAT ATCGAAGTCT TGACAGCAGA TATTGTCATA 480
AATCTGTTAC TTTCCTACAG AGATATCCAG GACTATGATT CTATTGTGAA GCTGGTAGAG 540
ACTTTAGAAA AACTGCCAAC CTTTGATTTG GCCTCCCATC ACCATGTGAA GTTTCATTAT 600
GCATTTGCAC TGAATAGGAG AAATCTCCCT GGTGACAGAG CAAAAGCTCT TGATATTATG 660
ATTCCCATGG TGCAAAGTGA AGGACAAGTT GCTTCAGATA TGTATTGCCT AGTTGGTCGA 720
ATCTACAAAG ATATGTTTTT GGACTCTAAT TTCACGGACA CTGAAAGCAG AGACCATGGA 780
GCTTCTTGGT TCAAAAAGGC ATTTGAATCT GAGCCAACAC TACAGTCAGG AATTAATTAT 840
GCGGTCCTCC TCCTGGCAGC TGGGCACCAG TTTGAATCTT CCTTTGAGCT CCGGAAAGTT 900
GGGGTGAAGC TAAGTAGTCT TCTTGGTAAA AAGGGAAACT TGGAAAAACT CCAGAGCTAC 960
TGGGAAGTTG GATTTTTTCT GGGAGCCAGT GTCCTAGCCA ATGACCATAT GAGAGTCATT 1020
CAAGCATCTG AAAAGCTTTT TAAACTGAAG ACACCAGCAT GGTACCTCAA GTCTATTGTA 1080
GAGACAATTT TGATATATAA GCATTTTGTG AAACTGACCA CAGAACAGCC TGTGGCCAAG 1140
CAAGAACTTG TGGACTTTTG GATGGATTTC CTGGTCGAGG CCACAAAGAC AGACGTTACT 1200
GTGGTTAGGT TTCCAGTATT AATATTAGAA CCAACCAAAA TCTATCAACC TTCTTACTTG 1260
TCTATCAACA ATGAAGTTGA GGAAAAGACA ATCTCTATTT GGCACGTGCT TCCTGATGAC 1320
AAGAAAGGTA TACATGAGTG GAATTTTAGT GCCTCTTCTG TCAGGGGAGT GAGTATTTCT 1380
AAATTTGAAG AAAGATGCTG CTTTCTTTAT GTGCTCCACA ATTCTGATGA TTTCCAAATC 1440
TATTTCTGTA CAGAACTTCA TTGTAAAAAG TTTTTTGAGA TGGTGAACAC CATTACCGAA 1500
GAGAAGGGGA GAAGCACAGA GGAAGGAGAC TGTGAAAGTG ACTCGCTGGA GTATGACTAT 1560
GAATATGATG AAAATGGTGA CAGAGTCGTT TTAGGAAAAG GCACTTACGG GATAGTCTAC 1620
GCAGGTCGGG ACTTGAGCAA CCAAGTCAGA ATTGCTATTA AGGAAATCCC AGAGAGAGAC 1680
AGCAGATACT CTCAGCCCCT GCATGAAGAA ATAGCATTGC ATAAGCACCT GAAGCACAAA 1740
AATATTGTCC AGTATCTGGG CTCTTTCAGT GAGAATGGTT TCATTAAAAT CTTCATGGAG 1800
CAGGTCCCTG GAGGAAGTCT TTCTGCTCTC CTTCGTTCCA AATGGGGTCC ATTAAAAGAC 1860
AATGAGCAAA CAATTGGCTT TTATACAAAG CAAATACTGG AAGGATTAAA ATATCTCCAT 1920
GACAATCAGA TAGTTCACCG CGACATAAAG GGTGACAATG TGTTGATTAA TACCTACAGT 1980
GGTGTTCTCA AGATCTCTGA CTTCGGGACA TCAAAGAGGC TTGCTGGCAT AAACCCCTGT 2040
ACTGAAACTT TTACTGGCAC CCTCCAGTAT ATGGCACCAG AAATAATAGA TAAAGGACCG 2100
AGAGGCTACG GAAAAGCAGC AGACATCTGG TCTCTGGGCT GTACAATCAT CGAAATGGCC 2160
ACAGGAAAAC CCCCATTTTA TGAACTGGGA GAACCACAAG CAGCTATGTT CAAGGTGGGA 2220
ATGTTTAAAG TCCACCCTGA GATCCCAGAG TCCATGTCTG CAGAGGCCAA GGCATTCATA 2280
CTGAAATGTT TTGAACCAGA CCCTGACAAG AGAGCCTGTG CTAACGACTT GCTTGTTGAT 2340
GAGTTTTTAA AAGTTTCAAG CAAAAAGAAA AAGACACAAC CTAAGCTTTC AGCTCTTTCA 2400
GCTGGATCAA ATGAATATCT CAGGAGTATA TCCTTGCCGG TACCTGTGCT GGTGGAGGAC 2460
ACCAGCAGCA GCAGTGAGTA CGGCTCAGTT TCACCCGACA CGGAGTTGAA AGCGGACCCC 2520
TTCTCTTTCA AAACAAGAGC CAAGTCCTGT GGAGAAAGAG ATGTCAAGGG AATTCGGACA 2580
CTCTTTTTGG GCATTCCAGA TGAGAATTTT GAAGATCACA GTGCTCCTCC TTCCCCTGAA 2640
GAAAAAGATT CTGGATTCTT CATGCTGAGG AAGGACAGTG AGAGGCGAGC TACCCTTCAC 2700
AGGATCCTGA CGGAAGACCA AGACAAAATT GTGAGAAACC TAATGGAATC TTTAGCTCAG 2760
GGGGCTGAAG AACCGAAACT AAAATGGGAA CACATCACAA CCCTCATTGC AAGCCTCAGA 2820
GAATTCGTGA GATCCACTGA CCGAAAAATC ATAGCCACCA CACTGTCAAA GCTGAAACTG 2880
GAGCTGGACT TCGACAGCCA CGGCATTAGC CAAGTCCAGG TGGTACTCTT TGGTTTTCAA 2940
GATGCTGTCA ATAAAGTTCT TCGGAATCAT AACATCAAGC CGCACTGGAT GTTTGCCTTA 3000
GACAGTATCA TCCGGAAGGC GGTACAGACA GCCATTACCA TCCTGGTTCC AGAACTAAGG 3060
CCACATTTCA GCCTTGCATC TGAGAGTGAT ACTGCTGATC AAGAAGACTT GGATGTAGAA 3120
GATGACCATG AAGAACAGCC TTCAAATCAA ACTGTCCGAA GACCTCAGGC TGTCTTTGAA 3180
GATGCCGTGG CTACCTCAGG CGTGAGCACG CTCAGTTCTA CTGTGTCTCA TGATTCCCAG 3240
AGTGCTCACC GGTCACTGAA TGTACAGCTT GGAAGGATGA AAATAGAAAC CAACAGATTA 3300
CTGGAAGAAT TGGTTCGGAA AGAGAAAGAA TTACAAGCAC TCCTTCATCG AGCTATTGAA 3360
GAAAAAGATC AAGAAATTAA ACACCTGAAG CTTAAGTCCC AACCCATAGA AATTCCTGAA 3420
TTGCCTGTAT TTCATCTAAA TTCTTCTGGC ACAAATACTG AAGATTCTGA ACTTACTGAC 3480
TGGCTGAGAG TGAATGGAGC TGATGAAGAC ACTATAAGCC GGTTTTTGGC TGAAGATTAT 3540
ACACTATTGG ATGTTCTCTA CTATGTTACA CGTGATGACT TAAAATGCTT GCGACTAAGG 3600
GGAGGGATGC TGTGCACACT GTGGAAGGCT ATCATTGACT TTCGAAACAA ACAGACTTGA 3660
Domain Profile
S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62
         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n
Q: 527   DRVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  581
         5789**************************...888775..9******************
S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119
         iv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  e++i +ytkqilegl+yLH+
Q: 582   IVQYLGSFSENGFIKIFMEQVPGGSLSALLRsKWGPLKdnEQTIGFYTKQILEGLKYLHD  641
         *******************************9*****9999*******************
S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178
         ++ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k
Q: 642   NQIVHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDK  698
         ***************************************...8*****************
S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238
         + +gyg++aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Peipe++s+e+k+
Q: 699   GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKA  758
         ************************************************************
S: 239   flekcleldpkkrpsaeeLLkhefl  263
         f+ kc+e dp+kr++a++LL +efl
Q: 759   FILKCFEPDPDKRACANDLLVDEFL  783
         **********************996
Domain Sequence
(FASTA)
DRVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60
GSFSENGFIK IFMEQVPGGS LSALLRSKWG PLKDNEQTIG FYTKQILEGL KYLHDNQIVH 120
RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII DKGPRGYGKA 180
ADIWSLGCTI IEMATGKPPF YELGEPQAAM FKVGMFKVHP EIPESMSAEA KAFILKCFEP 240
DPDKRACAND LLVDEFL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00361
EKS-ANC-00378
EKS-BOT-00387
EKS-CAE-00316
EKS-CAF-00390
EKS-CAP-00418
EKS-DAR-00769
EKS-DRM-00182
EKS-EQC-00380
EKS-FEC-00376
EKS-GAG-00327
EKS-GAA-00475
EKS-GOG-00384
EKS-HOS-00395
EKS-ICT-00372
EKS-LAC-00401
EKS-LOA-00395
EKS-MAM-00386
EKS-MAE-00046
EKS-MEG-00320
EKS-MIM-00057
EKS-MOD-00376
EKS-MUM-00421
EKS-MUP-00382
EKS-MYL-00386
EKS-ORN-00500
EKS-ORA-00336
EKS-ORC-00364
EKS-ORL-00460
EKS-OTG-00390
EKS-PAT-00368
EKS-PES-00346
EKS-POA-00379
EKS-RAN-00402
EKS-SAH-00359
EKS-SUS-00345
EKS-TAG-00460
EKS-TAR-00496
EKS-TEN-00496
EKS-TUT-00109
EKS-XET-00502
EKS-XIM-00493
Gene Ontology
GO:0005524; F:ATP binding
GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0070301; P:cellular response to hydrogen peroxide
GO:0010421; P:hydrogen peroxide-mediated programmed cell death
GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254; P:JNK cascade
KEGG
InterPros
IPR025136; DUF4071.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR013761; SAM/pointed.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF13281; DUF4071; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013