EKS-NOL-00339
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00339
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src422.83.9E-127241490250
StatusUnreviewed
Ensembl ProteinENSNLEP00000018281
UniProt AccessionG1RYF4;
Protein Name
Protein Synonyms/Alias
Gene NameBLK
Gene Synonyms/Alias BLK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000015038ENSNLEP00000024474ENSNLET00000032806
ENSNLEG00000015038ENSNLEP00000018281ENSNLET00000019190
OrganismNomascus leucogenys
Functional Description
Protein Length505
Protein Sequence
(FASTA)
MGLVSSKKPD KEKPIKEKDH SQRSPLKVST EDKDPPPLPP LVVFNHLTPP PPDEYPDEDE 60
HFVVALYDYT AMNDRDLQML KGEKLQVLKG TGDWWLAKSL VTGREGYVPS NFVARVESLE 120
VERWFFRSLG RKEAERQLLA PINKAGSFLI RESETNKGAF SLSVKDVTTQ GELIKHYQIR 180
SLDEGGYYIS PRITFPSLQA LVQHYSKKGD GLCQRLTLPC VSLAPQNPWA QDEWEIPRQS 240
LKLVRKLGSG QFGEVWMGYY KNNMKVAIKT LKEGTMSPEA FLGEANVMKA LQHERLVRLY 300
AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIADGMAY IERMNSIHRD 360
LRAANILVSE ALCCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS 420
FGVLLMEVVT YGRVPYPGMS NPEVIRNLER GYRMPRPDTC PPELYRGVIA ECWRSRPEER 480
PTFEFLQSVL EDFYTATERQ YELQP 505
Nucleotide Sequence
(FASTA)
ATGGGGCTGG TGAGCAGCAA AAAGCCGGAC AAGGAAAAGC CGATCAAGGA GAAGGACCAC 60
AGCCAACGGA GCCCCCTGAA GGTCAGCACT GAAGACAAGG ATCCCCCGCC ACTGCCACCC 120
CTGGTTGTCT TCAACCACCT TACTCCTCCA CCGCCTGATG AATACCCGGA TGAAGATGAG 180
CATTTCGTGG TGGCTCTGTA TGACTACACC GCCATGAATG ACCGGGACCT GCAGATGCTG 240
AAGGGGGAGA AGCTACAGGT CCTGAAGGGA ACTGGAGACT GGTGGCTGGC CAAGTCACTC 300
GTCACAGGAA GAGAAGGCTA TGTGCCCAGC AACTTTGTGG CCCGAGTGGA GAGCCTGGAA 360
GTAGAAAGGT GGTTCTTTAG ATCACTGGGC CGAAAGGAGG CCGAGAGGCA GCTTCTTGCT 420
CCAATCAACA AGGCTGGCTC CTTTCTTATC AGAGAGAGTG AAACCAACAA AGGTGCCTTC 480
TCCCTGTCTG TGAAGGACGT CACCACCCAG GGGGAGCTGA TCAAGCACTA TCAGATCCGC 540
TCCCTGGACG AAGGGGGCTA CTACATCTCC CCCCGGATCA CCTTCCCCTC GCTCCAGGCC 600
CTGGTGCAGC ACTATTCTAA GAAGGGGGAT GGTCTCTGCC AGAGGCTGAC CCTGCCCTGT 660
GTGAGCCTGG CCCCGCAGAA CCCCTGGGCC CAAGATGAAT GGGAAATCCC TCGGCAGTCT 720
CTCAAGCTGG TCAGGAAACT CGGGTCTGGA CAATTCGGCG AAGTCTGGAT GGGTTACTAC 780
AAAAACAACA TGAAGGTGGC CATTAAGACG CTGAAGGAGG GAACCATGTC TCCAGAAGCC 840
TTCCTGGGCG AGGCCAACGT GATGAAGGCT CTGCAGCACG AGCGGCTGGT CCGACTCTAT 900
GCAGTGGTCA CCAAGGAGCC CATCTACATT GTCACCGAGT ACATGGCCAG AGGATGCCTG 960
CTGGATTTCC TGAAGACAGA TGAAGGGAGC AGATTGTCAC TCCCAAGGCT GATTGACATG 1020
TCGGCACAGA TTGCTGACGG GATGGCATAC ATCGAGCGCA TGAATTCCAT CCACCGCGAC 1080
CTGCGGGCGG CCAACATCCT GGTGTCTGAG GCCTTGTGCT GCAAAATTGC TGATTTTGGC 1140
TTGGCTCGAA TCATCGACAG TGAATACACG GCCCAAGAGG GGGCCAAGTT CCCCATCAAG 1200
TGGACAGCCC CGGAAGCCAT CCACTTCGGG GTCTTCACCA TCAAAGCAGA CGTGTGGTCC 1260
TTTGGAGTCC TCCTGATGGA AGTCGTTACT TACGGGCGGG TGCCATACCC AGGGATGAGC 1320
AACCCCGAGG TCATCCGCAA CCTGGAGCGC GGCTACCGCA TGCCGCGCCC CGACACCTGC 1380
CCGCCCGAGC TGTACCGCGG CGTCATCGCC GAGTGCTGGC GCAGCCGGCC CGAGGAGCGG 1440
CCCACCTTCG AGTTCCTGCA GTCGGTGCTG GAGGACTTCT ACACGGCCAC CGAGCGGCAG 1500
TACGAGCTGC AGCCCTAG 1518
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lklv+klG+GqfGevw+g++k+++kva+ktlkegt+speafl ea+++k l+he+lv+ly
Q: 241   LKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY  300
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyivte+ma+G+lldflk++eg++l+lp+l+d++aq+a+Gmay+e++n ihr
Q: 301   AVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIADGMAYIERMNSIHR  359
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+e l++k+adfGlar+i d+eyta+egak+PikWtaPeai++g+ftik+dv
Q: 360   DLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADV  418
         **************************.899******************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelye.lllecwkkdpe  239
         WsfG+ll+e+vt+G+vPypGm+n ev++++ergyr+prp++cp ely+ +++ecw+++pe
Q: 419   WSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRgVIAECWRSRPE  478
         ************************************************9***********
S: 240   erPtfetlqevl  251
         erPtfe+lq+vl
Q: 479   ERPTFEFLQSVL  490
         ********9986
Domain Sequence
(FASTA)
LKLVRKLGSG QFGEVWMGYY KNNMKVAIKT LKEGTMSPEA FLGEANVMKA LQHERLVRLY 60
AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIADGMAY IERMNSIHRD 120
LRAANILVSE ALCCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS 180
FGVLLMEVVT YGRVPYPGMS NPEVIRNLER GYRMPRPDTC PPELYRGVIA ECWRSRPEER 240
PTFEFLQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00345
EKS-ANC-00360
EKS-BOT-00372
EKS-CAJ-00377
EKS-CAF-00372
EKS-CAP-00405
EKS-DAR-00751
EKS-EQC-00363
EKS-FEC-00359
EKS-GAM-00225
EKS-GAG-00314
EKS-GOG-00363
EKS-HOS-00379
EKS-ICT-00353
EKS-LAC-00386
EKS-LOA-00381
EKS-MAM-00373
EKS-MEG-00304
EKS-MOD-00360
EKS-MUM-00404
EKS-MUP-00366
EKS-ORN-00479
EKS-ORC-00351
EKS-OTG-00375
EKS-PAT-00352
EKS-PES-00329
EKS-POA-00361
EKS-PTV-00095
EKS-RAN-00386
EKS-SAH-00342
EKS-SUS-00325
EKS-TAG-00443
EKS-TAR-00476
EKS-TUT-00099
EKS-XIM-00469
Gene Ontology
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0050853; P:B cell receptor signaling pathway
GO:0032024; P:positive regulation of insulin secretion
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013