EKS-NOL-00265

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00265

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IRE	485.1	5.0E-146	571	832	262

Status

Unreviewed

Ensembl Protein

ENSNLEP00000018333

UniProt Accession

G1RYK6;

Protein Name

Protein Synonyms/Alias

Gene Name

ERN1

Gene Synonyms/Alias

ERN1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000015074	ENSNLEP00000018333	ENSNLET00000019244

Organism

Nomascus leucogenys

Functional Description

Protein Length

977

Protein Sequence
(FASTA)

MPAQRLLLLL TLLLPGLGIF GSTSTVTLPE TLLFVSTLDG SLHAVSKRTG SIKWTLKEDP 60

VLQVPTHVEE PAFLPDPNDG SLYTLGSKNN EGLTKLPFTI PELVQASPCR SSDGILYMGK 120

KQDIWYVIDL LTGEKQQTLS SAFADSLCPS TSLLYLGRTE YTITMYDTKT RELRWNATYF 180

DYAASLPEDD VDYKMSHFVS NGDGLVVTVD SESGDVLWIQ NYASPVVAFY VWQREGLRKV 240

MHINVAVETL RYLTFMSGEV GRITKWKYPF PKETEAKSKL TPTLYVGKYS TSLYASPSMV 300

HEGVAVVPRG STLPLLEGPQ TDGVTIGDKG ECVITPSTDL KFDPGLKSKS KLNYLRNYWL 360

LIGHHETPLS ASTKMLERFP NNLPKHRENV IPADSEKKSF EKVINLVDQT SENAPTTVSR 420

DVEEKPAHAP ARPEAPVDSM LKDVATIILS TFLLIGWVAF IITYPLSMHQ QQQLQHQQFQ 480

KELEKIQLLQ QQQQQLPFHP PGDTAQDGEL LDTSGPYSES SGTSSPSTSP RASNHSLCSG 540

SSASKAGSSP SLEQDDGDEE TSMVIVGKIS FCPKDVLGHG AEGTIVYRGM FDNRDVAVKR 600

ILPECFSFAD REVQLLRESD EHPNVIRYFC TEKDRQFQYI AIELCAATLQ EYVEQKDFAH 660

LGLEPITLLQ QTTSGLAHLH SLNIVHRDLK PHNILISMPN AHGKIKAMIS DFGLCKKLAV 720

GRHSFSRRSG VPGTEGWIAP EMLSEDCKEN PTYTVDIFSA GCVFYYVISE GSHPFGKSLQ 780

RQANILLGAC SLDCLHPEKH EDVIARELIE KMIAMDPQKR PSAKHVLKHP FFWSLEKQLQ 840

FFQDVSDRIE KESLDGPIVK QLERGGRAVV KMDWRENITV PLQTDLRKFR TYKGGSVRDL 900

LRAMRNKKHH YRELPAEVQE TLGSLPDDFV CYFTSRFPHL LAHTYRAMEL CSHERLFQPY 960

YFHEPPEPQP PVTPDAL 977

Nucleotide Sequence
(FASTA)

ATGCCGGCCC AGCGGCTGCT GCTGCTGCTG ACGCTGCTGC TGCCCGGCCT CGGGATTTTT 60

GGAAGTACCA GCACAGTGAC GCTTCCTGAA ACCTTGTTGT TTGTGTCAAC GCTGGATGGA 120

AGTTTGCATG CTGTCAGCAA GAGGACAGGC TCAATCAAAT GGACTTTAAA AGAAGATCCA 180

GTCCTGCAGG TCCCAACACA TGTGGAAGAG CCTGCCTTTC TCCCAGATCC TAATGATGGC 240

AGCCTGTATA CGCTTGGAAG CAAGAATAAT GAAGGCCTGA CGAAACTTCC TTTTACCATC 300

CCAGAATTGG TGCAGGCATC CCCGTGCCGA AGTTCAGATG GAATCCTCTA CATGGGTAAA 360

AAGCAGGACA TCTGGTATGT TATTGACCTC CTGACCGGGG AGAAGCAGCA GACTTTGTCA 420

TCGGCCTTTG CAGATAGTCT CTGCCCATCA ACCTCTCTTC TGTATCTTGG GCGAACAGAA 480

TACACCATCA CCATGTACGA CACCAAAACC CGAGAGCTCC GGTGGAATGC CACTTACTTT 540

GACTATGCAG CCTCGCTGCC CGAGGACGAC GTGGACTACA AGATGTCCCA CTTTGTGTCC 600

AATGGTGATG GGCTGGTGGT GACTGTGGAC AGTGAATCTG GGGACGTCCT GTGGATCCAA 660

AACTACGCCT CCCCTGTGGT GGCCTTTTAT GTCTGGCAGC GGGAGGGTCT GAGGAAGGTG 720

ATGCACATCA ATGTTGCTGT GGAGACCCTG CGCTATCTGA CCTTCATGTC TGGGGAGGTG 780

GGGCGCATCA CCAAATGGAA GTACCCGTTC CCCAAGGAGA CAGAGGCCAA GAGCAAGCTG 840

ACGCCCACTC TGTATGTTGG GAAATACTCT ACCAGCCTCT ATGCCTCTCC CTCAATGGTA 900

CACGAGGGGG TTGCTGTCGT GCCCCGCGGC AGCACACTTC CTTTGCTGGA AGGGCCCCAG 960

ACTGATGGCG TCACCATTGG GGACAAGGGG GAGTGTGTGA TCACGCCCAG CACGGACCTC 1020

AAGTTTGACC CTGGACTCAA AAGCAAGAGC AAGCTCAACT ACTTGAGGAA TTACTGGCTT 1080

CTGATAGGAC ACCATGAAAC CCCACTGTCT GCATCTACCA AGATGCTGGA GAGATTTCCC 1140

AACAATCTAC CCAAACATCG GGAAAATGTG ATTCCTGCTG ATTCGGAGAA AAAGAGCTTT 1200

GAGAAAGTTA TCAACCTGGT TGACCAGACT TCAGAAAACG CACCTACCAC CGTGTCTCGG 1260

GATGTGGAGG AGAAGCCCGC CCATGCCCCT GCCCGGCCCG AGGCCCCCGT GGACTCCATG 1320

CTCAAGGACG TGGCTACCAT CATCCTGAGC ACCTTCCTGC TGATTGGCTG GGTGGCCTTC 1380

ATCATCACCT ATCCCCTGAG CATGCATCAG CAGCAGCAGC TCCAGCACCA GCAGTTCCAG 1440

AAGGAACTGG AGAAGATCCA GCTCCTGCAG CAGCAGCAGC AGCAGCTGCC CTTTCACCCA 1500

CCTGGAGACA CGGCTCAGGA CGGCGAGCTC CTGGACACGT CCGGCCCATA CTCAGAGAGC 1560

TCGGGCACCA GCAGCCCCAG CACGTCCCCC AGGGCCTCCA ACCACTCGCT CTGCTCCGGC 1620

AGCTCTGCCT CCAAGGCTGG CAGCAGCCCC TCCCTGGAAC AAGACGATGG AGATGAAGAA 1680

ACCAGCATGG TGATAGTTGG GAAAATTTCC TTCTGTCCCA AGGATGTCCT GGGCCACGGA 1740

GCTGAGGGCA CAATTGTGTA CCGGGGCATG TTTGACAACC GCGACGTGGC CGTGAAGAGG 1800

ATCCTTCCCG AGTGTTTTAG CTTCGCAGAC CGTGAGGTCC AGCTGTTGCG AGAATCGGAT 1860

GAGCACCCGA ATGTGATCCG CTACTTCTGC ACGGAGAAGG ACCGGCAATT CCAGTACATT 1920

GCCATCGAGC TGTGTGCAGC CACCCTGCAA GAGTATGTGG AGCAGAAGGA CTTTGCGCAT 1980

CTTGGCCTGG AGCCCATCAC CTTGCTGCAG CAGACCACCT CGGGCCTGGC CCACCTCCAC 2040

TCCCTCAACA TCGTTCATCG AGACCTAAAG CCGCACAACA TTCTCATATC CATGCCCAAT 2100

GCACACGGCA AGATCAAGGC CATGATCTCC GACTTTGGCC TCTGCAAGAA GCTGGCAGTG 2160

GGCAGACACA GTTTCAGCCG CCGATCTGGG GTGCCTGGCA CAGAAGGCTG GATCGCTCCA 2220

GAGATGTTGA GCGAAGACTG TAAGGAGAAC CCTACCTACA CGGTGGACAT ATTTTCTGCA 2280

GGCTGCGTCT TTTACTACGT GATCTCTGAG GGCAGCCACC CTTTTGGCAA GTCCCTGCAG 2340

CGGCAGGCCA ACATCCTCCT GGGTGCCTGC AGCCTCGACT GCTTGCACCC AGAGAAGCAC 2400

GAAGACGTCA TTGCACGTGA ACTGATAGAG AAGATGATTG CAATGGATCC TCAGAAACGC 2460

CCCTCAGCGA AGCACGTGCT CAAACACCCA TTCTTCTGGA GCCTAGAGAA GCAGCTCCAG 2520

TTCTTCCAGG ACGTGAGCGA CAGAATAGAA AAGGAATCCC TGGATGGCCC AATCGTGAAG 2580

CAGTTAGAGA GAGGCGGGAG AGCTGTGGTG AAGATGGACT GGCGGGAGAA CATCACCGTC 2640

CCCCTCCAGA CAGACCTGCG TAAATTCAGG ACCTATAAAG GTGGTTCTGT CAGAGATCTC 2700

CTCCGAGCCA TGAGAAATAA GAAGCACCAC TACCGGGAGC TGCCTGCGGA GGTGCAGGAG 2760

ACGCTGGGGT CCCTCCCCGA CGACTTCGTG TGCTACTTCA CGTCTCGCTT CCCCCACCTC 2820

CTCGCACACA CCTACCGGGC CATGGAGCTG TGCAGCCACG AGAGACTCTT CCAGCCCTAC 2880

TACTTCCACG AGCCCCCAGA GCCGCAGCCC CCAGTGACTC CAGACGCCCT CTGA 2934

Domain Profile

S: 1     fspkdvlGkGaeGtvvfrGsfegrevavkrllsefvdlakrevkllresdehpnviryfc  60

         f+pkdvlG+GaeGt+v+rG+f++r+vavkr+l+e++++a+rev+llresdehpnviryfc

Q: 571   FCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFC  630

         79**********************************************************

S: 61    tekdrqfryialelcaaslqdyvedkdlelqkelepisllkqiasGlahlhslkivhrdl  120

         tekdrqf+yia+elcaa+lq+yve+kd++ + +lepi+ll+q++sGlahlhsl+ivhrdl

Q: 631   TEKDRQFQYIAIELCAATLQEYVEQKDFA-HLGLEPITLLQQTTSGLAHLHSLNIVHRDL  689

         *****************************.******************************

S: 121   kpqnilislpdakgklrvlisdfGlckkldvGkssfsrrsgvsGteGwiapelleeltke  180

         kp+nilis+p+a+gk++++isdfGlckkl+vG++sfsrrsgv+GteGwiape+l+e++ke

Q: 690   KPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKE  749

         ************************************************************

S: 181   rltsavdifslGcvfyyvlskGkhpfGdslkrqanilsgelsldklkeekdeeviaedli  240

         ++t++vdifs+Gcvfyyv+s+G+hpfG+sl+rqanil g++sld+l++ek+e+via++li

Q: 750   NPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELI  809

         ************************************************************

S: 241   skmidkdplkrpsakkvlkhplf  263

         +kmi++dp+krpsak+vlkhp+f

Q: 810   EKMIAMDPQKRPSAKHVLKHPFF  832

         **********************9

Domain Sequence
(FASTA)

FCPKDVLGHG AEGTIVYRGM FDNRDVAVKR ILPECFSFAD REVQLLRESD EHPNVIRYFC 60

TEKDRQFQYI AIELCAATLQ EYVEQKDFAH LGLEPITLLQ QTTSGLAHLH SLNIVHRDLK 120

PHNILISMPN AHGKIKAMIS DFGLCKKLAV GRHSFSRRSG VPGTEGWIAP EMLSEDCKEN 180

PTYTVDIFSA GCVFYYVISE GSHPFGKSLQ RQANILLGAC SLDCLHPEKH EDVIARELIE 240

KMIAMDPQKR PSAKHVLKHP FF 262

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0030176	; C:integral to endoplasmic reticulum membrane
GO:0005524	; F:ATP binding
GO:0016891	; F:endoribonuclease activity, producing 5'-phosphomonoesters
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006987	; P:activation of signaling protein activity involved in unfolded protein response
GO:0006397	; P:mRNA processing
GO:1900103	; P:positive regulation of endoplasmic reticulum unfolded protein response

KEGG

InterPros

IPR010513	; KEN_RNase_activator.
IPR011009	; Kinase-like_dom.
IPR018391	; PQQ_beta_propeller_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR006567	; PUG-dom.
IPR011047	; Quinonprotein_ADH-like.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF06479	; Ribonuc_2-5A; 1.

SMARTs

SM00564	; PQQ; 5.
SM00580	; PUG; 1.

Prosites

PS51392	; KEN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013