EKS-NOL-00060

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00060

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	368.0	2.9E-110	155	439	285

Status

Unreviewed

Ensembl Protein

ENSNLEP00000018443

UniProt Accession

G1RYW6;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK14

Gene Synonyms/Alias

CDK14;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000015172	ENSNLEP00000018443	ENSNLET00000019360

Organism

Nomascus leucogenys

Functional Description

Protein Length

489

Protein Sequence
(FASTA)

MQSPLAVWLP FCILLKQPCI ANQYLSEKTV CCKLPGQHMH GYFGCNAAAE PGYSAFLGTP 60

QICVTKMSTR NCQGMDSVIK PLDTIPEDKK VRVQRTQSTF DPFEKPANQV KRVHSENNAC 120

INFKTSSTGK ESPKVRRHSS PSSPTSPKFG KADSYEKLEK LGEGSYATVY KGKSKVNGKL 180

VALKVIRLQE EEGTPFTAIR EASLLKGLKH ANIVLLHDII HTKETLTLVF EYVHTDLCQY 240

MDKHPGGLHP DNVKLFLFQL LRGLSYIHQR YILHRDLKPQ NLLISDTGEL KLADFGLARA 300

KSVPSHTYSN EVVTLWYRPP DVLLGSTEYS TCLDMWGVGC IFVEMIQGVA AFPGMKDIQD 360

QLERIFLVLG TPNEDTWPGV HSLPHFKPEC FTLYSSKSLR QAWNKLSYVN HAEDLASKLL 420

QCSPKNRLSA QAALSHKYFS DLPPRLWELT DMSSIFTVPN VRLQPEAGES MRAFGKNNSY 480

GKSLSNSKH 489

Nucleotide Sequence
(FASTA)

ATGCAATCAC CATTAGCTGT TTGGCTCCCA TTCTGTATTC TTTTGAAGCA GCCCTGCATT 60

GCAAATCAAT ATCTTTCTGA AAAGACAGTG TGTTGTAAAT TGCCTGGACA GCATATGCAC 120

GGTTACTTTG GCTGCAATGC TGCTGCAGAG CCCGGTTACT CTGCCTTCCT GGGAACTCCA 180

CAGATATGTG TCACAAAGAT GTCTACACGG AACTGCCAGG GAATGGACTC AGTGATCAAA 240

CCCCTGGACA CAATTCCTGA GGATAAAAAA GTCAGAGTTC AGAGGACACA GAGCACTTTT 300

GACCCATTTG AGAAACCAGC TAATCAAGTA AAGAGGGTGC ATTCTGAGAA CAATGCTTGC 360

ATTAACTTTA AGACCTCCTC CACTGGCAAA GAGTCACCTA AAGTTAGGCG GCACTCCAGC 420

CCCAGCTCGC CAACAAGTCC CAAATTTGGA AAAGCTGACT CATATGAAAA GCTGGAAAAA 480

CTAGGGGAAG GATCTTATGC TACAGTATAC AAAGGGAAAA GCAAGGTAAA TGGGAAGTTG 540

GTAGCTCTGA AGGTGATCAG GCTGCAGGAA GAAGAAGGGA CACCTTTCAC AGCTATCAGG 600

GAAGCTTCTC TGTTAAAAGG ACTAAAACAT GCTAACATAG TACTACTTCA TGACATCATC 660

CATACCAAGG AGACACTGAC ACTTGTGTTT GAATATGTGC ACACTGATTT ATGTCAGTAC 720

ATGGACAAAC ACCCTGGGGG GCTGCATCCA GATAATGTGA AGTTGTTTTT ATTTCAGTTG 780

CTGCGAGGGC TGTCTTACAT CCACCAGCGT TATATTTTGC ACAGAGACCT GAAACCACAG 840

AACCTTCTGA TCAGTGACAC GGGGGAGTTA AAGCTGGCAG ATTTCGGTCT TGCAAGAGCA 900

AAATCCGTCC CTAGCCACAC ATACTCCAAC GAAGTGGTTA CCTTGTGGTA CAGACCTCCA 960

GATGTCCTTC TAGGCTCAAC AGAATATTCC ACCTGCCTTG ACATGTGGGG AGTAGGTTGC 1020

ATCTTTGTTG AAATGATCCA AGGAGTTGCT GCTTTTCCAG GAATGAAAGA CATTCAGGAT 1080

CAACTTGAAC GAATATTTCT GGTTCTTGGA ACGCCAAATG AGGACACATG GCCTGGAGTT 1140

CATTCTTTAC CACATTTTAA GCCAGAATGC TTTACCCTGT ACAGCTCTAA AAGCCTTAGA 1200

CAAGCGTGGA ATAAGCTCAG CTATGTGAAC CATGCAGAGG ACCTGGCCTC CAAGCTCCTA 1260

CAGTGTTCCC CAAAGAACAG ACTGTCGGCA CAGGCTGCCT TGAGCCACAA GTATTTTAGT 1320

GACCTGCCCC CACGGCTATG GGAACTCACC GATATGTCTT CTATTTTTAC CGTCCCAAAT 1380

GTGAGATTGC AACCAGAAGC TGGAGAAAGC ATGCGGGCCT TTGGGAAAAA CAATAGTTAC 1440

GGCAAAAGTC TATCAAACAG CAAGCACTGA 1470

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         yeklek+geG+y++vyk+k+k +g++vAlK irl++e eg p+ta+rE sllk lkh+ni

Q: 155   YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHANI  213

         99********************************998.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v L+++++ +k++l+Lvfe++++dL ++++k++  +l++++vk +l+qll+gl+y+H++

Q: 214   VLLHDIIH-TKETLTLVFEYVHTDLCQYMDKHPG-GLHPDNVKLFLFQLLRGLSYIHQRY  271

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLis++g+lklaDfGlara s+p++ty++evvTlwYr+P++Llg++eYst

Q: 272   ILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYST  331

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkse.idqlerifkllgtpsekvwpevsklpeyk.ksf  238

          +D+W+vgci++e+++  + f+g ++ +dqlerif +lgtp+e++wp+v++lp++k + f

Q: 332   CLDMWGVGCIFVEMIQGVAAFPGMKDiQDQLERIFLVLGTPNEDTWPGVHSLPHFKpECF  391

         ************************99679***************************7788

S: 239   pkkkkkklkekvkklk..ekaldllekllaldpkkRisakealqhkyf  284

         + +++k+l++ ++kl+  ++a dl +kll+++pk+R+sa++al+hkyf

Q: 392   TLYSSKSLRQAWNKLSyvNHAEDLASKLLQCSPKNRLSAQAALSHKYF  439

         889999******99997678***************************9

Domain Sequence
(FASTA)

YEKLEKLGEG SYATVYKGKS KVNGKLVALK VIRLQEEEGT PFTAIREASL LKGLKHANIV 60

LLHDIIHTKE TLTLVFEYVH TDLCQYMDKH PGGLHPDNVK LFLFQLLRGL SYIHQRYILH 120

RDLKPQNLLI SDTGELKLAD FGLARAKSVP SHTYSNEVVT LWYRPPDVLL GSTEYSTCLD 180

MWGVGCIFVE MIQGVAAFPG MKDIQDQLER IFLVLGTPNE DTWPGVHSLP HFKPECFTLY 240

SSKSLRQAWN KLSYVNHAED LASKLLQCSP KNRLSAQAAL SHKYF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000308	; C:cytoplasmic cyclin-dependent protein kinase holoenzyme complex
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0060828	; P:regulation of canonical Wnt receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013