EKS-NOL-00064
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00064
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/CDK351.72.7E-10513300288
StatusUnreviewed
Ensembl ProteinENSNLEP00000018614
UniProt AccessionG1RZD7;
Protein Name
Protein Synonyms/Alias
Gene NameCDK6
Gene Synonyms/Alias CDK6;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000015335ENSNLEP00000018614ENSNLET00000019544
ENSNLEG00000015335ENSNLEP00000024323ENSNLET00000032687
OrganismNomascus leucogenys
Functional Description
Protein Length326
Protein Sequence
(FASTA)
MEKDGLCRAD QQYECVAEIG EGAYGKVFKA RDLKNGGRFV ALKRVRVQTG EEGMPLSTIR 60
EVAVLRHLET FEHPNVVRLF DVCTVSRTDR ETKLTLVFEH VDQDLTTYLD KVPEPGVPTE 120
TIKDMMFQLL RGLDFLHSHR VVHRDLKPQN ILVTSSGQIK LADFGLARIY SFQMALTSVV 180
VTLWYRAPEV LLQSSYATPV DLWSVGCIFA EMFRRKPLFR GSSDVDQLGK ILDVIGLPGE 240
DDWPRDVALP RQAFHSKSAQ PIEKFVTDID ELGKDLLLKC LTFNPAKRIS AYSALSHPYF 300
QDLERCRENL DSHLPPSQNT SELNTA 326
Nucleotide Sequence
(FASTA)
ATGGAGAAGG ACGGCCTGTG TCGCGCTGAC CAGCAGTACG AATGCGTGGC GGAGATCGGG 60
GAGGGCGCCT ATGGGAAGGT GTTCAAGGCC CGCGACTTGA AGAACGGAGG CCGTTTCGTG 120
GCATTGAAGC GCGTGCGGGT GCAGACGGGC GAGGAGGGCA TGCCGCTCTC CACCATCCGC 180
GAGGTGGCGG TGCTGAGGCA CCTGGAGACC TTCGAGCACC CCAACGTGGT CAGGTTGTTT 240
GATGTGTGCA CAGTGTCACG AACAGACAGA GAAACCAAAC TAACTTTAGT GTTTGAACAT 300
GTTGATCAAG ACTTGACCAC TTACTTGGAT AAAGTTCCAG AGCCTGGAGT GCCCACTGAA 360
ACCATAAAGG ATATGATGTT TCAGCTTCTC CGAGGTCTGG ACTTTCTTCA TTCACACCGA 420
GTAGTGCATC GCGATCTAAA ACCACAGAAC ATTCTGGTGA CCAGCAGCGG ACAAATAAAA 480
CTCGCTGACT TCGGCCTTGC CCGCATCTAT AGTTTCCAGA TGGCTCTAAC CTCAGTGGTC 540
GTCACGCTGT GGTACAGAGC ACCCGAAGTC TTGCTCCAGT CCAGCTACGC CACCCCCGTG 600
GATCTCTGGA GTGTTGGCTG CATATTTGCA GAAATGTTTC GTAGAAAGCC TCTTTTTCGT 660
GGAAGTTCAG ATGTTGATCA ACTAGGAAAA ATCTTGGACG TAATTGGACT CCCAGGAGAA 720
GATGACTGGC CTAGAGATGT TGCCCTTCCC AGGCAGGCTT TTCATTCAAA ATCTGCCCAA 780
CCAATTGAGA AGTTTGTAAC AGATATCGAT GAACTAGGCA AAGACTTACT TCTGAAGTGT 840
TTGACATTTA ACCCAGCCAA AAGAATATCT GCCTACAGTG CCCTGTCTCA CCCATACTTC 900
CAGGACCTGG AAAGGTGCAG AGAAAACCTG GATTCCCATC TGCCGCCCAG CCAGAACACC 960
TCGGAGCTGA ATACAGCCTG A 981
Domain Profile
S: 1     yeklekigeGtygkvykakd.ketgevvAlKkirlekekegvpitalrEisllkel...k  56
         ye++++igeG+ygkv+ka+d k+ g++vAlK++r+++ +eg+p +++rE+++l++l   +
Q: 13    YECVAEIGEGAYGKVFKARDlKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLetfE  72
         899*****************888999*****************************98889
S: 57    hknivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleg  112
         h+n+v+L +v++     +++kl+Lvfe+++qdL+++l+k ++ ++++e++k +++qll+g
Q: 73    HPNVVRLFDVCTvsrtDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG  132
         ************99855569****************************************
S: 113   laylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelL  172
         l++lHs++++HRDlKpqN+L++++g++klaDfGlar +s ++  +t++vvTlwYraPe+L
Q: 133   LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTLWYRAPEVL  191
         *****************************************99.****************
S: 173   lgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklp  232
         l++ +Y t vD+Wsvgci+ae+++rkplf+g+s++dql +i++++g p e++wp+   lp
Q: 192   LQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEDDWPRDVALP  250
         *88.5*******************************************************
S: 233   eykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284
         +   +f++k+++ +++ v++++e + dll k+l+++p+kRisa +al+h+yf
Q: 251   RQ--AFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF  300
         95..59999999***************************************9
Domain Sequence
(FASTA)
YECVAEIGEG AYGKVFKARD LKNGGRFVAL KRVRVQTGEE GMPLSTIREV AVLRHLETFE 60
HPNVVRLFDV CTVSRTDRET KLTLVFEHVD QDLTTYLDKV PEPGVPTETI KDMMFQLLRG 120
LDFLHSHRVV HRDLKPQNIL VTSSGQIKLA DFGLARIYSF QMALTSVVVT LWYRAPEVLL 180
QSSYATPVDL WSVGCIFAEM FRRKPLFRGS SDVDQLGKIL DVIGLPGEDD WPRDVALPRQ 240
AFHSKSAQPI EKFVTDIDEL GKDLLLKCLT FNPAKRISAY SALSHPYF 288
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00064
EKS-ANC-00063
EKS-BOT-00069
EKS-CAJ-00065
EKS-CAF-00073
EKS-CAP-00067
EKS-CII-00028
EKS-CIS-00069
EKS-DAR-00082
EKS-DRM-00032
EKS-EQC-00067
EKS-FEC-00067
EKS-GAM-00030
EKS-GAG-00055
EKS-GAA-00084
EKS-GOG-00073
EKS-HOS-00071
EKS-LAC-00069
EKS-LOA-00067
EKS-MAM-00067
EKS-MEG-00052
EKS-MOD-00066
EKS-MUM-00071
EKS-MUP-00071
EKS-MYL-00072
EKS-OCP-00043
EKS-ORN-00088
EKS-ORA-00061
EKS-ORC-00065
EKS-ORL-00078
EKS-OTG-00072
EKS-PAT-00061
EKS-PES-00062
EKS-PEM-00037
EKS-POA-00064
EKS-PRC-00041
EKS-RAN-00064
EKS-SOA-00030
EKS-TAG-00057
EKS-TAR-00088
EKS-TEN-00090
EKS-TUT-00063
EKS-XET-00063
Gene Ontology
GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0001726; C:ruffle
GO:0005524; F:ATP binding
GO:0004693; F:cyclin-dependent protein kinase activity
GO:0043697; P:cell dedifferentiation
GO:0000080; P:G1 phase of mitotic cell cycle
GO:0042063; P:gliogenesis
GO:0045786; P:negative regulation of cell cycle
GO:2000773; P:negative regulation of cellular senescence
GO:0050680; P:negative regulation of epithelial cell proliferation
GO:0045638; P:negative regulation of myeloid cell differentiation
GO:0045668; P:negative regulation of osteoblast differentiation
GO:0001954; P:positive regulation of cell-matrix adhesion
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0045646; P:regulation of erythrocyte differentiation
GO:0010468; P:regulation of gene expression
GO:0009615; P:response to virus
GO:0003323; P:type B pancreatic cell development
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013