EKS-NOL-00278

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00278

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	402.1	1.0E-120	731	996	266

Status

Unreviewed

Ensembl Protein

ENSNLEP00000018753

UniProt Accession

G1RZS6;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

ALK

Gene Synonyms/Alias

ALK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000015414	ENSNLEP00000018753	ENSNLET00000019694

Organism

Nomascus leucogenys

Functional Description

Protein Length

1225

Protein Sequence
(FASTA)

WTVLQGRIGR PDNPFRVALE YISSGNRSLS AVDFFALKNC SEGTSPGSKM ALQSSFTCWN 60

GTVLQLGQAC DFHQDCAQGE DESQMCRKLP VGFYCNFEDG FCGWTQGTLS PHTPQWQVRT 120

LKDARFQDHR DHALLLSTTD VPTSESATVT SATFPAPIKS SPYELRMSWL IRGVLRGNVS 180

LVLVENKTGK EQGRMVWHVA AYEGLNLWQW TVLPLLDVSE RFWLQMVAWW GQGSRAIVAF 240

DNISISLDCY LTISGEDKIL QNTAPKSRNL FERNPNKELK PGETSPRQTP IFDPTVHWLF 300

TTCGASGPHG PHPGALSNTC KAAPSVMELG FEPRVLWLKV SPIPTTSFCF ISGYGAAGGK 360

GGKNTMMRSH GVSVLGIFNL EKDDTLYILV GQQGEDACPS TNQLIQKVCI GENNVIEEEI 420

RVNRSVHEWA GGGGGGGGAT YVFKMKDGVP VPLIIAAGGG GRAYGAKTDT FHPERLENNS 480

SVLGLNGNSG AAGGGGGWND NTSLLWAGKS LQEGATGGHS CPQAMKKWGW ETRGGFGGGG 540

GGCSSGGGGG GYIGGNAASN NDPEMDGEDG VSFISPLGIL YTPALKVMEG HGEVNIKHYL 600

NCSHCEVDEC HMDPESHQVI CFCDHGTVLA EDGISCIVSP TPEPHLPLSL ILSVVTSALV 660

ASCHVAADHP SAVYRRKHQE LQAMQMELQS PEYKLSKLRT STIMTDYNPN YCFAGKTSSI 720

SDLKEVPRKN ITLIRGLGHG AFGEVYEGQV SGMPNDPSPL QVAVKVRSLA LEPALGLLTL 780

SGLGPRHPNS FKCLQVTSNV QPGPMPLISL LSLTSSSSVA HFCLPTSQPS SLAMLDLLHV 840

ARDIACGCQY LEENHFIHRD IAARNCLLTC PGPGRVAKIG DFGMARDIYR ASYYRKGGCA 900

MLPVKWMPPE AFMEGIFTSK TDTWSFGVLL WEIFSLGYMP YPSKSNQEVL EFVTSGGRMD 960

PPKNCPGPVY RIMTQCWQHQ PEDRPNFAII LERIEYCTQD PDVINTALPI EYGPLAEEEE 1020

KVPVRPKDPE GVPPLLVSQQ AKREEERSPA APPPLPTTSS GKAAKKPTAA GVSVRVPRGP 1080

AMEGGHVNMA FSQSNPPSEL HKVQGSRNKP TSLWNPTYGS WFTEKPTKKK EPHERGNLGL 1140

EGSCTVPPNV ATGRLPGASL LLEPSSLTAN MKEVPLFRLR HFPCGNVNYG YQQQGLPLEA 1200

ATAPGAGHYE DTILKSKNSM NQPGP 1225

Nucleotide Sequence
(FASTA)

TGGACAGTGC TACAGGGAAG AATCGGGCGC CCAGACAACC CATTTCGAGT GGCCCTGGAA 60

TACATCTCCA GTGGAAACCG CAGCTTGTCT GCAGTGGACT TCTTTGCCCT GAAGAACTGC 120

AGTGAAGGAA CATCCCCAGG CTCCAAGATG GCCCTGCAGA GCTCCTTCAC TTGTTGGAAT 180

GGGACAGTCC TCCAGCTTGG GCAGGCCTGT GACTTCCACC AGGACTGCGC CCAGGGAGAA 240

GATGAGAGCC AGATGTGCCG GAAACTCCCT GTGGGTTTTT ACTGCAACTT TGAAGATGGC 300

TTCTGTGGCT GGACCCAAGG CACACTCTCA CCCCACACTC CTCAGTGGCA GGTCAGGACC 360

CTGAAGGATG CCCGGTTCCA GGACCACCGA GACCATGCTC TATTGCTCAG TACCACTGAT 420

GTCCCCACTT CTGAAAGTGC TACAGTGACC AGTGCTACAT TTCCCGCACC GATCAAGAGC 480

TCTCCATACG AACTCCGAAT GTCCTGGCTC ATTCGTGGAG TCTTGAGGGG AAACGTGTCC 540

TTGGTGCTAG TGGAGAACAA AACCGGGAAG GAGCAAGGCA GGATGGTCTG GCATGTCGCC 600

GCATATGAAG GCTTGAACCT GTGGCAGTGG ACGGTGTTAC CTCTCCTCGA TGTGTCTGAG 660

AGGTTCTGGC TGCAGATGGT CGCATGGTGG GGACAAGGAT CCAGAGCTAT CGTGGCTTTT 720

GACAATATCT CCATCAGCCT GGACTGCTAC CTCACCATTA GTGGAGAGGA CAAGATCCTG 780

CAGAATACAG CACCCAAATC AAGAAACCTG TTTGAGAGAA ACCCAAACAA GGAGCTGAAA 840

CCCGGGGAAA CTTCACCAAG ACAGACCCCC ATCTTTGACC CTACAGTTCA TTGGCTGTTC 900

ACCACATGTG GGGCCAGTGG GCCCCATGGG CCCCACCCAG GCGCACTTAG CAACACGTGT 960

AAGGCTGCAC CATCAGTGAT GGAGCTGGGA TTCGAACCCA GGGTGCTCTG GCTCAAAGTC 1020

TCCCCAATTC CCACTACCTC TTTCTGTTTC ATCTCAGGCT ACGGAGCTGC TGGCGGGAAA 1080

GGCGGGAAGA ACACCATGAT GCGGTCCCAC GGCGTGTCTG TGCTGGGCAT CTTCAACCTG 1140

GAGAAGGACG ACACACTGTA CATCCTGGTC GGGCAGCAGG GAGAGGACGC CTGCCCCAGT 1200

ACAAACCAGT TAATCCAGAA AGTCTGCATT GGAGAGAACA ATGTGATAGA AGAAGAAATC 1260

CGTGTGAACA GAAGTGTGCA TGAGTGGGCA GGAGGAGGAG GAGGAGGGGG TGGAGCCACC 1320

TACGTATTTA AGATGAAGGA TGGAGTGCCA GTGCCCCTGA TCATTGCAGC CGGAGGTGGC 1380

GGCAGGGCCT ACGGGGCCAA GACAGACACG TTCCACCCAG AGAGACTGGA GAATAACTCC 1440

TCGGTTCTAG GGCTAAATGG CAATTCCGGA GCCGCAGGTG GTGGAGGTGG CTGGAATGAT 1500

AACACTTCCT TGCTCTGGGC CGGAAAATCT TTGCAGGAGG GTGCCACCGG AGGACATTCC 1560

TGCCCCCAGG CCATGAAGAA GTGGGGGTGG GAGACAAGAG GGGGTTTCGG AGGGGGTGGA 1620

GGGGGGTGCT CCTCAGGTGG AGGAGGCGGA GGATATATAG GCGGCAATGC AGCCTCAAAC 1680

AATGACCCCG AAATGGATGG GGAAGATGGG GTTTCCTTCA TCAGTCCACT GGGCATCCTG 1740

TACACCCCAG CTTTAAAAGT GATGGAAGGC CACGGGGAAG TGAATATTAA GCATTATCTA 1800

AACTGCAGTC ACTGTGAGGT AGACGAATGT CACATGGACC CTGAAAGCCA CCAGGTCATC 1860

TGCTTCTGTG ACCACGGGAC GGTGCTGGCT GAGGATGGCA TCTCCTGCAT TGTGTCACCC 1920

ACCCCGGAGC CACACCTGCC ACTCTCGCTG ATCCTCTCTG TGGTGACCTC TGCCCTCGTG 1980

GCTTCCTGCC ATGTTGCAGC TGACCACCCA TCTGCAGTGT ACCGCCGGAA GCACCAGGAG 2040

CTGCAAGCCA TGCAGATGGA GCTGCAGAGC CCTGAGTACA AGCTGAGCAA GCTCCGCACC 2100

TCGACCATCA TGACCGACTA CAACCCCAAC TACTGCTTTG CTGGCAAGAC CTCCTCCATC 2160

AGTGACCTGA AGGAGGTACC GCGGAAAAAC ATCACCCTCA TTCGGGGTCT GGGCCATGGC 2220

GCCTTTGGGG AGGTGTATGA AGGCCAGGTG TCCGGAATGC CCAACGACCC AAGCCCCCTG 2280

CAAGTGGCTG TGAAGGTAAG AAGTCTCGCT CTTGAGCCTG CCCTTGGCTT GCTGACTCTG 2340

TCTGGGTTGG GGCCCAGGCA TCCAAATTCT TTCAAATGCC TCCAGGTGAC TTCTAATGTG 2400

CAGCCAGGGC CGATGCCCCT GATTTCCCTC CTCTCACTGA CAAGCTCCTC GTCAGTGGCC 2460

CACTTCTGTC TCCCCACAAG CCAGCCCTCC TCCCTGGCCA TGCTGGACCT TCTGCACGTG 2520

GCTCGGGACA TTGCCTGTGG CTGTCAGTAT TTGGAGGAAA ACCACTTCAT CCACCGAGAC 2580

ATTGCTGCCA GAAACTGCCT CTTGACCTGT CCAGGCCCTG GAAGAGTGGC CAAGATTGGA 2640

GACTTCGGGA TGGCCCGAGA CATCTACAGG GCGAGCTACT ATAGAAAGGG AGGCTGTGCT 2700

ATGCTGCCAG TTAAGTGGAT GCCCCCAGAG GCCTTCATGG AAGGAATATT CACTTCTAAA 2760

ACAGACACAT GGTCCTTTGG AGTGCTGCTG TGGGAAATCT TTTCTCTTGG ATATATGCCA 2820

TACCCCAGCA AAAGCAACCA GGAAGTTCTG GAGTTCGTCA CCAGTGGAGG CCGGATGGAC 2880

CCACCCAAGA ACTGCCCTGG GCCTGTATAC CGGATAATGA CTCAGTGCTG GCAACATCAG 2940

CCTGAAGACA GGCCCAACTT TGCCATCATT TTGGAGAGGA TTGAATACTG CACCCAGGAC 3000

CCAGATGTAA TCAACACTGC TTTGCCGATA GAATACGGTC CACTTGCGGA AGAGGAAGAG 3060

AAAGTGCCCG TGAGGCCCAA GGACCCTGAG GGGGTTCCTC CTCTCCTGGT CTCTCAACAG 3120

GCGAAACGGG AGGAGGAGCG CAGCCCAGCA GCCCCACCAC CTCTGCCTAC CACCTCCTCT 3180

GGCAAGGCTG CAAAGAAACC CACAGCTGCA GGGGTCTCTG TTCGAGTCCC TAGAGGGCCG 3240

GCCATGGAAG GGGGACACGT GAATATGGCA TTCTCTCAGT CCAACCCCCC TTCGGAGTTG 3300

CACAAGGTCC AGGGATCCAG AAACAAGCCC ACCAGCTTGT GGAACCCAAC GTACGGCTCC 3360

TGGTTTACAG AGAAACCCAC CAAAAAGAAG GAGCCACATG AGAGGGGTAA CCTGGGGCTG 3420

GAGGGAAGCT GTACTGTCCC ACCTAATGTT GCAACTGGGA GACTTCCGGG AGCCTCACTG 3480

CTCCTAGAGC CCTCTTCGCT GACTGCCAAT ATGAAGGAGG TACCTCTGTT CAGGCTACGT 3540

CACTTCCCTT GTGGGAATGT CAATTACGGC TACCAGCAAC AGGGCTTGCC CTTAGAAGCC 3600

GCTACTGCCC CTGGAGCTGG TCATTACGAG GACACCATTC TGAAAAGCAA GAATAGCATG 3660

AACCAGCCTG GGCCCTGA 3678

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         i+l+r+lG+GafGevyeg+vsg+p+d+s+l+vavk ++   + +  l +l+ +      +

Q: 731   ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKVRSLALEPA--LGLLTLS--GLGPR  786

         799********************************998776655..3444322..23458

S: 61    henivrliGvsleklpr.lillellaGGdlksflresrpkpeqlsslamkdllkvaldva  119

         h+n  +++ v+ + +p  + l+ ll+     s  + + p ++q+sslam dll+va+d+a

Q: 787   HPNSFKCLQVTSNVQPGpMPLISLLSLTSSSSVAHFCLP-TSQPSSLAMLDLLHVARDIA  845

         ************999972446667776666666666666.579*****************

S: 120   kGckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvk  179

         +Gc+yleen+fihrdiaarn+ll+++Gp+rvaki+dfGmardiyra+yyrkgg+a+lpvk

Q: 846   CGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVK  905

         ************************************************************

S: 180   wmppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkei  239

         wmppeaf+eGiftsktd+wsfGvllwe+fslG++pyp+ksnqevle+v++Ggr+d+pk++

Q: 906   WMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNC  965

         ************************************************************

S: 240   pgsvyrimtdcwkhepedrpkfvsilerlqa  270

         pg+vyrimt+cw+h+pedrp+f++iler+++

Q: 966   PGPVYRIMTQCWQHQPEDRPNFAIILERIEY  996

         ****************************986

Domain Sequence
(FASTA)

ITLIRGLGHG AFGEVYEGQV SGMPNDPSPL QVAVKVRSLA LEPALGLLTL SGLGPRHPNS 60

FKCLQVTSNV QPGPMPLISL LSLTSSSSVA HFCLPTSQPS SLAMLDLLHV ARDIACGCQY 120

LEENHFIHRD IAARNCLLTC PGPGRVAKIG DFGMARDIYR ASYYRKGGCA MLPVKWMPPE 180

AFMEGIFTSK TDTWSFGVLL WEIFSLGYMP YPSKSNQEVL EFVTSGGRMD PPKNCPGPVY 240

RIMTQCWQHQ PEDRPNFAII LERIEY 266

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0048666	; P:neuron development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR026830	; ALK.
IPR008985	; ConA-like_lec_gl_sf.
IPR011009	; Kinase-like_dom.
IPR002172	; LDrepeatLR_classA_rpt.
IPR000998	; MAM_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00629	; MAM; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00192	; LDLa; 1.
SM00219	; TyrKc; 1.

Prosites

PS50060	; MAM_2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013