EKS-NOL-00422
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00422
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK414.42.1E-12426321296
StatusUnreviewed
Ensembl ProteinENSNLEP00000018944
UniProt AccessionG1S0B6;
Protein Name
Protein Synonyms/Alias
Gene NameMAPK8
Gene Synonyms/Alias MAPK8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000015573ENSNLEP00000018944ENSNLET00000019896
OrganismNomascus leucogenys
Functional Description
Protein Length384
Protein Sequence
(FASTA)
MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 60
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 120
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180
MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMIK GGVLFPGTDH IDQWNKVIEQ 240
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 300
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 360
MDLEERTKNG VIRGQPSPLA QVQQ 384
Nucleotide Sequence
(FASTA)
ATGAGCAGAA GCAAGCGTGA CAACAATTTT TATAGTGTAG AGATTGGAGA TTCTACATTC 60
ACAGTCCTGA AACGATATCA GAATTTAAAA CCTATAGGCT CAGGAGCTCA AGGAATAGTA 120
TGCGCAGCTT ATGATGCCAT TCTTGAAAGA AATGTTGCAA TCAAGAAGCT AAGCCGACCA 180
TTTCAGAATC AGACTCATGC CAAGCGGGCC TACAGAGAGC TAGTTCTTAT GAAATGTGTT 240
AATCACAAAA ATATAATTGG CCTTTTGAAT GTTTTCACAC CACAGAAATC CCTAGAAGAA 300
TTTCAAGATG TTTACATAGT CATGGAGCTC ATGGATGCAA ATCTTTGCCA AGTGATTCAG 360
ATGGAGCTAG ATCATGAAAG AATGTCCTAC CTTCTCTATC AGATGCTGTG TGGAATCAAG 420
CACCTTCATT CTGCTGGAAT TATTCATCGG GACTTAAAGC CCAGTAATAT AGTAGTAAAA 480
TCTGACTGCA CTTTGAAGAT TCTTGACTTC GGTCTGGCCA GGACTGCAGG AACGAGTTTT 540
ATGATGACGC CTTACGTAGT GACTCGCTAC TACAGAGCAC CCGAGGTCAT CCTCGGCATG 600
GGCTACAAGG AAAACGTTGA CATTTGGTCA GTTGGGTGCA TCATGGGAGA AATGATCAAA 660
GGTGGTGTTT TGTTCCCAGG TACAGATCAT ATTGATCAGT GGAATAAAGT TATTGAACAG 720
CTTGGAACAC CATGTCCTGA ATTCATGAAG AAACTGCAAC CAACAGTAAG GACTTACGTT 780
GAAAACAGAC CTAAATATGC CGGATATAGC TTTGAGAAAC TCTTCCCTGA TGTCCTTTTC 840
CCAGCTGACT CGGAACACAA CAAACTTAAA GCCAGTCAGG CAAGGGATTT GTTATCCAAA 900
ATGCTGGTAA TAGATGCATC TAAAAGGATC TCTGTAGATG AAGCTCTCCA ACACCCGTAC 960
ATCAATGTCT GGTATGATCC TTCTGAAGCA GAAGCTCCAC CACCAAAGAT CCCTGACAAG 1020
CAGTTAGATG AAAGAGAACA CACAATAGAA GAGTGGAAAG AACTGATATA TAAGGAAGTT 1080
ATGGACTTGG AGGAGAGAAC CAAGAATGGA GTTATACGGG GGCAGCCCTC TCCTTTAGCA 1140
CAGGTGCAGC AGTGA 1155
Domain Profile
S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60
         y++lkp+g+Ga+g+v++a+d+  e++vaikklsrpfq++t+akr++REl l+k+++h+Ni
Q: 26    YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  85
         899*********************************************************
S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120
         i ll+vftp+++lee++dvY+v+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs
Q: 86    IGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  144
         ************************************9.**********************
S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180
         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  + 
Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  201
         **********************************976..*****************9.99
S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240
         y+++vDiWsvGCI++E+++g +lfpg+d+idq++k++e+lgtp  ef+kk++  ++r+y+
Q: 202   YKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQP-TVRTYV  260
         *****************************************************.5*****
S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288
         +++pk++  +fe+lfp+            + ++a+dLl+k+Lv+d++kRisv+eaL+hpY
Q: 261   ENRPKYAGYSFEKLFPDvlfpadsehnklKASQARDLLSKMLVIDASKRISVDEALQHPY  320
         *****************************99*****************************
S: 289   l  289
         +
Q: 321   I  321
         7
Domain Sequence
(FASTA)
YQNLKPIGSG AQGIVCAAYD AILERNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60
IGLLNVFTPQ KSLEEFQDVY IVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120
GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180
VDIWSVGCIM GEMIKGGVLF PGTDHIDQWN KVIEQLGTPC PEFMKKLQPT VRTYVENRPK 240
YAGYSFEKLF PDVLFPADSE HNKLKASQAR DLLSKMLVID ASKRISVDEA LQHPYI 296
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>
EKS-BOT-00465
EKS-CAJ-00470
EKS-CAF-00466
EKS-CAP-00497
EKS-CIS-00222
EKS-DRM-00223
EKS-EQC-00453
EKS-GAM-00271
EKS-GOG-00455
EKS-HOS-00474
EKS-ICT-00440
EKS-LOA-00470
EKS-MAM-00462
EKS-MEG-00380
EKS-MOD-00457
EKS-MUM-00498
EKS-MUP-00455
EKS-ORN-00587
EKS-ORC-00439
EKS-PES-00409
EKS-POA-00453
EKS-RAN-00483
EKS-SAH-00433
Gene Ontology
GO:0005524; F:ATP binding
GO:0035033; F:histone deacetylase regulator activity
GO:0004707; F:MAP kinase activity
GO:0071260; P:cellular response to mechanical stimulus
GO:0007258; P:JUN phosphorylation
GO:0043066; P:negative regulation of apoptotic process
GO:0032091; P:negative regulation of protein binding
GO:0018105; P:peptidyl-serine phosphorylation
GO:0090045; P:positive regulation of deacetylase activity
GO:0010628; P:positive regulation of gene expression
GO:0032880; P:regulation of protein localization
GO:0009411; P:response to UV
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR008351; MAPK_JNK.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR01772; JNKMAPKINASE.
Created Date20-Feb-2013