EKS-NOL-00107

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00107

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MLCK	388.3	1.5E-116	140	387	248

Status

Unreviewed

Ensembl Protein

ENSNLEP00000018999

UniProt Accession

G1S0H1;

Protein Name

Protein Synonyms/Alias

Gene Name

MYLK3

Gene Synonyms/Alias

MYLK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000015670	ENSNLEP00000018999	ENSNLET00000019954

Organism

Nomascus leucogenys

Functional Description

Protein Length

436

Protein Sequence
(FASTA)

GYSCCLQVPG TEPREQTPEG ARELSPLQES RSPGGVKAEE EKRAGAEPGT RSVARSDDND 60

HAAGALGLQQ GKGPGAGNPE PEQDCAARAL GRAEAVRRTP PGTEAGSVVL DDSPAPPAPF 120

EHRVVSVKET SISAGYEVCQ HEVLGGGRFG QVHRCTEKST KIIKVKSAKD REDVKNEISI 180

MNQLSHVNLI QLYDAFESKH SCTLVMEHVD GGELFDRITD EKYHLTELDV VLFTRQICEG 240

VHYLHQHYIL HLDLKPENIL CVNQTGHQIK IIDFGLARRY KPREKLKVNF GTPEFLAPEV 300

VNYEFVSFPT DMWSVGVITY MLLSGLSSFL GETDAETMNF IVNCSWDFDA DTFEGLSEEA 360

KDFVSRLLVK EKSCRMSATQ CLKHEWLNNL PAKASRSKAR LKSQLLLQKY IAQRKWKKHF 420

YVVTAANRLK KFPTSP 436

Nucleotide Sequence
(FASTA)

GGGTACTCCT GCTGCCTCCA AGTCCCTGGG ACTGAGCCCA GAGAACAGAC CCCTGAAGGA 60

GCCAGAGAGC TCTCCCCATT GCAGGAGAGC CGCAGCCCCG GGGGAGTGAA GGCAGAGGAA 120

GAGAAAAGGG CTGGGGCCGA GCCTGGCACG AGAAGCGTGG CCAGGAGCGA CGACAACGAC 180

CACGCGGCTG GGGCCCTGGG CCTGCAGCAG GGCAAAGGCC CAGGGGCGGG AAACCCTGAG 240

CCTGAGCAGG ACTGTGCAGC CAGGGCTCTG GGCAGAGCCG AAGCAGTAAG GAGGACGCCC 300

CCAGGTACTG AGGCTGGCAG CGTGGTTCTG GATGACAGTC CGGCCCCGCC AGCTCCTTTT 360

GAACACCGGG TAGTGAGCGT CAAGGAGACC TCCATCTCGG CGGGTTACGA GGTGTGCCAG 420

CACGAAGTCT TGGGAGGGGG TCGGTTTGGC CAGGTCCACA GGTGCACAGA GAAGTCCACC 480

AAGATCATCA AAGTGAAGAG CGCCAAGGAC CGGGAGGACG TGAAGAACGA GATCAGCATC 540

ATGAACCAGC TCAGCCACGT GAACCTGATC CAGCTCTATG ACGCCTTCGA GAGCAAGCAC 600

AGCTGCACCC TCGTCATGGA GCACGTGGAC GGGGGTGAGC TCTTTGACCG GATCACAGAC 660

GAGAAGTACC ACCTGACTGA GCTGGATGTG GTCCTGTTCA CCAGGCAGAT CTGCGAGGGC 720

GTGCATTACC TGCACCAGCA CTACATCCTG CACCTGGACC TCAAGCCGGA GAACATATTG 780

TGCGTCAATC AGACAGGACA TCAAATTAAG ATCATTGACT TTGGGCTGGC CAGAAGGTAC 840

AAGCCTCGAG AGAAGCTGAA GGTGAACTTC GGCACTCCTG AGTTCCTGGC CCCAGAAGTC 900

GTCAACTATG AGTTTGTCTC ATTCCCCACA GACATGTGGA GTGTGGGAGT CATCACCTAC 960

ATGCTACTCA GTGGCTTGTC CTCATTTCTA GGGGAAACAG ATGCAGAGAC CATGAATTTC 1020

ATTGTAAACT GTAGCTGGGA TTTTGATGCT GACACCTTTG AAGGGCTCTC GGAGGAGGCC 1080

AAGGACTTTG TTTCCCGGTT GCTGGTCAAA GAGAAGAGCT GCAGAATGAG TGCCACACAG 1140

TGCCTGAAAC ACGAATGGCT GAATAATTTG CCTGCCAAAG CTTCAAGATC CAAAGCTCGT 1200

CTCAAATCCC AACTACTGCT GCAAAAATAC ATAGCTCAAA GAAAATGGAA GAAACATTTC 1260

TATGTGGTGA CTGCTGCCAA CAGGTTAAAG AAATTTCCAA CTTCTCCC 1308

Domain Profile

S: 3     ikeelgkGkfgvvvkavekstgkklaakivkvrkekdkeevkkEieilnqlrHekliqly  62

         ++e lg G+fg+v++++ekst      ki+kv+++kd+e+vk+Ei+i+nql+H +liqly

Q: 140   QHEVLGGGRFGQVHRCTEKST------KIIKVKSAKDREDVKNEISIMNQLSHVNLIQLY  193

         6899***************98......8********************************

S: 63    dafeskeeivlvlElveggelferiveedyeltEeevvlfvrqvlealeylHkkgivHld  122

         dafesk++++lv+E v+ggelf+ri++e+y+ltE +vvlf+rq++e+++ylH+++i+Hld

Q: 194   DAFESKHSCTLVMEHVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLD  253

         ************************************************************

S: 123   lkpenillqskkskqiKlidFGlarklkkkeklkvlfgtpefvaPEvvnkepvslatDmW  182

         lkpenil+++++++qiK+idFGlar++k++eklkv+fgtpef+aPEvvn+e+vs+ tDmW

Q: 254   LKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMW  313

         ************************************************************

S: 183   svGvityvLlsGlsPFlgdndeetlenvssakydfdeeafkevseeakdFiskllvkekk  242

         svGvity+LlsGls Flg++d+et++ + ++++dfd+++f+ +seeakdF+s+llvkek+

Q: 314   SVGVITYMLLSGLSSFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKS  373

         ************************************************************

S: 243   kRmsaeeaLkhkwl  256

         +Rmsa+++Lkh+wl

Q: 374   CRMSATQCLKHEWL  387

         *************8

Domain Sequence
(FASTA)

QHEVLGGGRF GQVHRCTEKS TKIIKVKSAK DREDVKNEIS IMNQLSHVNL IQLYDAFESK 60

HSCTLVMEHV DGGELFDRIT DEKYHLTELD VVLFTRQICE GVHYLHQHYI LHLDLKPENI 120

LCVNQTGHQI KIIDFGLARR YKPREKLKVN FGTPEFLAPE VVNYEFVSFP TDMWSVGVIT 180

YMLLSGLSSF LGETDAETMN FIVNCSWDFD ADTFEGLSEE AKDFVSRLLV KEKSCRMSAT 240

QCLKHEWL 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0071347	; P:cellular response to interleukin-1
GO:0002528	; P:regulation of vascular permeability involved in acute inflammatory response

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013