EKS-NOL-00066

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00066

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	339.1	1.8E-101	39	321	283

Status

Unreviewed

Ensembl Protein

ENSNLEP00000019198

UniProt Accession

G1S116;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK10

Gene Synonyms/Alias

CDK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000015832	ENSNLEP00000019198	ENSNLET00000020170

Organism

Nomascus leucogenys

Functional Description

Protein Length

358

Protein Sequence
(FASTA)

MAEPDQESEQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY GIVYRARDTQ 60

TDEIVALKKV RMDKEKDGIP ISSLREITLL LRLRHPNIVE LKEVVVGNHL ESIFLVMGYC 120

EQDLASLLEN MPTPFSEAQV KCIVLQLRGL HHLPVFFYHR DLKVSNLLMT DKGCVKTADF 180

GLARAYGVPV KPMTPKVVTL WYRAPELLLG TTTQTTSIDM WAVGCILAEL LAHRPLLPGT 240

SEIHQIDLIV QLLGTPSENI WPGFSKLPLV GQYSLRKQPY NNLKHKFPWL SEAGLRLLHF 300

LFMYDPKKRA TAGDCLESSY FKEKPLPCEP ELMPTFPHHR NKRAAPATSE GQSKRCKP 358

Nucleotide Sequence
(FASTA)

ATGGCGGAGC CAGATCAGGA GTCCGAGCAG ATCCGTCTGA AGTGTATTCG TAAGGAGGGC 60

TTCTTCACGG TGCCTCCGGA ACACAGGCTG GGACGATGCC GGAGTGTGAA GGAGTTTGAG 120

AAGCTGAACC GCATTGGAGA GGGTACCTAC GGCATTGTGT ATCGGGCCCG GGACACCCAG 180

ACAGATGAGA TTGTTGCGCT GAAGAAGGTG CGGATGGACA AGGAGAAGGA TGGCATCCCC 240

ATCAGCAGTT TGCGGGAGAT CACGCTGCTG CTCCGCCTGC GTCATCCGAA CATCGTGGAG 300

CTGAAGGAGG TGGTTGTGGG GAACCACCTG GAGAGCATCT TCCTGGTGAT GGGTTACTGT 360

GAGCAGGACC TGGCCAGCCT GCTGGAGAAT ATGCCAACAC CCTTCTCGGA GGCCCAGGTC 420

AAGTGCATCG TGCTGCAGCT CCGGGGCCTC CACCACCTGC CAGTGTTTTT CTATCACAGG 480

GACCTGAAGG TTTCCAACTT GCTCATGACT GACAAGGGTT GTGTGAAGAC AGCGGATTTC 540

GGCCTGGCCC GGGCCTATGG TGTCCCAGTA AAGCCAATGA CCCCCAAGGT GGTGACTCTC 600

TGGTACCGTG CCCCTGAACT GCTGCTGGGA ACCACCACAC AGACCACCAG CATCGACATG 660

TGGGCTGTGG GCTGCATCCT GGCTGAGCTG CTGGCCCACA GGCCCCTTCT CCCCGGCACT 720

TCCGAGATTC ACCAGATCGA CTTGATCGTG CAGCTGCTCG GGACGCCCAG TGAGAATATC 780

TGGCCGGGTT TTTCCAAGCT GCCGCTGGTC GGCCAGTACA GCCTCCGGAA GCAGCCCTAC 840

AACAACCTGA AGCACAAGTT CCCGTGGCTG TCCGAGGCCG GGCTGCGCCT GCTGCACTTC 900

CTGTTCATGT ACGACCCTAA GAAAAGGGCG ACGGCCGGGG ACTGCCTGGA GAGCTCCTAC 960

TTCAAGGAGA AGCCCCTACC CTGTGAGCCG GAGCTCATGC CGACCTTTCC CCACCACCGC 1020

AACAAGCGGG CCGCCCCGGC CACCTCCGAG GGCCAGAGCA AGCGCTGTAA ACCCTGA 1077

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         +ekl++igeGtyg vy+a+d++t+e+vAlKk+r++kek+g+pi++lrEi+ll +l+h+ni

Q: 39    FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNI  98

         89**********************************************************

S: 61    vkLlevvakdk.kklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn  119

         v+L+evv+ ++ ++++Lv+ ++eqdL++ll+++++  +s+++vk ++lq l+gl++l

Q: 99    VELKEVVVGNHlESIFLVMGYCEQDLASLLENMPT-PFSEAQVKCIVLQ-LRGLHHLP-V  155

         ********5555***********************.************9.59**9995.5

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

          + HRDlK +NlL++++g++k aDfGlara+++p+k +t++vvTlwYraPelLlg+++ +

Q: 156   FFYHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQT  215

         789*********************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksf  238

         t++D+W+vgcilaell+++pl++g+sei+q++ i++llgtpse++wp++sklp +  +s+

Q: 216   TSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGqYSL  275

         *******************************************************988**

S: 239   pkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +k+++++lk+k++ l+e++l+ll+ l+++dpkkR +a ++l+++yf

Q: 276   RKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYF  321

         *********************************************8

Domain Sequence
(FASTA)

FEKLNRIGEG TYGIVYRARD TQTDEIVALK KVRMDKEKDG IPISSLREIT LLLRLRHPNI 60

VELKEVVVGN HLESIFLVMG YCEQDLASLL ENMPTPFSEA QVKCIVLQLR GLHHLPVFFY 120

HRDLKVSNLL MTDKGCVKTA DFGLARAYGV PVKPMTPKVV TLWYRAPELL LGTTTQTTSI 180

DMWAVGCILA ELLAHRPLLP GTSEIHQIDL IVQLLGTPSE NIWPGFSKLP LVGQYSLRKQ 240

PYNNLKHKFP WLSEAGLRLL HFLFMYDPKK RATAGDCLES SYF 283

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013