EKS-NOL-00195

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00195

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	459.9	2.3E-138	4	284	281

Status

Unreviewed

Ensembl Protein

ENSNLEP00000019989

UniProt Accession

G1S3A1;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL4

Gene Synonyms/Alias

CDKL4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000016471	ENSNLEP00000019989	ENSNLET00000020990

Organism

Nomascus leucogenys

Functional Description

Protein Length

377

Protein Sequence
(FASTA)

MEKYEKLAEI GEGSYGIVFK CRNKTSGQVV AIKKFVQSED NPVTKKIALR EIRTLKQLKH 60

PNLVNLTEVF RRKKKIYLVF EYCDHTLLNE LERNPNRVAD AVIKSVLWQT LQGLNFCHIH 120

NYMHRDMKPE NILITKQGII KICDFGFARI LIPGDAYTGY VATRWYRAPE LLVGDTHCGS 180

SVVIWAIGCV FAELLTGQPL WPGKSDTDQL YLIIRTLGSK IPRRQSIFNR FFHDISIPEP 240

EDKETLEEKF SDTHPVALSF MKGCLKMNPD DRLTCSQLLE SPYFDSFQED QIKRKACNKR 300

RNRRHQQVLP LKSAPRLFLK TKICQVQRNE TQTSGNQILP NGPTLQNSWV TLMTNINSAV 360

YQVTVLHLLS ENFEVKS 377

Nucleotide Sequence
(FASTA)

ATGGAAAAGT ATGAAAAATT AGCTGAGATT GGAGAAGGGT CTTATGGGAT TGTATTCAAA 60

TGCAGAAACA AAACCTCTGG ACAAGTAGTA GCTATTAAAA AATTTGTTCA ATCTGAAGAT 120

AATCCTGTTA CTAAGAAAAT AGCACTAAGA GAAATACGTA CGTTGAAGCA ATTAAAACAT 180

CCAAATCTTG TAAACCTCAC TGAAGTATTT AGAAGAAAAA AGAAAATATA TTTAGTGTTT 240

GAATATTGTG ATCATACACT TTTAAACGAG TTGGAAAGAA ACCCAAACAG AGTTGCTGAT 300

GCTGTGATCA AAAGTGTATT ATGGCAAACA CTTCAAGGTC TTAATTTCTG TCATATACAT 360

AATTATATGC ACCGAGATAT GAAACCTGAA AATATTCTAA TAACTAAGCA AGGAATAATC 420

AAGATTTGTG ACTTTGGGTT TGCACGAATT CTGATTCCAG GAGATGCCTA CACCGGTTAT 480

GTAGCTACGA GATGGTACCG AGCTCCTGAA CTTCTTGTGG GAGATACTCA CTGTGGTTCT 540

TCAGTCGTTA TATGGGCTAT TGGTTGCGTT TTTGCAGAGC TCCTGACAGG CCAGCCACTG 600

TGGCCTGGAA AATCAGATAC AGACCAACTT TATCTGATAA TCAGAACACT AGGTAGTAAA 660

ATCCCAAGAC GTCAATCAAT CTTTAACCGG TTTTTCCATG ACATCAGTAT ACCTGAACCA 720

GAAGACAAGG AAACTCTTGA AGAAAAGTTC TCAGACACTC ATCCTGTAGC TCTGAGCTTC 780

ATGAAGGGGT GTCTGAAGAT GAATCCAGAT GACAGATTAA CCTGTTCCCA ACTCCTGGAG 840

AGCCCCTACT TTGATTCTTT TCAAGAGGAC CAAATTAAAA GAAAAGCGTG TAACAAACGA 900

AGAAACAGAA GACACCAGCA GGTACTTCCG CTCAAAAGTG CACCTAGGCT TTTTCTCAAA 960

ACCAAGATCT GCCAGGTACA AAGGAATGAA ACTCAGACAT CTGGGAACCA AATTCTACCC 1020

AATGGGCCAA CATTGCAGAA CAGTTGGGTG ACTCTTATGA CAAACATTAA TTCTGCAGTT 1080

TATCAGGTGA CTGTCCTTCA CTTGCTTTCA GAAAACTTTG AAGTTAAATC A 1131

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         yekl+++GeGsyG+v+kcrnk++gq+vaikkf++sed+++ kkialrei+ lkqlkh+nl

Q: 4     YEKLAEIGEGSYGIVFKCRNKTSGQVVAIKKFVQSEDNPVTKKIALREIRTLKQLKHPNL  63

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnl evfrrkkk+ylvfey+d+t+l+eler+pn v + ++k++l+q+l++++fch +n +

Q: 64    VNLTEVFRRKKKIYLVFEYCDHTLLNELERNPNRVADAVIKSVLWQTLQGLNFCHIHNYM  123

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrd+kpenili+k+g++k+cdfGfar+l+ pgd+yt yvatrwyrapellvgdt+ G+sv

Q: 124   HRDMKPENILITKQGIIKICDFGFARILI-PGDAYTGYVATRWYRAPELLVGDTHCGSSV  182

         *****************************.******************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

          +waiGc++aelltG+pl+pgksd dqly+i++tlG+ ipr+q+if  n++f+ +++pe+

Q: 183   VIWAIGCVFAELLTGQPLWPGKSDTDQLYLIIRTLGSKIPRRQSIF--NRFFHDISIPEP  240

         **********************************************..68**********

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         ed+e+le+k+++ ++v+l+++k+clk++p++rl+c++ll+++yf

Q: 241   EDKETLEEKFSDTHPVALSFMKGCLKMNPDDRLTCSQLLESPYF  284

         ******************************************98

Domain Sequence
(FASTA)

YEKLAEIGEG SYGIVFKCRN KTSGQVVAIK KFVQSEDNPV TKKIALREIR TLKQLKHPNL 60

VNLTEVFRRK KKIYLVFEYC DHTLLNELER NPNRVADAVI KSVLWQTLQG LNFCHIHNYM 120

HRDMKPENIL ITKQGIIKIC DFGFARILIP GDAYTGYVAT RWYRAPELLV GDTHCGSSVV 180

IWAIGCVFAE LLTGQPLWPG KSDTDQLYLI IRTLGSKIPR RQSIFNRFFH DISIPEPEDK 240

ETLEEKFSDT HPVALSFMKG CLKMNPDDRL TCSQLLESPY F 281

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013