EKS-NOL-00289

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00289

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	348.7	1.9E-104	16	273	258

Status

Unreviewed

Ensembl Protein

ENSNLEP00000020079

UniProt Accession

G1S3J1;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K3

Gene Synonyms/Alias

MAP4K3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000016481	ENSNLEP00000020079	ENSNLET00000021085

Organism

Nomascus leucogenys

Functional Description

Protein Length

894

Protein Sequence
(FASTA)

MNPGFDLSRR NPQEDFELIQ RIGSGTYGDV YKARNVNTGE LAAIKVIKLE PGEDFAVVQQ 60

EIIMMKDCKH PNIVAYFGSY LRRDKLWICM EFCGGGSLQD IYHVTGPLSE LQIAYVSRET 120

LQGLYYLHSK GKMHRDIKGA NILLTDNGHV KLADFGVSAQ ITATIAKRKS FIGTPYWMAP 180

EVAAVERKGG YNQLCDLWAV GITAIELAEL QPPMFDLHPM RALFLMTKSN FQPPKLKDKM 240

KWSNSFHHFV KMALTKNPKK RPTAEKLLQH PFVTQHLTRS LAIELLDKVN NPDHSTYHDF 300

DDDDPEPLVA VPHRIHSTSR NVREEKTRSE INFGQVKFDP PLRKETEPHH ELPDSDGFLD 360

SSEEIYYTAR SNLDLQLEYG QGHQGSYFLG ANKSLLKSVE EELHQRGHVA HLEDDEGDDD 420

ESKHSTLKAK VPPPLPPKPK SIFIPQEMHS TEDENQGTIK RCPMSGSPAK PSQVPPRPPP 480

PRLPPQKPVA LGNGMSSFQL NGERDGSLCQ QQNEHRGTNL SRKEKKDVPK PISNGLPPTP 540

KVHMGACFSK VFNGCPLKIH CASSWINPDT RDQYLIFGAE EGIYTLNLNE LHETSMEQLF 600

PRRCTWLYVM NNCLLSISGK ASQLYSHNLP GLFDYARQMQ KLPVAIPAHK LPDRILPRKF 660

SVSAKIPETK WCQKCCVVRN PYTGHKYLCG ALQTSIVLLE WVEPMQKFML IKHIDFPIPC 720

PLRMFEMLVV PEQEYPLVCV GVSRGRDFNQ VVRFETVNPN STSSWFTESD TPQTNVTHVT 780

QLERDTILVC LDCCIKIVNL QGRLKSSRKL SSELTFDFQI ESIVCLQDSV LAFWKHGMQG 840

RSFRSNEVTQ EISDSTRIFR LLGSDRVVVL ESRPTDNPTA NSNLYILAGH ENSY 894

Nucleotide Sequence
(FASTA)

ATGAACCCCG GCTTCGATTT GTCCCGCCGG AACCCGCAGG AGGACTTCGA GCTGATTCAG 60

CGCATCGGCA GCGGCACCTA CGGCGACGTC TACAAGGCAC GGAATGTTAA CACTGGTGAA 120

TTAGCAGCAA TTAAAGTAAT AAAATTGGAA CCAGGAGAAG ACTTTGCAGT CGTGCAGCAA 180

GAAATTATTA TGATGAAAGA CTGTAAACAC CCAAATATTG TTGCTTATTT TGGAAGCTAT 240

CTCAGGCGAG ATAAGCTTTG GATTTGCATG GAGTTTTGTG GAGGTGGTTC TTTACAGGAT 300

ATTTATCACG TAACTGGACC TCTGTCAGAA CTGCAAATTG CATATGTTAG CAGAGAAACA 360

CTGCAGGGAT TATACTATCT TCACAGTAAA GGAAAAATGC ACAGAGATAT AAAGGGAGCT 420

AACATTCTAT TAACGGATAA TGGTCATGTG AAATTGGCTG ATTTTGGAGT ATCTGCACAG 480

ATAACAGCTA CAATTGCCAA ACGGAAGTCT TTCATTGGCA CACCATATTG GATGGCTCCA 540

GAAGTTGCAG CTGTTGAGAG GAAGGGGGGT TACAATCAAC TCTGTGATCT CTGGGCAGTA 600

GGAATCACTG CCATAGAACT TGCAGAGCTT CAGCCTCCTA TGTTTGACTT ACACCCAATG 660

AGAGCATTAT TTCTAATGAC AAAAAGCAAT TTTCAGCCTC CTAAACTAAA GGATAAAATG 720

AAGTGGTCAA ATAGTTTTCA TCACTTTGTG AAAATGGCAC TTACCAAAAA TCCGAAAAAA 780

AGACCTACTG CTGAAAAATT ATTACAGCAT CCTTTTGTAA CACAACATTT GACACGGTCT 840

TTGGCAATCG AGCTGTTGGA TAAAGTAAAT AATCCAGATC ATTCCACTTA CCATGATTTC 900

GATGATGATG ATCCTGAGCC TCTTGTTGCT GTACCACATA GAATTCACTC AACAAGTAGA 960

AATGTGAGAG AAGAAAAAAC ACGCTCAGAG ATAAACTTTG GCCAAGTGAA ATTTGATCCA 1020

CCCTTAAGAA AGGAGACAGA ACCACATCAT GAACTTCCCG ACAGTGATGG TTTTTTGGAC 1080

AGTTCAGAAG AAATATACTA CACTGCAAGA TCTAATCTGG ATCTGCAACT GGAATATGGA 1140

CAAGGACACC AAGGTAGTTA CTTTTTAGGT GCAAACAAGA GTCTTCTCAA GTCTGTTGAA 1200

GAAGAATTGC ATCAGCGAGG ACACGTGGCA CATTTAGAAG ATGATGAAGG AGATGATGAT 1260

GAATCTAAAC ATTCAACTCT GAAAGCAAAA GTTCCACCTC CTTTGCCACC AAAGCCTAAG 1320

TCTATCTTCA TACCACAGGA AATGCATTCT ACTGAGGATG AAAATCAAGG AACAATCAAG 1380

AGATGTCCCA TGTCAGGGAG CCCAGCAAAG CCATCCCAAG TTCCACCTAG ACCACCACCT 1440

CCCAGATTAC CCCCACAAAA ACCTGTTGCC TTAGGAAATG GAATGAGCTC CTTCCAGTTA 1500

AATGGTGAAC GAGATGGCTC ATTATGTCAA CAACAGAACG AACATAGAGG CACAAACCTT 1560

TCAAGAAAAG AAAAAAAAGA TGTACCAAAG CCTATTAGCA ATGGTCTTCC TCCAACACCT 1620

AAAGTGCATA TGGGTGCATG TTTTTCAAAA GTTTTTAATG GGTGTCCCTT GAAAATTCAC 1680

TGTGCATCAT CATGGATAAA CCCAGATACA AGAGATCAGT ACTTGATATT TGGTGCCGAA 1740

GAAGGGATTT ATACCCTCAA TCTTAATGAA CTTCATGAAA CATCAATGGA ACAGCTATTC 1800

CCTCGAAGGT GTACATGGTT GTATGTAATG AACAATTGCT TGCTATCAAT ATCTGGTAAA 1860

GCTTCTCAGC TTTATTCCCA TAATTTACCG GGGCTTTTTG ATTATGCAAG ACAAATGCAA 1920

AAGTTACCTG TTGCTATTCC AGCACACAAA CTCCCTGACA GAATACTGCC AAGGAAATTT 1980

TCTGTATCAG CAAAAATCCC TGAAACCAAA TGGTGCCAGA AGTGTTGTGT TGTAAGAAAT 2040

CCTTACACGG GCCATAAATA CCTATGTGGA GCACTTCAGA CTAGCATTGT TCTGTTAGAA 2100

TGGGTTGAAC CAATGCAGAA ATTTATGTTA ATTAAGCACA TAGATTTTCC TATACCATGT 2160

CCACTTAGAA TGTTTGAAAT GCTGGTAGTT CCTGAACAGG AGTACCCTTT AGTTTGTGTT 2220

GGTGTCAGTA GAGGTAGAGA CTTCAACCAA GTGGTTCGAT TTGAGACGGT CAATCCAAAT 2280

TCTACCTCTT CATGGTTTAC AGAATCAGAT ACCCCACAGA CAAATGTTAC TCATGTAACC 2340

CAACTGGAGA GAGATACTAT CCTTGTGTGC TTGGACTGTT GTATAAAAAT AGTAAATCTC 2400

CAAGGAAGAT TAAAATCTAG CAGGAAATTA TCATCAGAAC TCACCTTTGA TTTCCAGATT 2460

GAATCAATAG TGTGCCTACA AGACAGTGTG CTAGCTTTCT GGAAACATGG AATGCAAGGT 2520

AGAAGTTTTA GATCTAATGA GGTAACACAA GAAATTTCAG ATAGCACAAG AATTTTCAGG 2580

CTGCTTGGAT CTGACAGGGT CGTGGTTTTG GAAAGTAGGC CAACTGATAA CCCCACAGCA 2640

AATAGCAATT TGTACATCCT GGCGGGTCAT GAAAACAGTT ACTGA 2685

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +el+++ig+G++g+vy+ar+++tgel+aik+i+le  e+ + +q+ei ++k++khpniv+

Q: 16    FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVA  75

         899*********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s+l++++lw++me++ gGsl+d+++  ++ +l+E qiay+ re+l++L ylHsk+++

Q: 76    YFGSYLRRDKLWICMEFCGGGSLQDIYH--VTGPLSELQIAYVSRETLQGLYYLHSKGKM  133

         ****************************..******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdik++niLlt++g+VkL+dfgv+aq+++t +krk+++gtpywmAPEv a+e + gY++

Q: 134   HRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVErKGGYNQ  193

         ****************************************************98889***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237

          +D+w++GItaielae +pP++dl+p++al++++k++  ppklk+k k+s++f++fv+ +

Q: 194   LCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNfqPPKLKDKMKWSNSFHHFVKMA  253

         ******************************999999888*********************

S: 238   lqknpekRpsasellkhkFl  257

         l+knp+kRp+a++ll+h+F+

Q: 254   LTKNPKKRPTAEKLLQHPFV  273

         *******************7

Domain Sequence
(FASTA)

FELIQRIGSG TYGDVYKARN VNTGELAAIK VIKLEPGEDF AVVQQEIIMM KDCKHPNIVA 60

YFGSYLRRDK LWICMEFCGG GSLQDIYHVT GPLSELQIAY VSRETLQGLY YLHSKGKMHR 120

DIKGANILLT DNGHVKLADF GVSAQITATI AKRKSFIGTP YWMAPEVAAV ERKGGYNQLC 180

DLWAVGITAI ELAELQPPMF DLHPMRALFL MTKSNFQPPK LKDKMKWSNS FHHFVKMALT 240

KNPKKRPTAE KLLQHPFV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0006950	; P:response to stress

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013