EKS-NOL-00307

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00307

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	295.6	3.1E-88	21	287	267

Status

Unreviewed

Ensembl Protein

ENSNLEP00000020385

UniProt Accession

G1S4E7;

Protein Name

Protein Synonyms/Alias

Gene Name

MYO3A

Gene Synonyms/Alias

MYO3A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000016768	ENSNLEP00000020385	ENSNLET00000021401

Organism

Nomascus leucogenys

Functional Description

Protein Length

1621

Protein Sequence
(FASTA)

MFPLIGKTII FDNFPDPSDT WEITETIGKG TYGKVFKVLN KKNGQKAAVK ILDPIHDIDE 60

EIEAEYNILK ALPDHPNVVR FYGIYSKKDK VNGDKLWLVL ELCNGGSVTD LVKGFLKRGE 120

RMSEPLIAYI LHEALMGLQH LHNNKTIHRD VKGNNILLTT EKYILSFPLG VSAQLTSTWH 180

RRNTSVGTPF WMAPEVIACE QQLDTTYDAR CDTWSLGITA IELGDGDPPL ADLHPMRALF 240

KIPRNPPPKL RQPELWSAEF NDFISKCLTK DYEKRPTVSD LLQHKFITQI EGKDVMLQKQ 300

LMEFIGIHQC VGGTEKARHE RIHTKKENFN RSLIANLKDV DDLATLEVLD ENTVSEQLEK 360

CYSRDQIYIY VGDILIALNP FQSLGLYSTK HSKLYIGSKR TASPPHIFAM ADLGYQSMIT 420

YNSDQCIVIS GESGAGKTEN AHLLVQQLTV LGKANNRTLQ EKILQVNNLV EAFGNACTVI 480

NDNSSRFGKY LEMKFTSSGA VVGAQISEYL LEKSRVIHQA IGEKNFHIFY YIYAGLAEKK 540

KLAHYKLPEN KPPRYLQNDH LRTVQDIMNN SFYKSQYELI EQCFKVIGFT MEQLGSIYSI 600

LASILNVGNI EFSSVATEHQ IDKSHISNHT ALENCASLLC IQADELQEAL TSHCVVTRGE 660

TIIRPNTVEK ATDVRDAMAK TLYGRLFSWI VNCINSLLKH DSSPSGNGDE LSIGILDIFG 720

FENFKKNSFE QLCINIANEQ IQYYYNQHVF AWEQNEYLNE DVDARIIEYE DNRPLLDMFL 780

QKPMGLLSLL DEESRFPKAT DQTLVEKFEG NLKSQYFWRP KRMELSFGIH HYAGKVLYNA 840

SGFLAKNRDT LPTDIVLLLR SSDNNVIRQL VNHPLTKTGN LPHSKTKNVI NYQMRTSEKL 900

INLAKGDIGE ATRHARETTN MKTQTVASYF RYSLMDLLSK MVVGQPHFVR CIKPNNERQA 960

RKYDKEKVLL QLRYTGILET ARIRRLGFSH RILFANFIKR YYILCYKSSE EPPMSPDTCA 1020

TILEKAGLDN WALGKTKVFL KYYHVEQLNL MRKEAIDKLI LIQACVRAFL CSRRYQKIQE 1080

KRKESAIIIQ SAARGHLVRK QRKEIINVKN TAVTTIQTSD QEFDYKRNFE NTRESFVKKQ 1140

AENATSANER FISAPNNKGS VSVVKTSTFK PEEETTNAVE SKNRGYQTPK KMNNVYEEEV 1200

KQEFYLVGPE VSPKQKSIKD LEENSKLRKV EKEEAMIQSY YQRYTEERNC EESKAAYLER 1260

KAISERPSYP VPWLAENETS FKKTLEPTLS QRSIYQNANS TEKEKKTSVV TQSAPICSQE 1320

GGGGHLRHET VKERQVEPVT QAQEEEDKAA VFIQSKYRGY KRRQQLRKDK MSSFKHQRIV 1380

TTPTEVARNT HNLYSYPTKH EEINNIKMKD NKDSKATSER EACDLAMFSK QISKLSEEYF 1440

ILQKKLNEMI LSQQLKPLYL GVSHHNPINR RVSSQQCLSG ISKGEEPKIL RPPRRPRKPK 1500

TLNNPEDSTY YYLLHKSIQE EKRRPRKDSQ GKLLDLEDFY YKEFLPSRSG PKEHSPSLRE 1560

RRPQQELQNQ CIKANERCRE AESPEKEEEE KEEERGPAAN PYDFRRLLRK TSQRRRLVQQ 1620

S 1621

Nucleotide Sequence
(FASTA)

ATGTTTCCAT TAATTGGAAA AACAATCATC TTTGATAACT TTCCTGATCC TTCCGATACA 60

TGGGAAATCA CTGAGACAAT CGGCAAAGGA ACTTATGGGA AAGTTTTTAA AGTATTGAAT 120

AAGAAAAATG GCCAAAAAGC AGCAGTCAAA ATTCTTGATC CAATTCATGA TATTGATGAA 180

GAGATTGAAG CAGAATATAA CATCTTAAAA GCACTTCCTG ACCATCCTAA TGTGGTCAGA 240

TTCTATGGGA TATACTCTAA GAAGGATAAA GTAAATGGAG ACAAGCTGTG GTTGGTTCTT 300

GAGCTGTGCA ATGGAGGATC AGTGACTGAC CTTGTGAAAG GATTTCTGAA GAGGGGTGAA 360

AGAATGAGTG AGCCTCTAAT TGCCTATATT TTACATGAAG CACTAATGGG ACTTCAACAT 420

TTGCATAATA ACAAAACTAT CCACAGAGAT GTGAAAGGAA ATAACATTCT ATTGACCACT 480

GAAAAGTACA TCTTGTCTTT TCCTCTAGGT GTGTCTGCAC AGCTCACCAG CACCTGGCAC 540

CGTCGGAATA CATCCGTAGG AACACCGTTT TGGATGGCTC CTGAGGTGAT TGCATGTGAA 600

CAGCAATTGG ATACCACTTA TGATGCCAGA TGTGACACTT GGTCCCTGGG TATCACGGCC 660

ATTGAGCTGG GTGATGGAGA TCCTCCACTA GCTGACCTTC ATCCCATGAG AGCACTCTTC 720

AAAATACCAA GGAATCCACC CCCAAAACTA AGGCAGCCTG AGCTATGGTC AGCAGAATTC 780

AATGACTTCA TAAGCAAGTG CTTGACTAAA GATTATGAAA AGCGTCCAAC AGTGTCAGAT 840

CTTTTACAGC ATAAATTCAT TACTCAAATT GAGGGCAAAG ATGTGATGTT ACAAAAACAA 900

CTAATGGAAT TCATTGGCAT CCATCAATGC GTGGGAGGCA CAGAAAAAGC CAGACATGAA 960

CGTATTCACA CCAAGAAAGA GAACTTCAAC CGATCTCTAA TAGCCAATCT GAAGGATGTA 1020

GATGATTTAG CAACCCTAGA AGTTTTGGAT GAGAATACAG TCTCAGAGCA ACTTGAGAAG 1080

TGTTATTCCA GAGATCAGAT CTATATCTAT GTGGGAGACA TACTCATTGC TCTTAACCCT 1140

TTTCAGAGTC TGGGTCTTTA CTCCACAAAG CATTCCAAAC TATATATTGG ATCAAAGAGA 1200

ACTGCCAGTC CTCCTCACAT TTTTGCAATG GCTGACTTAG GATATCAATC TATGATAACA 1260

TATAATTCAG ATCAGTGCAT TGTTATTTCT GGAGAAAGTG GTGCTGGAAA GACTGAAAAT 1320

GCTCATCTTT TAGTTCAGCA GCTGACAGTG CTTGGAAAGG CTAATAACAG AACCTTGCAA 1380

GAGAAGATTT TACAAGTGAA CAATTTGGTG GAAGCCTTTG GCAATGCCTG CACTGTTATA 1440

AATGACAATT CTAGCAGATT TGGAAAATAC TTAGAAATGA AATTCACCTC TTCTGGAGCG 1500

GTAGTGGGAG CACAGATTTC TGAATATCTT CTGGAAAAAT CCCGAGTTAT CCACCAAGCT 1560

ATTGGAGAAA AAAATTTTCA TATTTTTTAC TACATTTATG CTGGTTTGGC TGAAAAGAAG 1620

AAACTAGCCC ATTACAAACT GCCTGAAAAT AAGCCTCCCA GGTACCTACA AAATGACCAC 1680

CTCAGAACAG TACAAGACAT CATGAATAAT AGTTTTTATA AATCCCAGTA TGAATTAATT 1740

GAGCAATGTT TCAAAGTCAT AGGTTTTACA ATGGAGCAAC TTGGTAGTAT ATACAGCATA 1800

CTCGCTTCAA TCTTGAATGT TGGCAACATT GAATTTTCTT CTGTGGCAAC TGAACACCAG 1860

ATTGACAAGA GCCACATTTC TAATCATACA GCCCTGGAGA ACTGTGCTTC TTTGCTTTGC 1920

ATTCAGGCAG ATGAGCTACA AGAAGCTCTC ACCTCCCACT GTGTGGTCAC TAGAGGAGAA 1980

ACAATTATAC GACCCAATAC TGTAGAAAAA GCTACCGATG TCAGGGATGC CATGGCTAAA 2040

ACTTTATATG GACGTCTCTT TAGTTGGATA GTCAATTGCA TTAACAGTTT GTTGAAGCAT 2100

GACTCATCAC CAAGTGGGAA TGGTGATGAG TTGAGCATTG GCATTCTTGA TATATTTGGC 2160

TTTGAAAATT TCAAAAAAAA TTCCTTCGAG CAGCTGTGCA TTAACATTGC AAATGAACAA 2220

ATTCAGTATT ATTATAATCA ACATGTGTTT GCATGGGAAC AGAATGAATA CCTAAATGAA 2280

GATGTGGATG CTAGAATTAT TGAATATGAG GATAACCGGC CCCTCTTAGA TATGTTTCTG 2340

CAAAAGCCAA TGGGTTTACT TTCCCTACTT GATGAAGAAA GTAGATTTCC CAAGGCCACT 2400

GACCAGACTC TTGTAGAAAA ATTTGAAGGT AACCTGAAAT CACAGTACTT CTGGAGACCC 2460

AAAAGAATGG AACTTAGTTT TGGAATTCAC CATTATGCAG GAAAGGTCCT CTATAATGCA 2520

AGTGGATTCT TAGCCAAAAA CAGAGACACC CTTCCAACTG ATATTGTGCT ACTTTTGAGG 2580

TCATCCGACA ACAATGTAAT TAGGCAACTA GTCAACCACC CTCTGACCAA AACAGGTAAT 2640

CTGCCACATT CTAAAACTAA AAATGTTATA AACTATCAAA TGAGGACTTC AGAAAAATTA 2700

ATCAACCTGG CAAAGGGTGA CATTGGAGAA GCCACACGTC ATGCCAGAGA GACAACCAAC 2760

ATGAAAACAC AAACAGTTGC ATCATATTTT AGATATTCCC TGATGGATTT GTTGTCTAAA 2820

ATGGTGGTGG GCCAACCTCA TTTTGTCCGT TGCATCAAAC CAAATAATGA GCGTCAGGCA 2880

AGAAAATATG ACAAAGAGAA AGTTCTGCTA CAGCTTCGGT ACACAGGAAT TCTGGAAACA 2940

GCAAGAATTC GAAGGCTAGG ATTCTCCCAT CGGATACTTT TTGCTAACTT TATAAAGCGG 3000

TACTATATTC TCTGCTACAA GTCGAGCGAG GAGCCCCCCA TGAGCCCTGA CACCTGTGCC 3060

ACCATTTTGG AAAAAGCTGG TCTCGATAAC TGGGCTCTTG GAAAAACAAA AGTGTTCCTT 3120

AAGTATTATC ACGTGGAACA GTTAAATCTA ATGCGAAAGG AAGCTATTGA CAAGCTTATT 3180

TTGATTCAAG CTTGTGTCAG AGCATTCTTG TGTTCAAGAA GATACCAAAA AATACAGGAG 3240

AAAAGGAAAG AAAGCGCTAT AATAATACAG TCAGCTGCAA GAGGACACCT TGTCAGGAAA 3300

CAAAGAAAAG AAATTATTAA CGTGAAAAAC ACAGCAGTAA CAACCATTCA GACTTCTGAT 3360

CAGGAATTCG ACTACAAGAG AAACTTTGAA AATACGAGGG AATCTTTCGT GAAGAAACAA 3420

GCAGAAAATG CAACCTCTGC TAATGAAAGA TTCATTTCAG CTCCAAATAA TAAAGGAAGT 3480

GTATCTGTTG TGAAGACTTC CACTTTCAAA CCTGAAGAGG AAACCACCAA TGCTGTGGAG 3540

AGTAAAAACA GAGGGTATCA GACTCCAAAA AAAATGAATA ATGTGTATGA GGAAGAGGTT 3600

AAGCAAGAAT TCTACCTTGT AGGGCCAGAA GTAAGCCCCA AACAGAAGTC TATCAAAGAC 3660

CTGGAAGAGA ACAGCAAGCT AAGGAAAGTG GAGAAAGAGG AAGCTATGAT CCAGAGTTAC 3720

TATCAGAGGT ACACAGAGGA GAGGAATTGT GAAGAGTCAA AAGCAGCATA TCTAGAAAGG 3780

AAGGCCATAT CAGAAAGGCC AAGCTACCCA GTGCCTTGGT TAGCTGAAAA TGAGACTTCC 3840

TTTAAAAAAA CTTTGGAACC TACACTTAGC CAAAGATCAA TTTATCAAAA TGCAAACAGC 3900

ACGGAAAAAG AAAAGAAGAC ATCTGTAGTT ACCCAGAGTG CACCAATATG CAGCCAGGAG 3960

GGAGGCGGAG GCCATCTGAG GCATGAGACA GTCAAAGAGA GGCAAGTTGA ACCAGTGACA 4020

CAGGCCCAGG AGGAAGAAGA TAAAGCAGCG GTATTCATTC AGAGCAAATA CCGGGGTTAC 4080

AAGAGAAGGC AGCAGTTGAG GAAGGACAAG ATGTCTTCTT TTAAGCATCA GAGGATTGTC 4140

ACAACACCAA CAGAAGTAGC AAGAAACACT CATAATTTGT ATTCCTATCC TACAAAACAT 4200

GAGGAAATCA ATAACATCAA GATGAAGGAT AACAAAGACT CGAAAGCAAC TTCAGAAAGA 4260

GAAGCATGTG ATTTGGCAAT GTTTTCAAAA CAGATATCAA AGTTATCTGA AGAATATTTC 4320

ATTCTGCAGA AAAAATTGAA TGAAATGATT TTGTCACAGC AACTGAAGCC ACTTTATCTG 4380

GGTGTCTCGC ACCATAACCC AATTAATAGA CGAGTTTCTT CTCAGCAGTG CCTCTCAGGT 4440

ATCTCTAAAG GAGAGGAGCC AAAAATATTG AGACCCCCAA GACGACCCCG GAAACCCAAA 4500

ACATTAAATA ACCCTGAAGA CTCCACATAC TATTATCTAC TACATAAGTC AATCCAAGAA 4560

GAAAAACGAA GACCGAGGAA AGACAGTCAG GGAAAATTAT TAGATTTGGA AGATTTCTAT 4620

TATAAGGAAT TTTTGCCCAG TCGTTCTGGA CCAAAGGAAC ATAGCCCTAG TTTAAGAGAA 4680

CGAAGACCAC AGCAAGAACT CCAGAATCAA TGTATTAAGG CTAATGAAAG GTGCCGAGAG 4740

GCTGAGAGCC CCGAGAAGGA GGAGGAGGAG AAGGAGGAGG AGAGAGGGCC AGCAGCCAAC 4800

CCCTACGACT TCAGGAGGCT TCTGCGCAAA ACCTCCCAGC GCCGGCGCCT CGTCCAGCAG 4860

TCC 4863

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkkl.khpniv  59

         +e++e+igkG++gkv++  +kk+g+++a+k+++  + +  ee++ e+++lk l +hpn+v

Q: 21    WEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIH-DIDEEIEAEYNILKALpDHPNVV  79

         7999*****************************998.9999**********99356****

S: 60    eylesflk.....eeelwlvmeylagGslsdlvk..eelkselkEeqiayilrevlkaLe  112

         ++++++ k      ++lwlv+e+++gGs++dlvk   ++ ++++E  iayil+e+l +L+

Q: 80    RFYGIYSKkdkvnGDKLWLVLELCNGGSVTDLVKgfLKRGERMSEPLIAYILHEALMGLQ  139

         *******988888899******************7778889*******************

S: 113   ylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaq  172

         +lH++k+iHrd+k++niLlt+e+ +    +gv+aql++t ++r+t vgtp+wmAPEvia+

Q: 140   HLHNNKTIHRDVKGNNILLTTEKYILSFPLGVSAQLTSTWHRRNTSVGTPFWMAPEVIAC  199

         *************************8889*******************************

S: 173   e...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfske  229

         e   +++Yd+++D wslGItaiel +g+pP++dl+p++al+ki++n+ppkl++++ +s e

Q: 200   EqqlDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAE  259

         9888899*****************************************************

S: 230   fkefvekclqknpekRpsasellkhkFl  257

         f++f++kcl+k++ekRp++s+ll+hkF+

Q: 260   FNDFISKCLTKDYEKRPTVSDLLQHKFI  287

         ***************************7

Domain Sequence
(FASTA)

WEITETIGKG TYGKVFKVLN KKNGQKAAVK ILDPIHDIDE EIEAEYNILK ALPDHPNVVR 60

FYGIYSKKDK VNGDKLWLVL ELCNGGSVTD LVKGFLKRGE RMSEPLIAYI LHEALMGLQH 120

LHNNKTIHRD VKGNNILLTT EKYILSFPLG VSAQLTSTWH RRNTSVGTPF WMAPEVIACE 180

QQLDTTYDAR CDTWSLGITA IELGDGDPPL ADLHPMRALF KIPRNPPPKL RQPELWSAEF 240

NDFISKCLTK DYEKRPTVSD LLQHKFI 267

Keyword

ATP-binding; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0031941	; C:filamentous actin
GO:0030175	; C:filopodium
GO:0016459	; C:myosin complex
GO:0030898	; F:actin-dependent ATPase activity
GO:0043531	; F:ADP binding
GO:0005524	; F:ATP binding
GO:0060002	; F:plus-end directed microfilament motor activity
GO:0004672	; F:protein kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0007605	; P:sensory perception of sound

KEGG

InterPros

IPR000048	; IQ_motif_EF-hand-BS.
IPR011009	; Kinase-like_dom.
IPR001609	; Myosin_head_motor_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00612	; IQ; 2.
PF00063	; Myosin_head; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00015	; IQ; 3.
SM00242	; MYSc; 1.
SM00220	; S_TKc; 1.

Prosites

PS50096	; IQ; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR00193

; MYOSINHEAVY.

Created Date

20-Feb-2013