EKS-NOL-00300
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00300
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20323.68.9E-9717271255
StatusUnreviewed
Ensembl ProteinENSNLEP00000020462
UniProt AccessionG1S4M8;
Protein NameMitogen-activated protein kinase kinase kinase kinase
Protein Synonyms/Alias
Gene NameMAP4K1
Gene Synonyms/Alias MAP4K1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000016835ENSNLEP00000020462ENSNLET00000021478
OrganismNomascus leucogenys
Functional Description
Protein Length817
Protein Sequence
(FASTA)
MDLVDPDIFN RDPRDHYDLL QRLGGGTYGE VFKARDKVSG DLVALKMVKM EPDDDVSTLQ 60
KEILILKTCR HANIVAYHGS YLWMQKLWIC MEFCGAGSLQ DIYQVTGSLS ELQISYVCRE 120
VLQGLAYLHS QKKIHRDIKG ANILINDAGE VRLADFGISA QIGATLARRL SFIGTPYWMA 180
PEVAAVALKG GYNELCDIWS LGITAIELAE LQPPLFDVHP LRVLFLMTKS GYQPPRLKEK 240
GKWSAAFHNF IKVTLTKSPK KRPSATKMLS VTLPSSRPSV QDSLGPSTTP EDMDNFADGS 300
LEVRSLRPAW PTWLQSTHRS SSLGIPDADC CRRHMEFRKL RGMETRPPAN TARLQPPRDL 360
RSSSPRKQLS ESSDDDYDDV DIPTPAEDTP PPLPPKPKFR SPSDEGPGSM GDDGQLSPGV 420
LVRCASGPPP HSPRPGPPPS TSSPHLTAHS EPSLWNPPSR ELDKPPLLPP KKEKMKRKGC 480
ALLVKLFNGC PLRIHSTAAW THPSTKDQHL LLGAEEGIFI LNRNDQEATL EMLFPSRTTW 540
VYSINNVLMS LSGKTPHLYS HSILGLLERK ETRAGNPIAH ISPHRLLARK NMVSTKIQDT 600
KGCRACCVAE GASSGGPFLC GALETSVVLL QWYQPMNKFL LVRQVLFPLP TPLSVFALLT 660
GPGSELPAVC IGVSPGRPGK SVLFHTVRFG ALSCWLGEMS TEHKGPVQVT QVEEDMVMVL 720
MDGSVKLVTP EGSPVRGLRT PEIPMTEAVE AVAMVGGQLQ AFWKHGVQVW ALGSDQLLQE 780
LRDPTLTFRL LGSPRPVVVE TRPVDDPTAP SNLYIQE 817
Nucleotide Sequence
(FASTA)
ATGGACCTCG TGGACCCTGA CATTTTCAAT AGAGACCCCC GGGACCACTA TGACCTGCTA 60
CAGCGACTGG GTGGCGGCAC GTATGGGGAA GTCTTTAAGG CTCGAGACAA GGTGTCAGGG 120
GACCTGGTGG CACTGAAGAT GGTGAAGATG GAGCCTGATG ATGATGTCTC CACCCTTCAG 180
AAGGAAATCC TCATATTGAA AACTTGCCGG CACGCCAACA TCGTGGCCTA CCATGGGAGT 240
TATCTCTGGA TGCAGAAACT CTGGATCTGC ATGGAATTCT GTGGTGCTGG TTCTCTCCAG 300
GACATCTACC AAGTGACAGG CTCCCTGTCA GAGCTCCAGA TTAGCTATGT CTGCCGGGAA 360
GTGCTCCAGG GACTGGCCTA TCTGCACTCA CAGAAGAAGA TACACAGGGA CATCAAGGGA 420
GCTAACATCC TCATCAATGA TGCTGGGGAG GTCAGATTGG CTGACTTTGG CATCTCGGCC 480
CAGATTGGGG CAACGCTGGC CAGACGCCTC TCTTTCATTG GGACACCCTA CTGGATGGCT 540
CCAGAAGTGG CAGCCGTGGC CCTGAAGGGA GGATACAACG AGCTGTGTGA CATCTGGTCC 600
CTGGGCATCA CGGCCATCGA ACTGGCCGAG CTACAGCCAC CGCTCTTTGA TGTGCACCCT 660
CTCAGAGTTC TCTTCCTCAT GACCAAGAGT GGCTACCAGC CTCCCCGACT GAAGGAAAAA 720
GGCAAATGGT CGGCTGCCTT CCACAACTTC ATCAAAGTCA CCCTGACTAA GAGTCCCAAG 780
AAACGACCCA GCGCCACCAA GATGCTCAGT GTAACCCTCC CTTCCTCAAG ACCCTCAGTC 840
CAGGATTCCC TGGGGCCTTC CACAACTCCC GAGGACATGG ATAACTTTGC AGATGGATCA 900
CTTGAGGTCA GGAGTTTGAG ACCAGCCTGG CCAACATGGT TGCAATCCAC CCACCGCTCC 960
AGCTCTCTGG GGATCCCAGA TGCAGACTGC TGTCGGCGGC ACATGGAGTT CAGGAAGCTC 1020
CGAGGAATGG AGACCAGACC CCCAGCCAAC ACCGCTCGCC TACAGCCCCC CCGAGACCTC 1080
AGGAGCAGCA GCCCCAGGAA GCAACTGTCA GAGTCGTCTG ACGATGACTA TGACGACGTG 1140
GACATCCCCA CCCCTGCAGA GGACACACCT CCTCCACTTC CCCCCAAGCC CAAGTTCCGT 1200
TCTCCATCAG ACGAGGGTCC TGGCAGTATG GGGGATGATG GGCAGCTGAG CCCGGGGGTG 1260
CTGGTCCGGT GTGCCAGTGG GCCCCCACCA CACAGCCCCC GTCCTGGGCC TCCCCCATCC 1320
ACCAGCAGCC CCCACCTCAC CGCCCATTCA GAACCCTCAC TCTGGAACCC ACCCTCCCGG 1380
GAGCTCGACA AGCCCCCACT TCTGCCCCCC AAGAAGGAAA AGATGAAGAG AAAGGGATGC 1440
GCCCTTCTGG TAAAGTTATT CAATGGCTGC CCCCTCCGGA TCCACAGCAC AGCCGCCTGG 1500
ACACATCCCT CCACCAAGGA CCAGCACCTG CTCCTGGGGG CAGAGGAAGG CATCTTCATC 1560
CTGAACCGGA ATGACCAGGA GGCCACGCTG GAGATGCTCT TTCCTAGCCG GACTACGTGG 1620
GTGTACTCCA TCAACAACGT TCTCATGTCT CTCTCAGGAA AGACCCCCCA CCTGTATTCT 1680
CATAGCATCC TGGGCCTGCT GGAACGGAAA GAGACCAGAG CAGGAAACCC CATCGCTCAC 1740
ATTAGCCCCC ACCGCCTACT GGCAAGGAAG AACATGGTTT CCACCAAGAT CCAGGACACC 1800
AAAGGCTGCC GGGCGTGCTG TGTGGCGGAG GGTGCGAGCT CTGGGGGCCC GTTCCTGTGC 1860
GGGGCATTGG AGACGTCCGT TGTCCTGCTT CAGTGGTACC AGCCCATGAA CAAATTCCTG 1920
CTCGTCCGGC AGGTGCTGTT CCCACTGCCG ACGCCTCTGT CCGTGTTCGC GCTGCTGACC 1980
GGGCCAGGCT CTGAGCTGCC CGCTGTGTGC ATCGGCGTGA GCCCCGGGCG ACCTGGCAAG 2040
TCGGTGCTCT TCCACACGGT GCGCTTTGGC GCGCTCTCTT GCTGGCTGGG CGAGATGAGC 2100
ACCGAGCACA AGGGACCAGT GCAGGTGACC CAGGTAGAGG AGGATATGGT GATGGTGTTG 2160
ATGGACGGCT CTGTGAAGCT GGTGACCCCG GAGGGGTCCC CAGTCCGGGG ACTTCGCACG 2220
CCTGAGATCC CCATGACCGA AGCGGTGGAG GCCGTGGCTA TGGTTGGAGG TCAGCTTCAG 2280
GCCTTCTGGA AGCATGGAGT TCAGGTGTGG GCTCTAGGCT CAGATCAGCT GCTACAGGAG 2340
CTGAGAGACC CTACCCTCAC TTTCCGTCTG CTTGGCTCCC CCAGGCCCGT AGTGGTGGAG 2400
ACACGCCCAG TGGATGATCC TACTGCTCCC AGCAACCTCT ACATCCAGGA ATGA 2454
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60
         y+ll+++g G++g+v++ar+k +g+lva+k++++e  +++++lqkei +lk+++h niv+
Q: 17    YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVA  76
         899*********************************************************
S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120
         y++s+l  ++lw++me++ +Gsl+d+++  ++ +l+E qi+y++revl++L+ylHs+k+i
Q: 77    YHGSYLWMQKLWICMEFCGAGSLQDIYQ--VTGSLSELQISYVCREVLQGLAYLHSQKKI  134
         ****************************..9*****************************
S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179
         Hrdik++niL+++ geV+L+dfg++aq+ +t ++r +++gtpywmAPEv a+  + gY+e
Q: 135   HRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVAlKGGYNE  194
         ***************************************************998999***
S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237
          +DiwslGItaielae +pP++d++pl++l++++k+   pp+lk+k k+s +f++f++  
Q: 195   LCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGyqPPRLKEKGKWSAAFHNFIKVT  254
         **********************************998889********************
S: 238   lqknpekRpsasellkh  254
         l+k+p+kRpsa+++l+ 
Q: 255   LTKSPKKRPSATKMLSV  271
         **************985
Domain Sequence
(FASTA)
YDLLQRLGGG TYGEVFKARD KVSGDLVALK MVKMEPDDDV STLQKEILIL KTCRHANIVA 60
YHGSYLWMQK LWICMEFCGA GSLQDIYQVT GSLSELQISY VCREVLQGLA YLHSQKKIHR 120
DIKGANILIN DAGEVRLADF GISAQIGATL ARRLSFIGTP YWMAPEVAAV ALKGGYNELC 180
DIWSLGITAI ELAELQPPLF DVHPLRVLFL MTKSGYQPPR LKEKGKWSAA FHNFIKVTLT 240
KSPKKRPSAT KMLSV 255
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00301
EKS-BOT-00322
EKS-CAJ-00343
EKS-CAF-00326
EKS-CAP-00354
EKS-EQC-00312
EKS-FEC-00307
EKS-GOG-00323
EKS-HOS-00332
EKS-ICT-00303
EKS-LOA-00343
EKS-MAM-00336
EKS-MOD-00314
EKS-MUM-00357
EKS-MUP-00315
EKS-MYL-00318
EKS-OTG-00330
EKS-PAT-00308
EKS-POA-00325
EKS-RAN-00337
EKS-SAH-00298
EKS-SUS-00281
Gene Ontology
GO:0005524; F:ATP binding
GO:0008349; F:MAP kinase kinase kinase kinase activity
GO:0005083; F:small GTPase regulator activity
GO:0000185; P:activation of MAPKKK activity
GO:0018105; P:peptidyl-serine phosphorylation
GO:0006950; P:response to stress
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR021160; MAPKKKK.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013