EKS-NOL-00141
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00141
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR504.07.9E-152500751252
StatusUnreviewed
Ensembl ProteinENSNLEP00000020533
UniProt AccessionG1S4S8;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR2
Gene Synonyms/Alias FGFR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000016854ENSNLEP00000020533ENSNLET00000021554
OrganismNomascus leucogenys
Functional Description
Protein Length751
Protein Sequence
(FASTA)
MGLTSTWRYG RGPGIGTVTM VSWGRFICLV VVTMATLSLA RPSFSLVEDT TLEPEEPPTK 60
YQISQPEVYV AAPGESLEVR CLLKDAAVIS WTKDGVHLGP NNRTVLIGEY LQIKGATPRD 120
SGLYACTATR TVDSETWYFM VNVTDAISSG DDEDDTDGAE DFVSENSNNK RAPYWTNTEK 180
MEKRLHAVPA ANTVKFRCPA GGNPTPTMRW LKNGKEFKQE HRIGGYKVRN QHWSLIMESV 240
VPSDKGNYTC VVENEYGSIN HTYHLDVVER SPHRPILQAG LPANASTVVG GDVEFVCKVY 300
SDAQPHIQWI KHVEKNGSKY GPDGLPYLKV LKAAGVNTTD KEIEVLYIRN VTFEDAGEYT 360
CLAGNSIGIS FHSAWLTVLP APGREKEITA SPDYLEIAIY CIGVFLIACM VVTVILCRMK 420
NTTKKPDFSS QPAVHKLTKR IPLRRQVTVS AESSSSMNSN TPLVRITTRL SSTADTPMLA 480
GVSEYELPED PKWEFPRDKL TLGKPLGEGC FGQVVMAEAV GIDKDKPKEA VTVAVKMLKD 540
DATEKDLSDL VSEMEMMKMI GKHKNIINLL GACTQDGPLY VIVEYASKGN LREYLRARRP 600
PGMEYSYDIN RVPEEQMTFK DLVSCTYQLA RGMEYLASQK CIHRDLAARN VLVTENNVMK 660
IADFGLARDI NNIDYYKKTT NGRLPVKWMA PEALFDRVYT HQSDVWSFGV LMWEIFTLGG 720
SPYPGIPVEE LFKLLKEGHR MDKPANCTNE L 751
Nucleotide Sequence
(FASTA)
ATGGGATTAA CGTCCACATG GAGATATGGA AGAGGACCGG GGATTGGTAC CGTAACCATG 60
GTCAGCTGGG GTCGTTTCAT CTGCCTGGTC GTGGTCACCA TGGCAACCTT GTCCCTGGCC 120
CGGCCCTCCT TCAGTTTAGT TGAGGATACC ACATTAGAGC CGGAAGAGCC ACCAACCAAA 180
TACCAAATCT CTCAACCAGA AGTGTACGTG GCTGCGCCAG GGGAGTCGCT AGAGGTGCGC 240
TGCCTGTTGA AAGATGCCGC CGTGATCAGT TGGACTAAGG ATGGGGTGCA CTTGGGGCCC 300
AACAATAGGA CAGTGCTTAT TGGGGAGTAC TTGCAGATAA AGGGCGCCAC GCCTAGAGAC 360
TCCGGCCTCT ATGCTTGTAC TGCCACTAGG ACTGTAGACA GTGAAACTTG GTACTTCATG 420
GTGAATGTCA CAGATGCCAT CTCATCCGGA GATGATGAGG ATGACACCGA TGGTGCAGAA 480
GATTTTGTCA GTGAGAACAG TAACAACAAG AGAGCACCAT ACTGGACCAA CACAGAAAAG 540
ATGGAAAAGC GGCTCCATGC TGTGCCTGCG GCCAACACTG TCAAGTTTCG CTGCCCAGCG 600
GGGGGGAACC CAACACCAAC CATGCGGTGG CTGAAAAACG GGAAGGAGTT TAAGCAGGAG 660
CATCGCATTG GAGGCTACAA GGTACGAAAC CAGCACTGGA GCCTCATTAT GGAAAGTGTG 720
GTCCCATCTG ACAAGGGAAA TTATACCTGT GTGGTGGAGA ATGAATACGG GTCCATCAAT 780
CACACATACC ACCTGGATGT TGTGGAGCGA TCGCCTCACC GGCCCATCCT CCAAGCCGGA 840
CTGCCGGCAA ATGCCTCCAC AGTGGTCGGA GGAGACGTAG AGTTTGTCTG CAAGGTTTAC 900
AGTGATGCCC AGCCCCACAT CCAGTGGATC AAGCACGTGG AAAAGAACGG CAGTAAATAC 960
GGGCCCGACG GGCTGCCCTA CCTCAAGGTT CTCAAGGCCG CCGGTGTTAA CACCACGGAC 1020
AAAGAGATTG AGGTTCTCTA TATTCGGAAT GTAACTTTTG AGGACGCTGG GGAATATACG 1080
TGCTTGGCGG GTAATTCTAT TGGGATATCC TTTCACTCTG CATGGTTGAC AGTTCTGCCA 1140
GCTCCTGGAA GAGAAAAGGA GATTACAGCT TCCCCAGACT ACCTGGAGAT AGCCATTTAC 1200
TGCATAGGGG TCTTCTTAAT CGCCTGTATG GTGGTAACAG TCATCCTGTG CCGAATGAAG 1260
AACACGACCA AGAAGCCAGA CTTCAGCAGC CAGCCGGCTG TGCACAAGCT GACCAAGCGC 1320
ATCCCCCTGC GGAGACAGGT AACAGTTTCG GCTGAGTCCA GCTCCTCCAT GAACTCCAAT 1380
ACCCCGCTGG TGAGGATAAC AACACGCCTC TCTTCGACGG CAGACACCCC CATGCTGGCA 1440
GGGGTCTCCG AGTATGAACT TCCAGAGGAC CCAAAATGGG AGTTTCCAAG AGATAAGCTG 1500
ACACTGGGCA AGCCCCTGGG AGAAGGTTGC TTTGGGCAAG TGGTCATGGC GGAAGCAGTG 1560
GGAATTGACA AAGACAAGCC CAAGGAGGCG GTCACCGTGG CCGTGAAGAT GTTGAAAGAT 1620
GATGCCACAG AGAAAGACCT TTCTGATCTG GTGTCCGAGA TGGAGATGAT GAAGATGATT 1680
GGGAAACACA AGAATATCAT AAATCTTCTT GGAGCCTGCA CACAGGATGG GCCTCTCTAT 1740
GTCATAGTTG AGTATGCCTC TAAAGGCAAC CTCCGAGAAT ACCTCCGAGC CCGGAGGCCA 1800
CCCGGAATGG AGTACTCCTA TGACATTAAC CGTGTTCCTG AGGAGCAGAT GACCTTCAAG 1860
GACTTGGTGT CATGCACCTA CCAGCTGGCC AGAGGCATGG AGTACTTGGC TTCCCAAAAA 1920
TGTATTCATC GAGATTTAGC AGCCAGAAAT GTTTTGGTAA CAGAAAACAA TGTGATGAAA 1980
ATAGCAGACT TTGGACTCGC CAGGGATATC AACAATATAG ACTATTACAA AAAGACCACC 2040
AATGGGCGAC TTCCAGTCAA GTGGATGGCT CCAGAAGCCC TGTTTGATAG AGTATACACT 2100
CATCAGAGTG ATGTCTGGTC CTTCGGGGTG TTAATGTGGG AGATCTTCAC TTTAGGGGGC 2160
TCGCCCTACC CAGGGATTCC AGTGGAGGAA CTTTTTAAGC TGCTGAAGGA AGGACACAGA 2220
ATGGATAAAC CAGCCAACTG CACCAACGAA CTGTAA 2256
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+kdl+dlvseme++k+
Q: 500   LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  559
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s+d ++++eeq+t+
Q: 560   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF  619
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt
Q: 620   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  679
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh
Q: 680   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  739
         ************************************************************
S: 241   rmekpakctkel  252
         rm+kpa+ct+el
Q: 740   RMDKPANCTNEL  751
         *********996
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF 120
KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPANCTN EL 252
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00139
EKS-ANC-00140
EKS-BOT-00148
EKS-CAE-00120
EKS-CAJ-00155
EKS-CAF-00154
EKS-DAR-00432
EKS-DRM-00071
EKS-EQC-00145
EKS-FEC-00140
EKS-GAM-00078
EKS-GAG-00125
EKS-GAA-00175
EKS-GOG-00147
EKS-HOS-00152
EKS-ICT-00144
EKS-LAC-00158
EKS-LOA-00149
EKS-MAM-00147
EKS-MOD-00147
EKS-MUM-00152
EKS-MUP-00151
EKS-ORN-00182
EKS-ORA-00130
EKS-ORC-00138
EKS-ORL-00170
EKS-OTG-00152
EKS-PAT-00137
EKS-PES-00132
EKS-PEM-00080
EKS-PTV-00139
EKS-RAN-00145
EKS-SAH-00142
EKS-TAG-00176
EKS-TAR-00191
EKS-TEN-00183
EKS-XET-00137
EKS-XIM-00176
Gene Ontology
GO:0005938; C:cell cortex
GO:0009986; C:cell surface
GO:0031012; C:extracellular matrix
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:0043410; P:positive regulation of MAPK cascade
GO:0010518; P:positive regulation of phospholipase activity
GO:0046777; P:protein autophosphorylation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013