EKS-NOL-00253
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00253
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR467.51.6E-140173460288
StatusUnreviewed
Ensembl ProteinENSNLEP00000020704
UniProt AccessionG1S5B6;
Protein Name
Protein Synonyms/Alias
Gene NameTGFBR1
Gene Synonyms/Alias TGFBR1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000017038ENSNLEP00000020704ENSNLET00000021739
OrganismNomascus leucogenys
Functional Description
Protein Length471
Protein Sequence
(FASTA)
ALQCFCHLCT KDNFTCVTDG LCFVSVTETT DKVIHNSMCI AEIDLIPRDR PFVCAPSSKT 60
GSVTTTYCCN QDHCNKIELP TTVKSSPGLG PVELAAVIAG PVCFVCISLM LMVYICHNRT 120
VIHHRVPNEE DPSLDRPFIS EGTTLKDLIY DMTTSGSGSG LPLLVQRTIA RTIVLQESIG 180
KGRFGEVWRG KWRGEEVAVK IFSSREERSW FREAEIYQTV MLRHENILGF IAADNKDNGT 240
WTQLWLVSDY HEHGSLFDYL NRYTVTVEGM IKLALSTASG LAHLHMEIVG TQGKPAIAHR 300
DLKSKNILVK KNGTCCIADL GLAVRHDSAT DTIDIAPNHR VGTKRYMAPE VLDDSINMKH 360
FESFKRADIY AMGLVFWEIA RRCSIGGIHE DYQLPYYDLV PSDPSVEEMR KVVCEQKLRP 420
NIPNRWQSCE ALRVMAKIMR ECWYANGAAR LTALRIKKTL SQLSQQEGIK M 471
Nucleotide Sequence
(FASTA)
GCGTTACAGT GTTTCTGCCA CCTCTGTACA AAAGACAATT TTACTTGTGT GACAGATGGG 60
CTCTGCTTTG TCTCTGTCAC AGAGACCACA GACAAAGTTA TACACAACAG CATGTGTATA 120
GCTGAAATTG ACTTAATTCC TCGAGATAGG CCGTTTGTAT GTGCGCCCTC TTCAAAAACT 180
GGGTCTGTGA CTACAACATA TTGCTGCAAT CAGGACCATT GCAATAAAAT AGAACTTCCA 240
ACTACTGTAA AGTCATCACC TGGCCTTGGT CCCGTGGAAC TGGCAGCTGT CATTGCTGGA 300
CCAGTGTGCT TCGTCTGCAT CTCACTCATG TTGATGGTCT ATATCTGCCA CAACCGCACT 360
GTCATTCACC ATCGAGTGCC AAATGAAGAG GACCCTTCAT TAGATCGCCC TTTTATTTCA 420
GAGGGTACTA CGTTGAAAGA CTTAATTTAT GATATGACAA CGTCAGGTTC TGGCTCAGGT 480
TTACCATTGC TTGTTCAGAG AACAATTGCG AGAACTATTG TGTTACAAGA AAGCATTGGC 540
AAAGGTCGAT TTGGAGAAGT TTGGAGAGGA AAGTGGCGGG GAGAAGAAGT TGCTGTTAAG 600
ATATTCTCCT CTAGAGAAGA ACGTTCGTGG TTCCGTGAGG CAGAGATTTA TCAAACTGTA 660
ATGTTACGTC ATGAAAACAT CCTGGGATTT ATAGCAGCAG ACAATAAAGA CAATGGTACT 720
TGGACTCAAC TCTGGTTGGT GTCAGATTAT CATGAGCATG GATCCCTTTT TGATTACTTA 780
AACAGATACA CAGTTACTGT GGAAGGAATG ATAAAACTTG CTCTGTCCAC GGCGAGCGGT 840
CTTGCCCATC TTCACATGGA GATTGTTGGT ACCCAAGGAA AGCCAGCCAT TGCTCATAGA 900
GATTTGAAAT CAAAGAATAT CTTGGTAAAG AAGAATGGAA CTTGCTGTAT TGCAGACTTA 960
GGACTGGCAG TAAGACATGA TTCAGCCACA GATACCATTG ATATTGCTCC AAACCACAGA 1020
GTGGGAACAA AAAGGTACAT GGCCCCTGAA GTTCTCGATG ATTCCATAAA TATGAAACAT 1080
TTTGAATCCT TCAAACGTGC TGACATCTAT GCAATGGGCT TAGTATTCTG GGAAATTGCT 1140
CGACGATGTT CCATTGGTGG AATTCATGAA GATTACCAAC TGCCTTATTA TGATCTTGTA 1200
CCTTCTGACC CATCAGTTGA AGAAATGAGA AAAGTTGTTT GTGAACAGAA GTTAAGGCCA 1260
AATATCCCAA ACAGATGGCA GAGCTGTGAA GCCTTGAGAG TAATGGCTAA AATTATGAGA 1320
GAATGTTGGT ATGCCAATGG AGCAGCTAGG CTTACAGCAT TGCGGATTAA GAAAACATTA 1380
TCACAACTCA GTCAACAGGA AGGCATCAAA ATGTAA 1416
Domain Profile
S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60
         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia
Q: 173   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  232
         57899*******************************************************
S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120
         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+
Q: 233   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  292
         ************************************************************
S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180
         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE
Q: 293   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  350
         *..*********************************************************
S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240
         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem
Q: 351   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  409
         ***********************************.************************
S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l
Q: 410   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  460
         *************************************************97
Domain Sequence
(FASTA)
IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60
ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120
GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180
DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 240
VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00257
EKS-ANC-00264
EKS-BOT-00275
EKS-CAE-00244
EKS-CAJ-00281
EKS-CAF-00281
EKS-CAP-00310
EKS-CII-00164
EKS-CIS-00044
EKS-DAR-00613
EKS-DRM-00141
EKS-EQC-00267
EKS-FEC-00261
EKS-GAM-00172
EKS-GAG-00229
EKS-GAA-00336
EKS-GOG-00274
EKS-ICT-00260
EKS-LAC-00287
EKS-LOA-00285
EKS-MEG-00218
EKS-MOD-00272
EKS-MUM-00306
EKS-MUP-00271
EKS-MYL-00278
EKS-OCP-00025
EKS-ORN-00353
EKS-ORA-00241
EKS-ORC-00259
EKS-ORL-00330
EKS-OTG-00281
EKS-PAT-00260
EKS-PES-00244
EKS-PEM-00147
EKS-POA-00267
EKS-PTV-00038
EKS-RAN-00290
EKS-SAH-00258
EKS-SOA-00024
EKS-SUS-00241
EKS-TAG-00288
EKS-TAR-00355
EKS-TAS-00017
EKS-TEN-00354
EKS-TUB-00025
EKS-TUT-00038
EKS-VIP-00014
EKS-XET-00348
Gene Ontology
GO:0044459; C:plasma membrane part
GO:0043235; C:receptor complex
GO:0005923; C:tight junction
GO:0005524; F:ATP binding
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0000186; P:activation of MAPKK activity
GO:0048870; P:cell motility
GO:0071560; P:cellular response to transforming growth factor beta stimulus
GO:0001837; P:epithelial to mesenchymal transition
GO:0060389; P:pathway-restricted SMAD protein phosphorylation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0030307; P:positive regulation of cell growth
GO:0008284; P:positive regulation of cell proliferation
GO:0051272; P:positive regulation of cellular component movement
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0060391; P:positive regulation of SMAD protein import into nucleus
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0042981; P:regulation of apoptotic process
GO:0031396; P:regulation of protein ubiquitination
KEGG
InterPros
IPR000472; Activin_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR003605; TGF_beta_rcpt_GS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
SMARTs
SM00467; GS; 1.
Prosites
PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013