EKS-NOL-00156
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00156
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb448.94.8E-135348608261
StatusUnreviewed
Ensembl ProteinENSNLEP00000020731
UniProt AccessionG1S5E3;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA5
Gene Synonyms/Alias RPS6KA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000017068ENSNLEP00000020731ENSNLET00000021768
OrganismNomascus leucogenys
Functional Description
Protein Length723
Protein Sequence
(FASTA)
MKVLKKATIV QKAKTTEHTR TERQVLEHIR QSPFLVTLHY AFQTETKLHL ILDYINGGEL 60
FTHLSQRERF TEHEVQIYVG EIVLALEHLH KLGIIYRDIK LENILLDSNG HVVLTDFGLS 120
KEFVADETER AYSFCGTIEY MAPDIVRGGD SGHDKAVDWW SLGVLMYELL TGASPFTVDG 180
EKNSQAEISR RILKSEPPYP QEMSALAKDL IQRLLMKDPK KRLGCGPRDA DEIKEHLFFQ 240
KINWDDLAAK KVPAPFKPVI RDELDVSNFA EEFTEMDPTY SPAALPQSSE KLFQGYSFVA 300
PSILFKRNAA VIDPLQFHMG VERPGVTNVA RSAMMKDSPF YQHYDLDLKD KPLGEGSFSI 360
CRKCVHKKSN QAFAVKIISK RMEANTQKEI TALKLCEGHP NIVKLHEVFH DQLHTFLVME 420
LLNGGELFER IKKKKHFSET EASYIMRKLV SAVSHMHDVG VVHRDLKPEN LLFTDENDNL 480
EIKIIDFGFA RLKPPDNQPL KTPCFTLHYA APELLNQNGY DESCDLWSLG VILYTMLSGQ 540
VPFQSHDRSL TCTSAVEIMK KIKKGDFSFE GEAWKNVSQE AKDLIQGLLT VDPNKRLKMS 600
GLRYNEWLQD GSQLSSNPLM TPDILGSSGA AVHTCVKATF HAFNKYKREG FCLQNVDKAP 660
LAKRRKMKKT STSTETRSSS SESSHSSSSH SHGKTTPTKT LQPSNPADSN NPETLFQFSD 720
SVA 723
Nucleotide Sequence
(FASTA)
ATGAAAGTTT TGAAAAAGGC AACAATAGTT CAAAAGGCCA AAACCACAGA GCATACAAGG 60
ACAGAACGAC AAGTCCTGGA GCACATTAGG CAGTCACCAT TTTTGGTGAC ATTACATTAT 120
GCTTTCCAGA CAGAAACCAA ACTTCATCTC ATTTTAGATT ATATAAATGG TGGTGAACTT 180
TTTACTCATC TTTCGCAAAG AGAGCGTTTC ACAGAGCACG AGGTGCAGAT TTATGTTGGA 240
GAGATTGTGC TTGCCCTCGA ACATCTCCAC AAGTTGGGGA TTATATATCG TGACATTAAG 300
CTTGAGAATA TTCTACTTGA TTCTAATGGC CATGTGGTGC TTACAGATTT TGGTCTGAGT 360
AAGGAGTTTG TGGCTGATGA AACTGAAAGA GCATATTCCT TTTGTGGAAC TATTGAATAC 420
ATGGCACCAG ATATTGTCAG AGGGGGAGAT TCAGGACATG ACAAGGCAGT TGACTGGTGG 480
AGTTTAGGTG TTCTAATGTA TGAATTACTA ACTGGAGCAT CTCCTTTCAC TGTTGATGGA 540
GAAAAAAATT CCCAAGCTGA GATATCTAGG AGAATATTAA AAAGTGAGCC TCCATATCCC 600
CAAGAAATGA GTGCTTTAGC TAAAGACCTA ATTCAGCGTC TTTTGATGAA AGATCCCAAG 660
AAGAGATTGG GATGTGGTCC ACGTGATGCA GATGAAATCA AAGAACATCT CTTCTTTCAG 720
AAAATAAATT GGGATGATTT AGCTGCCAAA AAAGTGCCTG CACCATTTAA GCCAGTCATT 780
CGAGATGAAT TAGATGTGAG TAACTTTGCA GAAGAGTTCA CAGAAATGGA TCCCACTTAT 840
TCTCCCGCAG CCCTGCCCCA GAGCTCTGAG AAGCTGTTTC AGGGCTATTC CTTTGTTGCT 900
CCTTCCATCC TATTCAAGCG TAATGCAGCT GTCATAGACC CTCTTCAGTT TCACATGGGA 960
GTTGAACGTC CTGGAGTGAC AAATGTTGCC AGGAGTGCAA TGATGAAGGA CTCTCCATTC 1020
TATCAACACT ATGACCTAGA TTTGAAGGAC AAACCACTGG GAGAAGGTAG TTTTTCAATT 1080
TGTCGAAAGT GCGTGCATAA AAAAAGTAAC CAAGCTTTTG CAGTCAAAAT AATCAGCAAA 1140
AGGATGGAAG CCAATACTCA GAAGGAAATA ACAGCTCTGA AACTCTGTGA AGGACACCCC 1200
AATATCGTGA AGTTGCATGA AGTTTTTCAT GATCAGCTTC ACACATTTCT AGTGATGGAA 1260
CTTCTGAATG GAGGAGAACT GTTTGAACGC ATTAAGAAAA AGAAGCACTT TAGTGAGACG 1320
GAAGCCAGCT ACATCATGAG GAAGCTTGTT TCAGCTGTAA GCCACATGCA TGATGTTGGA 1380
GTGGTGCACA GGGATCTGAA ACCTGAGAAT TTATTGTTCA CCGATGAAAA TGACAATTTG 1440
GAAATTAAAA TAATTGATTT TGGATTTGCA CGGCTAAAGC CACCGGATAA TCAGCCCCTG 1500
AAGACTCCAT GCTTCACCCT TCATTATGCG GCCCCAGAGC TCTTGAATCA GAATGGCTAC 1560
GATGAGTCCT GTGACTTGTG GAGCTTGGGT GTCATTTTGT ACACAATGTT GTCAGGACAG 1620
GTTCCCTTCC AATCTCATGA CCGAAGTTTG ACGTGTACCA GTGCAGTGGA AATCATGAAG 1680
AAAATTAAAA AGGGAGATTT CTCCTTTGAA GGAGAAGCCT GGAAGAATGT ATCCCAAGAG 1740
GCTAAAGATT TGATCCAAGG ACTTCTCACA GTTGATCCAA ACAAAAGGCT TAAAATGTCT 1800
GGCTTGAGGT ACAATGAATG GCTTCAAGAT GGCAGTCAGC TGTCCTCCAA TCCTCTGATG 1860
ACTCCGGATA TTCTAGGATC TTCGGGAGCT GCCGTGCATA CCTGTGTGAA AGCAACCTTC 1920
CACGCCTTTA ACAAATACAA GAGAGAGGGG TTTTGCCTTC AGAATGTCGA TAAGGCCCCT 1980
TTGGCTAAGA GAAGAAAAAT GAAAAAGACT AGCACCAGTA CCGAGACGCG CAGCAGTTCC 2040
AGTGAGAGTT CCCATTCTTC TTCCTCTCAT TCTCACGGTA AAACTACACC CACCAAGACA 2100
CTGCAGCCCA GCAATCCTGC TGACAGCAAT AACCCAGAGA CCCTCTTCCA GTTCTCAGAC 2160
TCAGTAGCTT AG 2172
Domain Profile
S: 2     evkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkd  60
         +++++lG+Gs+s+c++cvhk++nq+favkii+k+ +++t++ei++l+++e+hpniv+l++
Q: 348   LKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRmEANTQKEITALKLCEGHPNIVKLHE  407
         5789******************************9*************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         v++d+++++lv+ell+GGel++rikkkk+fse+eas+i+r+lv+av+++h++Gvvhrdlk
Q: 408   VFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK  467
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         pen+l++de+dn+e ikiidfGfa+lk+++n++lktpc+tl+++ape+l+++Gyde+cdl
Q: 468   PENLLFTDENDNLE-IKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDL  526
         **************.*********************************************
S: 181   wslGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvs  236
         wslGv+lytml+G+vpf    +++++++a+ei++kik+G+fs++Geaw++vs+eakdl++
Q: 527   WSLGVILYTMLSGQVPFqshdRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ  586
         *****************9998899************************************
S: 237   klltvdpakrlkleqllkhswl  258
         +lltvdp+krlk+++l++++wl
Q: 587   GLLTVDPNKRLKMSGLRYNEWL  608
         *********************7
Domain Sequence
(FASTA)
LKDKPLGEGS FSICRKCVHK KSNQAFAVKI ISKRMEANTQ KEITALKLCE GHPNIVKLHE 60
VFHDQLHTFL VMELLNGGEL FERIKKKKHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK 120
PENLLFTDEN DNLEIKIIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNQ NGYDESCDLW 180
SLGVILYTML SGQVPFQSHD RSLTCTSAVE IMKKIKKGDF SFEGEAWKNV SQEAKDLIQG 240
LLTVDPNKRL KMSGLRYNEW L 261
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00163
EKS-CAE-00125
EKS-CAJ-00167
EKS-CAF-00170
EKS-CAP-00162
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00452
EKS-DIO-00087
EKS-DRM-00077
EKS-EQC-00162
EKS-FEC-00153
EKS-GAG-00140
EKS-GAA-00192
EKS-GOG-00163
EKS-HOS-00169
EKS-ICT-00158
EKS-LAC-00173
EKS-LOA-00162
EKS-MAM-00160
EKS-MEG-00130
EKS-MOD-00162
EKS-MUP-00167
EKS-MYL-00173
EKS-ORN-00202
EKS-ORA-00141
EKS-ORC-00151
EKS-ORL-00189
EKS-OTG-00170
EKS-PAT-00153
EKS-PEM-00087
EKS-POA-00160
EKS-SAH-00157
EKS-TAG-00191
EKS-TAR-00209
EKS-TEN-00202
EKS-XET-00152
EKS-XIM-00197
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043990; P:histone H2A-S1 phosphorylation
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013