EKS-NOL-00068

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00068

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	338.8	2.3E-101	6	295	290

Status

Unreviewed

Ensembl Protein

ENSNLEP00000020905

UniProt Accession

G1S5W7;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK4

Gene Synonyms/Alias

CDK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000017205	ENSNLEP00000020905	ENSNLET00000021955

Organism

Nomascus leucogenys

Functional Description

Protein Length

303

Protein Sequence
(FASTA)

MATSRYEPVA EIGVGAYGTV YKARDPHSGH FVALKSVRVP NGGGAGGGLP ISTVREVALL 60

RRLEAFEHPN VVRLMDVCAT SRTDREIKVT LVFEHVDQDL RTYLDKAPPP GLPAETIKDL 120

MRQFLRGLDF LHANCIVHRD LKPENILVTS GGTVKLADFG LARIYSYQMA LTPVVVTLWY 180

RAPEVLLQST YATPVDMWSV GCIFAEMFRR KPLFCGNSEA DQLGKIFDLI GLPPEDDWPR 240

DVSLPRGAFP PRGPRPVQSV VPEMEESGAQ LLLEMLTFNP HKRISAFRAL QHSYLHKDEG 300

NPE 303

Nucleotide Sequence
(FASTA)

ATGGCTACCT CTCGATATGA GCCAGTCGCT GAAATTGGTG TCGGTGCCTA TGGGACAGTG 60

TACAAGGCCC GTGATCCCCA CAGTGGCCAC TTTGTGGCCC TCAAGAGTGT GAGAGTCCCC 120

AATGGAGGAG GAGCTGGAGG AGGCCTTCCC ATCAGCACAG TTCGTGAGGT GGCCTTACTG 180

AGGCGACTGG AGGCTTTTGA GCATCCCAAT GTTGTCCGGC TGATGGACGT CTGTGCCACA 240

TCCCGAACTG ACCGGGAGAT CAAGGTAACC CTGGTGTTTG AGCATGTAGA CCAGGACCTA 300

AGGACATATC TGGACAAGGC GCCCCCACCA GGCTTGCCAG CCGAAACCAT CAAGGATCTG 360

ATGCGCCAGT TTCTAAGAGG CCTAGATTTC CTTCATGCCA ATTGCATCGT TCACCGAGAT 420

CTGAAGCCAG AGAACATTCT GGTGACAAGT GGTGGAACAG TCAAGCTGGC TGACTTTGGC 480

CTAGCCAGAA TCTACAGCTA CCAGATGGCA CTTACACCCG TGGTTGTTAC ACTCTGGTAC 540

CGAGCTCCCG AAGTTCTTCT GCAGTCCACA TATGCAACAC CTGTGGACAT GTGGAGTGTT 600

GGCTGCATCT TTGCAGAGAT GTTTCGTCGA AAGCCTCTCT TCTGTGGAAA CTCTGAAGCC 660

GACCAGTTGG GCAAAATCTT TGACCTGATT GGGCTGCCTC CAGAAGATGA CTGGCCTCGA 720

GATGTATCCC TGCCCCGTGG AGCCTTTCCC CCCAGAGGGC CCCGCCCAGT GCAGTCGGTG 780

GTACCTGAGA TGGAGGAGTC GGGAGCACAG CTGCTGCTGG AAATGCTGAC TTTTAACCCG 840

CACAAGCGAA TCTCTGCCTT TCGAGCTCTG CAGCACTCTT ATCTACATAA GGATGAAGGT 900

AATCCGGAGT GA 912

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkel..  55

         ye +++ig G+yg+vyka+d ++g++vAlK++r+ +      g+pi+++rE++ll++l

Q: 6     YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGaggGLPISTVREVALLRRLea  65

         88899*****************************99874444***************988

S: 56    .khknivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqll  110

          +h+n+v+L++v+a     ++ k++Lvfe+++qdL ++l+k +  +l+ e++k l++q+l

Q: 66    fEHPNVVRLMDVCAtsrtDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL  125

         89************887444589*************************************

S: 111   eglaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPe  170

         +gl++lH+n i+HRDlKp+N+L+++ g++klaDfGlar +s ++  +t++vvTlwYraPe

Q: 126   RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTPVVVTLWYRAPE  184

         ******************************************999.**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         +Ll+++ Y t vD+Wsvgci+ae+++rkplf g+se dql +if+l+g p e++wp+  +

Q: 185   VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS  243

         ***985.*****************************************************

S: 231   lpeykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         lp+    fp++ ++ ++++v++++e++ +ll ++l+++p+kRisa +alqh+y+

Q: 244   LPRGA--FPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL  295

         ***65..*********************************************96

Domain Sequence
(FASTA)

YEPVAEIGVG AYGTVYKARD PHSGHFVALK SVRVPNGGGA GGGLPISTVR EVALLRRLEA 60

FEHPNVVRLM DVCATSRTDR EIKVTLVFEH VDQDLRTYLD KAPPPGLPAE TIKDLMRQFL 120

RGLDFLHANC IVHRDLKPEN ILVTSGGTVK LADFGLARIY SYQMALTPVV VTLWYRAPEV 180

LLQSTYATPV DMWSVGCIFA EMFRRKPLFC GNSEADQLGK IFDLIGLPPE DDWPRDVSLP 240

RGAFPPRGPR PVQSVVPEME ESGAQLLLEM LTFNPHKRIS AFRALQHSYL 290

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000785	; C:chromatin
GO:0005829	; C:cytosol
GO:0031965	; C:nuclear membrane
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0048146	; P:positive regulation of fibroblast proliferation
GO:0010468	; P:regulation of gene expression
GO:0042493	; P:response to drug

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013