EKS-NOL-00099

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00099

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	491.4	4.4E-148	370	620	251

Status

Unreviewed

Ensembl Protein

ENSNLEP00000021108

UniProt Accession

G1S6G9;

Protein Name

Protein Synonyms/Alias

Gene Name

TEC

Gene Synonyms/Alias

TEC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000017384	ENSNLEP00000021108	ENSNLET00000022183

Organism

Nomascus leucogenys

Functional Description

Protein Length

631

Protein Sequence
(FASTA)

MNFNTILEEI LIKRSQQKKK TSPLNYKERL FVLTKSMLTY YEGRAEKKYR KGFIDVSKIK 60

CVEIVKNDDG VIPCQNKYPF QVVHDANTLY IFAPSPQSRD LWVKKLKEEI KNNNNIMIKY 120

HPKFWTDGSY QCCRQTEKLA PGCEKYNLFE SSIRKALPPA PETKKRRPPP PIPLEEEDNS 180

EEIVVAMYDF QATEGHDLRL ERGQEYLILE KNDVHWWRAR DKYGNEGYIP SNYVTGKKSN 240

NLDQYEWYCR NMNRSKAEQL LHSEDKEGGF MVRDSSQPGL YTVSLYTKFG GEGSSGFRHY 300

HIKETTTSPK KYYLAEKHAF GSIPEIIEYH KHNAAGLVTR LRYPVSVKGK NAPTTAGFSY 360

EKWEINPSEL TFMRELGSGL FGVVRLGKWR AQYKVAIKAI REGAMCEEDF IEEAKVMMKL 420

THPKLVQLYG VCTQQKPIYI VTEFMERGCL LNFLRQRQGH FSRDVLLSMC QDVCEGMEYL 480

ERNSFIHRDL AARNCLVSEA GVVKVSDFGM ARYVLDDQYT SSSGAKFPVK WCPPEVFNYS 540

RFSSKSDVWS FGVLMWEVFT EGRMPFEKYT NYEVVTMVTR GHRLYQPKLA SSYVYEVMLR 600

CWQEKPEGRP SFEDLLRTID ELVECEETFG R 631

Nucleotide Sequence
(FASTA)

ATGAATTTTA ACACTATTTT GGAGGAGATT CTTATTAAAA GGTCACAGCA GAAAAAGAAG 60

ACATCGCCCT TAAACTACAA AGAGAGACTT TTTGTACTTA CAAAGTCCAT GCTAACCTAC 120

TATGAGGGTC GAGCAGAGAA GAAATACAGA AAGGGGTTTA TTGATGTTTC AAAAATCAAG 180

TGTGTGGAAA TAGTGAAGAA TGATGATGGT GTCATTCCCT GTCAAAATAA GTATCCATTT 240

CAGGTTGTTC ATGATGCTAA CACACTTTAC ATTTTTGCAC CTAGTCCACA GAGCAGGGAC 300

CTGTGGGTGA AGAAGTTAAA AGAAGAAATA AAGAACAACA ATAATATTAT GATTAAATAT 360

CATCCTAAAT TCTGGACAGA TGGAAGTTAT CAGTGTTGTA GACAAACTGA AAAATTAGCA 420

CCCGGATGTG AAAAATACAA TCTTTTTGAG AGTAGTATAA GGAAAGCACT ACCTCCAGCA 480

CCAGAAACAA AGAAGCGAAG GCCTCCCCCA CCAATTCCAC TAGAAGAAGA AGATAATAGT 540

GAAGAAATCG TTGTAGCCAT GTATGATTTC CAAGCGACAG AAGGACATGA TCTCAGATTA 600

GAGAGAGGCC AAGAGTATCT CATTTTAGAA AAGAATGATG TTCATTGGTG GAGAGCAAGA 660

GATAAATATG GGAATGAAGG ATATATCCCA AGTAATTATG TAACGGGAAA GAAATCAAAC 720

AACTTAGATC AATATGAATG GTATTGCAGA AATATGAATA GAAGCAAGGC AGAGCAACTC 780

CTCCACAGTG AAGATAAAGA AGGCGGTTTT ATGGTAAGAG ATTCCAGTCA ACCAGGCTTG 840

TACACAGTCT CCCTTTATAC CAAGTTTGGA GGAGAAGGTT CATCGGGTTT CAGGCATTAT 900

CATATAAAGG AAACAACAAC ATCTCCAAAG AAGTATTACC TAGCTGAAAA ACATGCTTTC 960

GGCTCCATTC CTGAGATTAT TGAATATCAT AAGCACAACG CAGCAGGACT TGTCACCCGG 1020

CTTCGGTACC CAGTTAGTGT GAAAGGGAAG AATGCACCCA CCACTGCAGG ATTCAGCTAT 1080

GAGAAATGGG AGATTAACCC TTCCGAACTG ACCTTTATGA GGGAATTGGG AAGTGGACTG 1140

TTTGGAGTTG TGAGGCTTGG CAAATGGCGA GCCCAGTACA AAGTCGCAAT CAAAGCTATT 1200

CGGGAAGGTG CAATGTGCGA GGAGGACTTT ATAGAAGAAG CTAAAGTGAT GATGAAACTG 1260

ACACACCCGA AGTTAGTGCA GCTTTATGGT GTATGCACCC AACAGAAACC GATATACATT 1320

GTTACCGAGT TCATGGAAAG GGGCTGCCTT CTGAATTTCC TCCGACAGAG ACAAGGTCAT 1380

TTCAGTAGAG ACGTGCTGCT GAGCATGTGT CAGGATGTGT GTGAAGGGAT GGAGTATCTG 1440

GAGAGAAACA GCTTCATCCA CAGAGATCTG GCTGCCAGAA ATTGTCTAGT AAGTGAGGCG 1500

GGAGTTGTAA AAGTATCTGA TTTTGGAATG GCCAGGTATG TTCTGGATGA TCAGTACACA 1560

AGTTCTTCTG GTGCTAAGTT TCCCGTGAAG TGGTGTCCAC CTGAAGTATT TAATTACAGC 1620

CGCTTCAGCA GCAAATCAGA TGTCTGGTCA TTTGGTGTTT TAATGTGGGA AGTATTCACG 1680

GAAGGCAGAA TGCCTTTTGA AAAATACACC AATTATGAAG TGGTAACCAT GGTTACTCGA 1740

GGCCACCGAC TCTACCAGCC AAAGTTGGCG TCCAGCTATG TATATGAGGT GATGCTGAGA 1800

TGTTGGCAGG AGAAACCAGA GGGAAGGCCT TCTTTTGAAG ATCTGCTGCG CACAATAGAT 1860

GAACTAGTTG AATGTGAAGA AACTTTTGGA AGATAA 1896

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+++elgsg fgvv+lgkwra+++vaikai+egam+eedfieeakvmmkl+hpklvqly

Q: 370   LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLY  429

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvc++qkpiyivte++e+gclln+lr++++++++++ll+mc+dvcegmeyler+sfihrd

Q: 430   GVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRD  489

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+e+ vvkvsdfg+aryvlddqy+ss+gakfpvkw+ppev++ys++ssksdvw

Q: 490   LAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVW  549

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         +fgvlmwevf+eg++p+ek++n+evv++v+rg+rly+pklas++vyevm +cw+ekpe+r

Q: 550   SFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASSYVYEVMLRCWQEKPEGR  609

         ************************************************************

S: 241   ptfkellsale  251

         p+f++ll+++

Q: 610   PSFEDLLRTID  620

         ********995

Domain Sequence
(FASTA)

LTFMRELGSG LFGVVRLGKW RAQYKVAIKA IREGAMCEED FIEEAKVMMK LTHPKLVQLY 60

GVCTQQKPIY IVTEFMERGC LLNFLRQRQG HFSRDVLLSM CQDVCEGMEY LERNSFIHRD 120

LAARNCLVSE AGVVKVSDFG MARYVLDDQY TSSSGAKFPV KWCPPEVFNY SRFSSKSDVW 180

SFGVLMWEVF TEGRMPFEKY TNYEVVTMVT RGHRLYQPKL ASSYVYEVML RCWQEKPEGR 240

PSFEDLLRTI D 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543	; F:phospholipid binding
GO:0050853	; P:B cell receptor signaling pathway
GO:0007229	; P:integrin-mediated signaling pathway
GO:0035556	; P:intracellular signal transduction
GO:0010543	; P:regulation of platelet activation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00402	; TECBTKDOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013