EKS-NOL-00075

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00075

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Musk	626.5	5.4E-189	575	855	281

Status

Unreviewed

Ensembl Protein

ENSNLEP00000021212

UniProt Accession

G1S6S3;

Protein Name

Protein Synonyms/Alias

Gene Name

MUSK

Gene Synonyms/Alias

MUSK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000017469	ENSNLEP00000021212	ENSNLET00000022288

Organism

Nomascus leucogenys

Functional Description

Protein Length

869

Protein Sequence
(FASTA)

MRELVNIPLV HILTLVAFSG TEKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS 60

WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCT ANNGVGGAVE SCGALQVKMK 120

PKITRPPINV KIIEGLKAVL PCTTMGNPKP SVSWIKGDSP LRENSRIAVL ESGSLRIHNV 180

QKEDAGQYRC VAKNSLGTAY SKVVKLEVEV FARILRAPES HNVTFGSFVT LHCTATGIPV 240

PTITWIENGN AVSSGSIQES VKDRVIDSRL QLFITKPGLY TCIATNKHGE KFTTAKAAAT 300

ISIAAFSKPQ KDNKGYCAQY RGEVCNAVLA KDALVFLNTS YADPEEAQEL LVHTAWNELK 360

VVSPVCRPAA EALLCNHIFQ ECSPGVVPTP IPICREYCLA VKELFCAKEW LAMEEKTHRG 420

LYRSEMHLLS VPECGKLPSM HWDPIACARL PHLDYNKENL KTFPPMTSSK PSVDIPNLPS 480

SSSSSFSVSP TYSMTVIISI MSSFAIFVLL TITTLYCCRR RKQWKNEKRE SAAVTLTTLP 540

SELLLDRLHP NPMYQRMPLL LNPKLLSLEY PRNNIEYVRD IGEGAFGRVF QARAPGLLPY 600

EPFTMVAVKM LKEEASADMQ ADFQREAALM AEFDNPNIVK LLGVCAVGKP MCLLFEYMAY 660

GDLNEFLRSM SPHTVCSLSH SDLSMRAQVS SPGPPPLSCA EQLCIARQVA AGMAYLSERK 720

FVHRDLATRN CLVGENMVVK IADFGLSRNI YSADYYKANE NDAIPIRWMP PESIFYNRYT 780

TESDVWAYGV VLWEIFSYGL QPYYGMAHEE VIYYVRDGNI LSCPENCPVE LYNLMRLCWS 840

KLPADRPSFT SIHRILERMC ERAEGTVSV 869

Nucleotide Sequence
(FASTA)

ATGAGAGAGC TCGTCAACAT TCCACTGGTA CATATTCTTA CTCTGGTTGC CTTCAGCGGA 60

ACTGAGAAAC TTCCAAAAGC TCCTGTCATC ACCACTCCTC TTGAAACAGT GGATGCCTTA 120

GTTGAAGAAG TGGCTACTTT CATGTGTGCA GTGGAATCCT ACCCCCAGCC TGAGATTTCC 180

TGGACTAGAA ATAAAATTCT CATTAAGCTC TTTGACACCC GGTACAGCAT CCGGGAGAAT 240

GGGCAGCTCC TCACCATCCT GAGTGTGGAA GACAGTGATG ATGGCATTTA CTGCTGCACG 300

GCCAACAATG GTGTGGGAGG AGCTGTGGAG AGTTGTGGAG CCCTGCAAGT GAAGATGAAA 360

CCTAAAATAA CTCGTCCTCC CATAAATGTG AAAATAATAG AGGGATTAAA AGCAGTCCTA 420

CCATGTACTA CAATGGGTAA TCCCAAACCA TCAGTGTCTT GGATAAAGGG AGACAGCCCT 480

CTCAGGGAAA ATTCCCGAAT TGCAGTTCTT GAATCTGGGA GCCTGAGGAT TCATAACGTA 540

CAAAAGGAAG ATGCAGGACA GTATCGATGT GTGGCAAAAA ACAGCCTCGG GACAGCATAT 600

TCCAAAGTGG TGAAGCTGGA AGTTGAGGTT TTTGCCAGGA TCCTGCGGGC TCCTGAATCC 660

CACAATGTCA CCTTTGGCTC CTTTGTGACC CTGCACTGTA CAGCAACAGG CATTCCTGTC 720

CCCACCATCA CCTGGATTGA AAACGGAAAT GCTGTTTCTT CTGGGTCCAT TCAAGAGAGT 780

GTGAAAGACC GAGTGATTGA CTCAAGACTG CAGCTGTTTA TCACCAAGCC AGGACTCTAC 840

ACATGCATAG CTACCAATAA GCACGGGGAG AAGTTCACTA CTGCCAAGGC TGCAGCCACC 900

ATCAGCATAG CAGCTTTCAG TAAACCACAG AAAGATAACA AAGGCTACTG CGCCCAGTAC 960

AGAGGGGAGG TGTGTAATGC AGTCCTGGCA AAAGATGCTC TTGTTTTTCT CAACACCTCC 1020

TATGCGGACC CTGAGGAGGC CCAAGAGCTA CTGGTCCACA CGGCCTGGAA TGAACTGAAA 1080

GTAGTGAGCC CAGTCTGCCG GCCAGCTGCT GAGGCTTTGT TGTGTAACCA CATCTTCCAG 1140

GAGTGCAGTC CTGGAGTAGT GCCTACTCCT ATTCCCATTT GCAGAGAGTA CTGCTTGGCA 1200

GTAAAGGAGC TCTTCTGTGC AAAAGAATGG CTGGCAATGG AAGAGAAGAC CCACAGAGGA 1260

CTCTACAGAT CCGAGATGCA TTTGCTGTCC GTGCCAGAAT GCGGCAAGCT TCCCAGCATG 1320

CACTGGGACC CCATAGCCTG TGCCAGACTG CCACATCTAG ATTATAACAA AGAAAACCTA 1380

AAAACATTCC CACCAATGAC GTCCTCAAAG CCAAGTGTGG ACATTCCAAA TTTGCCTTCC 1440

TCCTCCTCTT CTTCCTTCTC TGTCTCACCT ACATACTCCA TGACTGTAAT AATCTCCATC 1500

ATGTCCAGCT TTGCAATATT TGTGCTTCTT ACCATAACTA CTCTCTATTG CTGCCGAAGA 1560

AGAAAACAAT GGAAAAATGA AAAGAGAGAA TCAGCAGCTG TAACCCTCAC CACACTGCCT 1620

TCTGAGCTCC TACTAGATAG ACTTCATCCC AACCCCATGT ACCAGAGGAT GCCGCTCCTT 1680

CTGAACCCCA AATTGCTCAG CCTGGAGTAT CCAAGGAATA ACATTGAATA TGTGAGAGAC 1740

ATCGGAGAGG GAGCATTTGG AAGGGTGTTT CAAGCAAGGG CACCAGGCTT ACTTCCCTAT 1800

GAACCTTTCA CTATGGTGGC AGTAAAGATG CTCAAAGAAG AAGCCTCGGC AGATATGCAA 1860

GCGGACTTTC AGAGGGAGGC AGCCCTCATG GCAGAATTTG ACAACCCTAA CATTGTGAAG 1920

CTCTTAGGTG TGTGTGCTGT CGGGAAGCCA ATGTGCCTGC TCTTTGAATA CATGGCCTAT 1980

GGCGACCTCA ATGAGTTCCT CCGCAGCATG TCCCCTCACA CCGTGTGCAG CCTCAGTCAC 2040

AGTGACTTGT CTATGAGGGC TCAGGTCTCC AGCCCTGGAC CCCCACCCCT CTCCTGTGCT 2100

GAGCAGCTTT GCATTGCCAG GCAGGTGGCA GCTGGCATGG CTTACCTCTC AGAACGTAAG 2160

TTTGTTCACC GAGATTTAGC CACCAGGAAC TGCCTGGTGG GCGAGAACAT GGTGGTGAAA 2220

ATTGCCGACT TCGGCCTCTC CAGGAACATC TACTCAGCAG ACTACTACAA AGCTAATGAG 2280

AACGACGCTA TCCCTATCCG TTGGATGCCA CCAGAGTCCA TTTTTTATAA CCGCTACACT 2340

ACAGAGTCTG ATGTGTGGGC CTATGGCGTG GTCCTCTGGG AGATCTTCTC CTATGGCCTG 2400

CAGCCCTACT ATGGGATGGC CCATGAGGAG GTAATTTACT ACGTGCGAGA TGGCAACATC 2460

CTCTCCTGCC CTGAGAACTG CCCCGTGGAG CTGTACAATC TCATGCGTCT ATGTTGGAGC 2520

AAGCTGCCTG CAGACAGACC CAGTTTTACC AGTATTCACC GAATTCTGGA ACGCATGTGT 2580

GAGAGGGCAG AGGGAACTGT GAGTGTCTAA 2610

Domain Profile

S: 1     ieyvrdlgegafgrvfqarapgllpyeefllvavkmlkeeasadmqadfereaallaefd  60

         ieyvrd+gegafgrvfqarapgllpye+f++vavkmlkeeasadmqadf+reaal+aefd

Q: 575   IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFD  634

         89**********************************************************

S: 61    npnivkllgvcavgkpmcllfeymaygdlneflrslspytvcslshsdlslraqvsspdr  120

         npnivkllgvcavgkpmcllfeymaygdlneflrs+sp+tvcslshsdls+raqvssp++

Q: 635   NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGP  694

         ************************************************************

S: 121   lplseaellciarqvaagmaylserkfvhrdlatrnclvgetmvvkiadfglsrkiysad  180

         +pls+ae+lciarqvaagmaylserkfvhrdlatrnclvge+mvvkiadfglsr+iysad

Q: 695   PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSAD  754

         ************************************************************

S: 181   yykadendaipirwmplesilynrytlesdvwaygvvlweifsyalqpyyglaheeviky  240

         yyka+endaipirwmp+esi+ynryt+esdvwaygvvlweifsy+lqpyyg+aheevi+y

Q: 755   YYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYY  814

         ************************************************************

S: 241   vrdgnilacpentplelyalmrlcwsklpadrpsfasihri  281

         vrdgnil+cpen+p+ely+lmrlcwsklpadrpsf+sihri

Q: 815   VRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRI  855

         ***************************************98

Domain Sequence
(FASTA)

IEYVRDIGEG AFGRVFQARA PGLLPYEPFT MVAVKMLKEE ASADMQADFQ REAALMAEFD 60

NPNIVKLLGV CAVGKPMCLL FEYMAYGDLN EFLRSMSPHT VCSLSHSDLS MRAQVSSPGP 120

PPLSCAEQLC IARQVAAGMA YLSERKFVHR DLATRNCLVG ENMVVKIADF GLSRNIYSAD 180

YYKANENDAI PIRWMPPESI FYNRYTTESD VWAYGVVLWE IFSYGLQPYY GMAHEEVIYY 240

VRDGNILSCP ENCPVELYNL MRLCWSKLPA DRPSFTSIHR I 281

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR020067	; Frizzled_dom.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF01392	; Fz; 1.
PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50038	; FZ; 1.
PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013