EKS-NOL-00059

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00059

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	370.9	3.7E-111	134	430	297

Status

Unreviewed

Ensembl Protein

ENSNLEP00000021235

UniProt Accession

G1S6U6;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK9

Gene Synonyms/Alias

CDK9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000017490	ENSNLEP00000021235	ENSNLET00000022311

Organism

Nomascus leucogenys

Functional Description

Protein Length

487

Protein Sequence
(FASTA)

MQRDAPPRAP APAPRLPAPP IGAAASSGGG GGGGSGGGGG ASAAPAPPGL SGTTSPRGPG 60

GGRRAEEAGS APRGRKWPWR RKWRGRGGAW SAAAAGPGAG AAAAATGGGG GALEAAMAKQ 120

YDSVECPFCD EVKYEKLAKI GQGTFGEVFK ARHRKTGQKV ALKKVLMENE KEGFPITALR 180

EIKILQLLKH ENVVNLIEIC RTKASPYNRC KGSIYLVFDF CEHDLAGLLS NVLVKFTLSE 240

IKRVMQMLLN GLYYIHRNKI LHRDMKAANV LITRDGVLKL ADFGLARAFS LAKNSQPNRY 300

TNRVVTLWYR PPELLLGERD YGPPIDLWGA GCIMAEMWTR SPIMQGNTEQ HQLALISQLC 360

GSITPEVWPN VDNYELYEKL ELVKGQKRKV KDRLKAYVRD PYALDLIDKL LVLDPAQRID 420

SDDALNHDFF WSDPMPSDLK GMLSTHLTSM FEYLAPPRRK GSQITQQSTN QSRNPATTNQ 480

TEFERVF 487

Nucleotide Sequence
(FASTA)

ATGCAGCGGG ACGCGCCACC CCGAGCCCCA GCTCCGGCGC CCCGGCTCCC CGCGCCCCCG 60

ATCGGGGCCG CCGCCAGTAG TGGCGGCGGC GGAGGCGGGG GCAGCGGCGG CGGCGGAGGC 120

GCCTCTGCAG CTCCGGCTCC CCCTGGCCTC TCGGGAACTA CAAGTCCCAG GGGGCCTGGC 180

GGCGGGCGGC GGGCGGAAGA GGCGGGGTCG GCTCCGCGAG GCCGGAAGTG GCCGTGGAGG 240

CGGAAGTGGC GCGGCCGCGG AGGGGCCTGG AGTGCGGCGG CGGCGGGACC CGGAGCAGGA 300

GCGGCAGCAG CAGCGACTGG GGGCGGCGGC GGCGCGTTGG AGGCGGCCAT GGCAAAGCAG 360

TACGACTCGG TGGAGTGCCC CTTTTGTGAT GAAGTTAAAT ACGAGAAGCT CGCCAAGATC 420

GGCCAAGGCA CCTTCGGGGA GGTGTTTAAG GCCAGGCACC GCAAGACCGG CCAGAAGGTG 480

GCTCTGAAGA AGGTACTGAT GGAAAACGAG AAGGAGGGGT TCCCCATTAC AGCCTTGCGG 540

GAGATCAAGA TCCTTCAGCT TCTAAAACAC GAGAATGTGG TCAACTTGAT TGAGATTTGT 600

CGAACCAAAG CTTCCCCCTA TAACCGCTGC AAGGGTAGTA TATACCTGGT GTTTGACTTC 660

TGCGAGCATG ACCTTGCTGG GCTGTTGAGC AACGTTTTGG TCAAGTTCAC GCTGTCTGAG 720

ATCAAGAGGG TGATGCAGAT GCTGCTTAAC GGCCTCTACT ACATCCACAG GAATAAGATT 780

CTGCATAGGG ACATGAAGGC TGCTAATGTG CTTATCACTC GTGATGGGGT CCTGAAGCTG 840

GCAGACTTTG GGCTGGCCCG GGCCTTCAGC CTGGCCAAGA ACAGCCAGCC CAACCGCTAC 900

ACCAACCGTG TGGTGACACT CTGGTACCGG CCCCCGGAGC TGTTGCTCGG GGAGCGGGAC 960

TACGGCCCCC CCATTGACCT GTGGGGTGCT GGGTGCATCA TGGCAGAGAT GTGGACCCGC 1020

AGCCCCATCA TGCAGGGCAA CACGGAGCAG CACCAACTCG CCCTCATCAG TCAGCTCTGT 1080

GGCTCCATCA CCCCTGAGGT GTGGCCAAAC GTGGACAACT ATGAGCTGTA TGAAAAGCTG 1140

GAGTTGGTCA AGGGCCAGAA GCGGAAGGTG AAGGACAGGC TGAAGGCCTA TGTGCGTGAC 1200

CCATACGCCC TGGACCTCAT CGACAAGCTG CTGGTGCTGG ACCCTGCCCA GCGCATCGAC 1260

AGCGACGACG CCCTCAACCA TGACTTCTTC TGGTCCGACC CCATGCCCTC CGACCTCAAG 1320

GGCATGCTCT CCACCCACCT GACATCCATG TTCGAGTACC TGGCACCACC GCGCCGGAAG 1380

GGCAGCCAGA TCACCCAGCA GTCCACCAAC CAGAGTCGCA ATCCCGCCAC CACCAACCAG 1440

ACGGAGTTTG AGCGCGTCTT CTGA 1464

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         yekl+kig+Gt+g+v+ka++++tg++vAlKk+ +e+ekeg+pitalrEi++l+ lkh+n+

Q: 134   YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV  193

         99**********************************************************

S: 61    vkLlevva.......kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqllegl  113

         v+L+e++        + k ++yLvf+f+e+dL+ ll++    k++l+e+k+++++ll+gl

Q: 194   VNLIEICRtkaspynRCKGSIYLVFDFCEHDLAGLLSNVLV-KFTLSEIKRVMQMLLNGL  252

         ********99999988889*********************9.******************

S: 114   aylHsnkilHRDlKpqNlLiskegklklaDfGlaraf....ssplktytkevvTlwYraP  169

          y+H+nkilHRD+K++N+Li+++g+lklaDfGlaraf    +s+ ++yt++vvTlwYr+P

Q: 253   YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFslakNSQPNRYTNRVVTLWYRPP  312

         *************************************7776555557*************

S: 170   elLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevs  229

         elLlg+++Y+  +D+W++gci+ae++tr+p++qg++e++ql  i++l+g+++ +vwp+v

Q: 313   ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD  372

         ************************************************************

S: 230   klpeyk.ksfpkkkkkklkekvkklkek..aldllekllaldpkkRisakealqhkyf  284

         +++ y+  ++ k +k+k+k+++k++ ++  aldl++kll ldp++Ri++++al+h++f

Q: 373   NYELYEkLELVKGQKRKVKDRLKAYVRDpyALDLIDKLLVLDPAQRIDSDDALNHDFF  430

         ******7799999999999999887755469*************************98

Domain Sequence
(FASTA)

YEKLAKIGQG TFGEVFKARH RKTGQKVALK KVLMENEKEG FPITALREIK ILQLLKHENV 60

VNLIEICRTK ASPYNRCKGS IYLVFDFCEH DLAGLLSNVL VKFTLSEIKR VMQMLLNGLY 120

YIHRNKILHR DMKAANVLIT RDGVLKLADF GLARAFSLAK NSQPNRYTNR VVTLWYRPPE 180

LLLGERDYGP PIDLWGAGCI MAEMWTRSPI MQGNTEQHQL ALISQLCGSI TPEVWPNVDN 240

YELYEKLELV KGQKRKVKDR LKAYVRDPYA LDLIDKLLVL DPAQRIDSDD ALNHDFF 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0016605	; C:PML body
GO:0005524	; F:ATP binding
GO:0003677	; F:DNA binding
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0071345	; P:cellular response to cytokine stimulus
GO:0071157	; P:negative regulation of cell cycle arrest
GO:0006282	; P:regulation of DNA repair
GO:0031056	; P:regulation of histone modification
GO:0043111	; P:replication fork arrest

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013