EKS-NOL-00388

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00388

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/WEE	376.5	6.0E-113	298	568	271

Status

Unreviewed

Ensembl Protein

ENSNLEP00000021329

UniProt Accession

G1S740;

Protein Name

Protein Synonyms/Alias

Gene Name

WEE1

Gene Synonyms/Alias

WEE1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000017573	ENSNLEP00000021329	ENSNLET00000022412

Organism

Nomascus leucogenys

Functional Description

Protein Length

645

Protein Sequence
(FASTA)

MSFLRRQQPP PPRRAGAACT LRQKLIFSPC SDCEEEEEEE EEGSGHSTGE DSAFQEPDSP 60

LPPARSPTEP GPERRRSPGP APGSPGELEE DLLLPGACPG ADEAGGGAEG DSWEEEGFGS 120

SSPVKSPAAP YFLGSPFSPV RCGGPGDASP RGCGARRAGE GRCSPRPEHP GTPPHKTFRK 180

LRLFDTPHTP KSLLSKARGI DSSSVKLRGS SLFMDTEKSG KREFDVRQTP QVNINPFTPD 240

SLLLHSSGQC RRRKRTYWND SCGEDMEASD YELEDETRPA KRITITESNM KSRYTTEFHE 300

LEKIGSGEFG SVFKCVKRLD GCIYAIKRSK KPLAGSVDEQ NALREVYAHA VLGQHSHVVR 360

YFSAWAEDDH MLIQNEYCNG GSLADAISEN YRIMSYFKEA ELKDLLLQVG RGLRYIHSMS 420

LVHMDIKPSN IFISRTSIPN AASEEGDEDD WASNKVIFKI GDLGHVTRIS SPQVEEGDSR 480

FLANEVLQEN YTHLPKADIF ALALTVVCAA GAEPLPRNGD QWHEIRQGRL PRIPQVLSQE 540

FTELLKVMIH PDPERRPSAM ALVKHSVLLS ASRKSAEQLR IELNAEKFKN SLLQKELKKA 600

QMAKAAAEER ALFTDRMATR STTQSNRTSR LIGKKMNRSV SLTIY 645

Nucleotide Sequence
(FASTA)

ATGAGCTTCC TGCGCCGACA GCAGCCGCCG CCACCCCGCC GCGCCGGGGC GGCCTGCACC 60

TTGCGGCAGA AGCTGATCTT CTCGCCCTGC AGCGACTGTG AGGAAGAAGA GGAAGAGGAG 120

GAGGAGGGCA GCGGCCACAG CACTGGGGAG GACTCGGCCT TTCAAGAGCC CGACTCGCCG 180

CTGCCACCCG CGCGGAGCCC CACGGAGCCC GGGCCCGAGC GCCGCCGCTC GCCCGGGCCG 240

GCCCCCGGGA GCCCAGGCGA GCTGGAGGAG GACCTGTTGC TGCCCGGCGC CTGCCCGGGC 300

GCGGACGAGG CGGGCGGCGG GGCGGAGGGC GACTCGTGGG AGGAGGAGGG CTTCGGTTCC 360

TCGTCGCCGG TCAAGTCGCC GGCGGCCCCC TACTTCCTGG GTAGCCCGTT CTCGCCGGTG 420

CGCTGCGGCG GCCCGGGAGA TGCGTCGCCG CGGGGTTGCG GGGCGCGCCG GGCGGGCGAA 480

GGCCGCTGCT CGCCGCGGCC GGAACACCCG GGCACCCCGC CACACAAGAC CTTCCGCAAG 540

CTGCGACTCT TCGACACCCC GCACACGCCC AAGAGTTTGC TCTCCAAAGC TCGAGGAATT 600

GATTCCAGCT CTGTTAAACT CCGGGGTAGT TCTCTCTTCA TGGATACAGA AAAATCAGGA 660

AAAAGGGAAT TTGATGTGCG ACAGACTCCT CAAGTGAATA TTAATCCTTT TACTCCGGAT 720

TCTTTGTTGC TTCATTCCTC AGGACAGTGT CGTCGTAGAA AGAGAACGTA CTGGAATGAT 780

TCTTGTGGTG AAGACATGGA AGCCAGTGAT TATGAGCTTG AAGATGAAAC AAGACCTGCT 840

AAGAGAATTA CAATTACTGA AAGCAATATG AAGTCCCGGT ATACAACAGA ATTTCATGAG 900

CTAGAGAAAA TTGGCTCTGG AGAATTTGGT TCTGTATTTA AGTGTGTGAA GAGGCTGGAT 960

GGATGCATTT ATGCCATTAA GCGATCAAAA AAGCCATTGG CCGGCTCTGT TGATGAGCAG 1020

AACGCTTTGA GAGAAGTATA TGCTCATGCA GTGCTTGGAC AGCATTCTCA TGTAGTTCGA 1080

TATTTCTCTG CGTGGGCAGA AGATGATCAT ATGCTTATAC AGAATGAATA TTGTAATGGT 1140

GGAAGTTTAG CTGATGCTAT AAGTGAAAAC TACAGAATCA TGAGTTACTT TAAAGAAGCA 1200

GAGTTGAAGG ATCTCCTTTT GCAAGTTGGC CGAGGCTTGA GGTATATTCA TTCAATGTCT 1260

TTGGTTCACA TGGATATAAA ACCTAGTAAT ATTTTCATAT CTCGAACCTC AATCCCAAAT 1320

GCTGCCTCTG AAGAAGGAGA CGAAGATGAT TGGGCATCCA ACAAAGTTAT ATTTAAAATA 1380

GGTGATCTTG GGCATGTAAC AAGGATCTCC AGTCCACAAG TTGAAGAGGG CGATAGTCGT 1440

TTTCTTGCAA ATGAAGTTTT ACAGGAGAAT TATACCCATC TACCAAAAGC AGATATTTTT 1500

GCACTTGCCC TCACAGTGGT ATGTGCTGCT GGTGCTGAAC CTCTTCCAAG AAATGGAGAT 1560

CAATGGCATG AAATCAGACA GGGTAGATTA CCTCGGATAC CACAAGTGCT TTCCCAAGAA 1620

TTTACAGAGT TGCTAAAAGT TATGATTCAT CCAGATCCAG AGAGAAGACC TTCAGCAATG 1680

GCACTGGTAA AGCATTCAGT ATTGCTGTCC GCTTCTAGAA AGAGTGCAGA ACAATTACGA 1740

ATAGAATTGA ATGCCGAAAA GTTCAAAAAT TCACTTTTAC AAAAAGAACT CAAGAAAGCA 1800

CAGATGGCAA AAGCTGCAGC TGAGGAAAGA GCACTCTTCA CTGACCGGAT GGCCACTAGG 1860

TCCACCACCC AGAGTAATAG AACATCTCGA CTTATTGGAA AGAAAATGAA CCGCTCTGTC 1920

AGCCTTACTA TATACTGA 1938

Domain Profile

S: 1     FeevekiGkGefgevfkvvkredgklyAikkskkplkglskekkalrEvtahavlgqhen  60

         F+e+ekiG+Gefg+vfk+vkr+dg++yAik+skkpl+g+++e++alrEv+ahavlgqh++

Q: 298   FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH  357

         99**********************************************************

S: 61    vvryisaWeeddslyiqtElCeggsLeaalqeceakkkaleeaelkkilldlllglrylH  120

         vvry+saW+edd+++iq+E+C+ggsL++a++e+++++++++eaelk++ll++ +glry+H

Q: 358   VVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIH  417

         ************************************************************

S: 121   ssslvHlDikpenifi...................tkevtlklgDlGlvtelnsedkskv  161

         s+slvH+Dikp+nifi                   +++v++k+gDlG+vt++   ++++v

Q: 418   SMSLVHMDIKPSNIFIsrtsipnaaseegdeddwaSNKVIFKIGDLGHVTRI---SSPQV  474

         ****************************************************...9****

S: 162   eEGDsrylakEilqeeyskl.kaDiFslgltilevaanvelPsnGeaWhklRkgklpdei  220

         eEGDsr+la+E+lqe+y++l kaDiF+l+lt++++a++++lP+nG++Wh++R+g+lp +i

Q: 475   EEGDSRFLANEVLQENYTHLpKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLP-RI  533

         *********************************************************.**

S: 221   lkelsedlrellklmlepdperRptaeellkhevl  255

          ++ls++++ellk+m++pdperRp+a++l+kh+vl

Q: 534   PQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVL  568

         ********************************986

Domain Sequence
(FASTA)

FHELEKIGSG EFGSVFKCVK RLDGCIYAIK RSKKPLAGSV DEQNALREVY AHAVLGQHSH 60

VVRYFSAWAE DDHMLIQNEY CNGGSLADAI SENYRIMSYF KEAELKDLLL QVGRGLRYIH 120

SMSLVHMDIK PSNIFISRTS IPNAASEEGD EDDWASNKVI FKIGDLGHVT RISSPQVEEG 180

DSRFLANEVL QENYTHLPKA DIFALALTVV CAAGAEPLPR NGDQWHEIRQ GRLPRIPQVL 240

SQEFTELLKV MIHPDPERRP SAMALVKHSV L 271

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007067	; P:mitosis

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017164	; Wee1-like_protein_kinase.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013