EKS-NOL-00063

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00063

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	357.9	3.5E-107	4	289	286

Status

Unreviewed

Ensembl Protein

ENSNLEP00000021326

UniProt Accession

G1S737;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK2

Gene Synonyms/Alias

CDK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000017574	ENSNLEP00000021326	ENSNLET00000022409

Organism

Nomascus leucogenys

Functional Description

Protein Length

301

Protein Sequence
(FASTA)

MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTE TEGVPSTAIR EISLLKELNH 60

PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS 120

HRVLHRDLKP QNLLINTEGA IKLADFGLAR AFGVPVRTYT HEVSPFMSFF SELPKRILGY 180

AWNSYCVANW AHAWTSLSQV TRRALFPGDS EIDQLFRIFR TLGTPDEVVW PGVTSMPDYK 240

PSFPKWARQD FSKVVPPLDE DGRSLLSQML HYDPNKRISA KAALAHPFFQ DVTKPVPHLR 300

L 301

Nucleotide Sequence
(FASTA)

ATGGAGAACT TCCAAAAGGT GGAAAAGATC GGAGAGGGCA CATACGGAGT TGTGTACAAA 60

GCCAGAAACA AGTTGACGGG AGAAGTGGTG GCGCTTAAGA AAATCCGCCT GGACACTGAG 120

ACTGAGGGTG TGCCCAGTAC TGCCATCCGA GAGATCTCTC TGCTTAAGGA GCTTAACCAT 180

CCTAATATTG TCAAGCTGCT GGATGTCATT CACACAGAAA ATAAACTCTA CCTGGTTTTT 240

GAATTTCTGC ACCAAGATCT CAAGAAATTC ATGGATGCCT CTGCTCTCAC TGGCATTCCT 300

CTTCCCCTCA TCAAGAGCTA TCTGTTCCAG CTGCTCCAGG GCCTAGCTTT CTGCCATTCT 360

CATCGGGTCC TCCACCGAGA CCTTAAACCT CAGAATCTGC TTATTAACAC AGAGGGGGCC 420

ATCAAGCTAG CAGACTTTGG ACTAGCCAGA GCTTTTGGAG TCCCTGTTCG TACTTACACC 480

CATGAGGTGA GTCCCTTTAT GTCTTTTTTC TCTGAGCTTC CCAAGAGAAT CTTAGGGTAT 540

GCATGGAATT CATACTGTGT TGCTAACTGG GCTCACGCCT GGACTTCATT GTCTCAGGTG 600

ACTCGCCGGG CCCTATTCCC TGGAGATTCT GAGATTGACC AGCTCTTCCG GATCTTTCGG 660

ACTCTGGGGA CCCCAGATGA GGTGGTGTGG CCAGGAGTTA CTTCTATGCC TGATTACAAG 720

CCAAGTTTCC CCAAGTGGGC CCGGCAAGAT TTTAGTAAAG TTGTACCTCC CCTGGATGAA 780

GATGGACGGA GCTTGTTATC GCAAATGCTG CACTACGACC CTAACAAGCG GATCTCGGCC 840

AAGGCAGCCC TGGCTCACCC TTTCTTCCAG GATGTGACCA AGCCAGTACC CCATCTTCGA 900

CTCTGA 906

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++k+ekigeGtyg+vyka++k tgevvAlKkirl++e+egvp+ta+rEisllkel+h+ni

Q: 4     FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI  63

         89**********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         vkLl+v++ +++klyLvfefl+qdLkk++++++ ++++l  +ks+l+qll+gla++Hs++

Q: 64    VKLLDVIH-TENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR  122

         ********.99*************************************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevv...TlwYraPelLlgake  177

         +lHRDlKpqNlLi++eg +klaDfGlaraf++p++tyt+ev+    ++   P  +lg

Q: 123   VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVSpfmSFFSELPKRILGYAW  182

         *****************************************7222456788999******

S: 178   YstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykks  237

          s  v  W+        +tr++lf+g+seidql+rif++lgtp+e vwp+v+++p+yk s

Q: 183   NSYCVANWAHAWTSLSQVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS  242

         ************************************************************

S: 238   fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         fpk+++++++++v+ l+e++++ll+++l++dp+kRisak+al+h++f

Q: 243   FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF  289

         *********************************************98

Domain Sequence
(FASTA)

FQKVEKIGEG TYGVVYKARN KLTGEVVALK KIRLDTETEG VPSTAIREIS LLKELNHPNI 60

VKLLDVIHTE NKLYLVFEFL HQDLKKFMDA SALTGIPLPL IKSYLFQLLQ GLAFCHSHRV 120

LHRDLKPQNL LINTEGAIKL ADFGLARAFG VPVRTYTHEV SPFMSFFSEL PKRILGYAWN 180

SYCVANWAHA WTSLSQVTRR ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF 240

PKWARQDFSK VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFF 286

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0015030	; C:Cajal body
GO:0005768	; C:endosome
GO:0005524	; F:ATP binding
GO:0035173	; F:histone kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007049	; P:cell cycle
GO:0007265	; P:Ras protein signal transduction
GO:0060968	; P:regulation of gene silencing

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013