EKS-NOL-00348
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00348
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK294.18.7E-882217216
StatusUnreviewed
Ensembl ProteinENSNLEP00000021467
UniProt AccessionG1S7H7;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K12
Gene Synonyms/Alias MAP3K12;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000017692ENSNLEP00000021467ENSNLET00000022558
ENSNLEG00000017692ENSNLEP00000021466ENSNLET00000022557
OrganismNomascus leucogenys
Functional Description
Protein Length714
Protein Sequence
(FASTA)
EEVAVKKVRD LKETDIKHLR KLKHPNIITF KGVCTQAPCY CILMEFCAQG QLYEVLRAGR 60
PVTPSLLVDW SMGIAGGMNY LHLHKIIHRD LKSPNMLITY DDVVKISDFG TSKELSDKST 120
KMSFAGTVAW MAPEVIRNEP VSEKVDIWSF GVVLWELLTG EIPYKDVDSS AIIWGVGSNS 180
LHLPVPSSCP DGFKILLRQC WNSKPRNRPS FRQILLHLDI ASADVLSTPQ ETYFKSQAEW 240
REEVKLHFEK IKSEGTCLHR LEEELVMRRR EELRHALDIR EHYERKLERA NNLYMELNAL 300
MLQLELKERE LLRREQALER RCPGLLKPHP SRGLLHGNTM EKLIKKRNVP QKLSPHSKRP 360
DILKTESLLP KLDAALSGVG LPGCPKGPPS PGRSRRGKTR HRKASAKGSC GDLPGLRTAV 420
PPHEPGGPGS PGGLGGGPSA WEACPPALRG LHHDLLLRKM SSSSPDLLSA ALGSRGRGAT 480
GGAGDPGSPP PARGDTPPSE GSAPGSTSPD SPGGAKGEPP PPVGPGEGVG LLGTGREGTS 540
GRGGSRAGSQ HLTPAALLYR AAVTRSQKRG ISSEEEEGEV DSEVELTSSQ RWPQSLNMRQ 600
SLSTFSSENP SDGEEGTASE PSPSGTPEVG STNTDERPDE RSDDMCSQGS EIPLDPPPSE 660
VIPGPEPSSL PIPHQELLRG ERGPPNSEDS DCDSTELDNS NSVDALRPPA SLPP 714
Nucleotide Sequence
(FASTA)
GAGGAGGTGG CTGTGAAGAA GGTGCGAGAC CTCAAAGAGA CCGACATCAA GCACTTGCGA 60
AAGTTGAAGC ACCCCAACAT CATCACCTTC AAGGGTGTGT GCACCCAGGC TCCCTGCTAC 120
TGCATCCTCA TGGAGTTCTG CGCCCAGGGC CAGCTGTATG AGGTACTGCG GGCTGGCCGC 180
CCTGTCACCC CCTCTTTACT GGTTGACTGG TCCATGGGCA TCGCCGGTGG CATGAACTAC 240
CTGCACCTGC ACAAGATTAT CCACAGGGAT CTCAAGTCAC CCAACATGCT AATCACCTAC 300
GACGATGTGG TGAAGATCTC AGATTTTGGC ACTTCCAAGG AGCTGAGTGA CAAGAGCACC 360
AAGATGTCCT TTGCAGGGAC AGTAGCCTGG ATGGCCCCTG AGGTGATCCG CAATGAGCCT 420
GTGTCTGAGA AGGTCGACAT CTGGTCCTTT GGTGTGGTGC TGTGGGAACT GCTGACTGGT 480
GAGATCCCCT ACAAAGACGT AGATTCCTCA GCCATTATCT GGGGTGTGGG AAGCAACAGT 540
CTCCATCTGC CCGTGCCCTC CAGTTGCCCA GATGGTTTCA AGATCCTGCT TCGCCAGTGC 600
TGGAATAGCA AACCGCGAAA TCGCCCATCA TTCCGACAGA TCCTGCTGCA TCTGGACATT 660
GCCTCAGCTG ATGTACTCTC CACACCCCAG GAGACTTACT TTAAGTCCCA GGCAGAGTGG 720
CGGGAAGAAG TAAAACTGCA CTTTGAAAAG ATTAAGTCAG AAGGGACCTG TCTGCATCGC 780
CTAGAAGAGG AACTGGTGAT GAGGAGGAGG GAGGAGCTCA GACACGCCCT GGACATCAGG 840
GAGCACTATG AAAGGAAGCT GGAGAGAGCC AACAACCTGT ATATGGAACT TAATGCCCTC 900
ATGTTGCAGC TGGAACTCAA GGAGAGAGAG CTGCTCAGGC GAGAACAAGC TTTAGAGCGG 960
AGGTGCCCAG GCCTGCTGAA GCCCCACCCT TCCCGGGGCC TCCTGCATGG AAACACAATG 1020
GAGAAGCTTA TCAAGAAGAG GAATGTGCCA CAGAAGCTGT CACCCCATAG CAAAAGGCCA 1080
GATATCCTCA AGACGGAGTC TTTGCTCCCT AAACTAGATG CAGCCCTAAG TGGGGTTGGG 1140
CTTCCTGGGT GTCCTAAGGG CCCCCCCTCA CCAGGACGCA GTCGCCGTGG CAAGACCCGT 1200
CACCGCAAGG CCAGCGCCAA GGGGAGCTGT GGGGACCTGC CTGGGCTTCG TACAGCTGTG 1260
CCACCCCATG AACCTGGAGG ACCAGGAAGC CCAGGGGGCC TAGGAGGGGG ACCCTCAGCC 1320
TGGGAGGCCT GCCCTCCCGC CCTCCGTGGG CTTCATCATG ACCTCCTGCT CCGCAAAATG 1380
TCTTCATCGT CCCCAGACCT GCTGTCAGCA GCATTAGGGT CCCGGGGCCG AGGGGCCACA 1440
GGCGGAGCTG GGGATCCCGG CTCACCACCT CCAGCTCGGG GTGACACCCC ACCAAGTGAG 1500
GGCTCAGCCC CTGGCTCCAC CAGCCCAGAT TCACCTGGGG GAGCCAAAGG GGAGCCACCT 1560
CCTCCAGTAG GGCCTGGTGA AGGTGTGGGG CTTCTGGGAA CTGGAAGGGA AGGGACCTCA 1620
GGCCGGGGAG GAAGCCGGGC TGGGTCCCAG CACTTGACCC CAGCTGCACT GCTGTACAGG 1680
GCTGCCGTCA CCAGAAGTCA GAAACGTGGC ATCTCATCAG AAGAGGAGGA AGGAGAGGTA 1740
GACAGTGAAG TAGAGCTGAC ATCAAGCCAG AGGTGGCCTC AGAGCCTGAA CATGCGCCAG 1800
TCACTATCTA CCTTCAGCTC AGAGAATCCT TCAGATGGGG AGGAAGGCAC AGCTAGTGAA 1860
CCTTCCCCCA GTGGCACACC TGAAGTTGGC AGCACCAACA CTGATGAGCG GCCAGATGAG 1920
CGGTCTGATG ACATGTGCTC CCAGGGATCA GAAATCCCAC TGGACCCACC TCCTTCAGAG 1980
GTCATCCCCG GCCCTGAACC CAGCTCCCTG CCCATTCCAC ACCAGGAACT TCTCAGAGGA 2040
GAGCGGGGCC CTCCCAATTC TGAGGACTCA GACTGTGACA GCACTGAATT GGACAACTCC 2100
AACAGCGTTG ATGCCTTGCG GCCCCCAGCT TCCCTCCCTC CA 2142
Domain Profile
S: 24    evavKklreeaeekekleklereakllsklshpniiellGvcleepnlllvmeyveggsL  83
         evavKk+r+ +e+         ++k+l+kl+hpnii+++Gvc++ p+++++me++++g+L
Q: 2     EVAVKKVRDLKET---------DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQL  52
         7999999999999.........**************************************
S: 84    snvlhekskreidlevlvswalqiArGmaYLhseapkkiihrdLksknvLlseekktlki  143
         ++vl++   r ++++ lv+w++ iA Gm+YLh +   kiihrdLks+n+L+ + ++++ki
Q: 53    YEVLRA--GRPVTPSLLVDWSMGIAGGMNYLHLH---KIIHRDLKSPNMLI-TYDDVVKI  106
         ******..99************************...9*************.99******
S: 144   cdFGtarelsk.stkmsaagtlawmaPEvlkeekvseksDvwSygvvLWelltrevPykd  202
         +dFGt++els+ stkms+agt+awmaPEv+++e+vsek+D+wS+gvvLWellt+e+Pykd
Q: 107   SDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKD  166
         **********99************************************************
S: 203   lselaiaykvalkglrlpipsscpeklkkLmkecwnedpekRpsfseivks  253
         +++ ai+++v++++l+lp+psscp+ +k L+++cwn++p++Rpsf++i+ +
Q: 167   VDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLH  217
         ************************************************876
Domain Sequence
(FASTA)
EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC ILMEFCAQGQ LYEVLRAGRP 60
VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD DVVKISDFGT SKELSDKSTK 120
MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA IIWGVGSNSL 180
HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLH 216
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00355
EKS-ANC-00369
EKS-BOT-00381
EKS-CAJ-00386
EKS-CAF-00381
EKS-CAP-00413
EKS-DIO-00060
EKS-EQC-00370
EKS-FEC-00368
EKS-GOG-00371
EKS-ICT-00359
EKS-LAC-00398
EKS-LOA-00389
EKS-MAM-00380
EKS-MUM-00414
EKS-MUP-00373
EKS-MYL-00378
EKS-OCP-00078
EKS-ORN-00489
EKS-ORC-00358
EKS-ORL-00451
EKS-OTG-00383
EKS-PAT-00361
EKS-POA-00371
EKS-PRC-00080
EKS-PTV-00100
EKS-RAN-00396
EKS-SAH-00348
EKS-SUS-00332
EKS-TAR-00485
EKS-TEN-00482
EKS-XIM-00478
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013