EKS-NOL-00256
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00256
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR453.03.8E-136176460285
StatusUnreviewed
Ensembl ProteinENSNLEP00000021571
UniProt AccessionG1S7T1;
Protein Name
Protein Synonyms/Alias
Gene NameACVR1B
Gene Synonyms/Alias ACVR1B;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000017765ENSNLEP00000021570ENSNLET00000022662
ENSNLEG00000017765ENSNLEP00000021571ENSNLET00000022663
OrganismNomascus leucogenys
Functional Description
Protein Length466
Protein Sequence
(FASTA)
LLCACTSCLQ ANYTCETDGA CMVSIFNLDG MEHHVRTCIP KVELVPAGKP FYCLSSEDLR 60
NTHCCYTDYC NRIDLRVPSG HLKEPEHPSM WGPVELVGII AGPVFLLFLI IIIVFLVINY 120
HQRVYHNRQR LDMEDPSCEM CLSKDKTLQD LVYDLSTSGS GSGLPLFVQR TVARTIVLQE 180
IIGKGRFGEV WRGRWRGGDV AVKIFSSREE RSWFREAEIY QTVMLRHENI LGFIAADNKD 240
NGTWTQLWLV SDYHEHGSLF DYLNRYTVTI EGMIKLALSA ASGLAHLHME IVGTQGKPGI 300
AHRDLKSKNI LVKKNGMCAI ADLGLAVRHD AVTDTIDIAP NQRVGTKRYM APEVLDETIN 360
MKHFDSFKCA DIYALGLVYW EIARRCNSGG VHEEYQLPYY DLVPSDPSIE EMRKVVCDQK 420
LRPNIPNWWQ SYEALRVMGK MMRECWYANG AARLTALRIK TLSHLS 466
Nucleotide Sequence
(FASTA)
CTGCTGTGTG CGTGCACCAG CTGCCTCCAG GCCAACTACA CGTGTGAGAC AGATGGGGCC 60
TGCATGGTTT CCATTTTCAA TCTGGATGGG ATGGAGCACC ATGTGCGCAC CTGCATCCCC 120
AAAGTGGAGC TGGTCCCTGC CGGGAAGCCC TTCTACTGCC TGAGCTCAGA GGACCTGCGC 180
AACACCCACT GCTGCTACAC TGACTACTGC AACAGGATCG ACTTGAGGGT GCCCAGTGGT 240
CACCTCAAGG AGCCTGAGCA CCCGTCCATG TGGGGCCCGG TGGAGCTGGT AGGCATCATC 300
GCCGGCCCGG TGTTCCTCCT GTTCCTCATC ATCATCATTG TTTTCCTTGT CATTAACTAT 360
CATCAGCGTG TCTATCATAA CCGCCAGAGA CTGGACATGG AAGATCCCTC ATGTGAGATG 420
TGTCTCTCCA AAGACAAGAC GCTCCAGGAT CTCGTCTACG ATCTCTCCAC CTCAGGGTCT 480
GGCTCAGGGT TACCCCTCTT TGTCCAGCGC ACAGTGGCCC GAACCATCGT TTTACAAGAG 540
ATTATTGGCA AGGGTCGGTT TGGGGAAGTA TGGCGGGGCC GCTGGAGGGG TGGTGATGTG 600
GCTGTGAAAA TATTCTCTTC TCGTGAAGAA CGGTCTTGGT TCAGGGAAGC AGAAATATAC 660
CAGACGGTCA TGCTGCGCCA TGAAAACATC CTTGGATTTA TTGCTGCTGA CAATAAAGAT 720
AATGGCACCT GGACACAGCT GTGGCTTGTT TCTGACTATC ATGAGCACGG GTCCCTGTTT 780
GATTATCTGA ACCGGTACAC AGTGACAATT GAGGGGATGA TTAAGCTGGC CTTGTCTGCT 840
GCTAGTGGGC TGGCACACCT GCACATGGAG ATCGTGGGCA CCCAAGGGAA GCCTGGAATT 900
GCTCATCGAG ACTTAAAGTC AAAGAACATT CTGGTGAAGA AAAACGGCAT GTGTGCCATA 960
GCAGACCTGG GCCTGGCTGT CCGTCACGAT GCAGTCACTG ACACCATCGA CATTGCCCCG 1020
AATCAGAGGG TGGGGACCAA ACGATACATG GCCCCTGAAG TACTTGATGA AACCATTAAT 1080
ATGAAACACT TTGACTCCTT TAAATGTGCT GATATTTATG CCCTCGGGCT TGTATATTGG 1140
GAGATTGCTC GAAGATGCAA TTCTGGAGGA GTCCATGAAG AATATCAGCT GCCATATTAC 1200
GACTTAGTGC CCTCTGACCC TTCCATTGAG GAAATGCGAA AGGTCGTATG TGATCAGAAG 1260
CTGCGTCCCA ACATCCCCAA CTGGTGGCAG AGTTACGAGG CGCTGCGGGT GATGGGGAAG 1320
ATGATGCGAG AGTGCTGGTA TGCCAACGGC GCGGCCCGCC TGACGGCCCT GCGCATCAAG 1380
ACCCTCTCCC ATCTCAGC 1398
Domain Profile
S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60
         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia
Q: 176   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  235
         5789********************************************************
S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120
         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e +++lals+asGlahLH+eivgt+
Q: 236   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQ  295
         ************************************************************
S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180
         g  Kp iaHRDlkskNilvkk+++c+iaDlGLa+++++ ++++d+a n++vGtkRYmaPE
Q: 296   G--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPE  353
         *..*********************************************************
S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240
         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem
Q: 354   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNS-GGVHEEYQLPYYDLVPSDPSIEEM  412
         ***********************************.************************
S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvk  288
         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+k
Q: 413   RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIK  460
         **********************************************98
Domain Sequence
(FASTA)
IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60
ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIK LALSAASGLA HLHMEIVGTQ 120
GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHDAVTDT IDIAPNQRVG TKRYMAPEVL 180
DETINMKHFD SFKCADIYAL GLVYWEIARR CNSGGVHEEY QLPYYDLVPS DPSIEEMRKV 240
VCDQKLRPNI PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIK 285
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00258
EKS-ANC-00265
EKS-BOT-00276
EKS-CAJ-00282
EKS-CAF-00282
EKS-CAP-00311
EKS-DAR-00616
EKS-EQC-00268
EKS-FEC-00262
EKS-GAG-00230
EKS-GAA-00337
EKS-GOG-00275
EKS-HOS-00282
EKS-ICT-00261
EKS-LAC-00298
EKS-LOA-00286
EKS-MAM-00278
EKS-MIM-00020
EKS-MUM-00307
EKS-MUP-00280
EKS-MYL-00279
EKS-ORN-00355
EKS-ORC-00260
EKS-ORL-00331
EKS-OTG-00282
EKS-PAT-00270
EKS-PES-00245
EKS-POA-00268
EKS-RAN-00291
EKS-SAH-00257
EKS-SUS-00243
EKS-TAG-00289
EKS-TAR-00356
EKS-TEN-00355
EKS-XET-00349
EKS-XIM-00348
Gene Ontology
GO:0009986; C:cell surface
GO:0005887; C:integral to plasma membrane
GO:0017002; F:activin-activated receptor activity
GO:0005524; F:ATP binding
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0006917; P:induction of apoptosis
GO:0030308; P:negative regulation of cell growth
GO:0038092; P:nodal signaling pathway
GO:0032927; P:positive regulation of activin receptor signaling pathway
GO:0045648; P:positive regulation of erythrocyte differentiation
GO:0046777; P:protein autophosphorylation
GO:0006355; P:regulation of transcription, DNA-dependent
KEGG
InterPros
IPR000472; Activin_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR003605; TGF_beta_rcpt_GS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
SMARTs
SM00467; GS; 1.
Prosites
PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013