EKS-NOL-00114

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00114

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LRRK	369.9	6.2E-111	1884	2130	247

Status

Unreviewed

Ensembl Protein

ENSNLEP00000021815

UniProt Accession

G1S8H6;

Protein Name

Protein Synonyms/Alias

Gene Name

LRRK2

Gene Synonyms/Alias

LRRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000017957	ENSNLEP00000021815	ENSNLET00000022916

Organism

Nomascus leucogenys

Functional Description

Protein Length

2527

Protein Sequence
(FASTA)

MASGSCQGCE EDEETLKKLI VRLNNVQEGK QIETLVQILE DLLVFTYSEH ASKLFQGKNI 60

HVPLLIVLDS YMRVASVQQV GWSLLCKLIE ICPGTMQSLM GPQDVGNDWE VLGVHQLILK 120

MLTVHNASVN LSVIGLKTLD LLLTSGKITL LILDEESDIF MLIFDAMHSF PANDEVQKLG 180

CKTLCVLFER VSEEQLIEFV ENKDYMILLS ALTNFKDEEE IVLHVLHCLH SLAIPCNNVE 240

VLMSGNVRCY NIVVEAMKAF PISEQIQEVS CCLLHRLTLG NFFNILVLNE VHEFVVKAVQ 300

QYPENAALQI SALSCLALLT ETIFLNQDLE EKNENQENDD EGEEDKLFWL EACYKALTWH 360

RKNKHVQEAA CWALNNLLMY QNSLHEKIGD EDGHFPAHRE VMLSMLMHSS SKEVFQASAN 420

ALSTLLEQNV NFRKILLSKG IDLNVLELMQ KHIYSPEVAE SGCKMLNHLF EGSNTSLDTM 480

AAVVPKIITV MKCHETSLPV QLEALRAILH FIVPGMPEES REDTESHRKL NVVKKQCFKN 540

GIHKLVLAAL NRFIGNPGIQ KCGLKVISSI AHFPDALEML SLEGAMDSVL HTLQMYPDDQ 600

EIQCLGLSLI GYLIAKENLC IGTGHLLAKI LVSSLYRFKD VAEVQTKGFQ TILAILKLSA 660

SFSKLLVHHS FDLLIFHQMS SNIMEQKDQQ FLNLCCKCFA KVAMDDDLKN VMLERACDQN 720

NSIMVECLLL LGADANQTKE GSSLICQVCE KGSSPKLVEL LLNSGSREQD VRKALTISIG 780

KGDSQIISLL LRRLALDVAN NSICLGGFCI GKVEPSWLGP LFPDKTSNLR KQTNIASTLA 840

RMVIRYQMKS AVEEGTASGS DGNVSEDVLS KFDEWIFIPD SSMDSVFAQS DDLDSEGSEG 900

SFLVKKKSNS ISVGEFYQDA VLQRCSPNLQ RHSNSLGPIF DHEDLLRRKR KILSSDDSLR 960

SSKLQSHMKH SDSISSLASE REYITSLDLS ANELRDIDVL SQKCCISGHL EHLEKLELHQ 1020

NALTSFPEQL CETLKSLTHL DLHSNKFTSF PSYLLKMSCI ANLDVSRNDI GPSVVLDPTV 1080

KCPTLKQFNL SYNQLFFVPE NLTDVVEKLE QLILEGNKIS EIYFPLRLKE LKILNLSKNH 1140

ISSLSENFLE ACPKVESFSA RMNFLAAMPF LPPSMTSLKL SQNKFSCIPE AILNLPHLRS 1200

LDMSSNDIQY LPGPAHWKSL NLRELLFSHN QISILDLSEK AYLWSRVEKL HLSHNKLKEI 1260

PPEIGCLENL TSLDVSYNLE LRSFPNEMGK LSKIWDLPLD ELRLNFDFKH IGCKAKDIIR 1320

FLQQRLKKAV PYNRMKLMIV GNTGSGKTTL LQQLMKTKKS DLGMQSATVG IDVKDWPIQI 1380

RDKRKRDLVL NVWDFAGREE FYSTHPHFMT QRALYLAVYD LSKGQAEVDA MKPWLFNIKA 1440

RASSSPVILV GTHLDVSDEK QRKACVSKIT KELLNKRGFP AIRDYHFVNA TEESDALAKL 1500

RKTIINESLN FKIRDQLVVG QLIPDCYVEL EKIILSERKN VPIEFPVIDR KRLLQLVREN 1560

QLQLDENELP HAVHFLNESG VLLHFQDPAL QLSDLYFVEP KWLCKIMAQI LTVKVEGCPK 1620

HPKGIISRRD VEKFLSKKRR FPKNYMSQYF KLLEKFQIAL PIGEEYLLVP SSLSDHRPVI 1680

ELPHCENSEI IIRLYEMPYF PMGFWSRLIN RLLEISPYML SGRERALRPN RMYWRQGIYL 1740

NWSPEAYCLV GSEVLDNHPE SFLKITVPSC RKGCILLGQV VDHIDSLMEE WFPGLLEIDI 1800

CGEGETLLKK WALYSFNDGE EHQKILLDDL MKKAEEGDLL VNPDQPRLTI PISQIAPDLI 1860

LADLPRNIML NNDELEFEQA PEFLLGDGSF GSVYRAAYEG EEVAVKIFNK HTSLRLLRQE 1920

LVVLCHLHHP SLISLLAAGI RPRMLVMELA SKGSLDRLLQ QDKASLTRTL QHRIALHVAD 1980

GLRYLHSAMI IYRDLKPHNV LLFTLYPNAA IIAKIADYGI AQYCCRMGIK TSEGTPGFRA 2040

PEVARGNVIY NQQADVYSFG LLLYDILTTG GRIVEGLKFP NEFDELAIQG KLPDPVKEYG 2100

CAPWPMVEKL IKKCLKENPQ ERPTSAQVFD TLNSAELVCL MRHILLPKNV IVECMVATHH 2160

NSRNASIWLG CGHTDRGQLS FLDLNTEGYT SEEVADSRIL CLALVHLPVE KESWIVSGTQ 2220

SGTLLVINTK DGKKRHTLEK MTDSVTCLYC NSFSKQSKQK NFLLVGTADG NLAIFEDKTV 2280

KLKGAAPLKI LNIGNVSTPL MCLSESTNST ERNVMWGGCG TKIFSFSNDF TIQKLIETRT 2340

SQLFSYAAFS DSNIITVVVD TALYIAKQNS PVVEVWDKKT EKLCELIDCV HFLREVTGKE 2400

NKESKHKMSY SGRVKTLCLQ KNTALWIGTG GGHILLLDLS TRRVIRIIYN FCDSIRVMMT 2460

AQLGSLKNVM LVLGYNWKST EGTQQQKEIQ SCLTVWDINL PHEVQNLEKH IEVRKELAEK 2520

MRGTSVE 2527

Nucleotide Sequence
(FASTA)

ATGGCTAGTG GCAGCTGTCA GGGGTGCGAG GAGGACGAGG AAACTCTGAA GAAGTTGATA 60

GTCAGGCTGA ACAATGTCCA GGAAGGAAAA CAGATAGAAA CGCTGGTCCA AATCCTGGAG 120

GATCTGCTGG TGTTCACGTA CTCCGAGCAC GCCTCCAAGT TATTTCAAGG CAAAAATATC 180

CATGTGCCTC TGTTGATCGT CTTGGACTCA TATATGAGAG TCGCGAGTGT GCAGCAGGTG 240

GGTTGGTCAC TTCTGTGCAA ATTAATAGAA ATCTGTCCAG GTACAATGCA AAGCTTAATG 300

GGACCCCAGG ATGTTGGAAA TGATTGGGAA GTCCTTGGTG TTCACCAATT GATTCTTAAA 360

ATGCTAACAG TTCATAATGC CAGTGTAAAC TTGTCAGTGA TTGGACTGAA GACCTTAGAT 420

CTCCTCCTAA CTTCAGGTAA AATCACCTTG CTGATATTGG ATGAAGAAAG TGATATTTTC 480

ATGTTAATTT TTGATGCCAT GCACTCATTT CCAGCCAATG ATGAAGTCCA GAAACTTGGA 540

TGCAAAACTT TATGTGTGCT GTTTGAGAGA GTCTCAGAGG AGCAACTGAT TGAATTTGTT 600

GAGAACAAAG ATTATATGAT ATTGTTAAGT GCGTTAACAA ATTTTAAAGA TGAAGAGGAA 660

ATTGTGCTTC ATGTGCTGCA TTGTTTACAT TCCCTAGCGA TTCCTTGCAA TAATGTGGAA 720

GTCCTCATGA GTGGCAATGT CAGGTGTTAT AATATTGTGG TGGAAGCTAT GAAAGCATTC 780

CCTATCAGTG AACAAATTCA AGAAGTGAGT TGCTGTTTGC TCCATAGGCT TACATTAGGT 840

AATTTTTTCA ATATCCTGGT ATTAAACGAA GTCCATGAGT TTGTGGTGAA AGCTGTGCAG 900

CAGTACCCAG AGAACGCAGC ATTACAGATC TCAGCGCTCA GCTGTTTGGC CCTCCTCACT 960

GAGACTATTT TCTTAAATCA AGATTTAGAG GAAAAGAATG AGAATCAAGA GAATGATGAT 1020

GAGGGTGAAG AAGATAAATT GTTTTGGCTG GAAGCCTGTT ACAAAGCATT AACATGGCAT 1080

AGAAAGAACA AGCACGTGCA GGAGGCCGCA TGCTGGGCAC TAAATAATCT CCTTATGTAC 1140

CAAAACAGTT TACATGAGAA GATTGGAGAT GAAGATGGCC ATTTCCCAGC TCATAGGGAA 1200

GTGATGCTCT CCATGCTGAT GCATTCTTCA TCAAAGGAAG TTTTCCAGGC ATCTGCGAAT 1260

GCATTGTCAA CTCTCTTAGA ACAAAATGTT AATTTCAGAA AAATACTGTT ATCAAAAGGA 1320

ATAGACCTGA ATGTTTTGGA GTTAATGCAG AAGCATATAT ATTCTCCTGA AGTGGCTGAA 1380

AGTGGCTGTA AAATGCTAAA TCATCTTTTT GAAGGAAGCA ACACTTCCCT GGATACAATG 1440

GCAGCAGTGG TCCCCAAAAT AATAACAGTT ATGAAATGTC ATGAGACATC ATTACCAGTG 1500

CAGCTGGAGG CGCTTCGAGC TATTTTACAT TTTATAGTGC CAGGCATGCC AGAAGAATCC 1560

AGGGAGGATA CAGAATCTCA TCGTAAGCTA AATGTGGTTA AAAAACAGTG TTTCAAGAAT 1620

GGTATTCACA AACTGGTCCT AGCAGCTTTG AACAGGTTCA TTGGAAATCC TGGGATTCAG 1680

AAATGTGGAT TAAAAGTAAT TTCTTCTATT GCACATTTTC CTGATGCATT AGAGATGTTA 1740

TCCCTGGAAG GTGCTATGGA TTCAGTGCTT CACACACTGC AGATGTATCC AGATGACCAA 1800

GAAATTCAGT GTCTGGGTTT AAGTCTTATA GGATACTTGA TTGCAAAGGA GAATTTATGC 1860

ATAGGAACTG GACATCTGCT GGCAAAAATT CTGGTTTCCA GCTTATACCG ATTTAAGGAT 1920

GTTGCTGAAG TACAGACTAA AGGATTTCAG ACAATCTTAG CAATCCTCAA ATTGTCAGCA 1980

TCTTTTTCTA AGCTGCTGGT GCATCATTCA TTTGACTTAT TAATATTCCA TCAAATGTCT 2040

TCCAATATCA TGGAACAAAA GGATCAACAG TTTCTAAACC TCTGTTGTAA GTGTTTTGCA 2100

AAAGTAGCTA TGGATGATGA CTTAAAAAAT GTGATGCTAG AGAGAGCATG TGATCAGAAT 2160

AACAGCATCA TGGTTGAATG CTTGCTTCTG TTGGGAGCAG ATGCCAATCA AACAAAGGAG 2220

GGATCTTCTT TAATTTGTCA GGTATGTGAG AAAGGGAGCA GTCCCAAATT GGTGGAACTC 2280

TTACTGAATA GTGGATCTCG TGAACAAGAT GTACGAAAAG CGCTGACGAT AAGCATTGGG 2340

AAAGGTGACA GCCAGATCAT CAGCTTGCTC TTAAGGAGGC TGGCCCTGGA TGTGGCCAAC 2400

AATAGCATTT GCCTTGGAGG ATTTTGTATA GGAAAAGTTG AACCTTCTTG GCTTGGTCCT 2460

TTATTTCCAG ATAAGACTTC TAATTTAAGG AAACAAACAA ATATAGCATC TACACTAGCA 2520

AGAATGGTGA TCAGATATCA GATGAAAAGT GCCGTGGAAG AAGGAACAGC CTCAGGCAGC 2580

GATGGAAATG TTTCTGAAGA TGTGCTGTCT AAATTTGATG AATGGATCTT TATTCCTGAC 2640

TCTTCTATGG ACAGTGTGTT TGCTCAAAGT GATGATCTGG ATAGTGAAGG AAGTGAAGGC 2700

TCATTTCTTG TGAAAAAGAA ATCTAATTCA ATTAGTGTAG GAGAATTTTA CCAAGATGCC 2760

GTATTACAGC GTTGCTCACC AAATTTGCAA AGACATTCCA ATTCCTTGGG GCCCATTTTT 2820

GATCATGAAG ATTTACTGAG GCGAAAAAGA AAAATATTAT CTTCAGATGA TTCACTCAGA 2880

TCATCAAAAC TTCAATCCCA TATGAAGCAT TCAGACAGCA TTTCTTCTCT GGCTTCGGAG 2940

AGAGAATATA TTACATCACT AGACCTTTCA GCAAATGAAC TAAGAGATAT TGATGTCCTG 3000

AGCCAGAAAT GCTGTATAAG TGGTCATTTG GAGCATCTTG AAAAGCTGGA GCTTCACCAG 3060

AATGCACTCA CGAGCTTTCC AGAACAGCTA TGTGAAACTC TGAAGAGTTT GACACATTTG 3120

GACTTGCACA GTAATAAATT TACATCATTT CCTTCTTACT TGTTGAAAAT GAGTTGTATT 3180

GCTAACCTTG ATGTCTCTCG AAATGACATT GGACCCTCAG TGGTTTTAGA TCCTACAGTG 3240

AAATGTCCAA CTCTGAAACA GTTTAACCTG TCATATAACC AGCTGTTTTT TGTACCTGAG 3300

AACCTCACTG ATGTGGTAGA GAAACTGGAG CAGCTCATTT TAGAAGGAAA TAAAATATCA 3360

GAGATATACT TCCCCTTGAG ACTGAAGGAA CTGAAGATTT TAAACCTTAG TAAGAACCAC 3420

ATTTCATCCC TGTCAGAGAA CTTTCTTGAG GCTTGTCCTA AAGTGGAGAG TTTCAGTGCC 3480

AGAATGAATT TTCTTGCTGC TATGCCTTTC TTGCCTCCTT CCATGACAAG CCTAAAATTA 3540

TCTCAGAACA AATTTTCATG TATTCCAGAA GCAATTTTAA ATCTTCCACA CTTGCGGTCT 3600

TTAGATATGA GCAGCAATGA TATTCAGTAT CTACCAGGTC CTGCACACTG GAAATCTTTG 3660

AACTTAAGGG AACTCTTATT TAGCCATAAT CAGATCAGCA TCTTGGACTT GAGTGAAAAA 3720

GCATATTTAT GGTCTAGAGT AGAGAAACTG CATCTTTCTC ACAATAAACT GAAAGAGATT 3780

CCTCCTGAGA TTGGCTGTCT TGAAAATCTG ACGTCTCTGG ATGTCAGTTA CAACTTGGAA 3840

CTAAGATCCT TTCCCAATGA AATGGGGAAA TTAAGCAAAA TATGGGATCT TCCTTTGGAT 3900

GAACTGCGTC TTAACTTTGA TTTTAAACAT ATAGGATGTA AAGCCAAAGA CATCATAAGG 3960

TTTCTTCAAC AGCGGTTAAA AAAGGCTGTG CCTTATAACC GAATGAAACT TATGATTGTG 4020

GGAAATACTG GGAGTGGTAA AACCACCTTA TTGCAGCAAT TAATGAAAAC CAAGAAATCA 4080

GATCTTGGAA TGCAAAGTGC CACAGTTGGC ATAGATGTGA AAGACTGGCC TATCCAAATA 4140

AGAGACAAAA GAAAGAGAGA TCTCGTCCTA AATGTGTGGG ATTTTGCAGG TCGTGAGGAA 4200

TTCTATAGTA CTCATCCCCA TTTTATGACG CAGCGAGCAT TGTACCTTGC TGTCTATGAC 4260

CTCAGCAAGG GACAGGCTGA AGTTGATGCC ATGAAGCCTT GGCTCTTCAA TATAAAGGCT 4320

CGTGCTTCCT CTTCCCCTGT GATTCTCGTT GGCACACATT TGGATGTTTC TGATGAGAAG 4380

CAACGCAAAG CCTGCGTAAG TAAAATCACC AAGGAACTCC TGAATAAGCG AGGGTTCCCT 4440

GCCATACGAG ATTACCACTT TGTGAATGCC ACTGAGGAAT CGGATGCTTT GGCAAAACTT 4500

CGGAAAACCA TCATAAACGA GAGCCTTAAT TTCAAGATCC GAGATCAGCT TGTTGTTGGA 4560

CAGCTGATTC CAGACTGCTA TGTAGAACTT GAGAAAATCA TTTTATCCGA GCGTAAAAAC 4620

GTGCCAATTG AATTTCCTGT AATTGACCGG AAACGATTAT TACAACTAGT GAGAGAAAAT 4680

CAGCTGCAGT TAGATGAAAA TGAGCTTCCT CACGCAGTTC ACTTTCTAAA TGAATCAGGA 4740

GTCCTTCTTC ATTTTCAAGA CCCAGCACTG CAGTTAAGTG ACTTGTACTT TGTGGAACCC 4800

AAGTGGCTTT GTAAAATCAT GGCACAGATT TTAACAGTGA AAGTGGAAGG TTGTCCAAAA 4860

CACCCTAAGG GAATTATTTC GCGTAGAGAT GTGGAAAAAT TTCTTTCAAA GAAAAGGAGA 4920

TTTCCAAAGA ACTACATGTC ACAGTATTTT AAGCTCCTAG AAAAATTCCA GATTGCTTTG 4980

CCAATAGGAG AAGAATATTT GCTGGTTCCA AGCAGTTTGT CTGACCACAG GCCTGTGATA 5040

GAGCTTCCCC ATTGTGAGAA CTCTGAAATT ATCATCCGTC TATATGAAAT GCCTTATTTT 5100

CCAATGGGAT TTTGGTCAAG ATTAATCAAT CGATTACTTG AGATTTCACC TTACATGCTT 5160

TCAGGGAGAG AACGAGCACT TCGCCCAAAC AGAATGTATT GGCGACAAGG CATTTACTTA 5220

AATTGGTCTC CTGAAGCTTA TTGTCTGGTA GGATCTGAAG TCTTAGACAA TCATCCAGAG 5280

AGTTTCTTAA AAATTACAGT TCCTTCTTGT AGAAAAGGCT GTATTCTTTT GGGCCAAGTA 5340

GTGGACCACA TTGATTCTCT CATGGAAGAA TGGTTTCCTG GGCTGCTGGA GATTGACATT 5400

TGTGGTGAAG GAGAAACTCT GTTGAAGAAA TGGGCGTTAT ATAGTTTTAA TGATGGTGAA 5460

GAACATCAAA AAATCTTACT TGATGACTTG ATGAAGAAAG CAGAGGAAGG AGATCTCTTA 5520

GTAAATCCAG ATCAACCAAG GCTCACCATT CCAATATCTC AGATTGCCCC TGACTTGATT 5580

TTGGCTGACC TGCCCAGAAA TATTATGTTG AATAATGATG AGTTGGAATT TGAACAAGCT 5640

CCAGAGTTTC TCCTAGGTGA TGGCAGTTTT GGATCAGTTT ATCGAGCAGC CTATGAAGGA 5700

GAAGAAGTGG CTGTGAAGAT TTTTAATAAA CATACATCAC TTAGGCTGTT AAGACAAGAG 5760

CTTGTGGTGC TTTGCCACCT CCACCACCCC AGTTTGATAT CTCTGCTGGC AGCTGGGATT 5820

CGTCCCCGGA TGTTGGTGAT GGAGTTAGCC TCCAAGGGTT CCTTGGATCG CCTGCTTCAG 5880

CAGGACAAAG CCAGCCTCAC TAGAACTCTA CAGCACAGGA TTGCACTCCA TGTAGCTGAT 5940

GGTTTGAGAT ACCTCCACTC AGCCATGATT ATATACCGAG ACTTGAAACC CCACAATGTG 6000

CTGCTTTTCA CCCTGTATCC CAATGCTGCC ATCATTGCAA AGATTGCTGA CTACGGCATT 6060

GCTCAGTACT GCTGTAGAAT GGGGATAAAA ACATCAGAGG GCACACCAGG GTTTCGTGCA 6120

CCTGAAGTTG CCAGAGGAAA TGTCATTTAT AACCAACAGG CTGATGTTTA TTCATTTGGT 6180

TTACTACTCT ATGACATTTT GACAACTGGA GGTAGAATAG TAGAGGGCTT GAAGTTTCCA 6240

AATGAGTTTG ATGAATTAGC AATACAAGGA AAATTACCTG ATCCAGTTAA AGAATATGGT 6300

TGTGCCCCAT GGCCTATGGT TGAGAAATTA ATTAAAAAGT GTTTGAAAGA AAATCCTCAA 6360

GAAAGGCCTA CTTCTGCCCA GGTCTTTGAC ACTTTGAATT CAGCTGAATT AGTCTGTCTG 6420

ATGAGACACA TTTTATTACC TAAAAACGTA ATTGTTGAAT GCATGGTTGC TACACATCAC 6480

AACAGCAGGA ATGCAAGCAT TTGGCTGGGC TGTGGGCACA CCGACAGAGG ACAGCTCTCA 6540

TTTCTTGACT TAAATACTGA AGGATACACT TCGGAGGAAG TTGCTGATAG TAGAATATTG 6600

TGCTTAGCCT TGGTGCATCT TCCTGTTGAA AAGGAAAGCT GGATTGTGTC TGGGACACAG 6660

TCTGGTACTC TCCTGGTCAT CAATACCAAA GATGGGAAAA AGAGACATAC CCTAGAAAAG 6720

ATGACTGATT CTGTCACTTG TTTGTATTGC AATTCCTTTT CCAAGCAAAG CAAACAAAAA 6780

AATTTTCTTT TGGTTGGAAC CGCTGATGGC AATTTAGCAA TTTTTGAAGA TAAGACTGTT 6840

AAGCTTAAAG GAGCTGCTCC TTTGAAGATA CTAAATATAG GAAATGTCAG TACTCCATTG 6900

ATGTGTTTGA GTGAATCCAC AAATTCAACG GAAAGAAATG TAATGTGGGG AGGATGTGGC 6960

ACAAAGATTT TCTCCTTTTC TAATGATTTC ACCATTCAGA AACTCATTGA GACAAGAACA 7020

AGCCAACTAT TTTCTTATGC AGCTTTCAGT GATTCCAACA TCATAACAGT GGTGGTAGAC 7080

ACTGCTCTCT ATATTGCTAA GCAAAATAGC CCTGTAGTGG AAGTGTGGGA TAAGAAAACT 7140

GAAAAACTCT GCGAACTAAT AGACTGCGTG CACTTTTTAA GGGAGGTAAC AGGAAAAGAA 7200

AACAAGGAAT CTAAACACAA AATGTCTTAT TCTGGGAGAG TGAAAACTCT CTGCCTTCAG 7260

AAGAACACTG CTCTTTGGAT AGGAACTGGA GGAGGCCATA TTTTACTCCT GGATCTTTCA 7320

ACTCGTCGAG TTATACGTAT AATTTACAAC TTTTGTGATT CAATCAGAGT CATGATGACA 7380

GCACAGCTAG GAAGCCTTAA AAATGTCATG CTGGTATTGG GCTACAACTG GAAAAGTACT 7440

GAAGGTACAC AACAGCAGAA AGAGATACAA TCTTGCTTGA CTGTTTGGGA CATCAATCTT 7500

CCACATGAAG TGCAAAATTT AGAAAAACAC ATTGAAGTGA GAAAAGAATT AGCTGAAAAA 7560

ATGAGAGGAA CATCTGTTGA ATAA 7584

Domain Profile

S: 6     llGrGafGsvyraavkGeevavkafkiaadklkrdslelalkayselrqelsvLlalkhP  65

         llG+G+fGsvyraa++Geevavk+f+      k++sl+l       lrqel+vL++l+hP

Q: 1884  LLGDGSFGSVYRAAYEGEEVAVKIFN------KHTSLRL-------LRQELVVLCHLHHP  1930

         79************************......*******.......**************

S: 66    sivsLvgisikPlalvleLaplgsLdrlLsedkksssklgrtltkkialqvargleyLhk  125

         s++sL++++i+P++lv+eLa++gsLdrlL++dk+s   l+rtl+++ial+va+gl+yLh+

Q: 1931  SLISLLAAGIRPRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHS  1987

         *********************************99...**********************

S: 126   kkiiyrdLksenvLvwslspkeailikladyGisrqslrsGakgveGteGfraPeivrge  185

         ++iiyrdLk++nvL+++l+p++ai++k+adyGi+++++r+G+k++eGt+GfraPe++rg+

Q: 1988  AMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGN  2047

         ************************************************************

S: 186   vvydekvdvfsfGlllyell.sgkrpvegeeqlkivekl.lkGkrPvlvkeeevlptpll  243

         v+y++++dv+sfGllly++l +g r+veg ++++++++l ++Gk+P++vke++++p+p++

Q: 2048  VIYNQQADVYSFGLLLYDILtTGGRIVEGLKFPNEFDELaIQGKLPDPVKEYGCAPWPMV  2107

         ********************999*************************************

S: 244   d.LlveCwkekPekrPtasqvvs  265

         + L+++C+ke+P++rPt++qv++

Q: 2108  EkLIKKCLKENPQERPTSAQVFD  2130

         99*******************97

Domain Sequence
(FASTA)

LLGDGSFGSV YRAAYEGEEV AVKIFNKHTS LRLLRQELVV LCHLHHPSLI SLLAAGIRPR 60

MLVMELASKG SLDRLLQQDK ASLTRTLQHR IALHVADGLR YLHSAMIIYR DLKPHNVLLF 120

TLYPNAAIIA KIADYGIAQY CCRMGIKTSE GTPGFRAPEV ARGNVIYNQQ ADVYSFGLLL 180

YDILTTGGRI VEGLKFPNEF DELAIQGKLP DPVKEYGCAP WPMVEKLIKK CLKENPQERP 240

TSAQVFD 247

Keyword

ATP-binding; Complete proteome; GTP-binding; Leucine-rich repeat; Nucleotide-binding; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0032839	; C:dendrite cytoplasm
GO:0032473	; C:external side of mitochondrial outer membrane
GO:0043025	; C:neuronal cell body
GO:0005524	; F:ATP binding
GO:0005525	; F:GTP binding
GO:0034211	; F:GTP-dependent protein kinase activity
GO:0005096	; F:GTPase activator activity
GO:0003924	; F:GTPase activity
GO:0004708	; F:MAP kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0008340	; P:determination of adult lifespan
GO:0035640	; P:exploration behavior
GO:0048312	; P:intracellular distribution of mitochondria
GO:2000173	; P:negative regulation of branching morphogenesis of a nerve
GO:0061002	; P:negative regulation of dendritic spine morphogenesis
GO:0034260	; P:negative regulation of GTPase activity
GO:0007406	; P:negative regulation of neuroblast proliferation
GO:0014043	; P:negative regulation of neuron maturation
GO:0007528	; P:neuromuscular junction development
GO:0070997	; P:neuron death
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0060161	; P:positive regulation of dopamine receptor signaling pathway
GO:0043068	; P:positive regulation of programmed cell death
GO:0031398	; P:positive regulation of protein ubiquitination
GO:0046777	; P:protein autophosphorylation
GO:0040012	; P:regulation of locomotion
GO:0042391	; P:regulation of membrane potential
GO:0006979	; P:response to oxidative stress
GO:0007264	; P:small GTPase mediated signal transduction
GO:0022028	; P:tangential migration from the subventricular zone to the olfactory bulb

KEGG

InterPros

IPR020683	; Ankyrin_rpt-contain_dom.
IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR011009	; Kinase-like_dom.
IPR001611	; Leu-rich_rpt.
IPR025875	; Leu-rich_rpt_4.
IPR003591	; Leu-rich_rpt_typical-subtyp.
IPR013684	; MIRO-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020859	; ROC_GTPase.
IPR008271	; Ser/Thr_kinase_AS.
IPR005225	; Small_GTP-bd_dom.
IPR001806	; Small_GTPase.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR001680	; WD40_repeat.
IPR017986	; WD40_repeat_dom.

Pfam

PF00560	; LRR_1; 1.
PF12799	; LRR_4; 1.
PF08477	; Miro; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00369	; LRR_TYP; 1.
SM00320	; WD40; 1.

Prosites

PS51450	; LRR; 11.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS51424	; ROC; 1.

Prints

PR00449

; RASTRNSFRMNG.

Created Date

20-Feb-2013