EKS-NOL-00208

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00208

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/Haspin	315.9	1.9E-94	477	747	271

Status

Unreviewed

Ensembl Protein

ENSNLEP00000022714

UniProt Accession

G1SB20;

Protein Name

Protein Synonyms/Alias

Gene Name

GSG2

Gene Synonyms/Alias

GSG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000018847	ENSNLEP00000022714	ENSNLET00000023872

Organism

Nomascus leucogenys

Functional Description

Protein Length

790

Protein Sequence
(FASTA)

MAASLPGPGS RLFRTYGAAV GRRQRRPGRE AAQWFPPQDR RRFFNSSGSS NTSIGDPSQS 60

DDPDDPDDPD FPGSPVGRRR RRPGGRVPKD RPSLTVTPKR WKLRARPSLT VSPGRLGLRA 120

RPPQKCSTPC GPLRLPPFLS RDLSVCGQPR DGDELGSSAS LFSSLASPGP GSPTPRDSVI 180

SIGTSASLVA ASAVPSGLHL PEVSLDRASL PCSQEEATGG ARLTKMVHQT RARLRSALFG 240

LMNSGTPEDS EFGADGKNMR ESCYKRKLVG NGPEGPGLSS TGKRRATGQD SCQERGLQEA 300

VRREHQEASV SKGCIVPGGV DRLERTRSSR KSKHQEATET SLLHSHHFKK GQKMGKDSFP 360

TQDLTPLQNA CFWTKTRASF SFHKKKIVTD VSEVCSIYTT ATSLSGSLLS ECSNRPVMNR 420

TSGALSSWHS SSMYLLSPLN TLSISNKKAS DAEKVYGECS QKGPVPFSHC LPTEKLQRCE 480

KIGEGVFGEV FQTIADHTPV AIKIIAIEGP DLVNGSHQKT FEEILPEIII SKELSLLSSE 540

VCNRTEGFIG LNAVHCVQGS YPPLLLKAWD HYNSTKGSAN DRPDFFKDDQ LFIVMEFEFG 600

GIDLEQMRTK LSSLATAKSI LHQLTASLAV AEASLRFEHR DLHWGNVLLK KTSLKELHYT 660

LHGKSSTIPS RGLQVSIIDY TLSRLERDGI VVFCDVSMDE DLFTGDGDYQ FDIYRLMKKE 720

NNNRWGEYHP YSNVLWLHYL TDKILKQMTF KTKCNTPAMK QIKRKIQEFH RTMLNFSSAT 780

DLLCQHSLFK 790

Nucleotide Sequence
(FASTA)

ATGGCTGCTT CGCTCCCGGG ACCTGGGAGC CGGCTTTTCC GCACTTATGG GGCTGCGGTC 60

GGCAGGAGAC AGCGGCGGCC GGGCCGGGAA GCCGCGCAGT GGTTCCCGCC GCAGGACCGG 120

AGGCGTTTCT TCAACAGCAG CGGCAGCAGC AACACCAGCA TCGGCGACCC CTCGCAGTCC 180

GACGATCCTG ACGATCCCGA CGACCCCGAC TTCCCCGGCA GCCCGGTGGG GCGGCGGCGG 240

AGGCGTCCCG GCGGCCGAGT CCCCAAGGAC CGGCCCAGCC TGACCGTGAC CCCAAAGCGC 300

TGGAAGCTGC GAGCTCGCCC GAGCCTAACC GTGAGCCCAG GACGCCTGGG GCTGCGAGCT 360

CGACCCCCGC AGAAATGCAG CACACCCTGC GGCCCGCTCC GACTTCCGCC CTTCCTCAGC 420

CGGGACCTCA GCGTGTGCGG CCAGCCCAGG GACGGCGACG AGCTGGGCAG CAGTGCCTCC 480

CTGTTCAGCT CTCTGGCCTC TCCCGGCCCC GGGTCCCCAA CGCCAAGGGA CAGTGTCATC 540

TCCATCGGCA CCTCCGCCTC TCTGGTTGCA GCCTCAGCCG TCCCGAGCGG CCTCCACCTC 600

CCGGAAGTCT CCCTGGACCG TGCATCTCTC CCCTGCTCCC AGGAGGAAGC GACAGGAGGA 660

GCCAGGCTCA CCAAGATGGT CCACCAAACC CGTGCCAGGC TCAGGTCAGC TCTCTTTGGC 720

CTTATGAACT CAGGAACCCC TGAGGATTCT GAGTTTGGGG CAGATGGGAA GAATATGAGG 780

GAGTCCTGCT ATAAAAGGAA ACTGGTGGGA AATGGACCGG AGGGTCCAGG TCTGTCAAGC 840

ACAGGCAAGA GGAGGGCCAC AGGCCAGGAC TCTTGCCAAG AGAGAGGGCT TCAAGAGGCC 900

GTCCGGAGAG AGCATCAGGA GGCCAGTGTT TCCAAGGGCT GCATTGTGCC AGGGGGAGTC 960

GACAGGCTGG AGAGAACTAG ATCAAGCCGG AAGAGCAAAC ATCAGGAGGC AACGGAAACC 1020

TCTCTCCTCC ATTCCCACCA CTTTAAAAAG GGCCAAAAGA TGGGAAAAGA TTCGTTCCCC 1080

ACCCAGGACC TGACTCCTTT ACAGAATGCC TGCTTTTGGA CCAAAACCAG GGCTTCCTTC 1140

AGTTTCCACA AGAAGAAAAT TGTGACTGAT GTGTCAGAGG TCTGCAGCAT CTATACAACT 1200

GCCACTTCTC TCTCTGGATC CCTCCTATCA GAATGTTCAA ACCGGCCTGT CATGAACAGA 1260

ACAAGTGGTG CTCTGTCCTC TTGGCATTCC TCCTCTATGT ATTTGCTAAG CCCCTTAAAC 1320

ACTCTAAGTA TTTCAAACAA AAAGGCATCT GATGCTGAAA AGGTTTATGG GGAATGCAGT 1380

CAGAAGGGTC CTGTCCCCTT TAGCCATTGC CTTCCCACAG AAAAACTACA ACGCTGTGAG 1440

AAGATTGGGG AAGGGGTGTT TGGCGAAGTG TTTCAAACGA TTGCTGATCA CACACCTGTA 1500

GCCATAAAAA TCATTGCTAT TGAAGGACCA GATTTAGTCA ATGGATCCCA TCAGAAAACC 1560

TTTGAGGAAA TCCTGCCAGA GATCATCATC TCCAAAGAGT TGAGCCTCTT ATCCAGTGAA 1620

GTGTGCAACC GCACAGAAGG CTTTATCGGG CTGAACGCAG TGCACTGTGT CCAGGGATCT 1680

TACCCTCCCT TGCTCCTCAA AGCCTGGGAT CACTATAATT CAACCAAAGG CTCTGCAAAT 1740

GACCGGCCTG ATTTTTTTAA AGACGACCAG CTCTTCATTG TGATGGAATT TGAGTTTGGA 1800

GGGATTGACT TAGAGCAAAT GAGAACCAAG TTGTCTTCCT TGGCTACTGC AAAGAGCATT 1860

CTACACCAGC TCACAGCCTC CCTCGCAGTG GCAGAGGCAT CACTGCGCTT TGAGCACCGA 1920

GACTTACACT GGGGGAATGT GCTCTTAAAG AAAACCAGCC TCAAAGAACT CCACTACACC 1980

CTCCATGGGA AGAGCAGCAC TATCCCCAGC CGCGGGCTGC AAGTGAGCAT CATTGACTAC 2040

ACCCTGTCGC GCTTGGAACG GGATGGGATT GTGGTTTTCT GTGACGTTTC CATGGATGAG 2100

GACCTGTTTA CCGGTGATGG TGACTACCAG TTTGACATCT ACAGGCTCAT GAAGAAGGAG 2160

AATAACAACC GCTGGGGTGA ATATCACCCT TATAGTAATG TGCTCTGGCT GCATTACCTG 2220

ACAGACAAGA TTCTGAAACA AATGACCTTC AAGACTAAAT GTAACACTCC TGCCATGAAG 2280

CAAATTAAGA GAAAGATCCA GGAGTTCCAC AGGACAATGC TGAACTTCAG CTCTGCCACT 2340

GACTTGCTCT GCCAGCACAG TCTATTTAAG TAA 2373

Domain Profile

S: 2     ekvkklGeGayGevfsvtwkgkevvlKiiplegsdv........keealkEliilkklsk  53

         ++++k+GeG++Gevf+++ ++++v++Kii++eg+d+        +ee+l+E+ii+k+ls

Q: 477   QRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLvngshqktFEEILPEIIISKELSL  536

         79**********************************************************

S: 54    lske..nstpnFlellgakvvkgdvpkellkawdkydkekes..........dqlylvll  101

         ls+e  n+t++F+ l+ +++v+g++p++llkawd+y+++k+s          dql++v++

Q: 537   LSSEvcNRTEGFIGLNAVHCVQGSYPPLLLKAWDHYNSTKGSandrpdffkdDQLFIVME  596

         ************************************************************

S: 102   leeggtsldni..klksesqllsilqqlvlslaiaekelkfeHrDlhlgNvLikktkkke  159

         +e+gg++l+++  kl+s ++++sil+ql++sla+ae++l+feHrDlh+gNvL+kkt+ ke

Q: 597   FEFGGIDLEQMrtKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKE  656

         ************************************************************

S: 160   leYtldgkkiklkskgvlvtiIDftksrlvkkdkevvyedlevdeelfegkgdkqfdvyr  219

         l+Ytl+gk+++++s+g++v+iID+t+sr  ++d+ vv++d+++de+lf+g+gd+qfd+yr

Q: 657   LHYTLHGKSSTIPSRGLQVSIIDYTLSR-LERDGIVVFCDVSMDEDLFTGDGDYQFDIYR  715

         ****************************.9******************************

S: 220   lmranvknewkefepktnllwltylsskllkk  251

         lm+++++n+w e++p++n+lwl+yl++k+lk+

Q: 716   LMKKENNNRWGEYHPYSNVLWLHYLTDKILKQ  747

         ******************************85

Domain Sequence
(FASTA)

QRCEKIGEGV FGEVFQTIAD HTPVAIKIIA IEGPDLVNGS HQKTFEEILP EIIISKELSL 60

LSSEVCNRTE GFIGLNAVHC VQGSYPPLLL KAWDHYNSTK GSANDRPDFF KDDQLFIVME 120

FEFGGIDLEQ MRTKLSSLAT AKSILHQLTA SLAVAEASLR FEHRDLHWGN VLLKKTSLKE 180

LHYTLHGKSS TIPSRGLQVS IIDYTLSRLE RDGIVVFCDV SMDEDLFTGD GDYQFDIYRL 240

MKKENNNRWG EYHPYSNVLW LHYLTDKILK Q 271

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Tarsius syrichta"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0031965	; C:nuclear membrane
GO:0005819	; C:spindle
GO:0005524	; F:ATP binding
GO:0072354	; F:histone kinase activity (H3-T3 specific)
GO:0007243	; P:intracellular protein kinase cascade
GO:0007064	; P:mitotic sister chromatid cohesion
GO:0071459	; P:protein localization to chromosome, centromeric region
GO:0090231	; P:regulation of spindle checkpoint

KEGG

InterPros

IPR024604	; DUF3635.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF12330	; DUF3635; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013