EKS-ORA-00130
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00130
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR247.71.3E-73500641142
StatusUnreviewed
Ensembl ProteinENSOANP00000000755
UniProt AccessionF7EXS2;
Protein Name
Protein Synonyms/Alias
Gene NameFGFR2
Gene Synonyms/Alias FGFR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000000474ENSOANP00000000755ENSOANT00000000756
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length642
Protein Sequence
(FASTA)
MGLKSTCRYG KGPGIGTVKM VICGRLLCLV VVTMATCSLA RPSFNLVEDT TLEPEEPPTK 60
YQISQPDVYT ALPGDSLELR CLLKDAIMIS WTKDGVQLGP NNRTVLIGEY LQIKGATSRD 120
SGLYACSAAR TVDSETLYFM VNITDAISSG DDEDDSDGSE DFVNDNNNDS GAPYWTNTEK 180
MEKRLHAVPA ANTVKFRCPA GGNPIPSMRW LKNGKEFKQE HRIGGYKVRN QHWSLIMESV 240
VPSDKGNYTC VVENEYGSIN HTYHLDVVER SPHRPILQAG LPANASTVVG GDVEFVCKVY 300
SDAQPHIQWI KHVEKNGSKH GPDGLPYLKV LKAAGVNTTD KEIEVLYIRN VTFEDAGEYT 360
CLAGNSIGIS FHSAWLTVLP APVKEKEITA SPDYLEIAIY CVGVFLIACM MVVVIVCRMK 420
TTTEKPDFSS QPAVHKLTKR IPLRRQVTVS ADSSSSMNSN TPLVRITTRL SSTADAPMLA 480
GVSEYELPED PKWEFPRDKL TLGKPLGEGC FGQVVMAEAV GIDKEKPKEA VTVAVKMLKD 540
DATEKDLSDL VSEMEMMKMI GKHKNIINLL GACTQDGPLY VIVEYASKGN LREFLRARRP 600
PGMEYSFDIN RVPEEQMTFK DLVSCTYQLA RGMEYLASQK VC 642
Nucleotide Sequence
(FASTA)
ATGGGATTAA AGTCCACGTG CAGATATGGA AAAGGACCCG GGATCGGCAC CGTAAAGATG 60
GTCATCTGTG GTCGCCTTCT GTGTCTTGTT GTGGTTACCA TGGCAACGTG TTCTTTGGCA 120
CGACCATCCT TCAATTTGGT TGAAGACACC ACCCTGGAGC CCGAAGAACC ACCAACCAAA 180
TACCAAATCT CCCAGCCTGA TGTGTACACA GCCCTCCCTG GAGATTCCCT TGAGTTGCGC 240
TGCCTGTTGA AAGATGCCAT CATGATCAGT TGGACTAAGG ATGGGGTCCA GTTGGGCCCC 300
AACAATAGGA CAGTGCTTAT TGGGGAATAT TTGCAGATTA AAGGTGCCAC CTCTAGAGAT 360
TCAGGCCTCT ATGCTTGTTC TGCTGCTAGG ACTGTAGACA GTGAAACCTT ATACTTCATG 420
GTCAATATTA CAGATGCGAT TTCATCGGGC GATGATGAAG ATGACAGTGA TGGCTCTGAG 480
GATTTTGTCA ATGATAACAA TAATGACTCA GGAGCCCCAT ATTGGACCAA TACTGAAAAG 540
ATGGAGAAGA GATTACATGC TGTCCCAGCA GCCAATACAG TCAAATTTCG TTGTCCTGCT 600
GGGGGAAACC CAATACCAAG CATGAGATGG TTAAAGAATG GAAAAGAATT TAAACAAGAG 660
CATCGCATTG GTGGTTATAA GGTACGAAAC CAGCACTGGA GTCTCATTAT GGAAAGTGTG 720
GTGCCATCTG ATAAAGGAAA TTATACATGT GTAGTAGAAA ATGAATATGG CTCCATCAAT 780
CACACATATC ACCTTGATGT TGTTGAACGA TCACCTCATC GGCCCATCCT CCAAGCGGGG 840
TTACCAGCCA ATGCCTCTAC AGTGGTCGGG GGTGACGTGG AGTTTGTCTG CAAAGTTTAC 900
AGTGATGCCC AGCCCCACAT TCAGTGGATA AAGCATGTAG AAAAGAATGG CAGTAAACAT 960
GGGCCGGATG GGTTACCGTA CCTTAAGGTA TTAAAGGCCG CCGGTGTAAA CACCACGGAC 1020
AAAGAGATTG AGGTTCTCTA TATTCGGAAT GTAACTTTTG AGGATGCGGG GGAGTATACG 1080
TGCTTGGCGG GTAATTCTAT TGGGATATCC TTTCACTCTG CATGGTTGAC AGTTCTGCCA 1140
GCACCCGTAA AAGAAAAGGA GATCACAGCA TCCCCAGACT ACCTGGAGAT AGCCATTTAC 1200
TGCGTTGGGG TCTTCTTAAT TGCCTGTATG ATGGTGGTCG TCATCGTGTG CCGTATGAAG 1260
ACCACCACCG AGAAACCTGA CTTCAGTAGC CAGCCTGCAG TGCATAAGCT GACAAAGCGT 1320
ATCCCCCTGC GGAGACAGGT AACAGTTTCT GCAGACTCCA GCTCTTCCAT GAACTCCAAT 1380
ACGCCTCTCG TGCGGATAAC AACCCGTCTC TCATCAACTG CCGATGCTCC AATGCTAGCC 1440
GGGGTCTCAG AGTATGAGTT GCCAGAGGAT CCAAAATGGG AGTTCCCCAG GGACAAGCTG 1500
ACATTGGGCA AACCCCTTGG AGAGGGCTGC TTTGGACAGG TTGTCATGGC AGAAGCAGTG 1560
GGAATCGACA AAGAAAAACC CAAGGAGGCA GTTACTGTGG CAGTGAAGAT GTTGAAAGAT 1620
GATGCCACCG AGAAAGATCT CTCTGATCTG GTGTCAGAGA TGGAGATGAT GAAGATGATT 1680
GGAAAGCACA AAAATATCAT CAATCTTCTT GGGGCCTGTA CTCAAGATGG TCCTTTATAT 1740
GTGATAGTTG AGTATGCTTC CAAAGGAAAC CTGCGAGAAT TCCTTCGAGC ACGCAGACCA 1800
CCTGGAATGG AATATTCATT TGACATCAAC CGGGTACCAG AAGAACAGAT GACGTTCAAA 1860
GATTTAGTTT CATGCACATA CCAACTAGCA AGAGGGATGG AGTACTTAGC CTCACAAAAG 1920
GTATGTTAG 1929
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aea+g+dk+k+k++vtvavkmlk+dat+kdl+dlvseme++k+
Q: 500   LTLGKPLGEGCFGQVVMAEAVGIDKEKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  559
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyviveya+kGnlreflrarrp+g+e+s d ++++eeq+t+
Q: 560   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREFLRARRPPGMEYSFDINRVPEEQMTF  619
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkc  142
         kdlvs++yq+arGmeylas+k+
Q: 620   KDLVSCTYQLARGMEYLASQKV  641
         ********************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA VGIDKEKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREFLRARR PPGMEYSFDI NRVPEEQMTF 120
KDLVSCTYQL ARGMEYLASQ KV 142
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Repeat; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Pteropus vampyrus"; ?>
EKS-BOT-00148
EKS-FEC-00140
EKS-GOG-00147
EKS-ICT-00144
EKS-LOA-00149
EKS-MOD-00147
EKS-NOL-00141
EKS-ORC-00138
EKS-PTV-00139
Gene Ontology
GO:0005938; C:cell cortex
GO:0009986; C:cell surface
GO:0031012; C:extracellular matrix
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0045165; P:cell fate commitment
GO:0007267; P:cell-cell signaling
GO:0050673; P:epithelial cell proliferation
GO:0008285; P:negative regulation of cell proliferation
GO:0045839; P:negative regulation of mitosis
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0035265; P:organ growth
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0051781; P:positive regulation of cell division
GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0002053; P:positive regulation of mesenchymal cell proliferation
GO:0010518; P:positive regulation of phospholipase activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0046777; P:protein autophosphorylation
GO:0060687; P:regulation of branching involved in prostate gland morphogenesis
GO:0010453; P:regulation of cell fate commitment
GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway
GO:0040014; P:regulation of multicellular organism growth
GO:0051150; P:regulation of smooth muscle cell differentiation
GO:0008589; P:regulation of smoothened signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013