EKS-ORA-00003
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00003
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph518.32.9E-156654911258
StatusUnreviewed
Ensembl ProteinENSOANP00000000775
UniProt AccessionF7EX10;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA3
Gene Synonyms/Alias EPHA3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000000485ENSOANP00000000775ENSOANT00000000776
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length1016
Protein Sequence
(FASTA)
MDCHVSILLF LICSLLSCCG ELMLHPANEV NLLDSKAIQG ELGWISYPSH GWEEISGVDE 60
HYTPIRTYQV CNVMDHSQNN WLRTNWVPRN SAQKIYVELK FTLRDCNSIP LVLGTCKETF 120
NLYYMESDDD HGVKFREHQF TKIDTIAADE SFTQMDLGDR ILKLNTEVRE VGPVSRKGFY 180
LAFQDVGACV ALVSVRVYFK KCPFTVKNLA MFPDTVPMDS QSLVEVRGSC VNHSKEEDPP 240
RMYCSTEGEW LVPIGRCLCD AGYEERGSAC QACRSGFYKA SAGNMKCTKC PPHSSTHEDG 300
SVNCKCEKNY FRTEQDPPSM ACTRPPSSPR NVISNINETS VILDWSWPLD TGGRKDVTFN 360
IICKKCGGNN RLCEPCSPHV RFLPRQIGLT NTTVTVVDLL AHTNYTFEID ALNGVSHRAS 420
ISRQFAAVSI TTNQAAPSPV TVIRKEQTSR NSVSLSWQEP EHPNGIILDY EVKYYEKPKQ 480
EQETSYTILR ARGTNVTISG LKPVTIYVFQ IRARTAAGYG TNSRKFEFET SPDSFSISSE 540
NSQVVMIAIS SAVAIILLTV VVYILIGSRV TGFCCQLLSL SCRTPSNILQ KAAAILHIFC 600
GYNKSKPNTD EKRLHFGNGH LKLPGLRTYI DPHTYEDPNQ AVHEFAKELD ATTISIDKVV 660
GAGEFGEVCS GRLKLPSKKE ISVAIKTLKV GYTEKQRRDF LGEASIMGQF DHPNIIRLEG 720
VVTKSKPVMI VTEYMENGSL DSFLRKHDAQ FTVIQLVGML RGIASGMKYL SDMGYVHRDL 780
AARNILINSN LVCKVSDFGL SRVLEDDPEA AYTTRGGKIP IRWTSPEAIA YRKFTSASDV 840
WSYGIVLWEV MSYGERPYWE MSNQDVIKAV DEGYRLPPPM DCPAALYQLM LDCWQKDRNN 900
RPKFEQIVSI LDKLIRNPSS LKIITSAAAR PSNLLLDQSS IDITTFRKTG DWLNGIRTGQ 960
CKEIFTGVEY SSCDTIAKIS TEDMKKVGVT IVGPQKKIIS SLKALETHTK NGPVPV 1016
Nucleotide Sequence
(FASTA)
ATGGATTGTC ACGTCTCCAT CCTCCTCTTT CTCATCTGTT CGCTGCTCAG CTGCTGCGGG 60
GAACTGATGC TCCATCCTGC CAATGAAGTT AATCTACTGG ATTCAAAAGC AATTCAAGGG 120
GAACTGGGCT GGATCTCCTA TCCATCACAT GGGTGGGAAG AAATCAGTGG TGTTGATGAA 180
CACTATACTC CTATCAGGAC CTACCAGGTG TGCAATGTCA TGGATCACAG TCAGAATAAT 240
TGGTTGAGAA CCAACTGGGT CCCGCGCAAC TCAGCTCAGA AGATTTATGT GGAACTCAAG 300
TTTACCCTGC GAGACTGTAA TAGCATTCCC TTAGTACTGG GTACCTGCAA GGAGACTTTC 360
AACCTGTACT ACATGGAGTC CGATGACGAT CATGGGGTCA AATTCCGGGA GCATCAATTT 420
ACAAAGATTG ACACTATTGC AGCTGATGAG AGTTTCACCC AAATGGATCT CGGGGATCGA 480
ATTCTCAAAC TCAACACGGA GGTTCGAGAG GTAGGACCTG TCAGTAGGAA AGGCTTTTAT 540
CTGGCTTTTC AAGACGTTGG CGCCTGTGTG GCCTTGGTGT CAGTGAGAGT ATACTTCAAA 600
AAGTGTCCTT TCACAGTAAA AAACTTGGCT ATGTTTCCAG ACACAGTTCC CATGGACTCT 660
CAGTCCCTTG TGGAAGTGCG GGGATCTTGT GTTAATCATT CCAAGGAAGA GGACCCACCC 720
AGGATGTACT GCAGCACAGA GGGCGAGTGG CTGGTGCCCA TTGGCAGGTG TTTATGTGAT 780
GCTGGCTATG AAGAGAGAGG TTCTGCGTGC CAAGCTTGTC GATCTGGTTT CTACAAGGCC 840
TCTGCCGGAA ATATGAAGTG TACCAAGTGT CCACCTCATA GCTCTACCCA TGAAGATGGT 900
TCAGTGAACT GCAAGTGTGA GAAGAATTAC TTCCGGACGG AGCAAGACCC CCCTTCTATG 960
GCTTGCACCC GACCTCCATC CTCCCCAAGG AATGTTATCT CTAATATCAA CGAGACCTCT 1020
GTTATTCTGG ACTGGAGTTG GCCTTTGGAC ACTGGAGGTC GGAAGGATGT CACCTTCAAC 1080
ATCATATGTA AAAAATGTGG GGGAAACAAC AGGCTATGTG AACCCTGCAG CCCACATGTG 1140
CGTTTCCTGC CTCGCCAAAT TGGGCTCACC AACACCACAG TGACCGTGGT AGATCTCCTT 1200
GCCCATACAA ACTACACATT TGAGATCGAT GCTCTTAACG GAGTATCTCA CCGCGCCTCC 1260
ATCTCGAGAC AGTTTGCAGC AGTGAGCATC ACGACCAACC AGGCGGCTCC ATCACCCGTT 1320
ACTGTAATTA GGAAGGAGCA GACATCCAGG AACAGTGTTT CTCTGTCTTG GCAAGAACCT 1380
GAACATCCAA ATGGGATCAT CTTGGACTAC GAGGTCAAGT ACTATGAAAA GCCAAAGCAG 1440
GAGCAAGAGA CAAGTTATAC AATTTTAAGA GCAAGAGGAA CGAATGTTAC CATCAGTGGC 1500
CTCAAACCTG TTACAATTTA TGTATTCCAA ATCCGAGCTC GAACAGCAGC TGGTTATGGG 1560
ACTAACAGCC GCAAGTTTGA GTTTGAAACA AGTCCAGATT CTTTCTCCAT TTCCAGTGAA 1620
AATAGCCAAG TTGTAATGAT TGCCATTTCG TCTGCAGTAG CTATTATTCT TCTTACTGTC 1680
GTGGTGTACA TACTGATTGG GAGCAGAGTC ACTGGATTTT GCTGTCAGTT GCTTTCACTC 1740
TCTTGCAGAA CCCCCTCAAA CATTCTCCAG AAAGCTGCTG CAATATTGCA CATATTTTGC 1800
GGATATAACA AATCAAAACC CAATACAGAT GAGAAGAGGC TTCATTTTGG AAACGGACAC 1860
TTAAAACTTC CAGGCCTCAG AACTTACATA GATCCACATA CCTATGAAGA CCCTAACCAA 1920
GCCGTTCATG AATTTGCCAA GGAATTGGAT GCTACAACTA TATCAATTGA CAAAGTTGTC 1980
GGAGCAGGTG AATTTGGAGA GGTGTGCAGT GGCCGCCTAA AGCTTCCTTC CAAAAAGGAA 2040
ATTTCTGTTG CCATCAAAAC CCTGAAAGTC GGCTACACTG AAAAGCAAAG GAGAGACTTT 2100
TTGGGAGAGG CAAGCATCAT GGGACAGTTT GACCATCCCA ACATCATTCG ACTGGAAGGA 2160
GTTGTTACCA AAAGTAAGCC TGTCATGATC GTCACTGAAT ATATGGAGAA TGGATCTTTG 2220
GATAGTTTCT TACGGAAACA CGACGCCCAG TTTACAGTCA TACAGCTGGT GGGGATGCTT 2280
CGGGGAATAG CATCGGGTAT GAAATACCTA TCAGACATGG GCTATGTACA TCGTGACTTG 2340
GCTGCTCGCA ACATACTAAT CAACAGTAAC CTGGTGTGCA AGGTCTCAGA TTTTGGTCTT 2400
TCGCGTGTTT TAGAGGATGA TCCCGAAGCT GCTTACACAA CAAGAGGAGG AAAGATCCCG 2460
ATCCGGTGGA CATCTCCAGA AGCCATTGCA TATCGGAAAT TTACATCAGC CAGTGATGTA 2520
TGGAGTTATG GGATTGTTCT CTGGGAGGTG ATGTCCTATG GAGAGAGACC ATATTGGGAG 2580
ATGTCCAATC AGGATGTAAT TAAAGCTGTG GATGAAGGCT ACCGACTGCC GCCTCCCATG 2640
GACTGTCCAG CTGCCTTGTA TCAGCTGATG TTGGACTGCT GGCAGAAAGA CAGAAACAAC 2700
AGACCTAAGT TTGAGCAGAT TGTCAGCATC CTGGACAAGC TTATCCGGAA TCCCAGCAGC 2760
CTGAAAATCA TCACCAGTGC GGCTGCAAGG CCATCCAATC TTCTTCTGGA CCAAAGCAGC 2820
ATCGATATCA CCACCTTCCG CAAGACTGGT GACTGGCTCA ATGGCATCCG GACAGGACAG 2880
TGCAAGGAGA TCTTTACAGG CGTGGAGTAC AGTTCATGTG ATACAATAGC CAAAATTTCC 2940
ACTGAGGATA TGAAGAAAGT TGGTGTCACT ATTGTTGGGC CACAGAAGAA GATTATCAGC 3000
AGTCTTAAAG CCCTAGAAAC ACATACAAAG AATGGTCCGG TTCCTGTATA A 3051
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++i+kv+GaGefGevcsGrlklp+k+ei+vaiktlk g+tekqrrdfl easi+Gqfdhp
Q: 654   ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHP  713
         689*********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtkskpvmivteymeng+ldsflrk+d qftviqlvgmlrGiasgmkylsdm
Q: 714   NIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDM  773
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnil+nsnlvckvsdfGlsrvledd+eaaytt+ggkipirwt+peaiayrk
Q: 774   GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRK  833
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGivlwev+syGerpyw+msnqdvika++egyrlpppmdcpaalyqlmldc
Q: 834   FTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDC  893
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqkdr++rpkfeqivsil
Q: 894   WQKDRNNRPKFEQIVSIL  911
         ***************986
Domain Sequence
(FASTA)
ISIDKVVGAG EFGEVCSGRL KLPSKKEISV AIKTLKVGYT EKQRRDFLGE ASIMGQFDHP 60
NIIRLEGVVT KSKPVMIVTE YMENGSLDSF LRKHDAQFTV IQLVGMLRGI ASGMKYLSDM 120
GYVHRDLAAR NILINSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TSPEAIAYRK 180
FTSASDVWSY GIVLWEVMSY GERPYWEMSN QDVIKAVDEG YRLPPPMDCP AALYQLMLDC 240
WQKDRNNRPK FEQIVSIL 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00002
EKS-ANC-00002
EKS-CAE-00001
EKS-CAJ-00002
EKS-CAF-00003
EKS-EQC-00003
EKS-FEC-00004
EKS-GAG-00003
EKS-GAA-00003
EKS-GOG-00002
EKS-HOS-00003
EKS-ICT-00002
EKS-LOA-00002
EKS-MAM-00002
EKS-MEG-00002
EKS-MOD-00002
EKS-MUM-00002
EKS-MUP-00002
EKS-MYL-00003
EKS-NOL-00002
EKS-ORN-00002
EKS-ORC-00002
EKS-OTG-00001
EKS-PAT-00002
EKS-PES-00003
EKS-POA-00002
EKS-PRC-00002
EKS-RAN-00003
EKS-SUS-00002
EKS-TAG-00004
EKS-TAS-00002
EKS-TEN-00001
EKS-TUT-00001
EKS-XET-00001
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013