EKS-ORA-00210

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00210

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	390.5	3.4E-117	46	297	252

Status

Unreviewed

Ensembl Protein

ENSOANP00000001207

UniProt Accession

F6RDT7;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK3

Gene Synonyms/Alias

MARK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000000773	ENSOANP00000001207	ENSOANT00000001208

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

743

Protein Sequence
(FASTA)

MKRDTEKHTS HGDGRQEVTS RTGRSGARCR NSIASCADEQ PHIGNYRLLK TIGKGNFAKV 60

KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE VIETEKTLYL 120

IMEYASGGEV FDYLVAHGRM KEKEARAKFR QIVSAVQYCH QKHIVHRDLK AENLLLDADM 180

NIKIADFGFS NEFTVGNKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG VILYTLVSGS 240

LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPTKRGTLEQ IMKDRWINAG 300

HEDDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS KMKYDEITAT YLLLGRKSSE 360

LDASDSSSSS NLSLAKVRPS SDLNNSTGQS PHHKVQRSIS SSQKQRRYSD HAGPSIPPVM 420

AYPKRSQTST ADTDLKEEGI QSRKSGSSAV GGRGVAPASP MLGSANNPNK ADIPERKKSS 480

TVPSNNTTSG GMTRRNTYVC SERTTADRHS VIQNGKENST IPDQRTPVAS THSISSAATP 540

DRIRFPRGTA SRSTFHGQPR ERRTATYNGP PASPSLSHEA TPLSQTRSRG STNLFSKLTS 600

KLTRRNMSFR FIKRLPTEYE RNGRSEGSSR NVAADQKDEN KEAKPRSLRF TWSMKTTSSM 660

DPNDMMREIR KVLDANNCDY EQRERFLLFC VHGDGHAENL VQWEMEVCKL PRLSLNGVRF 720

KRISGTSIAF KDVASKIANE LKL 743

Nucleotide Sequence
(FASTA)

ATGAAACGAG ACACCGAAAA ACACACGTCT CACGGAGATG GGCGACAAGA AGTTACTTCT 60

CGAACTGGGC GCTCTGGTGC TCGCTGTAGA AACTCCATAG CCTCCTGTGC AGATGAGCAA 120

CCCCATATTG GAAACTACAG ACTTCTGAAA ACTATTGGCA AGGGGAATTT TGCAAAAGTC 180

AAACTGGCAA GGCACATCCT TACCGGCAGA GAGGTTGCAA TAAAAATAAT TGACAAAACA 240

CAGCTGAATC CAACCAGTCT ACAGAAGCTC TTCAGAGAAG TAAGAATAAT GAAGATTTTA 300

AACCATCCAA ATATAGTTAA GTTATTTGAA GTAATTGAAA CCGAAAAAAC ACTGTACTTA 360

ATCATGGAAT ATGCAAGTGG AGGTGAGGTA TTTGACTATT TGGTTGCACA TGGAAGAATG 420

AAGGAAAAGG AAGCCCGAGC TAAATTTAGA CAGATAGTAT CTGCAGTGCA GTATTGCCAC 480

CAAAAGCATA TTGTTCACAG GGATCTCAAA GCTGAAAATC TATTGCTTGA TGCCGATATG 540

AACATTAAAA TAGCAGACTT TGGTTTTAGC AACGAATTTA CAGTTGGCAA TAAACTGGAC 600

ACATTTTGTG GCAGTCCTCC TTATGCAGCT CCAGAACTCT TCCAGGGCAA GAAATATGAT 660

GGACCTGAAG TTGATGTTTG GAGCCTAGGT GTCATTCTGT ACACTCTCGT GAGTGGATCT 720

CTTCCTTTTG ATGGACAGAA CCTAAAGGAA CTGAGAGAGA GAGTATTAAG AGGAAAATAC 780

AGAATTCCTT TCTACATGTC CACGGACTGT GAAAACCTCC TCAAACGTTT TCTGGTGCTA 840

AATCCAACTA AAAGAGGCAC TCTCGAGCAA ATCATGAAGG ACAGGTGGAT CAATGCTGGC 900

CATGAAGACG ATGAGCTTAA ACCATTCGTT GAACCAGAAC TAGATATCTC GGACCAGAAA 960

AGAATAGATA TTATGGTGGG AATGGGGTAT TCACAAGAAG AAATTCAAGA ATCTCTTAGT 1020

AAAATGAAAT ATGATGAAAT CACAGCTACG TATTTGTTGT TGGGGAGGAA ATCTTCTGAG 1080

CTGGATGCCA GTGATTCCAG TTCCAGCAGC AATCTTTCCC TTGCAAAGGT TAGGCCAAGC 1140

AGTGATCTCA ATAATAGCAC TGGACAATCT CCCCATCATA AAGTGCAGAG AAGCATATCT 1200

TCAAGCCAAA AGCAGCGACG GTACAGTGAC CACGCTGGAC CATCAATTCC TCCAGTCATG 1260

GCATATCCAA AAAGGAGCCA GACCAGTACC GCAGATACTG ATCTTAAAGA AGAAGGAATT 1320

CAATCCAGGA AATCAGGCAG CAGTGCTGTT GGGGGACGGG GAGTGGCTCC AGCCAGCCCC 1380

ATGCTGGGAA GTGCAAACAA TCCTAATAAG GCAGATATTC CTGAACGGAA GAAGAGTTCC 1440

ACAGTCCCTA GTAATAATAC AACATCTGGA GGAATGACGC GGCGAAATAC GTACGTCTGT 1500

AGCGAAAGAA CCACCGCGGA TCGGCATTCC GTTATTCAAA ATGGCAAGGA AAACAGCACT 1560

ATTCCCGATC AGAGAACGCC CGTCGCTTCG ACCCACAGCA TCAGCAGCGC CGCCACCCCG 1620

GATCGCATCC GCTTTCCGAG AGGGACGGCC AGTCGCAGCA CTTTCCATGG CCAGCCCCGG 1680

GAGCGGCGCA CAGCCACTTA CAACGGCCCG CCGGCATCAC CCAGCCTGTC CCATGAAGCC 1740

ACGCCACTTT CCCAGACCCG AAGCAGGGGC TCCACTAACC TCTTTAGTAA ATTAACGTCC 1800

AAACTCACCC GCAGAAACAT GTCTTTCAGG TTTATCAAAA GGCTCCCGAC TGAATATGAG 1860

CGGAACGGGA GATCTGAGGG TTCAAGTCGC AACGTGGCAG CCGACCAGAA GGACGAAAAC 1920

AAGGAAGCCA AGCCCCGTTC CCTCCGGTTT ACCTGGAGCA TGAAAACCAC CAGCTCCATG 1980

GACCCCAATG ACATGATGAG AGAGATCCGC AAGGTCCTGG ACGCCAATAA CTGTGACTAC 2040

GAACAGCGAG AGCGTTTTTT GCTCTTCTGC GTCCACGGGG ACGGACACGC GGAAAACCTG 2100

GTCCAGTGGG AAATGGAGGT GTGTAAGCTG CCAAGATTGT CTCTGAACGG CGTCCGCTTC 2160

AAGCGCATAT CGGGAACGTC CATAGCTTTT AAAGACGTCG CTTCCAAAAT CGCCAACGAG 2220

CTAAAGCTGT AA 2232

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++va+Kii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 46    YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  105

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lyl++eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k+iv

Q: 106   VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIV  165

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 166   HRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  225

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+++Lv +p+kR

Q: 226   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPTKR  285

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i+k++w+

Q: 286   GTLEQIMKDRWI  297

         ***********7

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGREVAIK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETE KTLYLIMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKHIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTV GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK RFLVLNPTKR 240

GTLEQIMKDR WI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013