EKS-ORA-00148

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00148

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TTK	462.9	3.7E-139	558	824	267

Status

Unreviewed

Ensembl Protein

ENSOANP00000002055

UniProt Accession

F7G2V9;

Protein Name

Protein Synonyms/Alias

Gene Name

TTK

Gene Synonyms/Alias

TTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000001287	ENSOANP00000002055	ENSOANT00000002056

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

893

Protein Sequence
(FASTA)

MKLIPKEIRN RAASTWFFSP PFPSGVEMEV EDPNGGGLTI TSIMNKVRDL KNKFKNEDLT 60

DELNSTKIST DTTDNSGTVN QIMMTANNPE DWLNFLLRVE KNGVLQNDGL LNKLIGRYSQ 120

AIGALPPEKY GQNESFARIQ VRFAELKAIQ EPDDARDHFQ MAKANCKKFA FVHISFAQFE 180

LSQGNFKKSK QLLQKAMECG AVPQEMLEMA MQNLKLGKRQ LLSEEEKENF SVSSTMPSQD 240

SFPNPLGQLQ SRSISRDSGG LSTNGARFLN GENISPQDID KALSNQNPLK PFSKPKLACP 300

FGRVPVKLLN SPNDTVRTDG PVAPSFTKRP TTGAECSNAA SREPKPSGVD SYELRNLKVS 360

DEKSLETTDD STLTLKNKIE ARLPVNKRDL CLAKNPTAET KTPQPEQKPA ESNRKQRQPD 420

FPGSSRKSES SNPNPIAFPN MWRVPEVPLK SGLEHRCPSF EPPGGSISKQ SPPSEAVPSK 480

PESKLTCGTP SSRTVDDYMA CFRTPVVKSV FPSGGPISTP FKQPSLLQTQ TPATPFQSFQ 540

VPPSFSSNEC ITVKGRMYSI LKQIGSGGSS KVFQVLNDKK QIYAIKHVNL EEADHQTIES 600

YQNEIAHLKK LQPHSDKIIR LYDFEITDQH IYMVMECGNI DLNSWLRKKK TINTWERKSY 660

WENMLEAVHT IHQHGIVHSD LKPANFLIVD GMLKLIDFGI ANQMQPDVTS IVKDSQVGTV 720

NYMPPEAIKD MSSSREAGKS KSKISPKSDV WSLGCILYCM TYGKTPFQHI TNQITKLHAI 780

IDPSYEIEFP DIAEKDLQDV LKRCLIRNPK DRISIPELLT HPYVHIQTQA QPDGHISQET 840

SEEMKRVLGQ LVGLNSPNSV LRAAKTLYEQ CNRRESRDVS SPARRSDRKW KNK 893

Nucleotide Sequence
(FASTA)

ATGAAGTTGA TCCCGAAGGA GATTCGGAAT CGGGCAGCCT CGACGTGGTT TTTTTCTCCC 60

CCCTTTCCCT CGGGCGTAGA AATGGAGGTC GAGGATCCGA ATGGCGGCGG ACTGACGATC 120

ACATCTATCA TGAACAAAGT GAGGGATCTC AAAAACAAGT TTAAAAACGA AGACCTCACC 180

GACGAGCTCA ATTCGACTAA AATCTCGACC GATACCACAG ATAATTCGGG GACTGTTAAC 240

CAAATTATGA TGACTGCCAA CAACCCAGAG GACTGGTTAA ATTTCTTGCT CAGAGTGGAG 300

AAAAACGGGG TCCTTCAGAA TGACGGTTTG CTCAATAAAC TGATTGGCCG TTACAGTCAA 360

GCGATCGGAG CGCTTCCTCC AGAGAAATAT GGTCAGAATG AGAGTTTTGC CCGTATTCAA 420

GTGAGATTCG CTGAGCTGAA AGCAATTCAA GAGCCAGATG ACGCCCGTGA CCACTTTCAG 480

ATGGCCAAAG CAAACTGCAA GAAGTTTGCT TTCGTACACA TCTCTTTTGC ACAGTTCGAA 540

CTCTCTCAAG GAAATTTCAA AAAAAGCAAA CAGCTTCTTC AGAAAGCGAT GGAGTGTGGG 600

GCCGTCCCCC AAGAGATGTT GGAAATGGCC ATGCAGAATC TGAAGTTGGG CAAACGGCAG 660

TTGCTCTCTG AGGAGGAAAA GGAGAATTTT TCTGTCTCTT CCACTATGCC CTCCCAAGAC 720

TCATTTCCAA ACCCACTCGG ACAGTTACAG AGCAGGAGCA TAAGTCGCGA TTCTGGAGGA 780

CTCTCCACAA ATGGAGCCAG ATTTCTGAAC GGGGAGAACA TATCTCCTCA AGATATCGAT 840

AAAGCGTTGA GTAATCAAAA TCCCTTGAAG CCATTCAGCA AGCCTAAACT GGCATGTCCG 900

TTCGGAAGGG TCCCAGTTAA ACTGTTAAAC AGCCCAAATG ACACAGTGAG AACGGACGGT 960

CCGGTGGCTC CAAGTTTTAC AAAGAGGCCA ACGACTGGAG CAGAATGTTC GAACGCAGCC 1020

TCCCGCGAAC CCAAACCAAG CGGTGTGGAT TCTTACGAAC TGAGAAATTT GAAGGTATCG 1080

GATGAAAAGA GTTTGGAAAC TACCGATGAC TCAACTTTAA CACTAAAAAA TAAAATCGAA 1140

GCACGTCTTC CAGTTAATAA AAGAGATCTG TGTCTCGCAA AAAATCCGAC CGCAGAAACG 1200

AAAACTCCGC AGCCTGAACA AAAGCCGGCC GAAAGCAACC GGAAGCAGAG GCAGCCGGAT 1260

TTCCCTGGGA GTAGTCGAAA ATCCGAGTCG TCGAACCCAA ACCCTATCGC GTTTCCAAAT 1320

ATGTGGCGCG TCCCGGAAGT GCCCCTGAAG AGCGGCCTAG AGCACAGGTG TCCCAGTTTC 1380

GAACCTCCTG GCGGGTCTAT TTCAAAACAG TCACCACCCT CCGAAGCGGT TCCATCGAAG 1440

CCGGAGTCCA AGCTCACTTG CGGCACGCCG AGTAGTCGAA CGGTGGATGA CTATATGGCC 1500

TGTTTTCGAA CTCCTGTGGT GAAGAGCGTC TTCCCTTCGG GGGGCCCGAT TTCCACCCCT 1560

TTCAAGCAGC CTTCCCTCCT CCAGACCCAG ACCCCGGCGA CTCCGTTCCA GAGTTTTCAG 1620

GTTCCACCAT CATTTTCATC AAATGAATGC ATTACAGTGA AAGGAAGAAT GTATTCGATA 1680

TTGAAACAGA TAGGAAGCGG AGGTTCAAGT AAGGTGTTTC AAGTCTTGAA TGACAAGAAG 1740

CAGATATACG CCATCAAGCA CGTGAACTTA GAAGAAGCAG ACCATCAAAC AATCGAGAGC 1800

TATCAGAATG AAATTGCTCA CTTGAAGAAA CTACAACCCC ATAGCGATAA GATCATCCGC 1860

CTTTATGACT TTGAAATCAC TGACCAACAT ATCTACATGG TAATGGAATG TGGAAATATT 1920

GACCTGAATA GTTGGCTCAG AAAGAAAAAG ACAATCAACA CCTGGGAACG GAAGAGCTAC 1980

TGGGAAAATA TGTTGGAAGC TGTTCATACG ATCCACCAGC ACGGCATCGT ACACAGCGAT 2040

CTGAAGCCGG CTAACTTCCT GATAGTCGAT GGAATGTTAA AGCTCATCGA TTTTGGCATC 2100

GCAAACCAAA TGCAGCCAGA TGTGACTAGC ATCGTCAAAG ATTCCCAGGT CGGCACTGTG 2160

AATTACATGC CTCCGGAGGC GATCAAAGAT ATGTCTTCCT CCCGGGAGGC TGGGAAATCC 2220

AAATCGAAGA TCAGCCCCAA GAGTGACGTC TGGTCGCTGG GGTGCATTCT CTACTGTATG 2280

ACCTACGGGA AGACTCCGTT TCAGCATATA ACCAATCAGA TCACGAAATT GCACGCTATC 2340

ATCGATCCCA GTTACGAAAT AGAATTTCCC GATATTGCAG AAAAAGATCT GCAGGATGTA 2400

CTAAAGCGTT GTTTGATTAG GAATCCTAAA GACCGAATAT CAATTCCTGA ACTCCTGACC 2460

CATCCTTATG TTCACATTCA AACGCAGGCC CAGCCAGACG GTCACATCTC TCAGGAGACG 2520

TCCGAGGAAA TGAAACGGGT CCTGGGCCAG CTCGTCGGTC TGAATTCTCC TAACTCCGTT 2580

TTAAGAGCGG CCAAGACTTT ATACGAGCAG TGCAATCGCA GGGAAAGCCG CGATGTATCT 2640

TCACCGGCGA GACGCTCGGA TCGGAAGTGG AAAAACAAGT GA 2682

Domain Profile

S: 1     yeilkklGsGGsskvfkvksekkrvyalkvvdleaaddqtidgykneielleklqdqs.k  59

         y+ilk++GsGGsskvf+v+++kk++ya+k+v+le+ad+qti++y+nei+ l+klq +s k

Q: 558   YSILKQIGSGGSSKVFQVLNDKKQIYAIKHVNLEEADHQTIESYQNEIAHLKKLQPHSdK  617

         99********************************************************9*

S: 60    virlydyeledsllylvmecGdidlnkilkkkksiepdyelvsyykemleavkvihqhGi  119

         +irlyd+e++d+++y+vmecG+idln++l+kkk+i+  +e++sy+++mleav++ihqhGi

Q: 618   IIRLYDFEITDQHIYMVMECGNIDLNSWLRKKKTINT-WERKSYWENMLEAVHTIHQHGI  676

         ************************************9.**********************

S: 120   vhsdlkPanfllvdGilklidfGianavaedttsivkesqvGtvnylaPealkdmsssqs  179

         vhsdlkPanfl+vdG+lklidfGian++++d tsivk+sqvGtvny++Pea+kdmsss

Q: 677   VHSDLKPANFLIVDGMLKLIDFGIANQMQPDVTSIVKDSQVGTVNYMPPEAIKDMSSS--  734

         **********************************************************..

S: 180   sereaekskikvsrksdvwslGcilylllygktPfgsirnqvskllaiinPdveiefPei  239

           rea+ksk+k+s+ksdvwslGcily ++ygktPf++i nq++kl+aii+P+ eiefP+i

Q: 735   --REAGKSKSKISPKSDVWSLGCILYCMTYGKTPFQHITNQITKLHAIIDPSYEIEFPDI  792

         ..**********************************************************

S: 240   tsniekslvellkaclkrnPkkrisvdellsspfv  274

         +   ek+l+++lk cl rnPk+ris++ell++p+v

Q: 793   A---EKDLQDVLKRCLIRNPKDRISIPELLTHPYV  824

         *...*****************************96

Domain Sequence
(FASTA)

YSILKQIGSG GSSKVFQVLN DKKQIYAIKH VNLEEADHQT IESYQNEIAH LKKLQPHSDK 60

IIRLYDFEIT DQHIYMVMEC GNIDLNSWLR KKKTINTWER KSYWENMLEA VHTIHQHGIV 120

HSDLKPANFL IVDGMLKLID FGIANQMQPD VTSIVKDSQV GTVNYMPPEA IKDMSSSREA 180

GKSKSKISPK SDVWSLGCIL YCMTYGKTPF QHITNQITKL HAIIDPSYEI EFPDIAEKDL 240

QDVLKRCLIR NPKDRISIPE LLTHPYV 267

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR011990	; TPR-like_helical.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013