EKS-ORA-00211

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00211

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	385.6	1.0E-115	59	310	252

Status

Unreviewed

Ensembl Protein

ENSOANP00000002264

UniProt Accession

F7GE34;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK1

Gene Synonyms/Alias

MARK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000001429	ENSOANP00000002264	ENSOANT00000002265

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

793

Protein Sequence
(FASTA)

MSARTPLPTV NERDTENHTS VDGYTEPHIQ PTKSSRQNVP RCRNSIASTT DEQPHIGNYR 60

LLKTIGKGNF AKVKLARHVL TGREVAVKII DKTQLNPTSL QKLFREVRIM KILNHPNIVK 120

LFEVIETEKT LYLVMEYASG GEVFDYLVAH GRMKEKEARA KFRQIVSAVQ YCHQKCIVHR 180

DLKAENLLLD ADMNIKIADF GFSNEFTIGN KLDTFCGSPP YAAPELFQGK KYDGPEVDVW 240

SLGVILYTLV SGSLPFDGQN LKELRERVLR GKYRIPFYMS TDCENLLKKL LVLNPVKRGS 300

LAQIMKDRWM NVGHEEEELK PYLEPEPDFN DTKRIDIMVT MGFSREEINE SLINQKYNEV 360

MATYLLLGRK PPEFEGSESM SSGNLCLRSR PSSDLNNSSI QSPAHLKVQR SISANQKQRR 420

FSDHAGPAIP PAVSYTKRSQ ANSVESEQKE EWDKDVSRKL SSTTVGSKGE MAVSPLVGPE 480

RKKSTIPSNN VFPGGGMTRR NTYVCERTTD RYSVIQNGKD SSLMEMSVSG TPSAGSAVAS 540

AIPSTRPRHQ KSMSASGHPI KVTLPTIKDG TEAYRPGATQ RAPAASPSAH SISTSTPDRT 600

RFPRGSSSRS TFHGEQLRER RNATYNGPPA SPSHETGAFS HARRGTSTGI ISKITSKFVR 660

RDPSEGEASG RTDTSRSTSG EPKEREKEDT KDSKPRSLRF TWSMKTTSSM DPNDMMREIR 720

KVLDANNCDY EQKERFLLFC VHGDARQDSL VQWEMEVCKL PRLSLNGVRF KRISGTSIAF 780

KNIASKIANE LKL 793

Nucleotide Sequence
(FASTA)

ATGTCGGCCC GGACGCCATT GCCAACGGTG AACGAGCGGG ATACGGAGAA CCATACATCT 60

GTGGATGGAT ACACCGAACC ACACATCCAG CCTACAAAAT CAAGTAGGCA AAATGTCCCC 120

CGGTGTAGAA ACTCCATTGC ATCAACAACA GATGAGCAAC CTCACATTGG CAATTATCGT 180

TTGCTAAAAA CGATAGGAAA AGGAAACTTT GCAAAGGTGA AATTAGCAAG ACATGTTCTT 240

ACAGGTAGAG AGGTTGCTGT GAAAATAATA GATAAGACTC AGCTAAATCC TACCAGTCTA 300

CAAAAATTGT TTCGAGAGGT ACGAATAATG AAGATATTGA ATCATCCCAA TATAGTGAAA 360

CTATTTGAAG TTATTGAAAC GGAGAAGACA CTATATTTAG TAATGGAGTA TGCTAGTGGA 420

GGAGAAGTAT TTGATTACTT AGTTGCCCAT GGAAGAATGA AAGAGAAAGA GGCTCGTGCA 480

AAATTTAGGC AGATTGTGTC TGCTGTACAG TACTGTCATC AGAAGTGCAT TGTTCATCGT 540

GATCTTAAGG CAGAAAACCT TCTCCTGGAT GCGGACATGA ATATAAAAAT AGCAGACTTT 600

GGTTTTAGTA ATGAATTTAC TATTGGAAAC AAATTGGACA CTTTCTGTGG AAGCCCACCC 660

TATGCTGCTC CTGAACTTTT CCAAGGAAAG AAATATGATG GACCAGAAGT GGATGTATGG 720

AGCCTTGGAG TCATTCTTTA TACATTAGTC AGTGGGTCAC TGCCATTTGA TGGGCAGAAT 780

CTAAAGGAAT TACGGGAACG AGTCTTACGA GGAAAATATC GTATTCCATT TTATATGTCC 840

ACAGACTGTG AAAATCTTCT CAAAAAATTA TTGGTACTGA ATCCTGTAAA ACGAGGGAGC 900

TTAGCACAAA TAATGAAAGA TCGGTGGATG AATGTTGGTC ATGAAGAAGA AGAATTAAAG 960

CCATATCTTG AGCCCGAGCC AGATTTCAAT GATACAAAAC GAATAGACAT TATGGTCACT 1020

ATGGGTTTTT CAAGGGAGGA GATAAATGAA TCATTAATAA ATCAGAAATA TAATGAAGTC 1080

ATGGCTACTT ACCTGCTTTT GGGTAGAAAA CCACCTGAAT TTGAAGGAAG TGAGTCTATG 1140

TCCAGTGGTA ACCTGTGCCT AAGATCCCGA CCCAGCAGTG ATCTCAACAA CAGTTCGATT 1200

CAGTCTCCTG CTCACCTGAA GGTCCAACGG AGTATATCCG CAAATCAGAA GCAACGACGT 1260

TTCAGTGATC ATGCCGGTCC AGCCATCCCT CCTGCTGTAT CGTATACAAA AAGGTCCCAG 1320

GCAAACAGCG TGGAGAGTGA GCAGAAAGAG GAATGGGACA AAGACGTATC ACGTAAACTT 1380

AGCAGCACTA CAGTTGGATC CAAAGGGGAG ATGGCCGTAA GTCCTCTTGT AGGACCAGAA 1440

AGAAAAAAGT CTACAATTCC AAGCAACAAT GTATTTCCTG GTGGTGGCAT GACTAGAAGG 1500

AACACATATG TATGTGAACG TACTACTGAT CGCTATTCAG TAATACAGAA TGGAAAAGAT 1560

AGCAGTCTGA TGGAAATGTC TGTAAGTGGC ACCCCTTCCG CAGGCTCTGC TGTTGCTTCA 1620

GCTATACCCT CCACTCGACC TCGACACCAG AAGTCCATGT CTGCCTCCGG TCATCCAATA 1680

AAAGTTACCT TGCCAACCAT CAAAGATGGC ACTGAAGCTT ACCGACCAGG TGCAACTCAG 1740

AGAGCGCCTG CTGCTTCCCC ATCTGCTCAT AGTATTAGCA CGTCTACTCC AGACCGAACC 1800

CGATTTCCTC GTGGGAGTTC CAGTCGAAGC ACTTTTCATG GTGAGCAGCT CCGAGAACGA 1860

CGCAATGCTA CTTATAATGG ACCACCTGCC TCACCGTCAC ATGAAACTGG TGCATTTTCA 1920

CATGCCAGGA GGGGGACGTC AACTGGTATA ATAAGCAAAA TTACTTCCAA GTTTGTCCGC 1980

AGGGATCCAA GTGAAGGCGA AGCCAGTGGC AGAACTGACA CCTCAAGGAG TACTTCTGGG 2040

GAACCAAAAG AAAGGGAGAA GGAGGACACT AAAGATTCAA AGCCTCGTTC CTTGCGATTC 2100

ACTTGGAGCA TGAAGACCAC CAGTTCCATG GACCCCAATG ACATGATGAG AGAGATCCGA 2160

AAAGTATTAG ATGCAAATAA CTGCGATTAT GAACAAAAGG AAAGGTTTTT GCTTTTCTGC 2220

GTCCATGGTG ATGCCCGACA GGATAGCCTC GTTCAGTGGG AGATGGAAGT CTGCAAGTTG 2280

CCCCGATTGT CACTCAACGG AGTCCGCTTC AAAAGAATAT CCGGGACTTC TATTGCATTT 2340

AAGAACATTG CATCCAAAAT CGCAAATGAG CTTAAGCTGT AA 2382

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 59    YRLLKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  118

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 119   VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIV  178

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 179   HRDLKAENLLLDADMNIKIADFGFSNEFTIGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  238

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+klLv +p kR

Q: 239   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPVKR  298

         ************************************************************

S: 241   atieeilkhewl  252

          ++ +i+k++w+

Q: 299   GSLAQIMKDRWM  310

         ***********8

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH VLTGREVAVK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKCIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTI GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KLLVLNPVKR 240

GSLAQIMKDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0070300	; F:phosphatidic acid binding
GO:0005546	; F:phosphatidylinositol-4,5-bisphosphate binding
GO:0001786	; F:phosphatidylserine binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013