EKS-ORA-00134
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00134
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/RSK368.42.6E-11044305262
StatusUnreviewed
Ensembl ProteinENSOANP00000003529
UniProt AccessionF6TPX7;
Protein Name
Protein Synonyms/Alias
Gene NameRPS6KB1
Gene Synonyms/Alias RPS6KB1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000002226ENSOANP00000003529ENSOANT00000003530
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length478
Protein Sequence
(FASTA)
GQISESMDHG GVGPYELGME HCEKFEISET SVNRGPEKIR PECFELLRVL GKGGYGKVFQ 60
VRKVTGANTG KIFAMKVLKK AMIVRNAKDT AHTKAERNIL EEVKHPFIVD LIYAFQTGGK 120
LYLILEYLSG GELFMQLERE GIFMEDTACF YLAEISMALG HLHQKGIIYR DLKPENIMLN 180
HQGHVKLTDF GLCKESIHDG TVTHTFCGTI EYMAPEILMR SGHNRAVDWW SLGALMYDML 240
TGAPPFTGEN RKKTIDKILK CKLNLPPYLT QEARDLLKKL LKRNAASRLG AGPGDAGEVQ 300
AHPFFRHINW EELLARKVEP PFKPLLQSEE DVSQFDSKFT RQTPVDSPDD STLSESANQV 360
FLGFTYVAPS VLESVKEKFS FEPKIRSPRR FIGSPRTPVS PVKFSPGDFW GRGASASTVT 420
TQPPVEYPME TSGIEQMDVT TSGEASAPLP IRQPNSGPYK KQAFPMISKR PEHLRMNL 478
Nucleotide Sequence
(FASTA)
GGTCAGATAA GTGAAAGTAT GGACCATGGA GGAGTCGGAC CATATGAATT GGGCATGGAG 60
CATTGTGAAA AATTTGAAAT CTCAGAAACG AGTGTGAACA GAGGGCCAGA AAAAATCAGA 120
CCGGAATGCT TTGAACTACT TCGCGTACTT GGTAAAGGGG GCTATGGAAA GGTTTTCCAA 180
GTACGTAAAG TAACAGGAGC TAATACTGGG AAAATATTTG CCATGAAGGT GCTTAAAAAG 240
GCGATGATAG TAAGAAATGC AAAAGATACA GCCCATACAA AAGCAGAGAG AAATATCCTG 300
GAGGAAGTGA AGCATCCCTT CATTGTGGAT TTAATTTATG CCTTTCAGAC TGGTGGAAAA 360
CTCTACCTCA TTCTTGAGTA TCTCAGTGGA GGCGAACTAT TTATGCAGTT AGAAAGAGAG 420
GGAATATTTA TGGAAGACAC AGCCTGCTTT TACTTGGCAG AAATCTCCAT GGCTTTGGGG 480
CACTTACATC AAAAAGGGAT CATCTACCGA GACCTGAAGC CGGAAAATAT CATGCTTAAT 540
CACCAAGGTC ATGTAAAATT GACAGACTTT GGACTATGCA AAGAATCTAT TCACGACGGA 600
ACGGTCACGC ACACGTTCTG TGGAACAATA GAATACATGG CCCCTGAAAT CTTGATGAGA 660
AGTGGCCATA ACCGTGCTGT GGACTGGTGG AGTTTGGGGG CATTAATGTA TGACATGCTG 720
ACTGGAGCAC CCCCATTCAC TGGGGAGAAC AGAAAGAAAA CAATTGACAA AATACTCAAA 780
TGTAAACTCA ATTTGCCTCC CTACCTCACA CAAGAAGCTC GAGATCTGCT GAAAAAGCTG 840
CTAAAAAGGA ATGCTGCTTC TCGACTTGGA GCTGGCCCTG GGGATGCTGG AGAAGTTCAG 900
GCTCATCCTT TCTTCAGACA CATTAACTGG GAAGAACTGT TGGCTCGGAA GGTGGAGCCT 960
CCCTTTAAAC CTCTGTTGCA ATCCGAAGAA GATGTGAGCC AGTTTGATTC AAAGTTTACA 1020
CGTCAAACAC CTGTTGACAG CCCAGATGAC TCAACTCTCA GTGAAAGTGC CAACCAGGTC 1080
TTTCTGGGTT TTACATATGT GGCTCCATCT GTACTGGAAA GCGTGAAAGA GAAGTTTTCA 1140
TTTGAACCAA AAATTCGATC TCCTCGTAGA TTCATTGGCA GCCCTAGGAC ACCAGTCAGC 1200
CCTGTCAAGT TTTCTCCTGG AGACTTCTGG GGAAGAGGTG CTTCCGCCAG CACGGTGACG 1260
ACGCAGCCAC CTGTGGAGTA TCCCATGGAG ACTAGCGGAA TAGAACAAAT GGACGTGACG 1320
ACGAGCGGAG AGGCATCGGC ACCCCTTCCG ATCCGCCAGC CTAACTCTGG GCCCTACAAA 1380
AAACAAGCCT TTCCCATGAT CTCCAAACGG CCGGAGCACC TGCGCATGAA TCTATGA 1437
Domain Profile
S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58
         fell+vlgkG+ygkvf+vrkv++ +tgk++a+Kvlkka +v+  k++++tk+er+iLeev
Q: 44    FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRnaKDTAHTKAERNILEEV  103
         89***********************************9999999****************
S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118
         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f+e++a+f+lae+++al +lH
Q: 104   KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH  163
         ************************************************************
S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178
         +kg++yrDLkpeNi+l+++ghvkltDfgl+ke+i ++++ +++fcgT+ey+aPe+l+r+g
Q: 164   QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESI-HDGTVTHTFCGTIEYMAPEILMRSG  222
         *********************************9.9999999******************
S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238
         +++avD+wslG+l+y+mLtG++Pftge+rk+t+++ilk+k  l+lp +  l++ea+dl+k
Q: 223   HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK--LNLPPY--LTQEARDLLK  278
         ****************************************..9*****..**********
S: 239   klLkkdpakRlga...taeeikehkfl  262
         klLk++ a+Rlga   +a e+++h+f+
Q: 279   KLLKRNAASRLGAgpgDAGEVQAHPFF  305
         *************9*9*********97
Domain Sequence
(FASTA)
FELLRVLGKG GYGKVFQVRK VTGANTGKIF AMKVLKKAMI VRNAKDTAHT KAERNILEEV 60
KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL FMQLEREGIF MEDTACFYLA EISMALGHLH 120
QKGIIYRDLK PENIMLNHQG HVKLTDFGLC KESIHDGTVT HTFCGTIEYM APEILMRSGH 180
NRAVDWWSLG ALMYDMLTGA PPFTGENRKK TIDKILKCKL NLPPYLTQEA RDLLKKLLKR 240
NAASRLGAGP GDAGEVQAHP FF 262
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00147
EKS-ANC-00148
EKS-BOT-00154
EKS-CAE-00124
EKS-CAJ-00159
EKS-CAF-00162
EKS-CAP-00155
EKS-CHH-00022
EKS-DAR-00441
EKS-DIO-00085
EKS-DRM-00075
EKS-EQC-00153
EKS-FEC-00145
EKS-GAM-00080
EKS-GAG-00132
EKS-GAA-00182
EKS-GOG-00154
EKS-HOS-00160
EKS-ICT-00151
EKS-LAC-00164
EKS-LOA-00154
EKS-MAM-00153
EKS-MEG-00122
EKS-MOD-00155
EKS-MUM-00159
EKS-MUP-00159
EKS-MYL-00163
EKS-NOL-00148
EKS-OCP-00101
EKS-ORN-00191
EKS-ORL-00181
EKS-OTG-00160
EKS-PAT-00145
EKS-PES-00137
EKS-POA-00151
EKS-PTV-00145
EKS-RAN-00152
EKS-SAH-00149
EKS-SOA-00029
EKS-SUS-00135
EKS-TAG-00183
EKS-TAR-00200
EKS-TEN-00192
EKS-TUT-00147
EKS-VIP-00075
EKS-XET-00143
EKS-XIM-00184
EKS-SCP-00040
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0071363; P:cellular response to growth factor stimulus
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0045931; P:positive regulation of mitotic cell cycle
GO:0045948; P:positive regulation of translational initiation
GO:0043491; P:protein kinase B signaling cascade
GO:0031929; P:TOR signaling cascade
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016238; Ribosomal_S6_kinase.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013