EKS-ORA-00353

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00353

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	195.0	2.7E-57	710	942	233

Status

Unreviewed

Ensembl Protein

ENSOANP00000003631

UniProt Accession

F7AKL5;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

PDGFRB

Gene Synonyms/Alias

PDGFRB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000002294	ENSOANP00000003631	ENSOANT00000003632

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

1081

Protein Sequence
(FASTA)

LSPEGTLPLP SLGSQAVWIP LRGSVPPAGS WGLVITPGDP EIILNVSSTF SLTCSGAEAP 60

VAWERGPQLL PAPPSVRQDD GTFVSTLTLE NVTGLDSGEY SCSQGLEPAI KRRVYVFVPD 120

PSLVFLPAPL EDLFIFLAGD GEATIPCRVT DPGLVVTLYE KKVDIPLPVP YDPHRGFTGL 180

FEDKTYICRA TVGDGEVDSD TYYIYRIQVS TINVSMSAVQ TVVRQGENIT VMCTARGSEV 240

INFDWAYPRK ESGRPVNLVT DFLSGTAYDI RSILHIPSAE LGDSGTYICN VSEGYGDHRD 300

VKDINITVVA QGFMHLHTEL GSTEFAELHK SCELQVQVEA YPQPTILWLK DNKTLSQGNA 360

NEISISNRNL SETRYESTLT LVRVKVNEGG RYTLRAFHDD DVQEFSFHLQ INVPAKVVEL 420

TESHPSSGEQ ILTCRSQGMP QPQVTWFTCS DFKSCAQARH PSPSPQPATE EAQQVPSRIR 480

YATPPPPAIP RLPSPQFPTL SQSLAFRCHP APNHHSDPYS TDVIDQSLPF KVVVISAILA 540

LVVLTVISLV ILIVLWQKVS TGSETVPSGT QSSTEIVYVQ WGQEGKHRFS WQPQKELTLI 600

REHETSGSAQ LLLGKKWEKT SETKASSPPL ASPLSPSLPS PATARSSEKQ ALMSELKIMS 660

HLGPHLNIVN LLGACTKGGR LPLPPHPPSP GPPLPPFGVI PEAFPGPLGL EPHTSLSLES 720

DGGYMDMSKD DSVDYVPMLS MKGEIKYADL ETSNYVTPYD SYNPADPHGP TPERTFRATL 780

VNESPLLSYM DLVGFSYQVA NGMEFLASKN CVHRDLAARN VLICEGKLVK ICDFGLARDI 840

MRDSNYISKG SVSHSSAPAS RSPSWARSRA SRPSHGFFIW RLVSLTHLPL PALRHLRTYL 900

RFIYTKYRRL TDSHLFSYEV MQKCWEEKFE IRPSFSQLVL LLEGLLGEGY KKRYQQVDEE 960

FLRSEHPAVL RIRPQLPGLG RPGAPPDTGS VLYTAVRGNG GENNYIIPLP DPKPEGGSHD 1020

DLPPDGSHSL ASSTLNEVNT SSTISCDSPL EPQEEPEPEP EVEAAGQPQP GLPAEVEDSF 1080

L 1081

Nucleotide Sequence
(FASTA)

CTCTCGCCCG AGGGGACTCT GCCCCTCCCA AGCTTGGGTT CCCAGGCTGT TTGGATCCCA 60

CTGAGAGGGT CCGTCCCGCC TGCAGGCAGC TGGGGTCTGG TTATCACTCC TGGGGACCCT 120

GAGATCATCC TCAACGTGTC CAGCACCTTT TCTCTGACCT GTTCGGGGGC TGAGGCCCCG 180

GTGGCGTGGG AACGGGGGCC GCAGCTCCTG CCCGCTCCCC CATCCGTCCG CCAGGACGAC 240

GGCACCTTTG TCAGCACCTT GACTCTGGAG AACGTCACGG GGCTGGACAG CGGAGAATAC 300

AGCTGCTCCC AGGGCCTGGA ACCTGCCATC AAACGGCGAG TCTATGTCTT TGTGCCAGAC 360

CCTTCGCTGG TTTTCCTCCC CGCTCCCCTG GAGGATCTGT TCATCTTCCT GGCTGGAGAC 420

GGAGAGGCCA CCATCCCGTG CCGGGTGACG GACCCCGGCC TCGTGGTCAC CCTGTATGAG 480

AAGAAGGTGG ATATCCCGCT GCCCGTCCCC TACGATCCCC ATCGTGGCTT TACGGGCCTC 540

TTCGAGGACA AGACCTACAT CTGCAGGGCC ACCGTCGGCG ACGGGGAGGT GGACTCGGAT 600

ACCTACTACA TCTACCGGAT CCAAGTGTCC ACCATCAATG TGTCCATGAG CGCGGTCCAG 660

ACGGTGGTGC GACAGGGAGA GAACATCACA GTCATGTGCA CTGCCAGGGG GAGCGAGGTC 720

ATCAACTTCG ACTGGGCCTA TCCCCGGAAG GAGAGCGGAA GGCCGGTCAA CCTAGTGACG 780

GACTTCCTGT CGGGGACGGC TTACGACATC CGCTCCATCC TGCACATCCC TAGCGCTGAG 840

CTGGGGGACT CGGGCACCTA CATCTGCAAC GTCTCCGAGG GCTACGGCGA CCACAGAGAC 900

GTGAAAGACA TCAACATCAC CGTGGTTGCA CAGGGCTTCA TGCATCTGCA CACGGAGCTG 960

GGCAGCACAG AGTTTGCCGA GCTGCACAAG AGCTGCGAGC TGCAGGTGCA GGTGGAGGCC 1020

TATCCACAGC CCACCATCCT GTGGCTCAAA GACAACAAGA CCCTCAGCCA GGGAAACGCC 1080

AACGAGATCT CCATCTCCAA CAGGAACCTG TCGGAAACCA GGTACGAGTC GACCCTGACC 1140

CTGGTGCGGG TGAAGGTGAA CGAGGGCGGC CGCTACACCC TGCGAGCTTT CCACGATGAT 1200

GATGTCCAGG AATTCTCCTT TCACCTGCAG ATCAACGTGC CAGCCAAGGT GGTGGAGCTT 1260

ACCGAGAGCC ACCCCAGCAG CGGCGAGCAG ATCCTGACGT GTCGCTCCCA GGGAATGCCC 1320

CAGCCTCAAG TCACCTGGTT CACCTGCAGC GACTTCAAGA GCTGCGCACA AGCACGGCAT 1380

CCCAGTCCTA GCCCTCAACC TGCAACAGAG GAGGCTCAGC AAGTCCCTTC AAGAATAAGG 1440

TACGCAACCC CCCCCCCCCC CGCCATTCCC CGCCTTCCCA GTCCTCAGTT TCCCACCCTT 1500

TCCCAGTCAC TGGCATTCCG CTGCCACCCC GCTCCCAACC ATCACTCAGA CCCATATAGC 1560

ACAGACGTAA TCGATCAGTC TCTGCCCTTT AAGGTGGTGG TAATCTCAGC CATCCTGGCC 1620

CTGGTGGTCC TCACCGTCAT CTCCCTGGTG ATCCTGATCG TGCTGTGGCA GAAGGTAAGT 1680

ACCGGCTCTG AGACTGTGCC CTCGGGGACA CAGTCCTCCA CAGAGATAGT ATACGTACAA 1740

TGGGGACAAG AGGGAAAACA TAGATTCAGC TGGCAACCGC AAAAGGAACT CACCCTCATC 1800

CGAGAGCATG AGACTTCTGG CTCTGCCCAG CTGCTCCTGG GGAAGAAATG GGAAAAAACC 1860

TCCGAGACGA AAGCCTCCTC GCCTCCCTTG GCCTCACCCT TATCCCCGTC CCTTCCGTCC 1920

CCAGCCACCG CCAGGAGCAG TGAGAAGCAG GCCCTCATGT CGGAATTGAA GATCATGAGC 1980

CACCTGGGGC CCCACCTGAA TATCGTCAAC CTGCTGGGAG CCTGCACCAA AGGAGGTAGA 2040

CTCCCCCTGC CTCCCCACCC TCCCAGCCCG GGACCTCCCT TGCCCCCCTT CGGGGTCATC 2100

CCAGAAGCCT TCCCAGGCCC CCTCGGCTTG GAGCCCCACA CATCGCTGTC CTTGGAGAGC 2160

GACGGGGGCT ACATGGACAT GAGCAAGGAC GACTCAGTGG ACTACGTGCC CATGCTGAGC 2220

ATGAAGGGGG AGATCAAGTA CGCCGACCTC GAGACCTCCA ACTACGTGAC CCCCTATGAC 2280

AGTTACAACC CTGCAGACCC CCATGGGCCA ACTCCTGAGA GGACCTTCAG GGCCACCCTG 2340

GTCAATGAGT CTCCCCTCCT CAGCTACATG GATCTGGTGG GCTTTAGTTA CCAAGTGGCC 2400

AATGGCATGG AATTCCTCGC CTCCAAGAAC TGCGTCCACC GAGATCTGGC TGCCAGGAAC 2460

GTGCTGATCT GCGAGGGGAA ACTGGTCAAG ATCTGTGACT TTGGCCTGGC TCGGGACATC 2520

ATGAGAGACT CCAACTACAT CTCCAAGGGC AGCGTGAGTC ACTCGTCTGC CCCTGCCTCC 2580

CGCTCACCTT CCTGGGCCAG GAGTAGGGCC AGTAGGCCCA GCCACGGGTT TTTTATTTGG 2640

AGACTTGTTT CCTTGACTCA TCTTCCCCTC CCAGCCCTAC GGCACTTACG TACATACCTG 2700

CGATTTATTT ATACTAAGTA CCGTCGACTG ACTGACTCCC ATCTCTTCAG CTACGAGGTC 2760

ATGCAGAAAT GCTGGGAGGA GAAGTTTGAG ATCCGACCTT CCTTTTCCCA GCTGGTGCTG 2820

CTCTTGGAAG GTCTCCTGGG GGAGGGCTAC AAGAAGAGAT ACCAGCAGGT GGACGAAGAG 2880

TTTCTGAGAA GCGAACACCC CGCCGTGCTC CGGATCCGCC CCCAGCTCCC CGGCCTGGGC 2940

CGTCCCGGGG CCCCTCCGGA CACCGGCTCG GTTCTCTACA CGGCCGTGCG GGGGAACGGG 3000

GGCGAGAACA ACTACATCAT CCCCCTGCCC GACCCCAAGC CCGAGGGCGG CAGCCATGAC 3060

GACCTGCCCC CGGACGGCTC CCACAGCCTC GCCAGCTCCA CCCTGAATGA GGTCAATACG 3120

TCCTCCACCA TTTCCTGCGA CAGCCCTCTG GAGCCCCAGG AAGAGCCAGA GCCGGAACCG 3180

GAGGTGGAGG CGGCAGGCCA GCCGCAGCCC GGGCTACCGG CGGAGGTGGA GGACAGTTTC 3240

CTGTAG 3246

Domain Profile

S: 127   lrsksslssesseeyvdlkkd................vsdvssskadklasekkks....  166

         l+ ++sls es++ y+d++kd                ++d+++s++ +++++++

Q: 710   LEPHTSLSLESDGGYMDMSKDdsvdyvpmlsmkgeikYADLETSNYVTPYDSYNPAdphg  769

         677999*******************************99999999999998876542222

S: 167   .alerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkv  225

          + er+ +a+l +e s  l+++dl+ fsyqva+Gmeflaskncvhrdlaarnvl++eGk+

Q: 770   pTPERTFRATLVNE-SPLLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKL  828

         2689********99.99*******************************************

S: 226   vkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifsl  285

         vkicdfGlardim+dsny++kG+        ap s   s    ++   s+G ++w + sl

Q: 829   VKICDFGLARDIMRDSNYISKGSVS---HSSAPASRSPSWARSRASRPSHGFFIWRLVSL  885

         ***********************94...678*****************************

S: 286   GstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344

            p p l    ++ + i + yr    ++  +  ye+mqkcwe+++e rpsf+qlv ll

Q: 886   THLPLPALRHLRTYLRFIYTKYRRLTDSHLFS--YEVMQKCWEEKFEIRPSFSQLVLLL  942

         ***********************999999875..*********************9986

Domain Sequence
(FASTA)

LEPHTSLSLE SDGGYMDMSK DDSVDYVPML SMKGEIKYAD LETSNYVTPY DSYNPADPHG 60

PTPERTFRAT LVNESPLLSY MDLVGFSYQV ANGMEFLASK NCVHRDLAAR NVLICEGKLV 120

KICDFGLARD IMRDSNYISK GSVSHSSAPA SRSPSWARSR ASRPSHGFFI WRLVSLTHLP 180

LPALRHLRTY LRFIYTKYRR LTDSHLFSYE VMQKCWEEKF EIRPSFSQLV LLL 233

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005019	; F:platelet-derived growth factor beta-receptor activity
GO:0005021	; F:vascular endothelial growth factor-activated receptor activity
GO:0060326	; P:cell chemotaxis
GO:0006807	; P:nitrogen compound metabolic process
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046488	; P:phosphatidylinositol metabolic process
GO:0048015	; P:phosphatidylinositol-mediated signaling
GO:0030335	; P:positive regulation of cell migration
GO:0038091	; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0043552	; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863	; P:positive regulation of phospholipase C activity
GO:0032516	; P:positive regulation of phosphoprotein phosphatase activity
GO:0046777	; P:protein autophosphorylation
GO:0050730	; P:regulation of peptidyl-tyrosine phosphorylation
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.
IPR009134	; Tyr_kinase_VEGFR_rcpt_N.

Pfam

PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 2.

SMARTs

SM00409	; IG; 1.
SM00408	; IGc2; 1.

Prosites

PS50835	; IG_LIKE; 4.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

PR00109	; TYRKINASE.
PR01832	; VEGFRECEPTOR.

Created Date

20-Feb-2013