EKS-ORA-00388

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00388

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	323.7	1.1E-96	1	188	188

Status

Unreviewed

Ensembl Protein

ENSOANP00000004245

UniProt Accession

F7B5F7;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000002665	ENSOANP00000004245	ENSOANT00000004246

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

1285

Protein Sequence
(FASTA)

MVMEYMPGGD LVNLMSNYDV PEKWAKFYTA EVVLALDAIH SMGLIHRDVK PDNMLLDKHG 60

HLKLADFGTC MKMDETGMVH CDTAVGTPDY ISPEVLKSQG GDGYYGRECD WWSVGVFLFE 120

MLVGDTPFYA DSLVGTYSKI MDHKNSLSFP EDAEISKHAK NLICAFLTDR EVRLGRNGVE 180

EIKQHSFFKS DQWNWDSIRE TAAPVVPELS SDIDSSNFDD IEDDKGDVET FPIPKAFVGN 240

QLPFIGFTYY RENLLLSDFP PSCRENDSIQ SRKKEDIQES VQIQKKIFML EQHLNSEIQA 300

KDEVEQKYKS VTTRLEKVTK ELEDEVTSRK NVESALRQLE REKALLQHKN AEYQRKAEHE 360

ADKKRNLEND VNSLKDQLED LKKRNQSSQI SNEKVIQLQR QLDEANALLR TESDTAARLR 420

KNQTESSKQI QQLEVNNREL QDKNCLLENA KLKLEKDFIN LQSALESEKR DRTHGSEMIS 480

DLQGRISCLE EEVKTGKSSV AKLEMEKRQL QERFTDLEKE KSNMEIDMTY KLKVIQQSLE 540

QEEAEHKATK ARLADKNKIY ESIEEAKSEA MKEMEKKLLE ERTLKQKVEN LLLEAEKRCS 600

MLDCDLKQSQ QKINELLKQK DKLNEDVKNL TLKIEQETQK RCLTQNDLKM QTQQVNTLKM 660

SEKQIKQENN HLIEIKLSLE KQNGELRKER QDADGQMKEL QDQLEAEQYF STLYKTQVRE 720

LKEECEEKIK LCKEMQQKIQ ELQDEKDSLA AQLEITLTKA DSEQLARSIA EEQYSDLEKE 780

KIMKELEIKE MMARHKQELT EKDATIGSLE EANRTLTSDV ANLANEKEEL NNKAKEIQEQ 840

ISRLKDEETS VSIIKAQYEK QLLNERTLKT QAVNKLAEIM NRKDPVKRGA DTDVRRKEKE 900

NRKLHMELKS EREKLTQMMI KYQKEMNEMQ AQIAEESQIR IELQMTLDSK DSDIEQLRSQ 960

LQTIHIGLDS SSIGSGPGEA EADDGFPVHI TQSHTMESMS FTYQRSSTSL NIATKPSGSH 1020

MLLDSDSDSE EEFLSCAPFS SESDSAESRL EGWLSLPVRN NTKKFGWVKK YVIVSSKKIL 1080

FYDSEQDKEQ SNPYMVLDID KLFHVRPVTQ TDVYRADSKE IPRIFQILYA NEGESKKEQE 1140

FPVEPVGEKS NCICHKGHEF IPTLYHFPTN CEACMKPLWH MFKPPPALEC RRCHIKCHKD 1200

HMDKKEEIIA PCKVYYDIST AKNLLLLANS TEEQQKWVSR LVKKIPKKPP APDPFARSSP 1260

RTSMKVQPNQ SIRRPSRQLP PNKPS 1285

Nucleotide Sequence
(FASTA)

ATGGTAATGG AGTATATGCC TGGTGGAGAC CTTGTGAACC TTATGAGTAA CTACGATGTG 60

CCTGAAAAAT GGGCCAAATT CTACACAGCT GAAGTCGTCC TTGCTCTTGA TGCAATTCAC 120

TCCATGGGCT TAATCCATAG GGATGTGAAG CCTGACAACA TGCTTTTGGA TAAGCATGGA 180

CATCTGAAAT TAGCAGATTT TGGCACTTGT ATGAAAATGG ATGAGACAGG CATGGTACAC 240

TGCGATACGG CTGTTGGGAC ACCTGATTAC ATATCACCTG AAGTACTGAA ATCTCAAGGA 300

GGTGATGGCT ACTATGGGCG AGAGTGTGAC TGGTGGTCTG TAGGAGTTTT CCTTTTTGAG 360

ATGCTTGTTG GGGATACTCC ATTTTATGCA GACTCGCTAG TAGGAACATA CAGCAAAATC 420

ATGGATCACA AAAACTCACT TAGCTTTCCT GAAGATGCAG AAATTTCCAA GCATGCAAAG 480

AACCTCATCT GTGCTTTCTT AACTGACAGA GAAGTGCGAC TTGGGAGAAA TGGGGTAGAA 540

GAAATCAAGC AGCATTCTTT CTTTAAGAGC GATCAATGGA ATTGGGATAG CATACGAGAA 600

ACTGCTGCTC CTGTTGTACC TGAACTCAGC AGTGATATTG ACAGCAGCAA TTTTGATGAC 660

ATTGAAGATG ATAAAGGAGA TGTAGAAACC TTTCCAATTC CCAAAGCCTT TGTGGGAAAT 720

CAACTGCCTT TTATAGGATT TACGTACTAC AGAGAAAATC TGTTGCTCAG TGACTTTCCT 780

CCATCCTGTA GAGAAAACGA TTCAATACAG TCAAGGAAAA AAGAGGATAT TCAAGAGTCT 840

GTACAGATTC AAAAAAAAAT ATTCATGTTA GAACAACACC TCAACAGTGA GATCCAAGCC 900

AAAGATGAAG TAGAACAGAA GTACAAATCT GTTACCACTC GACTGGAGAA GGTGACAAAG 960

GAGCTGGAAG ATGAGGTTAC TTCAAGGAAA AATGTGGAAT CTGCTTTGAG ACAGTTGGAA 1020

AGAGAGAAGG CACTTCTTCA GCATAAGAAT GCGGAGTACC AGCGGAAAGC AGAACATGAA 1080

GCAGATAAAA AAAGGAATCT GGAAAATGAT GTTAACAGCT TGAAAGATCA GCTTGAAGAT 1140

TTGAAAAAAA GAAATCAAAG CTCTCAGATA TCCAATGAGA AAGTCATTCA GCTTCAGAGA 1200

CAACTGGATG AAGCCAATGC TTTACTGAGA ACAGAGTCAG ATACTGCAGC CAGATTAAGG 1260

AAGAATCAAA CAGAAAGTTC AAAGCAGATT CAGCAACTGG AAGTTAACAA CAGGGAACTA 1320

CAAGACAAAA ACTGCTTGCT GGAGAATGCA AAACTTAAGC TTGAAAAAGA CTTCATCAAT 1380

CTTCAGTCAG CTCTAGAATC GGAAAAGAGA GACCGTACTC ATGGGTCGGA GATGATTAGT 1440

GATTTACAAG GTAGAATATC TTGTCTGGAG GAAGAAGTAA AAACTGGGAA AAGCTCTGTA 1500

GCAAAATTGG AAATGGAGAA GAGGCAACTA CAGGAGAGAT TTACAGATTT GGAAAAAGAA 1560

AAGAGCAATA TGGAGATAGA CATGACATAC AAATTGAAAG TTATACAGCA GAGCCTGGAA 1620

CAGGAAGAAG CTGAACATAA AGCCACAAAA GCCCGGTTAG CAGATAAGAA TAAGATCTAT 1680

GAATCTATTG AGGAGGCCAA GTCAGAAGCC ATGAAAGAAA TGGAGAAGAA ACTCTTGGAA 1740

GAAAGAACTT TAAAACAGAA AGTTGAAAAC CTTTTGTTGG AAGCTGAAAA AAGATGTTCT 1800

ATGTTGGACT GTGATCTCAA ACAGTCACAA CAGAAAATAA ATGAGCTTCT TAAGCAGAAG 1860

GATAAACTAA ATGAGGATGT TAAGAACTTG ACATTAAAAA TAGAGCAAGA AACACAGAAG 1920

CGTTGTCTTA CACAAAATGA CCTGAAAATG CAAACGCAGC AGGTCAACAC GTTGAAAATG 1980

TCAGAGAAAC AGATAAAACA AGAAAATAAC CATCTGATTG AAATAAAATT GAGCTTGGAA 2040

AAGCAAAATG GCGAGCTTCG CAAAGAACGG CAAGATGCGG ATGGGCAGAT GAAAGAGCTC 2100

CAAGATCAAC TTGAAGCTGA GCAATATTTT TCGACTCTAT ACAAAACACA AGTTCGGGAA 2160

CTTAAAGAAG AATGTGAAGA GAAGATCAAG CTTTGTAAAG AGATGCAGCA GAAGATTCAG 2220

GAATTGCAAG ATGAGAAGGA CTCCTTGGCT GCACAGCTTG AGATCACCCT GACCAAAGCC 2280

GATTCAGAGC AGCTGGCTCG TTCCATTGCT GAAGAACAGT ACTCCGATTT GGAAAAGGAG 2340

AAGATCATGA AAGAGCTGGA GATCAAAGAG ATGATGGCAA GACACAAACA GGAGCTTACT 2400

GAGAAAGATG CCACCATAGG ATCTCTTGAA GAAGCCAATA GAACACTAAC TAGTGATGTG 2460

GCTAATCTGG CAAATGAGAA AGAAGAATTG AATAACAAAG CGAAAGAAAT CCAGGAACAA 2520

ATTTCAAGAT TGAAAGATGA AGAAACAAGT GTATCCATTA TTAAGGCACA ATATGAGAAG 2580

CAACTGCTAA ATGAAAGAAC ATTGAAAACA CAGGCTGTGA ATAAATTGGC TGAGATCATG 2640

AATCGGAAGG ATCCTGTCAA ACGTGGTGCT GACACTGATG TGAGGAGGAA AGAGAAGGAG 2700

AATAGAAAGC TGCACATGGA ACTTAAATCT GAACGTGAAA AGTTAACTCA GATGATGATC 2760

AAATATCAGA AGGAGATGAA TGAAATGCAG GCCCAAATAG CCGAAGAAAG CCAGATCCGG 2820

ATCGAGTTGC AGATGACCCT GGACAGCAAG GACAGTGACA TCGAACAGCT GCGCTCCCAG 2880

CTTCAGACCA TACACATTGG CCTGGATAGC TCCAGTATTG GCAGCGGACC AGGAGAGGCA 2940

GAGGCGGATG ATGGCTTCCC AGTTCATATT ACTCAGTCAC ATACTATGGA GTCCATGTCT 3000

TTCACCTACC AGCGCTCTTC CACCTCTCTC AATATTGCCA CTAAGCCTTC TGGTTCTCAC 3060

ATGCTTCTCG ACTCTGATTC TGACTCAGAG GAAGAATTCT TGTCTTGCGC ACCCTTTTCT 3120

TCGGAATCTG ATAGTGCAGA ATCAAGATTA GAGGGATGGC TTTCATTACC TGTACGAAAT 3180

AACACTAAAA AGTTTGGATG GGTTAAAAAG TATGTGATCG TAAGCAGTAA GAAGATTCTT 3240

TTCTATGACA GTGAACAAGA TAAAGAACAA TCTAATCCTT ATATGGTATT AGATATAGAC 3300

AAATTGTTCC ATGTCCGTCC GGTCACACAG ACAGATGTAT ATAGAGCAGA TTCCAAAGAG 3360

ATTCCAAGGA TATTTCAGAT ATTATATGCT AATGAAGGGG AAAGCAAGAA GGAGCAAGAA 3420

TTTCCTGTGG AACCAGTGGG CGAAAAGTCT AACTGTATTT GCCACAAAGG ACATGAATTT 3480

ATACCCACTC TGTATCATTT TCCAACTAAC TGTGAGGCTT GTATGAAGCC GCTCTGGCAC 3540

ATGTTTAAAC CTCCTCCTGC TCTAGAGTGC CGTCGCTGCC ATATCAAATG TCATAAAGAT 3600

CACATGGATA AGAAGGAAGA GATTATAGCA CCTTGCAAAG TATATTATGA TATTTCAACG 3660

GCAAAGAATC TACTACTATT AGCCAATTCT ACAGAAGAAC AGCAGAAGTG GGTTAGTCGG 3720

TTGGTGAAAA AGATACCCAA AAAACCTCCA GCACCAGACC CTTTTGCTCG ATCATCTCCT 3780

AGAACTTCCA TGAAGGTACA GCCAAACCAG TCTATTCGAC GGCCAAGTCG ACAGCTTCCT 3840

CCAAACAAAC CAAGCTAA 3858

Domain Profile

S: 76    lvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelgyvhrdikpdnilldk  135

         +vmey++GGdl++l+s+y+  +pe++a+fy+ae+vlald++h++g++hrd+kpdn+lldk

Q: 1     MVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDK  58

         8******************..9**************************************

S: 136   sGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegkgeygkecdwwslGvi  195

         +Gh+kladfG+c+k++e+g+v++++avGtpdyispevlk+++ g+g+yg+ecdwws+Gv+

Q: 59    HGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVF  117

         *****************************************9.*****************

S: 196   lyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdlikklltsreerlgre  255

         l+e+lvg+tpfya+slv tyski++hk+sl+fped+++s++ak+li+++lt+re rlgr+

Q: 118   LFEMLVGDTPFYADSLVGTYSKIMDHKNSLSFPEDAEISKHAKNLICAFLTDREVRLGRN  177

         ************************************************************

S: 256   giedlkkhpff  266

         g+e++k+h+ff

Q: 178   GVEEIKQHSFF  188

         **********9

Domain Sequence
(FASTA)

MVMEYMPGGD LVNLMSNYDV PEKWAKFYTA EVVLALDAIH SMGLIHRDVK PDNMLLDKHG 60

HLKLADFGTC MKMDETGMVH CDTAVGTPDY ISPEVLKSQG GDGYYGRECD WWSVGVFLFE 120

MLVGDTPFYA DSLVGTYSKI MDHKNSLSFP EDAEISKHAK NLICAFLTDR EVRLGRNGVE 180

EIKQHSFF 188

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013