EKS-ORA-00426

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00426

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	413.3	3.4E-124	18	273	256

Status

Unreviewed

Ensembl Protein

ENSOANP00000004414

UniProt Accession

F7B506;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000002772	ENSOANP00000004414	ENSOANT00000004415

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

898

Protein Sequence
(FASTA)

MFPLKNAEIG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTVTH PRLCQYVDIS 60

RGKHERLVVV AEHCERNLED LLRERKPGSC SQVLQIAFEV LQGLQYMNQH GLVHRALSPH 120

NVLLDREGHV KLAKFGLYHM TAHGVDVDFP IGYPSYLAPE VIAQGVIKPG DHMPSEKPLP 180

SGPKSDVWSL GIILFELCMG RKLFHSLDIA ERLKFLLTLG CVDDTVIVLA EEHGCLDIIK 240

ELPENVMSLL KKCLTFHPSK RPTPDELLRD KMFSEVSPLY PSFHKPAGLF SPSLRCADLT 300

LPEDISQLCE DKDMKDADSD YLAERSIEEV YYLWCLAGGD LEKELVNKEI IRSKPPVCTL 360

PNFLFEDGES FGQGRDRSSL LDDTTVTLSL CQLRNRLKDV GGEVFYPLLE DDRTNLPHSN 420

SNNELSTVTT LPLIIREKDT EYQLNRIVLF DRLLKAYPYK KNQIWKEARV DIPPLMRGLT 480

WAALLGVEGA IEAKYDAIDK DTPIPTDRQI EVDIPRCHQY DELLSSPEGH AKFRRVLKAW 540

VVSHPDLVYW QGLDSLCAPF LYLNFNNEAL AYACMSAFIP KYLYNFFLKD NSHVIQEYLT 600

VFSQMIAFHD PELSNHLNEI GFIPDLYAIP WFLTMFTHVF PLHKIFHLWD TLLLGNSSFP 660

FCIGVAILQQ LRDRLLANGF NECILLFSDL PEIDIERCVR ESINLFCWTP KSVTYRQHAQ 720

PPKQTIDPSG GRNSAPYFST DFQDAPLTDL SRESIDLDDL KSEVSPRISA EDLIDLCELT 780

GLGHFKTPTK KTKSNKPKLL VVDIRNSEDF NRGHIPGSIN IPFSSALAAE GELPQGPATA 840

TLHNYRGKVI VIVGHVAKHT AAFSAHLVKH RYPRVCILDG GINKIKPTGL LTVPSPQI 898

Nucleotide Sequence
(FASTA)

ATGTTTCCCC TGAAAAATGC TGAAATTGGC GCCTTTACAT TCTTTGCCTC AGCTCTGCCT 60

CATGATGTGT GTGGGAGCAA TGGCCTTCCT CTTACGCCAA ATTCCATCAA AATCCTCGGG 120

CGTTTTCAAA TCCTCAAGAC CGTCACCCAC CCAAGACTTT GTCAGTATGT GGACATTTCT 180

AGAGGCAAAC ACGAGAGACT GGTGGTGGTA GCCGAACACT GTGAAAGGAA TCTGGAAGAC 240

TTACTGCGAG AGAGGAAACC TGGAAGCTGC TCGCAGGTCC TGCAAATCGC ATTTGAGGTC 300

CTCCAGGGCT TGCAGTACAT GAACCAACAC GGCCTGGTTC ACCGTGCACT GTCTCCTCAC 360

AACGTCCTCT TGGACCGAGA GGGACATGTT AAATTGGCTA AATTTGGACT TTACCACATG 420

ACAGCCCATG GCGTTGATGT TGATTTTCCT ATAGGGTACC CATCATATCT GGCACCCGAA 480

GTAATTGCCC AAGGAGTCAT CAAACCTGGC GATCATATGC CAAGCGAGAA GCCGTTACCG 540

TCTGGCCCCA AATCGGACGT GTGGTCTCTC GGCATTATTT TATTTGAACT TTGCATGGGA 600

AGGAAATTAT TTCATAGCTT GGACATTGCT GAAAGGCTTA AGTTTCTACT AACATTAGGC 660

TGCGTGGATG ATACTGTGAT TGTCCTGGCT GAAGAACATG GATGCCTAGA CATCATAAAG 720

GAGCTCCCTG AAAATGTGAT GAGTCTGTTG AAAAAGTGTC TCACCTTCCA TCCTTCGAAG 780

AGACCAACCC CGGATGAGTT ACTACGGGAC AAGATGTTCA GCGAAGTGTC CCCTTTGTAT 840

CCATCCTTCC ACAAACCCGC TGGTCTGTTT TCACCTTCTC TGAGATGTGC TGATTTAACT 900

CTCCCTGAGG ACATCAGTCA GCTGTGCGAA GATAAAGACA TGAAAGATGC AGATAGCGAT 960

TACCTAGCAG AACGATCCAT TGAAGAAGTT TATTACCTGT GGTGTTTAGC TGGTGGAGAC 1020

TTGGAGAAGG AGCTTGTCAA CAAGGAAATC ATTCGATCGA AACCTCCGGT CTGCACACTT 1080

CCCAATTTCC TCTTTGAAGA TGGTGAGAGC TTTGGTCAAG GACGCGATCG GAGCTCCCTG 1140

TTGGATGACA CGACTGTGAC CTTGTCGCTC TGCCAACTGA GAAATAGACT GAAAGACGTT 1200

GGTGGGGAAG TGTTTTACCC TCTGCTCGAA GATGATCGGA CTAATCTACC CCACTCAAAC 1260

AGTAATAACG AGCTGTCTAC TGTCACCACC CTCCCTCTGA TCATCCGAGA GAAGGACACG 1320

GAGTACCAAC TAAACAGAAT TGTGCTATTT GATAGACTCC TGAAGGCCTA TCCGTACAAG 1380

AAAAATCAAA TTTGGAAAGA AGCCAGAGTT GACATTCCTC CTCTCATGAG AGGGTTAACC 1440

TGGGCTGCTC TCCTGGGAGT TGAGGGTGCC ATTGAGGCCA AGTATGATGC CATTGATAAA 1500

GACACTCCAA TTCCTACAGA TAGACAGATT GAAGTTGATA TTCCTCGCTG TCATCAGTAC 1560

GATGAATTGT TGTCGTCCCC GGAAGGTCAC GCAAAGTTCA GGCGGGTATT AAAAGCCTGG 1620

GTGGTTTCCC ACCCAGATCT CGTGTACTGG CAAGGTCTTG ATTCCCTTTG CGCTCCATTC 1680

CTCTACTTAA ATTTCAACAA CGAGGCTCTG GCTTACGCTT GCATGTCAGC TTTTATCCCC 1740

AAGTATTTGT ATAACTTCTT TCTGAAAGAC AACTCACACG TCATCCAAGA ATATCTGACG 1800

GTGTTCTCTC AGATGATTGC ATTCCATGAT CCGGAGCTGA GTAATCATCT CAATGAGATT 1860

GGCTTTATTC CAGATCTTTA TGCCATTCCT TGGTTTCTCA CCATGTTTAC ACATGTCTTT 1920

CCATTGCACA AGATCTTCCA CCTCTGGGAC ACATTACTAC TGGGGAATTC CTCCTTCCCA 1980

TTCTGCATCG GAGTCGCCAT CTTACAGCAG CTACGGGACC GGCTTTTGGC CAACGGCTTT 2040

AACGAGTGCA TTCTCCTCTT CTCCGACTTA CCAGAAATTG ACATAGAACG CTGTGTCCGT 2100

GAGTCAATCA ACCTGTTTTG CTGGACTCCG AAAAGCGTGA CCTACAGGCA GCACGCACAA 2160

CCTCCAAAGC AGACCATCGA TCCCAGCGGC GGGAGAAATT CAGCGCCCTA TTTCTCGACA 2220

GATTTTCAAG ATGCTCCCTT GACAGACCTG TCACGAGAAT CCATCGACCT GGATGATCTG 2280

AAATCTGAGG TATCACCCCG AATTTCAGCC GAGGACCTGA TTGATTTGTG TGAGCTGACG 2340

GGATTGGGCC ATTTCAAAAC TCCCACCAAA AAAACCAAAT CCAACAAGCC AAAGCTGCTG 2400

GTGGTCGACA TCCGGAACAG TGAAGACTTT AATCGTGGTC ACATTCCAGG AAGCATCAAC 2460

ATTCCGTTTA GCTCAGCACT CGCGGCGGAG GGAGAACTCC CTCAGGGCCC GGCCACAGCC 2520

ACGCTGCACA ACTACAGAGG GAAAGTTATT GTCATCGTGG GACACGTGGC CAAGCACACA 2580

GCCGCGTTTT CAGCTCACCT GGTGAAGCAC AGATATCCAA GGGTTTGCAT CCTTGATGGG 2640

GGCATTAATA AGATCAAGCC AACTGGTCTT CTCACAGTTC CGTCCCCTCA GATATGA 2697

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk+++h+rLcqY+disrgkher++vvaeh+e++

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTVTHPRLCQYVDISRGKHERLVVVAEHCERN  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         LeDll+erkp s+s+vl+ia+evl+gl+y+n+h++vhral+p+++lldr+g+ vkLak+G

Q: 78    LEDLLRERKPGSCSQVLQIAFEVLQGLQYMNQHGLVHRALSPHNVLLDREGH-VKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+ta+G dvdfpigy+sylaPe+i+q+         ++k+l++++ksDvWsLg+il+e

Q: 137   LYHMTAHGVDVDFPIGYPSYLAPEVIAQGvikpgdhmpSEKPLPSGPKSDVWSLGIILFE  196

         ************************************************************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf++ld++erlk+ll+l++vd+t+i+laee++cldiik+l+e++ +llkkCLt+

Q: 197   LCMGRKLFHSLDIAERLKFLLTLGCVDDTVIVLAEEHGCLDIIKELPENVMSLLKKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

         +pskRp+pdell++k+f

Q: 257   HPSKRPTPDELLRDKMF  273

         **************987

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT VTHPRLCQYV DISRGKHERL VVVAEHCERN 60

LEDLLRERKP GSCSQVLQIA FEVLQGLQYM NQHGLVHRAL SPHNVLLDRE GHVKLAKFGL 120

YHMTAHGVDV DFPIGYPSYL APEVIAQGVI KPGDHMPSEK PLPSGPKSDV WSLGIILFEL 180

CMGRKLFHSL DIAERLKFLL TLGCVDDTVI VLAEEHGCLD IIKELPENVM SLLKKCLTFH 240

PSKRPTPDEL LRDKMF 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013