EKS-ORA-00299
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00299
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PEK163.38.7E-48166442277
StatusUnreviewed
Ensembl ProteinENSOANP00000004447
UniProt AccessionF7B3Y4;
Protein Name
Protein Synonyms/Alias
Gene NameEIF2AK1
Gene Synonyms/Alias EIF2AK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000002795ENSOANP00000004447ENSOANT00000004448
ENSOANG00000002795ENSOANP00000028740ENSOANT00000032536
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length479
Protein Sequence
(FASTA)
MQEEEEEEEE EEGAEEPEKP LPLPAIDFPS EGPDIRFDES DVPAELQAAK GPLPQLTFSS 60
SVANQLLLVS LLEHLCHVHE PKPDSSKRMF QMLCQTFTKM GLLSSFTCSE EFSSLRLHHN 120
RAITELMRVV KQKVIHEACL QVRNCQTVRA TEVNFEAQTS RYLNEFEEMS ILGKGGYGKV 180
FKVRNKLDGQ FYAIKKILIK KATKRDCMKV LREVKVLAGL QHPNIVGYHT AWLEHVHSEP 240
SWGKRISVRR PLLRLSLDRE SARDEHCVQN DESSDSSIIF ADSASKERPF GEKRVENLNN 300
KLVQYSDSVT RNDNDCESSP YLHGDFRVNA GTRLIGFEHG LSQEYSSEIE ENFTSTEESS 360
EENLSIVGQT EMHYHLMLHI QMQFCEISLW DWISDRNKNS GECMDESSCP YLMGSVASKI 420
FRELLEGVYY IHNMGVVHRD LKIVSCSWAL FSFFYSVQPP HTVLCTNPEI FFFKVLITM 479
Nucleotide Sequence
(FASTA)
ATGCAGGAGG AGGAGGAGGA GGAGGAGGAG GAGGAAGGCG CCGAGGAGCC GGAGAAGCCG 60
CTGCCGCTTC CCGCCATAGA CTTTCCCTCC GAGGGCCCGG ACATCCGATT CGATGAATCC 120
GATGTTCCGG CAGAACTCCA AGCTGCGAAA GGACCTCTTC CTCAACTCAC GTTCTCTTCT 180
TCAGTTGCAA ACCAGCTATT GCTTGTTTCA CTGTTAGAAC ATCTGTGCCA TGTGCATGAA 240
CCAAAGCCGG ATTCTTCCAA ACGCATGTTC CAAATGCTCT GTCAGACTTT TACCAAAATG 300
GGATTGCTTT CTTCTTTCAC CTGCAGTGAA GAATTTAGTT CTTTGAGGCT TCATCACAAC 360
AGAGCTATTA CAGAATTAAT GAGGGTAGTC AAACAGAAAG TCATTCATGA GGCATGCCTG 420
CAAGTCAGGA ATTGTCAAAC TGTTAGAGCA ACAGAAGTAA ACTTTGAAGC ACAAACATCT 480
CGTTACTTAA ATGAATTCGA AGAAATGTCC ATCCTTGGAA AAGGCGGATA TGGGAAAGTA 540
TTCAAGGTCA GGAATAAATT AGATGGGCAA TTTTATGCCA TTAAAAAAAT TCTGATCAAG 600
AAAGCTACCA AAAGGGATTG TATGAAGGTA CTTCGGGAAG TTAAGGTCTT GGCCGGTCTA 660
CAACATCCTA ATATTGTAGG TTATCATACT GCTTGGTTAG AACATGTTCA CTCAGAACCA 720
TCATGGGGTA AAAGGATTTC TGTTAGGCGG CCACTTCTCA GGCTGTCATT AGACCGGGAA 780
AGTGCCAGAG ATGAACATTG TGTTCAAAAT GATGAAAGTA GTGACTCATC CATTATCTTC 840
GCTGATTCAG CCTCAAAGGA GAGACCGTTT GGAGAAAAAC GGGTTGAAAA TCTGAACAAT 900
AAACTGGTGC AGTATTCTGA TTCAGTCACA AGGAATGATA ATGATTGTGA ATCATCCCCT 960
TACCTGCATG GAGATTTCAG AGTTAATGCT GGTACTAGAT TGATTGGTTT CGAACATGGT 1020
CTTTCACAAG AGTACAGTTC AGAAATAGAG GAAAATTTCA CCTCCACTGA GGAATCTTCT 1080
GAAGAAAATT TGTCCATAGT TGGGCAAACT GAGATGCATT ATCATCTAAT GCTCCACATA 1140
CAGATGCAAT TTTGTGAAAT TTCCCTTTGG GATTGGATTT CTGATCGAAA TAAAAACAGT 1200
GGAGAGTGTA TGGATGAATC TTCCTGTCCT TATCTCATGG GAAGTGTTGC ATCCAAAATT 1260
TTTCGAGAGT TGCTGGAAGG TGTATACTAT ATCCATAACA TGGGAGTTGT ACACCGGGAT 1320
CTCAAGATTG TAAGCTGTTC ATGGGCTTTA TTCTCCTTTT TCTATTCTGT TCAACCCCCT 1380
CATACTGTGC TCTGCACAAA CCCAGAAATA TTTTTCTTCA AGGTCCTGAT CACCATGTGA 1440
Domain Profile
S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakke.lekverevkaLaklehpni  59
         fee+ +lGkGg+g+V+k++nkld++ yaik+i ++ka+k+ ++kv+revk+La l+hpni
Q: 166   FEEMSILGKGGYGKVFKVRNKLDGQFYAIKKILIKKATKRdCMKVLREVKVLAGLQHPNI  225
         899***********************************999*******************
S: 60    vrYfaawleekeesl.............................................  74
         v Y++awle+ +++                                              
Q: 226   VGYHTAWLEHVHSEPswgkrisvrrpllrlsldresardehcvqndessdssiifadsas  285
         **********9876678***********99999999999999999998888888888888
S: 75    .........................................................td.  76
                                                                  ++ 
Q: 286   kerpfgekrvenlnnklvqysdsvtrndndcesspylhgdfrvnagtrligfehglsQEy  345
         888888888888888888888888888888888888888888888888888877776333
S: 77    sseveaeaeleesesseesdtk.........llyiqmelceketLkdwiderk......l  121
         sse+e++++++e++s+e+ +           +l+iqm++ce  +L+dwi++r+      +
Q: 346   SSEIEENFTSTEESSEENLSIVgqtemhyhlMLHIQMQFCE-ISLWDWISDRNknsgecM  404
         4445544444444444443333788888888**********.********9998999988
S: 122   lesrselvm.....rlfkqllegleylHskgliHrdLk  154
         +es++ ++m     ++f++lleg+ y+H++g++HrdLk
Q: 405   DESSCPYLMgsvasKIFRELLEGVYYIHNMGVVHRDLK  442
         899999999****************************9
Domain Sequence
(FASTA)
FEEMSILGKG GYGKVFKVRN KLDGQFYAIK KILIKKATKR DCMKVLREVK VLAGLQHPNI 60
VGYHTAWLEH VHSEPSWGKR ISVRRPLLRL SLDRESARDE HCVQNDESSD SSIIFADSAS 120
KERPFGEKRV ENLNNKLVQY SDSVTRNDND CESSPYLHGD FRVNAGTRLI GFEHGLSQEY 180
SSEIEENFTS TEESSEENLS IVGQTEMHYH LMLHIQMQFC EISLWDWISD RNKNSGECMD 240
ESSCPYLMGS VASKIFRELL EGVYYIHNMG VVHRDLK 277
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00318
EKS-ANC-00332
EKS-BOT-00340
EKS-CAJ-00349
EKS-CAF-00348
EKS-CAP-00374
EKS-CIS-00092
EKS-DAR-00704
EKS-EQC-00332
EKS-FEC-00331
EKS-GAG-00286
EKS-GAA-00423
EKS-GOG-00338
EKS-HOS-00347
EKS-ICT-00324
EKS-LAC-00356
EKS-LOA-00351
EKS-MAM-00345
EKS-MEG-00281
EKS-MOD-00336
EKS-MUM-00375
EKS-MUP-00334
EKS-MYL-00339
EKS-ORN-00444
EKS-ORC-00319
EKS-ORL-00411
EKS-OTG-00345
EKS-PAT-00323
EKS-PES-00300
EKS-POA-00332
EKS-PTV-00080
EKS-RAN-00355
EKS-SAH-00319
EKS-SUS-00303
EKS-TAG-00416
EKS-TAR-00447
EKS-TEN-00443
EKS-XIM-00431
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0020037; F:heme binding
GO:0008285; P:negative regulation of cell proliferation
GO:0046986; P:negative regulation of hemoglobin biosynthetic process
GO:0046777; P:protein autophosphorylation
GO:0046501; P:protoporphyrinogen IX metabolic process
GO:0010999; P:regulation of eIF2 alpha phosphorylation by heme
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR015516; Haem-reg_EIF2A_Kinase.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
Pfam
PF00069; Pkinase; 2.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013