EKS-ORA-00170
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00170
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/LISK440.62.1E-132326587262
StatusUnreviewed
Ensembl ProteinENSOANP00000004642
UniProt AccessionF7B2P9;
Protein Name
Protein Synonyms/Alias
Gene NameLIMK1
Gene Synonyms/Alias LIMK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000002923ENSOANP00000004642ENSOANT00000004643
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length630
Protein Sequence
(FASTA)
NDLPLCADCG QSIFDGQYLQ ALNADWHSDC FRCCECGASL SHQYYEKDGR LYCKKDYWMR 60
FGELCHGCSE QINKGLIMVA GEQKYHPECF ICLTCAFIGD GDTYALVERS KLYCGRCYYQ 120
MVVTPVMEQS LPDSPSFHIP HTVTLVSIPA SADGKRGLSV SIDQHYGAPG CGSDFPHTVR 180
VRGCVPGALG GQTGNSLGGR AGINGTPIRH VPLDEIDLLI QETSRLLQLT IEHDPHDALA 240
RGPGPPASPP ADLHSPPALT PARTPGPTDL GPPCQRPVLR RYSIDKSPGS GSPGSSGSRG 300
SQPNNGRSGS LRAVSRTHRV FRPSDLIHGE VLGKGCFGQA IKVTHRETGE VMVMKELIRF 360
DEETQRTFLK EVKVMRGLEH PNVLRFIGVL YKDKRLNFIT EYIKGGTLRG LIKSMDSQYP 420
WSQRVSFAKD IASGMAYLHS MSVIHRDLNS HNCLVRENKS VVVADFGLAR LMVEDKGQPD 480
QLKTLKKPDR KKRYTVVGNP YWMAPEMING RSYYEKGDVF SFWIIIGRVN ADPDYLPRTM 540
DFGLNIRGFL DRYCPPSCPP SFFPIAVQCC DLDPEKRPSF LSLEQWLETL HRHLELRLPL 600
GSQLEQLEQG FWAGHRRGDG GLPAHPEVPD 630
Nucleotide Sequence
(FASTA)
AATGACTTGC CTCTCTGCGC CGACTGTGGC CAGAGCATCT TCGATGGGCA GTACCTCCAA 60
GCCCTGAACG CCGATTGGCA CTCCGACTGC TTCAGGTGCT GTGAATGCGG GGCCTCCTTG 120
TCCCATCAGT ACTACGAAAA AGATGGCCGT CTCTACTGCA AGAAGGATTA CTGGATGCGC 180
TTCGGGGAGC TCTGTCACGG CTGCTCTGAG CAGATCAACA AGGGGCTCAT CATGGTGGCC 240
GGGGAGCAGA AGTACCACCC GGAATGTTTC ATCTGCCTCA CCTGCGCCTT CATCGGCGAC 300
GGAGACACCT ACGCGCTGGT GGAGCGCTCC AAACTCTACT GCGGGCGCTG CTATTACCAG 360
ATGGTGGTGA CGCCGGTGAT GGAGCAGAGC CTGCCCGACT CTCCGAGCTT CCACATCCCG 420
CACACCGTCA CCCTGGTGTC CATCCCCGCC TCGGCCGACG GCAAGAGAGG CCTCTCGGTG 480
TCCATCGACC AGCACTACGG CGCCCCGGGC TGCGGCTCCG ACTTCCCCCA TACCGTCCGG 540
GTGCGAGGGT GCGTGCCGGG GGCTTTGGGA GGCCAGACTG GGAATAGTTT GGGGGGACGG 600
GCAGGTATCA ACGGCACCCC CATCCGCCAC GTCCCCCTGG ACGAGATCGA CCTGCTCATC 660
CAGGAGACCA GCCGGCTGCT GCAGCTCACC ATCGAGCACG ACCCCCACGA CGCCCTGGCC 720
CGCGGGCCCG GACCCCCGGC CAGCCCCCCG GCGGACCTGC ACAGCCCCCC GGCCCTCACC 780
CCGGCCCGCA CCCCCGGCCC CACCGACCTC GGGCCTCCCT GTCAGAGGCC CGTCCTGCGC 840
AGATACAGCA TCGACAAGTC CCCCGGCTCG GGCTCTCCGG GCTCGTCGGG CTCCCGGGGC 900
TCCCAGCCTA ACAACGGCCG CTCCGGCTCT CTCCGGGCCG TGTCCCGCAC ACACCGCGTC 960
TTCCGGCCGT CGGACCTGAT CCACGGCGAG GTGCTGGGCA AGGGCTGCTT CGGGCAGGCC 1020
ATCAAGGTGA CGCATCGGGA GACGGGAGAG GTCATGGTGA TGAAGGAGCT TATCCGGTTT 1080
GATGAGGAGA CGCAGAGAAC CTTCCTGAAA GAGGTGAAGG TGATGAGGGG CCTCGAACAC 1140
CCTAACGTCC TCCGGTTCAT CGGCGTGCTC TACAAGGACA AGCGGCTCAA CTTCATCACC 1200
GAGTACATCA AGGGCGGGAC TCTCCGGGGT CTCATCAAGA GCATGGACAG CCAGTACCCG 1260
TGGAGTCAGC GTGTGAGCTT TGCCAAAGAC ATCGCATCTG GCATGGCCTA CCTGCACTCC 1320
ATGAGCGTCA TTCACCGGGA CCTCAACTCC CACAACTGCC TGGTGCGAGA GAACAAGAGC 1380
GTGGTGGTGG CGGACTTCGG CCTGGCCCGG CTCATGGTGG AGGACAAGGG TCAGCCCGAC 1440
CAGCTCAAGA CGCTGAAGAA ACCGGATCGG AAAAAACGCT ACACCGTGGT GGGGAACCCA 1500
TACTGGATGG CTCCGGAGAT GATCAACGGT AGGAGCTACT ATGAGAAAGG GGACGTGTTC 1560
TCCTTCTGGA TCATCATCGG CCGCGTGAAC GCCGACCCCG ACTACCTTCC CCGCACGATG 1620
GACTTTGGCC TCAACATCCG GGGCTTCCTG GACCGCTACT GCCCCCCCAG CTGCCCCCCG 1680
AGCTTCTTCC CCATCGCCGT CCAGTGCTGC GACCTGGATC CCGAGAAGAG GCCGTCCTTC 1740
CTCAGTCTGG AGCAGTGGCT GGAAACCCTT CACCGGCACC TGGAGCTCCG CCTGCCCCTG 1800
GGGTCGCAGC TGGAGCAGCT GGAGCAAGGC TTCTGGGCCG GCCACCGGCG GGGGGACGGC 1860
GGGCTGCCCG CCCACCCCGA AGTGCCGGAC 1890
Domain Profile
S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60
         li+ge+lGkG+f++++kvthr++Gevmv+kelir+dee+++++lkevk++r lehpnvl+
Q: 326   LIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRGLEHPNVLR  385
         689*********************************************************
S: 61    fiGvlvkdkklhllteyiegGtlkellkskes.lpwtqrvrlakdiasGlsylhskgiih  119
         fiGvl+kdk+l+++teyi+gGtl+ l+ks++s +pw+qrv++akdiasG++ylhs+++ih
Q: 386   FIGVLYKDKRLNFITEYIKGGTLRGLIKSMDSqYPWSQRVSFAKDIASGMAYLHSMSVIH  445
         *******************************99***************************
S: 120   rdlnsknclvredksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaP  179
         rdlns+nclvre+ksvvvadfGlarl+ve++ ++++l++lkk drkkr+tvvG+PywmaP
Q: 446   RDLNSHNCLVRENKSVVVADFGLARLMVEDKGQPDQLKTLKKPDRKKRYTVVGNPYWMAP  505
         ************************************************************
S: 180   evlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPea  239
         e+++g+sy ek dvfsf i    ii+rv+adPdylPrt+dfgl+++ f +++++  cP++
Q: 506   EMINGRSYYEKGDVFSFWI----IIGRVNADPDYLPRTMDFGLNIRGFLDRYCPPSCPPS  561
         ******************9....69***********************************
S: 240   flklavvccdldpesrpsfeelekkl  265
         f+++av+ccdldpe+rpsf +le++l
Q: 562   FFPIAVQCCDLDPEKRPSFLSLEQWL  587
         ***********************997
Domain Sequence
(FASTA)
LIHGEVLGKG CFGQAIKVTH RETGEVMVMK ELIRFDEETQ RTFLKEVKVM RGLEHPNVLR 60
FIGVLYKDKR LNFITEYIKG GTLRGLIKSM DSQYPWSQRV SFAKDIASGM AYLHSMSVIH 120
RDLNSHNCLV RENKSVVVAD FGLARLMVED KGQPDQLKTL KKPDRKKRYT VVGNPYWMAP 180
EMINGRSYYE KGDVFSFWII IGRVNADPDY LPRTMDFGLN IRGFLDRYCP PSCPPSFFPI 240
AVQCCDLDPE KRPSFLSLEQ WL 262
KeywordComplete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00180
EKS-ANC-00185
EKS-BOT-00191
EKS-CAF-00197
EKS-CAP-00216
EKS-DIO-00098
EKS-EQC-00186
EKS-FEC-00179
EKS-GAM-00108
EKS-GAG-00164
EKS-GAA-00234
EKS-GOG-00189
EKS-HOS-00197
EKS-ICT-00183
EKS-LAC-00202
EKS-LOA-00189
EKS-MAM-00192
EKS-MAE-00074
EKS-MEG-00151
EKS-MIM-00089
EKS-MOD-00190
EKS-MUM-00194
EKS-MUP-00195
EKS-MYL-00196
EKS-OCP-00125
EKS-ORN-00242
EKS-ORC-00174
EKS-ORL-00227
EKS-OTG-00197
EKS-PAT-00182
EKS-POA-00188
EKS-RAN-00185
EKS-SAH-00188
EKS-SUS-00165
EKS-TAG-00217
EKS-TAR-00248
EKS-TEN-00245
EKS-TUT-00179
EKS-XET-00223
EKS-XIM-00238
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005925; C:focal adhesion
GO:0043005; C:neuron projection
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0008270; F:zinc ion binding
GO:0051444; P:negative regulation of ubiquitin-protein ligase activity
GO:0032233; P:positive regulation of actin filament bundle assembly
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781; Znf_LIM.
Pfam
PF00412; LIM; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00132; LIM; 2.
Prosites
PS00478; LIM_DOMAIN_1; 1.
PS50023; LIM_DOMAIN_2; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013