EKS-ORA-00126
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00126
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR554.63.6E-167477753277
StatusUnreviewed
Ensembl ProteinENSOANP00000005151
UniProt AccessionF6SM70;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR1
Gene Synonyms/Alias FGFR1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000003252ENSOANP00000005151ENSOANT00000005152
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length821
Protein Sequence
(FASTA)
MWSWKCLLFW AVLVTATLCP ARAAPTLPEH ALPWGAPVEV ESSLAHPGDL LQLRCRLRDD 60
VQSINWLRDG VQLAESNRTR ITGEEVEVRD AVPSDSGLYA CVTTPSGSDI TYFSVNVSDA 120
LPSAEDDDDD DDSSSEEKET DNTKPNRTPV APYWTSPEKM EKKLHAVPAA KTVKFKCPSS 180
GTPSPTLRWL KNGKEFKPDH RIGGYKVRYA TWSIIMDSVV PSDKGNYTCI VENKYGSINH 240
TYQLDVVERS PHRPILQAGL PANKTVALGS NVEFVCKVYS DPQPHIQWLK HIEVNGSKIG 300
PDNLPYVQIL KTAGVNTTDK EMEVLHLRNV SFEDAGEYTC LAGNSIGISH HSAWLTVLEA 360
LEERPAVMTS PLYLEIIIYC TGAFLISCMV GTVIVYKMKS GTKKSDFHSQ MAVHKLAKSI 420
PLRRQVTVSA DSSTSMNSGV LLVRPSRLSS SGTPMLAGVS EYELPEDPRW ELPRDRLVLG 480
KPLGEGCFGQ VVLAEAIGLD KDKPNRVTKV AVKMLKSDAT EKDLSDLISE MEMMKMIGKH 540
KNIINLLGAC TQDGPLYVIV EYASKGNLRE YLQARRPPGL EYCYNPSHAP EEQLSSKDLV 600
SCAYQVARGM EYLASKKCIH RDLAARNVLV TEDNVMKIAD FGLARDIHHI DYYKKTTNGR 660
LPVKWMAPEA LFDRIYTHQS DVWSFGVLLW EIFTLGGSPY PGVPVEELFK LLKEGHRMDK 720
PSNCTNDLYM MMRDCWHAVP SQRPTFKQLV EDLDRIVALT SNQEYLDLSV PLDQYSPGFP 780
DTRSSTCSSG EDSVFSHDPL PEEPCLPRHP AQLANGGLKR R 821
Nucleotide Sequence
(FASTA)
ATGTGGAGCT GGAAGTGCCT CCTCTTCTGG GCTGTGCTGG TCACAGCCAC ACTCTGCCCT 60
GCCAGAGCAG CCCCAACACT GCCCGAACAC GCCCTGCCCT GGGGAGCCCC CGTGGAAGTG 120
GAGTCCTCAT TGGCCCACCC TGGCGATCTG CTGCAGCTGC GCTGCCGGCT GCGGGACGAT 180
GTGCAGAGCA TCAACTGGCT GCGGGACGGG GTGCAGCTGG CGGAGAGCAA CCGCACCCGC 240
ATCACTGGGG AGGAGGTGGA GGTGCGGGAT GCCGTGCCCT CCGACTCTGG CCTCTACGCC 300
TGCGTGACAA CACCCTCCGG CAGCGACATC ACCTACTTCT CCGTCAACGT CTCAGATGCC 360
CTCCCATCGG CTGAGGATGA CGACGACGAT GATGATTCCT CTTCCGAAGA GAAGGAGACG 420
GACAACACCA AACCAAACCG TACGCCTGTG GCTCCCTATT GGACATCTCC AGAAAAGATG 480
GAGAAGAAGC TGCACGCGGT GCCGGCAGCC AAGACGGTGA AGTTCAAGTG TCCTTCAAGC 540
GGCACCCCCA GTCCTACACT GCGTTGGCTG AAAAATGGCA AAGAGTTCAA ACCCGACCAC 600
CGGATCGGGG GTTATAAGGT CCGTTATGCC ACCTGGAGCA TCATCATGGA CTCGGTGGTG 660
CCATCTGATA AGGGCAACTA CACCTGTATT GTGGAGAACA AGTATGGCAG TATTAACCAC 720
ACTTATCAAC TGGACGTTGT GGAACGGTCA CCTCACCGGC CCATCCTGCA GGCTGGACTA 780
CCTGCCAACA AGACAGTGGC TCTGGGCAGC AACGTGGAGT TTGTATGCAA AGTGTACAGT 840
GACCCACAGC CCCACATCCA ATGGCTGAAG CACATCGAGG TGAATGGGAG CAAGATTGGC 900
CCAGACAACC TACCTTACGT CCAGATCCTG AAGACGGCCG GAGTTAATAC CACCGACAAG 960
GAGATGGAAG TGCTGCACTT AAGGAATGTC TCCTTTGAGG ATGCGGGGGA GTATACATGC 1020
TTGGCGGGTA ACTCTATCGG GATCTCCCAT CACTCTGCAT GGTTGACCGT TCTGGAAGCC 1080
CTGGAGGAGC GACCGGCGGT GATGACCTCC CCTCTGTACC TGGAGATCAT CATCTACTGC 1140
ACAGGGGCCT TCCTCATCTC CTGCATGGTG GGGACCGTCA TAGTTTATAA GATGAAGAGC 1200
GGCACTAAGA AGAGCGACTT CCACAGCCAG ATGGCTGTAC ACAAGTTGGC CAAGAGTATT 1260
CCCCTGCGTA GACAGGTAAC AGTGTCGGCT GACTCCAGCA CCTCCATGAA CTCGGGGGTT 1320
CTGCTGGTGC GGCCCTCACG CCTCTCCTCC AGTGGAACCC CGATGCTGGC TGGGGTCTCG 1380
GAGTATGAGC TGCCTGAGGA TCCCCGCTGG GAACTGCCCC GGGACAGGTT GGTGCTAGGC 1440
AAACCTTTAG GTGAGGGCTG CTTCGGACAG GTGGTACTGG CGGAGGCCAT TGGCCTGGAC 1500
AAAGACAAGC CCAACCGGGT GACCAAGGTG GCGGTCAAGA TGCTGAAATC AGATGCAACA 1560
GAAAAGGACC TGTCAGATCT GATCTCTGAA ATGGAGATGA TGAAGATGAT TGGGAAGCAC 1620
AAGAACATTA TCAATCTGCT GGGGGCCTGC ACACAGGATG GCCCGCTTTA TGTCATCGTG 1680
GAATATGCAT CTAAGGGCAA CCTTCGTGAG TACCTCCAGG CCCGGCGGCC CCCTGGATTA 1740
GAATACTGTT ACAACCCCAG CCATGCCCCT GAGGAGCAAC TTTCCTCCAA GGATCTGGTC 1800
TCTTGTGCCT ACCAGGTGGC CCGGGGCATG GAATATCTTG CCTCTAAAAA GTGCATACAC 1860
CGGGACCTGG CAGCCCGGAA TGTCCTTGTG ACCGAGGACA ATGTGATGAA GATCGCAGAT 1920
TTTGGCCTGG CTCGGGATAT CCATCACATC GACTACTACA AAAAGACCAC CAATGGACGG 1980
CTGCCTGTGA AATGGATGGC CCCTGAGGCC TTGTTTGACC GGATCTACAC ACACCAGAGT 2040
GATGTATGGT CTTTCGGGGT ACTGCTGTGG GAAATCTTCA CCTTGGGCGG CTCTCCCTAC 2100
CCCGGCGTTC CTGTGGAGGA ACTCTTCAAG CTGCTGAAGG AGGGTCATCG CATGGACAAA 2160
CCTAGCAACT GCACCAATGA CCTGTACATG ATGATGAGGG ATTGCTGGCA TGCGGTGCCT 2220
TCTCAGCGAC CCACCTTCAA GCAGCTGGTG GAGGACCTAG ACCGTATTGT GGCCTTGACC 2280
TCCAACCAGG AGTACCTGGA TCTCTCAGTG CCCCTGGACC AGTATTCGCC CGGCTTCCCG 2340
GACACTCGCA GTTCTACCTG CTCCTCGGGG GAGGATTCTG TCTTCTCCCA CGACCCACTG 2400
CCCGAGGAGC CCTGCCTGCC CCGCCATCCA GCCCAGCTTG CTAATGGGGG ACTCAAGAGG 2460
CGCTGA 2466
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+
Q: 477   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  536
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+a+eeql++
Q: 537   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHAPEEQLSS  596
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt
Q: 597   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  656
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh
Q: 657   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  716
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kp++ct++ly++mr+cwha++s+rptfkqlvedl
Q: 717   RMDKPSNCTNDLYMMMRDCWHAVPSQRPTFKQLVEDL  753
         ***********************************97
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHAPEEQLSS 120
KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180
TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240
RMDKPSNCTN DLYMMMRDCW HAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00140
EKS-ANC-00142
EKS-BOT-00147
EKS-CAE-00120
EKS-CAJ-00152
EKS-CAF-00156
EKS-CAP-00148
EKS-CII-00090
EKS-CIS-00182
EKS-DAR-00434
EKS-DRM-00072
EKS-EQC-00147
EKS-FEC-00138
EKS-GAM-00076
EKS-GAG-00126
EKS-GAA-00173
EKS-GOG-00148
EKS-HOS-00154
EKS-ICT-00142
EKS-LAC-00157
EKS-LOA-00147
EKS-MAM-00145
EKS-MOD-00148
EKS-MUM-00153
EKS-MUP-00152
EKS-MYL-00157
EKS-NOL-00142
EKS-ORN-00182
EKS-ORC-00139
EKS-ORL-00171
EKS-OTG-00153
EKS-PAT-00139
EKS-PES-00133
EKS-PEM-00079
EKS-POA-00144
EKS-RAN-00147
EKS-SAH-00143
EKS-SUS-00129
EKS-TAG-00177
EKS-TAR-00192
EKS-TEN-00184
EKS-XET-00136
EKS-XIM-00177
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008201; F:heparin binding
GO:0043066; P:negative regulation of apoptotic process
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0001759; P:organ induction
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0045787; P:positive regulation of cell cycle
GO:0043406; P:positive regulation of MAP kinase activity
GO:0090080; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0002053; P:positive regulation of mesenchymal cell proliferation
GO:0010863; P:positive regulation of phospholipase C activity
GO:0046777; P:protein autophosphorylation
GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0048378; P:regulation of lateral mesodermal cell fate specification
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013