EKS-ORA-00127
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00127
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR478.75.0E-144445710266
StatusUnreviewed
Ensembl ProteinENSOANP00000005325
UniProt AccessionF6VBA5;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR3
Gene Synonyms/Alias FGFR3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000003354ENSOANP00000005325ENSOANT00000005326
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length769
Protein Sequence
(FASTA)
EELVFSSGDT ILLSCDPAGS MPIQWLKDGT GVEPNNTTHV GQRLLTITNV SSADSGFYSC 60
RRRDSRDILG NFSVRVTDSP SSGDDEDDDD EMEDAGAPYW TRPERMDKKL LAVPAANTVR 120
FRCPAAGNPA PTIHWLKNGK EFKGEHRIGG IKLRHQQWSL VMESVVPSDR GNYTCVVENE 180
HGSIRQTYTL DVLERSPHRP ILQAGLPANQ TVVVGSDVEF HCKVYSDAQP HIQWLKHVEV 240
NGSKYGADGT PYVTVLKTAG VNTTDKELEI LSLRNVTLED AGEYTCLAGN SIGFSHHSAW 300
LAVLPSTEEL VEVEESGSVY AGVLSYGVGF FLLILVVVAV TICRVKMPSK KAMSAPSVQK 360
VSKFPLKRQV TESRYKVPFP SAWPTVRVYP PALGLSYRER GQGLPLGGIE GPGLGLEAEG 420
RGCWSLGLAR PIVRKPVGRT GWVMGQVVSL LGQLGTSRDH NSLPPPLPVT PPADDATDKD 480
LSDLVSEMEM MKMIGKHKNI INLLGACTQD GPLYVLVEYA SKGNLREFLR ARRPPGLGYS 540
FDTCKLAEEQ LTCKDLVSGA YQVARGMEYL ASQKCIHRDL AARNVLVTED SVMKIADFGL 600
ARDVHNIDYY KKTTNGRLPV KWMAPEALFD RVYTHQSDVW SFGVLLWEIF TLGGSPYPGI 660
PVEELFKLLK EGHRMDKPGN CTHDLYMIMR ECWHAVPSQR PTFKQLVEDL DRILTVTSTD 720
EYLDLSAPLE QYSPACQDTH STCSSGDDSV FAHEPCLPQP QCGPSPIRT 769
Nucleotide Sequence
(FASTA)
GAGGAGCTGG TCTTCAGCAG CGGAGACACC ATCCTGCTGT CCTGTGATCC TGCGGGCTCC 60
ATGCCCATTC AGTGGCTCAA AGATGGCACC GGGGTGGAGC CCAACAACAC GACACATGTC 120
GGGCAGAGGC TGCTGACCAT CACCAATGTG TCCTCGGCAG ATTCGGGCTT CTACAGCTGC 180
CGGCGCAGAG ACTCCCGCGA CATCCTCGGC AACTTCAGCG TCAGAGTGAC TGATTCTCCA 240
TCGTCAGGCG ACGATGAAGA TGATGATGAC GAAATGGAAG ACGCAGGGGC CCCATATTGG 300
ACCCGGCCAG AGAGGATGGA CAAGAAGCTT CTGGCGGTGC CGGCCGCCAA CACCGTCCGC 360
TTCCGCTGCC CTGCGGCCGG GAACCCGGCC CCGACCATCC ACTGGCTGAA GAACGGCAAG 420
GAGTTCAAGG GGGAGCACCG CATCGGGGGG ATCAAGCTGC GGCACCAGCA GTGGAGCCTG 480
GTCATGGAGA GCGTGGTGCC GTCGGACCGG GGGAACTACA CGTGTGTGGT AGAGAACGAA 540
CACGGCAGCA TCCGGCAGAC CTACACGCTC GATGTGCTGG AGCGATCGCC GCACCGGCCC 600
ATCCTGCAGG CTGGCTTGCC CGCCAACCAG ACGGTGGTGG TGGGCAGTGA CGTGGAGTTC 660
CACTGCAAGG TGTACAGTGA CGCCCAGCCC CACATCCAGT GGCTGAAGCA CGTGGAGGTC 720
AACGGCAGCA AGTATGGTGC CGACGGGACG CCATACGTCA CCGTGCTCAA GACGGCAGGC 780
GTTAATACCA CGGATAAGGA GCTAGAAATT CTGTCCTTGC GCAATGTTAC TTTGGAGGAC 840
GCGGGGGAGT ATACTTGTCT TGCTGGGAAC TCTATTGGGT TTTCCCATCA TTCTGCATGG 900
CTGGCGGTGT TACCATCTAC GGAAGAGCTG GTGGAAGTGG AGGAGTCAGG CAGTGTGTAC 960
GCCGGCGTCC TCAGCTACGG AGTGGGGTTC TTCCTGCTCA TCCTGGTGGT GGTTGCGGTG 1020
ACAATCTGCA GGGTGAAGAT GCCCTCCAAG AAGGCCATGA GCGCCCCCTC TGTGCAGAAG 1080
GTCTCCAAAT TCCCACTCAA GCGACAGGTA ACAGAAAGTA GATACAAGGT TCCTTTTCCC 1140
TCTGCTTGGC CAACTGTCCG CGTCTACCCC CCTGCCCTGG GCCTGTCGTA CAGGGAGAGG 1200
GGGCAAGGGC TGCCTTTGGG TGGGATCGAG GGTCCTGGAT TGGGGCTGGA GGCAGAGGGC 1260
CGGGGATGCT GGAGCCTAGG GCTGGCAAGG CCAATTGTGA GGAAGCCAGT GGGACGCACG 1320
GGGTGGGTGA TGGGCCAGGT TGTGAGCCTT TTGGGTCAGT TAGGCACTTC CCGTGACCAC 1380
AACTCTCTCC CCCCGCCTCT TCCTGTGACC CCCCCGGCAG ATGATGCCAC AGATAAGGAC 1440
CTCTCGGACC TGGTCTCTGA AATGGAGATG ATGAAAATGA TCGGGAAACA CAAAAACATT 1500
ATCAACTTGC TGGGAGCCTG CACCCAGGAT GGACCCCTGT ATGTCCTGGT GGAATATGCA 1560
TCCAAGGGCA ACCTGCGGGA ATTCCTGCGA GCCCGCCGGC CCCCTGGCTT GGGCTACTCA 1620
TTCGACACCT GCAAGCTAGC CGAGGAGCAG CTCACCTGCA AGGACTTGGT GTCGGGCGCC 1680
TACCAGGTAG CTCGGGGCAT GGAGTACCTG GCGTCCCAAA AGTGCATACA CCGGGACTTG 1740
GCCGCCCGGA ACGTGCTGGT CACCGAGGAC AGCGTCATGA AAATCGCCGA CTTTGGCCTT 1800
GCCAGAGATG TTCATAACAT TGACTACTAC AAGAAGACCA CCAATGGCCG GCTGCCCGTC 1860
AAGTGGATGG CCCCCGAGGC ATTGTTCGAC CGAGTCTACA CCCACCAGAG CGACGTCTGG 1920
TCTTTTGGGG TGCTCCTCTG GGAGATCTTC ACTCTGGGAG GCTCCCCCTA CCCTGGGATT 1980
CCAGTCGAGG AACTCTTCAA ACTCCTGAAA GAAGGTCATC GCATGGACAA GCCAGGGAAC 2040
TGCACACATG ACTTGTACAT GATTATGCGT GAGTGCTGGC ATGCAGTACC ATCACAGAGA 2100
CCGACCTTCA AGCAGCTGGT GGAAGATCTG GACCGGATTC TCACTGTAAC ATCTACCGAC 2160
GAGTACCTGG ACCTTTCAGC ACCGCTGGAG CAGTATTCCC CGGCCTGCCA GGACACACAC 2220
AGCACCTGCT CCTCTGGGGA CGATTCCGTG TTTGCCCACG AGCCTTGCCT CCCCCAGCCC 2280
CAGTGCGGGC CCAGCCCCAT CCGGACGTGA 2310
Domain Profile
S: 13    Gqvvk.aeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkliGkhkniinll  71
         Gqvv     +g  +d+++    + v    +datdkdl+dlvseme++k+iGkhkniinll
Q: 445   GQVVSlLGQLGTSRDHNSLPPPLPVTPPADDATDKDLSDLVSEMEMMKMIGKHKNIINLL  504
         666541345677777777777777888889******************************
S: 72    GactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqltekdlvsfayqva  131
         Gactq+Gplyv+veya+kGnlreflrarrp+g  +s d++k +eeqlt+kdlvs ayqva
Q: 505   GACTQDGPLYVLVEYASKGNLREFLRARRPPGLGYSFDTCKLAEEQLTCKDLVSGAYQVA  564
         ************************************************************
S: 132   rGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkttnGrlpvkwma  191
         rGmeylas+kcihrdlaarnvlvted+v+kiadfGlardvh+idyykkttnGrlpvkwma
Q: 565   RGMEYLASQKCIHRDLAARNVLVTEDSVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMA  624
         ************************************************************
S: 192   pealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGhrmekpakctke  251
         pealfdrvyt+qsdvwsfGvllwei+tlGgspypgi+veelfkllkeGhrm+kp +ct++
Q: 625   PEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPGNCTHD  684
         ************************************************************
S: 252   lyvlmrecwhakaserptfkqlvedl  277
         ly++mrecwha++s+rptfkqlvedl
Q: 685   LYMIMRECWHAVPSQRPTFKQLVEDL  710
         ************************97
Domain Sequence
(FASTA)
GQVVSLLGQL GTSRDHNSLP PPLPVTPPAD DATDKDLSDL VSEMEMMKMI GKHKNIINLL 60
GACTQDGPLY VLVEYASKGN LREFLRARRP PGLGYSFDTC KLAEEQLTCK DLVSGAYQVA 120
RGMEYLASQK CIHRDLAARN VLVTEDSVMK IADFGLARDV HNIDYYKKTT NGRLPVKWMA 180
PEALFDRVYT HQSDVWSFGV LLWEIFTLGG SPYPGIPVEE LFKLLKEGHR MDKPGNCTHD 240
LYMIMRECWH AVPSQRPTFK QLVEDL 266
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00142
EKS-CAF-00155
EKS-CAP-00149
EKS-EQC-00146
EKS-GAG-00124
EKS-GOG-00150
EKS-ICT-00141
EKS-LAC-00156
EKS-LOA-00146
EKS-MEG-00114
EKS-MOD-00146
EKS-MUM-00152
EKS-MUP-00153
EKS-ORN-00181
EKS-OTG-00154
EKS-PAT-00138
EKS-PES-00131
EKS-RAN-00146
EKS-SAH-00141
EKS-TAG-00175
EKS-XET-00135
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0009898; C:internal side of plasma membrane
GO:0005764; C:lysosome
GO:0048471; C:perinuclear region of cytoplasm
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0030154; P:cell differentiation
GO:0000165; P:MAPK cascade
GO:0043066; P:negative regulation of apoptotic process
GO:0050680; P:negative regulation of epithelial cell proliferation
GO:0045839; P:negative regulation of mitosis
GO:0045879; P:negative regulation of smoothened signaling pathway
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0045597; P:positive regulation of cell differentiation
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0090080; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010518; P:positive regulation of phospholipase activity
GO:0031398; P:positive regulation of protein ubiquitination
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0046777; P:protein autophosphorylation
GO:0048678; P:response to axon injury
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013