EKS-ORA-00102

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00102

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	225.9	6.7E-67	1065	1325	261

Status

Unreviewed

Ensembl Protein

ENSOANP00000005602

UniProt Accession

F7DQY6;

Protein Name

Protein Synonyms/Alias

Gene Name

MST1R

Gene Synonyms/Alias

MST1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000003529	ENSOANP00000005602	ENSOANT00000005603

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

1393

Protein Sequence
(FASTA)

MGPDIGLLLL TLLHVPGGTG SKDPWTCPRI PFASTRNFTV KYEVQNFTAS GPVQGLLAYG 60

SEEGAAVFVA TRNRLYVLNA ALESQGVLST GPVSDPTCET CASCKDGAAD PRRSYSKDTD 120

NQVLVMDPFE SWLFSCGSTL QGRCFLHELK PHEGSFHIDR TLCLFSPEHN KLTACPDCVA 180

SPMGTRALVL EESYSVYFYV ASSLNSTVAS QYSPGSVSIR RLKGSQDGFS PDFQMLSVLP 240

TYQDSYPIEY VYAFHYDSFA FFLTVQREKL EASTYHTRLI RLSAKESNLG QYRELVLDCR 300

FETKRRRRHA QGPPAHRVYN VLQAAHQAPV ASRLAEELNI PVGEKVLFGA FAVSQDGSSA 360

PSPNSAVCAF PMKMINKAIE KGMNGCCEPG ALKKRVFRGL EFFQPKGFCP GPPGEVFKDS 420

NVTCWNFPTF IPTNSYRVDL FNGRLNDVLL TALHVTPLGN ATVAHMGTAD GRILQVELAR 480

SLNYLLYVSN FSLGSEQPVM REVSRLEDHL FFAAGNKVYK VPIKGPGCRH FLTCSRCLRA 540

ERFMDCGWCE DMCTRQEECR GTWQRDHCPP VITKFHPRSG PTRGNTRLTL CGMDFQSCIH 600

CSSPPGTQNV TVGQSPCRLL PKDNLDLRYE PKKDFVEELE CELEAAGTQM PGPANVTLSI 660

SQEPHHRSFR VYGSSVLGGF TFVEPVVTSI RPQFGPLAGG TQLSIQGQNL NVGDGQQVLI 720

NGTECHLDSQ TEKLLLCTIP PGGHLGNASI TLRIGGALFP TPKPFQYLKN PRIISITPNC 780

SFRDSHITIR GTHLSSVWHM AVSFNDGKEE VKNLECEGTL STERLCKVPD YAVLGQAGGV 840

PGNLSIWAGR TILYHLPHFR YYPRPQSPHT NESQYESKIL LSPGMETVAI KYFGMDAVAG 900

CMEVNMTVGG KHCLSKVLND VVICHLPRGL DIPPRGAPVQ VCVNGECWGQ GRVVRENLAS 960

SLPGIIVGIL LTFVLLASCL LAMLMLRYKN KKKELGSDYR SGSGVLDGEG RSHGWQDRGP 1020

SSTGSSSGSR VPLRRVVSIR MEDLNPELLA EVKDVLIPSE QLQTHCDQVI GKGNFGIVYH 1080

GKYTDPSQNC IHCAVKSLYR EYARGIGWPR RCPLEGIPFR WVLSPSALRL SGLAFPPRGP 1140

PGHLSPFLPA TEPTLRTVTS SPQNPTVKDL IGFGLQVARG MEYLAGKKFV HRDLAARNCM 1200

LLDHFPTTFL RTGEAGKARG RGHKRSYYVS FHFKARSPWE RVSWGHTNPD APSPPQWSFG 1260

VLLWELMTRG ASPYPDIDPF DIMHYLARGR RLPQPEYCPH SLYKVMGQCW VPASTERPSF 1320

RDLAGELERI SASLRGEHYV NLNGGYVNLE LSPLLPPAPS SEDELDQTDD EMEGKTAKIR 1380

LRPSLSSPAS APL 1393

Nucleotide Sequence
(FASTA)

ATGGGGCCTG ACATCGGGCT GCTGCTCCTG ACACTGCTCC ATGTCCCAGG AGGGACGGGC 60

AGTAAGGATC CCTGGACGTG TCCCCGGATT CCCTTCGCTT CCACTCGGAA CTTCACCGTG 120

AAGTACGAGG TCCAAAACTT CACTGCCAGC GGCCCCGTTC AAGGCCTGTT GGCTTACGGG 180

AGTGAGGAGG GTGCCGCGGT TTTTGTGGCC ACGCGGAACC GGCTGTATGT GCTGAATGCA 240

GCCCTGGAGA GCCAGGGAGT GCTGAGCACT GGCCCCGTGA GCGACCCGAC CTGTGAGACC 300

TGCGCCTCAT GCAAAGATGG GGCTGCAGAT CCACGGAGGT CCTATTCCAA GGACACAGAC 360

AACCAGGTAC TTGTAATGGA CCCCTTTGAG TCATGGCTGT TCAGCTGTGG GAGCACCTTA 420

CAGGGCCGCT GCTTCCTTCA CGAGCTCAAG CCCCACGAAG GTTCATTCCA CATAGACCGC 480

ACCCTGTGTC TCTTCTCTCC GGAGCACAAC AAACTCACCG CCTGCCCAGA CTGTGTGGCC 540

AGCCCGATGG GCACCCGCGC TCTGGTGCTG GAGGAAAGTT ACTCCGTGTA CTTCTACGTG 600

GCCTCGTCCC TCAACTCCAC CGTGGCCTCC CAGTACAGCC CCGGCTCGGT CTCCATTCGC 660

CGGCTGAAGG GCAGCCAGGA TGGCTTCTCC CCAGACTTCC AGATGCTGTC AGTGCTGCCC 720

ACGTACCAGG ACTCCTATCC CATTGAGTAC GTCTATGCCT TCCATTACGA CTCATTTGCG 780

TTCTTCCTGA CCGTGCAGCG GGAGAAATTG GAGGCCAGCA CCTACCACAC GCGGCTGATC 840

CGGCTGAGCG CCAAGGAGAG CAACCTGGGC CAGTACCGGG AGCTGGTCCT GGACTGCCGC 900

TTCGAGACCA AGCGGCGGAG GCGCCATGCC CAGGGGCCAC CTGCCCACAG GGTATACAAT 960

GTGCTCCAAG CAGCGCACCA GGCCCCTGTG GCCTCCAGAC TGGCTGAGGA GCTGAACATC 1020

CCGGTGGGGG AGAAGGTGCT CTTCGGGGCC TTTGCTGTGA GCCAGGATGG CAGCTCGGCT 1080

CCGAGCCCCA ACTCCGCCGT CTGTGCCTTT CCTATGAAAA TGATCAACAA GGCCATCGAG 1140

AAGGGCATGA ATGGGTGCTG TGAGCCTGGG GCCCTCAAGA AGAGGGTATT CCGGGGTCTC 1200

GAGTTCTTCC AGCCCAAAGG GTTCTGCCCT GGTCCGCCAG GTGAAGTATT TAAGGACTCC 1260

AATGTCACCT GCTGGAACTT TCCCACGTTC ATCCCCACCA ATAGCTACCG TGTGGACCTG 1320

TTCAACGGGC GGCTGAACGA CGTTCTACTC ACCGCACTCC ATGTCACCCC CCTGGGCAAT 1380

GCCACTGTGG CGCATATGGG CACTGCCGAT GGGCGGATCC TTCAGGTGGA ATTGGCAAGA 1440

TCCCTCAACT ACCTGTTGTA CGTATCCAAC TTCTCTCTGG GCTCAGAGCA GCCCGTGATG 1500

CGGGAGGTGA GCCGGCTGGA GGATCATCTG TTCTTTGCCG CGGGCAACAA GGTGTACAAA 1560

GTGCCCATCA AAGGTCCCGG CTGTCGGCAC TTCCTGACCT GCAGCCGGTG CCTGCGGGCA 1620

GAACGTTTCA TGGACTGTGG CTGGTGTGAG GATATGTGCA CCCGGCAGGA GGAGTGCCGT 1680

GGTACCTGGC AGCGGGACCA CTGTCCGCCC GTTATCACTA AGTTCCACCC GCGTAGCGGT 1740

CCCACACGAG GCAACACAAG ATTGACACTA TGTGGCATGG ACTTCCAGAG CTGTATCCAT 1800

TGCAGTTCCC CCCCAGGCAC CCAGAATGTC ACTGTGGGCC AGAGTCCCTG CAGGCTGCTG 1860

CCCAAAGACA ACCTAGATCT CAGGTATGAG CCCAAGAAGG ACTTTGTGGA GGAGCTGGAG 1920

TGTGAGTTGG AGGCTGCAGG AACGCAGATG CCAGGCCCTG CCAATGTGAC CCTCAGCATC 1980

TCCCAGGAAC CTCATCATCG CTCCTTCCGA GTATATGGCT CCTCCGTCCT GGGAGGGTTC 2040

ACGTTTGTGG AACCAGTGGT GACGTCCATC CGGCCCCAGT TTGGCCCGCT GGCTGGGGGC 2100

ACCCAGCTGT CCATCCAGGG TCAGAACCTG AATGTCGGGG ATGGCCAACA GGTGCTCATC 2160

AATGGGACCG AGTGCCACCT GGACAGCCAG ACTGAGAAGC TGCTACTGTG CACCATTCCT 2220

CCAGGGGGGC ACCTGGGCAA TGCCTCCATC ACCCTCCGCA TTGGGGGAGC CTTGTTCCCC 2280

ACCCCCAAGC CTTTCCAGTA CCTGAAGAAC CCCCGTATCA TCAGCATCAC ACCCAACTGC 2340

AGTTTCAGGG ACTCCCACAT CACTATCCGG GGTACCCACC TTTCCTCAGT GTGGCATATG 2400

GCTGTCTCGT TCAATGATGG GAAAGAGGAG GTGAAAAATC TGGAATGTGA AGGGACCCTG 2460

AGCACGGAGC GACTCTGCAA AGTTCCAGAC TACGCTGTCC TGGGCCAGGC AGGGGGCGTC 2520

CCTGGGAACC TGAGCATCTG GGCTGGCAGG ACCATCCTGT ACCACCTCCC TCACTTCCGT 2580

TACTACCCTC GGCCCCAGTC CCCCCACACC AACGAAAGCC AGTACGAGAG CAAGATCCTG 2640

TTGTCCCCGG GGATGGAAAC GGTGGCCATC AAGTATTTCG GGATGGATGC GGTGGCTGGC 2700

TGCATGGAGG TCAACATGAC AGTGGGTGGG AAGCACTGTC TCTCCAAAGT ACTGAACGAC 2760

GTGGTCATCT GCCACCTCCC CAGAGGCCTG GACATCCCTC CGAGAGGGGC CCCTGTTCAG 2820

GTCTGTGTGA ATGGGGAGTG CTGGGGACAG GGCCGGGTGG TGCGGGAGAA CCTGGCCTCA 2880

TCCCTGCCAG GCATCATCGT GGGCATACTG CTGACCTTCG TCCTGCTGGC CAGCTGTCTT 2940

CTGGCCATGT TGATGCTCAG GTACAAGAAC AAGAAGAAGG AGCTGGGTTC AGACTACAGG 3000

AGCGGCTCTG GAGTCTTGGA CGGCGAGGGC CGTAGCCATG GCTGGCAGGA TCGGGGCCCC 3060

TCATCCACTG GCAGCAGCAG CGGCTCACGT GTCCCCCTCA GAAGGGTCGT GTCCATCCGT 3120

ATGGAGGACC TGAACCCCGA GCTTCTGGCC GAGGTGAAGG ATGTCCTGAT TCCCTCGGAG 3180

CAGCTGCAGA CACACTGCGA TCAGGTCATT GGCAAAGGTA ACTTTGGAAT CGTCTATCAC 3240

GGCAAGTACA CTGACCCATC CCAGAATTGC ATCCACTGTG CCGTCAAGTC TCTGTACCGT 3300

GAGTATGCCC GGGGGATAGG GTGGCCGAGA AGGTGCCCGC TGGAAGGGAT ACCTTTCAGG 3360

TGGGTCCTGA GCCCATCAGC ACTCAGACTC TCTGGGCTGG CATTCCCCCC CCGGGGGCCA 3420

CCTGGCCACC TCTCCCCCTT CTTGCCTGCC ACTGAGCCTA CCCTGAGAAC AGTCACATCT 3480

TCTCCCCAGA ACCCCACAGT CAAGGATCTC ATCGGCTTTG GCTTGCAAGT GGCCAGAGGC 3540

ATGGAGTACC TGGCAGGAAA GAAATTTGTG CACAGGGACC TGGCAGCCCG GAACTGCATG 3600

CTCCTGGACC ACTTTCCTAC TACATTTCTT CGTACTGGGG AGGCCGGAAA GGCCAGGGGG 3660

AGAGGCCACA AGAGGAGCTA CTATGTTTCT TTCCACTTCA AAGCAAGAAG CCCTTGGGAA 3720

CGTGTGTCTT GGGGGCATAC CAATCCTGAT GCCCCTTCTC CTCCCCAGTG GTCCTTTGGT 3780

GTGCTGCTGT GGGAGCTGAT GACCCGAGGA GCATCACCCT ACCCTGATAT CGACCCCTTC 3840

GACATCATGC ACTATCTGGC CCGGGGTCGG CGCCTGCCTC AGCCTGAATA CTGCCCACAC 3900

TCCCTGTACA AGGTGATGGG ACAGTGCTGG GTCCCAGCCT CCACGGAGAG ACCCAGCTTC 3960

AGGGACCTGG CAGGGGAACT GGAACGCATC TCTGCCTCCC TGCGCGGAGA GCACTACGTC 4020

AACCTGAATG GTGGATACGT CAACTTGGAG CTCAGCCCCC TATTGCCTCC CGCTCCCAGT 4080

TCTGAAGACG AGCTGGACCA GACTGACGAC GAGATGGAGG GGAAGACGGC AAAGATCAGA 4140

CTCCGCCCCT CTCTGAGTAG CCCTGCCTCA GCCCCTCTCT AG 4182

Domain Profile

S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksl..eritdiekveeflreglvmkeldh  59

         + ++viGkG fG+vy+g+++d++++ i++avksl  e ++ i+   +   eg+  + +

Q: 1065  HCDQVIGKGNFGIVYHGKYTDPSQNCIHCAVKSLyrEYARGIGWPRRCPLEGIPFRWVLS  1124

         789*******************************555578999999**************

S: 60    pnvlsllGialddeglplvvlpymkkGd.lksfirneernltvkdllefalqvakgmeyl  118

         p  l+l G+a+++ g p  + p++   +   + + ++ +n+tvkdl++f+lqva+gmeyl

Q: 1125  PSALRLSGLAFPPRGPPGHLSPFLPATEpTLRTVTSSPQNPTVKDLIGFGLQVARGMEYL  1184

         ***********************97654334556777789********************

S: 119   askkfvhrdlaarnclldekl...tvkvadfGlardvldkelyvveeerdarlpvkwlal  175

         a kkfvhrdlaarnc+l +++    ++  + G ar   +k +y v+ + +ar p   ++

Q: 1185  AGKKFVHRDLAARNCMLLDHFpttFLRTGEAGKARGRGHKRSYYVSFHFKARSPWERVSW  1244

         *****************9998332467889999999989999999999999***877776

S: 176   eslqtfkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdk  235

            +  +    +   wsfGvllwel+trga+py+++++fd+++yl++grrl++peycp++

Q: 1245  GHTNPDA---PSPPQWSFGVLLWELMTRGASPYPDIDPFDIMHYLARGRRLPQPEYCPHS  1301

         6555444...67789*********************************************

S: 236   lydvmlkcwkakpaerpqfsdlvs  259

         ly+vm +cw + + erp+f dl

Q: 1302  LYKVMGQCWVPASTERPSFRDLAG  1325

         ********************9975

Domain Sequence
(FASTA)

HCDQVIGKGN FGIVYHGKYT DPSQNCIHCA VKSLYREYAR GIGWPRRCPL EGIPFRWVLS 60

PSALRLSGLA FPPRGPPGHL SPFLPATEPT LRTVTSSPQN PTVKDLIGFG LQVARGMEYL 120

AGKKFVHRDL AARNCMLLDH FPTTFLRTGE AGKARGRGHK RSYYVSFHFK ARSPWERVSW 180

GHTNPDAPSP PQWSFGVLLW ELMTRGASPY PDIDPFDIMH YLARGRRLPQ PEYCPHSLYK 240

VMGQCWVPAS TERPSFRDLA G 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0001725	; C:stress fiber
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004872	; F:receptor activity
GO:0007275	; P:multicellular organismal development
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0051897	; P:positive regulation of protein kinase B signaling cascade

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013