EKS-ORA-00005
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00005
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph508.53.0E-153585844260
StatusUnreviewed
Ensembl ProteinENSOANP00000005866
UniProt AccessionF7DPU2;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB3
Gene Synonyms/Alias EPHB3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000003700ENSOANP00000005865ENSOANT00000005867
ENSOANG00000003700ENSOANP00000005866ENSOANT00000005868
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length950
Protein Sequence
(FASTA)
ETLMDTKWAT SELAWTAHPE TGWEEVSGYD EALNPIRTYQ VCNVQEASQN NWLRTGFVQR 60
QEVQRVYVEL KFTVRDCNSI PNIPGSCKET FNLFYYEADG DVASASSPFW MENPYVKVDT 120
IAPDESFSRL EAGRVNTKVR SFGPLSKAGF YLAFQDLGAC MSLISVRAFY KKCARTIAGF 180
ALFPETLTGA EPTSLVIAPG TCVPNAVEVS VPLKLYCNGD GEWMVPVGAC TCAAGFEAAA 240
KETQCQACPL GSFKAKQGDG PCLPCPANSR TTAAGATVCS CHSNFYRADS DPPDSACTTV 300
PSPPWSVISN VNETSLVLEW SEPRELGGRD DLLYNVICKK CSRCDDNVEF VPRQLGLTER 360
WVRVSRLLAH TRYSFEVQAV NGVSGKSPHP PRYTAVNITT NQAAPSEVPT MHLHSSSGSS 420
LTLSWAPPER PNGIILDYEM KYFEKSEGIA STVTSQDSVF LDGLRPDARY VVQVRARTVR 480
YQYSHPAELR PPTSPSPQCP GAQQLQEQLP LIVGSATAGL VFLVAVFVIA VVCLRKQRHN 540
SDSEYTEKLQ QYIAPGVKVY IDPFTYEDPN EAVREFAKEI DVSCVKIEEV IGAGEFGEVC 600
RGRLKQPGRR ELFVAIKTLK VGYTERQRRD FLSEASIMGQ FDHPNIIRLE GVVTKSRPVM 660
ILTEFMENCA LDSFLRLNDG QFTVIQLVGM LRGIAAGMKY LSEMNYVHRD LAARNILVNS 720
NLVCKVSDFG LSRFLEDDPA DPTYTSSLGG KIPIRWTAPE AIAYRKFTSA SDVWSYGIVM 780
WEVMSYGERP YWDMSNQDVI NAVEQDYRLP PPMDCPTALH QLMLDCWVRD RNLRPKFAQI 840
VNTLDKLIRN AASLKVIASV QTGVSQPLLD RTVPDYTTFT TVGDWLDAIK MGRYKESFVS 900
AGFASFDLVA QMTAEDLLRI GVTLAGHQKK ILSSIQDMRL QMNQTLPVQV 950
Nucleotide Sequence
(FASTA)
GAGACCCTCA TGGACACAAA ATGGGCGACT TCGGAGCTGG CGTGGACGGC CCATCCGGAG 60
ACTGGGTGGG AAGAGGTGAG CGGCTACGAC GAGGCGCTGA ACCCGATCCG GACGTACCAG 120
GTGTGCAACG TGCAGGAGGC CAGCCAGAAC AACTGGCTGC GGACCGGTTT TGTGCAGCGC 180
CAGGAGGTGC AGCGGGTCTA TGTGGAGCTC AAGTTCACGG TGCGGGACTG CAACAGCATC 240
CCCAACATCC CCGGCTCCTG CAAGGAGACC TTCAACCTCT TCTACTATGA GGCCGATGGC 300
GACGTGGCCT CTGCCTCCAG CCCCTTCTGG ATGGAGAACC CGTATGTGAA GGTGGACACC 360
ATCGCGCCCG ACGAGAGCTT CTCTCGTCTG GAGGCCGGGC GCGTCAACAC CAAAGTGCGC 420
AGCTTCGGAC CCCTGTCCAA GGCCGGCTTC TACCTGGCCT TTCAGGACCT GGGGGCCTGC 480
ATGTCGCTCA TCTCGGTCCG CGCCTTCTAC AAGAAGTGTG CCCGCACCAT CGCCGGCTTC 540
GCGCTCTTCC CCGAGACCCT CACGGGGGCC GAGCCCACCT CCCTGGTTAT CGCCCCGGGC 600
ACCTGCGTCC CCAACGCCGT GGAGGTCTCG GTGCCCCTCA AACTCTACTG CAACGGGGAC 660
GGCGAGTGGA TGGTGCCTGT GGGCGCCTGC ACCTGTGCCG CCGGCTTTGA GGCTGCCGCC 720
AAGGAGACGC AGTGCCAGGC CTGTCCCTTG GGGAGCTTCA AGGCCAAGCA GGGGGATGGG 780
CCCTGTCTGC CCTGCCCCGC CAACAGCCGC ACGACCGCGG CCGGAGCCAC CGTCTGCAGC 840
TGCCACAGCA ACTTCTACCG GGCCGACTCG GACCCGCCGG ACAGCGCCTG CACCACGGTG 900
CCATCCCCGC CGTGGAGCGT CATCTCCAAC GTGAACGAGA CGTCGCTGGT GCTGGAGTGG 960
AGCGAGCCGC GGGAACTGGG GGGCCGCGAC GATCTGCTCT ACAACGTCAT CTGCAAAAAG 1020
TGCTCCCGCT GCGACGACAA CGTGGAGTTC GTGCCGCGGC AGCTGGGTCT GACCGAGCGG 1080
TGGGTGCGAG TGAGCCGTCT GCTGGCCCAC ACGCGCTACA GCTTTGAGGT GCAGGCCGTC 1140
AACGGGGTCT CGGGCAAGAG CCCTCACCCC CCGCGCTATA CTGCCGTCAA CATCACCACC 1200
AACCAGGCCG CCCCCTCGGA GGTACCCACG ATGCACCTGC ACAGCAGCTC GGGCAGCAGC 1260
CTGACCCTGT CCTGGGCCCC TCCTGAGAGG CCTAATGGCA TCATCCTGGA CTACGAGATG 1320
AAATACTTTG AGAAGAGCGA GGGAATCGCG TCCACTGTGA CTAGCCAGGA CTCGGTATTC 1380
CTGGACGGGC TGAGGCCCGA TGCCCGCTAC GTAGTTCAGG TCCGAGCTCG CACTGTGCGG 1440
TATCAGTACA GCCACCCTGC TGAGTTGAGA CCACCGACCT CCCCTTCCCC TCAATGCCCA 1500
GGTGCCCAAC AGCTCCAAGA GCAGCTCCCG CTCATCGTGG GCTCGGCCAC TGCTGGACTC 1560
GTCTTCCTCG TGGCCGTCTT CGTCATCGCC GTCGTCTGTC TCAGGAAGCA ACGTCACAAC 1620
TCGGACTCGG AGTACACTGA GAAGCTGCAA CAGTACATTG CCCCTGGCGT GAAAGTTTAC 1680
ATCGATCCCT TCACCTACGA GGATCCGAAT GAGGCCGTGA GGGAATTTGC CAAAGAGATC 1740
GACGTCTCGT GCGTCAAGAT CGAGGAGGTG ATCGGAGCTG GGGAGTTCGG GGAGGTGTGC 1800
AGGGGCCGAC TGAAGCAGCC GGGCCGGCGG GAGCTGTTCG TTGCCATCAA GACGCTGAAG 1860
GTGGGGTACA CGGAGCGGCA GCGGCGGGAC TTTCTGAGCG AAGCCTCCAT CATGGGCCAG 1920
TTTGACCATC CCAACATCAT CCGGCTGGAG GGTGTGGTCA CCAAGAGCCG CCCCGTCATG 1980
ATCCTCACCG AGTTCATGGA GAACTGTGCC TTGGATTCCT TCCTGCGGCT GAACGACGGG 2040
CAGTTCACGG TGATCCAGCT GGTGGGCATG CTACGCGGGA TCGCCGCGGG CATGAAGTAC 2100
CTCTCGGAGA TGAACTACGT CCACCGCGAC CTGGCGGCCC GCAACATCCT GGTCAACAGC 2160
AATCTGGTCT GCAAGGTCTC TGACTTTGGC CTCTCCCGTT TCCTCGAGGA TGACCCTGCC 2220
GACCCCACCT ACACCAGCTC CCTGGGCGGG AAGATCCCTA TCCGCTGGAC GGCCCCCGAA 2280
GCCATCGCCT ACCGCAAGTT CACGTCGGCC AGTGATGTCT GGAGCTACGG GATCGTCATG 2340
TGGGAAGTGA TGAGCTACGG AGAGCGGCCC TACTGGGACA TGAGCAACCA GGACGTGATC 2400
AATGCAGTGG AACAGGACTA TCGTCTGCCC CCACCCATGG ACTGTCCCAC CGCGCTGCAC 2460
CAGCTCATGC TGGACTGCTG GGTACGCGAC CGGAACCTGC GGCCCAAGTT CGCCCAGATC 2520
GTCAACACTC TGGACAAGCT GATCCGCAAC GCCGCCAGCC TGAAGGTCAT CGCCAGCGTC 2580
CAGACCGGGG TGTCCCAACC ACTGCTGGAC CGCACAGTGC CCGACTACAC CACCTTCACC 2640
ACCGTGGGCG ACTGGCTGGA CGCCATCAAG ATGGGGCGGT ACAAGGAGAG TTTCGTCAGC 2700
GCTGGCTTCG CCTCCTTCGA CCTCGTGGCC CAGATGACAG CAGAGGACCT GCTCCGGATC 2760
GGGGTGACTC TGGCCGGTCA CCAGAAGAAG ATCCTGAGCA GCATCCAGGA CATGCGGCTG 2820
CAGATGAACC AGACTCTCCC GGTGCAGGTC TGA 2853
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevc+Grlk+pg+re+ vaiktlk g+te+qrrdflseasi+Gqfdhp
Q: 585   VKIEEVIGAGEFGEVCRGRLKQPGRRELFVAIKTLKVGYTERQRRDFLSEASIMGQFDHP  644
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtks+pvmi+te+men+aldsflr +dgqftviqlvgmlrGia+gmkyls+m
Q: 645   NIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEM  704
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt+s ggkipirwtapeaiay
Q: 705   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPaDPTYTSSlGGKIPIRWTAPEAIAY  764
         ***********************************9*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+syGerpywdmsnqdvi+a+e++yrlpppmdcp+al+qlml
Q: 765   RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLML  824
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcw +dr+ rpkf+qiv++l
Q: 825   DCWVRDRNLRPKFAQIVNTL  844
         *****************975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVCRGRL KQPGRRELFV AIKTLKVGYT ERQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT KSRPVMILTE FMENCALDSF LRLNDGQFTV IQLVGMLRGI AAGMKYLSEM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDPADPTY TSSLGGKIPI RWTAPEAIAY 180
RKFTSASDVW SYGIVMWEVM SYGERPYWDM SNQDVINAVE QDYRLPPPMD CPTALHQLML 240
DCWVRDRNLR PKFAQIVNTL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00007
EKS-ANC-00006
EKS-BOT-00005
EKS-CAJ-00014
EKS-CAF-00007
EKS-CAP-00005
EKS-DAR-00007
EKS-DIO-00001
EKS-EQC-00007
EKS-FEC-00005
EKS-GAM-00001
EKS-GAG-00007
EKS-GAA-00005
EKS-GOG-00006
EKS-HOS-00008
EKS-ICT-00006
EKS-LAC-00005
EKS-LOA-00005
EKS-MAM-00006
EKS-MEG-00006
EKS-MIM-00001
EKS-MOD-00005
EKS-MUM-00007
EKS-MUP-00007
EKS-MYL-00008
EKS-NOL-00007
EKS-ORN-00006
EKS-ORC-00007
EKS-ORL-00004
EKS-OTG-00006
EKS-PAT-00007
EKS-PES-00005
EKS-PEM-00001
EKS-POA-00004
EKS-PTV-00003
EKS-RAN-00007
EKS-SAH-00006
EKS-SUS-00005
EKS-TAG-00006
EKS-TAR-00004
EKS-TEN-00005
EKS-TUT-00006
EKS-XET-00006
EKS-XIM-00005
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0008046; F:axon guidance receptor activity
GO:0005003; F:ephrin receptor activity
GO:0007411; P:axon guidance
GO:0016477; P:cell migration
GO:0046777; P:protein autophosphorylation
GO:0043088; P:regulation of Cdc42 GTPase activity
GO:0022407; P:regulation of cell-cell adhesion
GO:0032314; P:regulation of Rac GTPase activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013